简介：AbstractIntroduction:Vitiligo and psoriasis are common skin diseases, while its co-occurrence in one patient is rare.Here, we reported a patient with co-occurrence of vitiligo and psoriasis.Case presentation:An 11-year-old girl developed depigmented patches on her right chin for 6 months. The noticed areas of depigmented skin steadily increased in size with no clinical symptoms. Wood’s lamp examination and laser scanning confocal revealed the clinical diagnosis of co-occurrence of vitiligo and psoriasis.Discussion:Speculations related to co-pathogenesis of vitiligo and psoriasis are still elusive, some explanations of this phenomenon like of isomorphic reaction, shared genetic basis of autoimmunity and inflammation, shared cellular immune pathways including Th1, Th17 and related cellular molecules such as TNF-α, IFN-α, IL-17 have been reported.Conclusion:The analysis and summary of the underlying association in co-occurrence of psoriasis and vitiligo may amplify future therapeutic options for both disease. Clinicians should pay attention to the methods that could simultaneously improve these two conditions.

简介：摘要： 从试验技术研究方面入手 ,组织安排开采倾斜近地表矿体地表及围岩变形的平面应力模型试验， 和高地应力条件下， 坚硬脆性围岩洞室周边应力分布及围岩变形与破坏的平面应变模型试验 ,并用相关数值计算软件进行模型试验结果的对比分析。

简介：【摘要】：目的：分析孕 11～ 13+6周胎儿超声的临床价值 。方法： 采取在 2018年 6 月 2019年 6 月期间出现产前超声异常的胎儿，并进行回顾性 的分析 。 结果：进行正规产检的单胎妊娠的孕妇有 3000 例，经过产前检查发现异常的有 70 例，在 11 周 -13+6 周检查后出现异常的有 50 例，其中有严重畸形的胎儿共 30 例，染色体相关检查 20 例中，有 7 例异常，其中有 2 例核型异常， 5 例 NIPT 阳性，而中晚期检查出 34 例异常胎儿 。结论：通过早期的孕检能够有效的发现胎儿是否出现了异常，还需要结合相关的诊疗指标，尽量做到早诊断早干预早治疗，这样才能保证母婴的健康。

简介：摘要目的分析中重型新生儿血友病的临床特点，提高对中重型新生儿血友病的认识。方法对2012年1月至2019年6月我院NICU收治的11例中重型新生儿血友病的病例资料进行回顾性分析，分析11例患儿的临床特征，实验室检查结果，治疗和预后。结果11例患儿均为男性，均为甲型血友病。7例并发颅内出血，其中1例颅内出血较重，并发脑疝。其余颅内出血患儿仅2例有神经系统异常。1例右侧肾上腺血肿，1例腹膜后血肿。9例有黄疸表现，7例患儿黄疸出现均在生后2 d内，最早出现在生后12 h，总胆红素最高388 μmol/L。11例活化部分凝血活酶时间(APTT)明显延长，凝血因子Ⅷ明显缺乏，8例中间型，3例重型。4例行基因检测。3例患儿输注新鲜冰冻血浆及冷沉淀，其余患儿输注重组凝血因子Ⅷ制剂。经治疗10例患儿病情好转后出院，1例患儿家长放弃治疗后死亡。结论中重型新生儿血友病常并发颅内、腹腔等隐匿部位出血，常伴发高胆红素血症，应及时行影像学检查排除隐匿部位出血，尽早行凝血功能及凝血因子活性检测，并按照不同出血部位不同预期因子水平计算予以补充凝血因子。

简介：【摘要】电力公司的政工人员作为影响政治思想工作有效性的主要因素，其对于公司公司思想文化的建设具有重要的促进作用。只有保证电力公司的政工队伍建设的有效性，人员政治思想理念的先进性，才能使得公司具有足够的思想活力，从而获得经济及社会利益的双重丰收。因此，在电力行业快速发展的背景下，必须要深入公司政工人员作用的发挥策略。

简介：摘要： 近些年，随着我国的发展， 我国经济、政治、文化实力的不断增强，无论是在信息技术的发展还是企业的发展上都迎来了无限可能，人们消费能力的不断增长，对电力企业提出了新的发展要求，本文将就企业政工人员素质对政工队伍建设的重要意义做简单的探讨。

简介：摘要：近年来，随着国家对环保产业的重视，水务行业发展势头迅猛，竞争愈发激烈，水务公司想要保持发展优势，维持原有的利润水平就必须强化内部管理，从内部寻求降本增效的方法。在这样的背景下，水务运营公司开始通过绩效考核等管理手段，不断地提升项目管理水平，进行了一系列的探索，在指标的选择、范围的选择等方面取得了初步的成果，也为今后的绩效管理提供的经验。

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简介：摘要： 采用西门子 S7-200系列的可编程控制器为该温度控制系统的核心控 制 器件采用PID算法，选择 PT100为温度传感器对 室 内的温度进行采集，将采集到的温度信号转为模拟信号通过EM235模块直接传输给 PLC， PLC对 传输来的信号，通过控制温度的模块来控制温度保持在适宜的温度。

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简介：摘要目的探讨7型腺病毒肺炎患儿的临床特征。方法回顾性分析2019年1月至2019年9月厦门市儿童医院收治的20例7型腺病毒肺炎患儿的临床资料，对患儿的临床表现、实验室检查、肺部影像学资料、纤维支气管镜镜下表现、治疗方案及疗效等进行分析，并随访观察患儿预后情况。结果20例7型腺病毒肺炎患儿均伴有发热、咳嗽，易出现呼吸困难；易引发肝功能异常、心肌损伤等合并症。20例患儿均有不同程度的乳酸脱氢酶(LDH)升高，重症患儿常合并降钙素原(PCT)升高。易混合其他病原体感染，其中以肺炎支原体感染居多，其次是流感嗜血杆菌、肺炎链球菌、烟曲霉菌。胸部影像学检查可见肺实变不张，以左下肺、右下肺为主，合并患侧少量胸腔积液。部分患儿后期遗留支气管扩张或闭塞性细支气管炎；经纤维支气管镜检查主要表现为气道黏膜充血、水肿，部分出现黏液栓甚至塑型支气管炎形成。所有患儿经综合治疗后均病情好转出院。结论7型腺病毒肺炎发病急，病情重，合并症多，病程长，缺乏特异性治疗，且易出现混合感染，导致病情迁延、反复，加大治疗难度，后期遗留后遗症概率高。适时行纤维支气管镜及肺泡灌洗治疗，对于疾病的诊断及治疗均有非常重要的意义。

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简介：摘要目的分析2～7岁儿童功能性便秘的影响因素。方法采用病例对照研究方法，选取2019年5月20日至2019年9月20日在北京大学第三医院儿科就诊的2～7岁功能性便秘儿童及同期同年龄健康对照儿童为研究对象。通过问卷研究对象收集一般情况、排便情况及可能影响便秘产生的因素，包括0.5岁内抗生素使用、乳儿期喂养情况、饮食偏好、运动、过敏相关病史、父母病史、家庭收入、主要看护人等信息，采用二元Logistic回归模型分析功能性便秘的影响因素。结果共纳入研究对象203例，其中便秘组儿童81例，健康对照组122例。粪便粗大、粪便干结、排便疼痛和排便次数减少是功能性便秘最常见的症状。添加辅食及上幼儿园是该年龄段儿童出现功能性便秘最常见的诱因。单因素分析发现，6月龄内应用抗生素史、挑食偏食习惯、运动量及变应性疾病、便秘相关家族史及父亲变应性疾病背景、主要看护人是否为父母差异均有统计学意义(均P<0.05)。二元Logistic回归分析显示，父亲有变应性疾病病史(OR＝2.302，95%CI：1.109～4.780)、0.5岁内应用抗生素(OR＝2.300，95%CI：1.053～5.022)、父母有便秘病史(OR＝2.151，95%CI：1.106～4.128)及偏好主食的饮食习惯(OR＝3.526，95%CI：1.402～8.867)是2～7岁儿童发生功能性便秘的影响因素。结论父母有便秘病史、父亲有变应性疾病病史及偏好主食的饮食习惯可能是功能性便秘发生的影响因素。

简介：1、浙江临安大气成分本底国家野外科学观测研究站  311300， 2、浙江省杭州市临安区气象局 311300， 3、中国气象科学研究院浙江分院 311300 摘要： 2019年 7月 12日 10时到 13日 20时临安区普降大暴雨，全区面雨量 140.2 mm，最大清凉峰风景区 195.8毫米，直接经济损失 3814.5万元。此次过程中，临安上空中高层槽的稳定维持，低层急流发展、低涡东移为降水提供良好动力条件。来自南海和东海的水汽先后补充，使中低层大气有较好的水汽提条件。本文通过对此次天气过程的降水机制分析 ,为本地暴雨预报预警等灾害天气提供参考依据，对于防灾减灾和减少灾害损失具有一定的现实意义。

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简介：AbstractBackground:Circular RNA ciRS-7 has been reported to be involved in the progression of various cancers. However, ciRS-7 expression and its role in clear cell renal cell carcinoma (ccRCC) progression remains unclear. This study aimed to investigate the effect of ciRS-7 expression on ccRCC and the related signaling pathway.Methods:ciRS-7 expression was analyzed using quantitative reverse transcription polymerase chain reaction in 87 pairs of ccRCC and matched adjacent normal tissues. The role of ciRS-7 in ccRCC cell proliferation and invasion was determined using the cell counting kit-8 and invasion assays, respectively. Potential mechanisms underlying the role of ciRS-7 in promoting ccRCC progression were explored by Western blotting. The relationship between the expression of ciRS-7 and features of ccRCC was analyzed by the Chi-square test and progression-free survival was determined using a Kaplan-Meier plot.Results:ciRS-7 was overexpressed in ccRCC tissues compared with that in matched adjacent normal tissues. In addition, ciRS-7 up-regulation was closely associated with tumor diameter (P = 0.050), clinical stage (P = 0.009), and distant metastasis (P = 0.007). ciRS-7 knockdown in 786O and 769P cells markedly inhibited their proliferative and invasive abilities. In addition, ciRS-7 inhibition reduced phosphorylated epidermal growth factor receptor (p-EGFR) and phosphorylated serine/threonine kinase (p-Akt) levels.Conclusions:ciRS-7 up-regulation could promote ccRCC cell proliferation and invasion, which may be related with the EGFR/Akt signaling pathway. ciRS-7 might be a potential ccRCC therapeutic target.

简介：AbstractImportance:Graves’ disease (GD) is rare in children under the age of 7 years. Children with this disease exhibit greater thyrotoxicity at diagnosis and require a longer course of medical therapy, compared with pubertal and postpubertal children and adults.Objective:To investigate the clinical features and identify predictors of remission in children under the age of 7 years with GD.Methods:This retrospective study included 77 children who were diagnosed with GD under the age of 7 years and were treated in the Department of Endocrinology, Beijing Children’s Hospital from 2010 to 2018. Clinical manifestations, laboratory data, and follow-up records were collected for all patients. Children who achieved remission of treatment with methimazole were compared with those who had persistent disease to identify which variables were associated with remission; multiple logistic regression and Cox regression analyses were used to evaluate interactions among predictive variables.Results:Sixty-three boys and 14 girls were included; the median age at diagnosis was 4.2 years (interquartile range: 3.2-5.3 years). Forty-six (56.7%) patients had no family history of thyroid disease, 17 patients had family history of thyroid disease and 14 patients with unknown family history. Of the 77 patients, 18 (23.4%) patients achieved remission of treatment with methimazole and 59 patients did not; moreover, 51 (66.2%) had Graves’ ophthalmopathy. Univariate analyses revealed no significant differences between the remission group and non-remission group in terms of age at diagnosis, sex, initial goiter size, or initial thyroid hormone concentration. However, there were a trend of correlation between the initial level of thyroid peroxidase antibody (TPOAb) and remission status (univariate analysis OR 1.002, P = 0.038; multivariate analysis OR 1.004, P = 0.019). Similar results were observed in univariate analysis of the initial thyrotropin receptor antibody (TRAb) level, but this association was not significant in multivariate analysis. Cox regression analyses revealed that children with high TRAb level required longer duration of remission, compared with low TRAb level (OR 0.950, 95% CI 0.904-0.997, P = 0.037).Interpretation:Initial TRAb level was an independent predictor of remission outcome in young children under the age of 7 years with GD. Initial TRAb level may predict the likelihood of remission in patients with young-age-of-onset GD.

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简介：摘要泛素-蛋白酶途径可调节多种细胞过程，近年来以该途径为导向的研究逐渐增多。特异性蛋白酶7作为其调节泛素化动力学的关键成分——去泛素化酶家族成员之一，参与病毒复制、肿瘤、神经系统病变、炎症反应等多种疾病的相关蛋白调控。在过去十多年进行了一系列的相关疾病及其抑制剂研究，一些抑制剂已经初步显现出其对肿瘤、炎症等疾病的治疗意义。本文就特异性蛋白酶7的结构、功能及其与疾病的关联和其抑制剂进行综述。