简介:Objective:Estimationofactivityaccumulatedintumorandorgansisveryimportantinpredictingtheresponseofradiopharmaceuticalstreatment.Inthisstudy,wesynthesized177Lutetium(177Lu)-trastuzumabironoxidenanoparticlesasadoubleradiopharmaceuticalagentfortreatmentandbetterestimationoforganactivityinanewwaybymagneticresonanceimaging(MRI).Methods:177Lu-trastuzumab-ironoxidenanoparticlesweresynthesizedandallthequalitycontroltestssuchaslabelingyield,nanoparticlesizedetermination,stabilityinbufferandbloodserumupto4d,immunoreactivityandbiodistributioninnormalmiceweredetermined.Inmicebearingbreasttumor,liverandtumoractivitieswerecalculatedwiththreemethods:singlephotonemissioncomputedtomography(SPECT),MRIandorganextraction,whichwerecomparedwitheachother.Results:Thegoodresultsofqualitycontroltests(labelingyield:61%±2%,meannanoparticlehydrodynamicsize:41±15nm,stabilityinbuffer:86%±5%,stabilityinbloodserum:80%±3%,immunoreactivity:80%±2%)indicatedthat177Lu-trastuzumab-ironoxidenanoparticlescouldbeusedasadoubleradiopharmaceuticalagentinmicebearingtumor.Resultsshowedthat177Lu-trastuzumab-ironoxidenanoparticleswithMRIhadtheabilitytomeasureorganactivitiesmoreaccuratethanSPECT.Conclusions:Co-conjugatingradiopharmaceuticaltoMRIcontrastagentssuchasironoxidenanoparticlesmaybeagoodwayforbetterdosimetryinnuclearmedicinetreatment.
简介:Inthepresentanalysisontherelationshipsamongthedepthoflithospherebrittlefracture,seismotectonicsandgeothermalanomalousactiveinTibetanplateauwereinvestigatedusingtheseismicdadafromISCandChineseseismicnetandgeothermaldata.Theresultssuggestthattheregionofanomalouslygeothermalactivityalmostcoincideswiththatofthenormalfaultingtypeearthquake.Thegeothermalanomalyactivityregioncoincidesspatiallywiththatoftheeventsdeeperthan60kmaswellas.Thenormalfaultingearthquakesmaybemainlytectonicactivityregimesuntil110kmdeepinthethermalanomalyregion.ThestrikedirectionsofeventsarelikelytheN-Sdirection,coincidingwiththestrikeofthethermalanomalyactivebelts.Theearthquakesalignalongthenormalfaultsandfaulted-depressionzonewiththeN-Sdirection.Thethermalanomalyactivityalsodistributesalongthefaulted-depressionzone.Manyeventsdeeperthan60kmexistintheanomalouslygeothermalactivityregionintheplateau.Eventsextendtobottomofthelithosphereof110kmfromthesurface,likecolumnarseismiccrowd.ThelithosphereextendsalongtheE-WdirectionduetotheE-WextensionalstressinthecentralandsouthernTibetanplateau,altitudeoftheplateau.ThetensionalstressintheE-WresultsinthelithospherefracturesandthenormalfaultsstrikingN-Sdirection,grabensandfaulted-depressionzones.Thermalmaterialfromtheasthenospherewellsupwardtothesurfacealongdeepseismicfracturesandfaultsthroughthethickcrust.TheanomalouslythermalactivitiesareattributabletotheupwellingthermalmaterialfromthemantleinthealtitudeofTibetanplateau.
简介:ByapplyinganewvortexdetectionmethodtotheECMWF40-yrreanalysis(ERA40)datafrom1985to2002,theclimatologyofsummervorticeshasbeeninvestigatedinfivesubtropicalregions,i.e.,thenorthwesternPacific,northeasternPacific,northwesternAtlantic,northeasternAtlantic,andAustralia-SouthPacific,followedbyvalidationwithNCEP/NCARreanalysisdata.Resultsareasfollows:(1)ThespatialdistributionsofERA40vortexactivities(VAC)werewellconsistentwiththoseofNCEP/NCARreanalysis(NRA)resultsinallregions,especiallyinnorthwesternPacific.(2)Becauseofdifferentmodelresolutions,boththenumberandintensityofvorticesobtainedfromNRAweresignificantlyweakerthanERA40's.(3)Vorticesmainlycruisedincoastsandtheadjacentseas,fromwheretothelandortheopenseavortexactivitiesweregraduallydecreased.(4)ThereweretwoactivecentersinthenorthwesternPacific:onewaslocatedinSouthChinaSeaandtheother,asthelargestcenterofthefiveregions,spreadfromtheeastsideofthePhilippinestoJapan.(5)OverthenorthwesternAtlantic,mostvorticesoccurredinPanamaanditswest-sideoffshore.(6)ThespatialdistributionsofvorticeswerealikebetweenthenortheasternPacificandnortheasternAtlantic,bothspreadingfromcoaststothewest-sideseaat5°-20°N.(7)IntheAustralia-SouthPacific,vorticeswerenotasactiveasthoseintheotherfourregions,andmostlytookplaceintheequator-sideofnearoceanareas.(8)ExceptthenorthwesternPacificandnorthwesternAtlantic,theVACinterannualvariationsintheotherthreeregionsweredifferentbetweenERA40andNRAdata.(9)InthenorthwesternPacificandnorthwesternAtlantic,theVACinterannualvariationcouldbeseparatedtoseveraldistinctstages.(10)Sincethemid1980s,meanvortexintensitywasgettingincreasedinthenorthwesternPacific,whichwasmostsignificantinthesubtropicalareasonaglobalbasis.InthewesternNorthAtlantic,therewasadecreasing(increasing)trendofthemeanvortexintensitybefo
简介:在allosteric酶和底层之间的有约束力的过程上的使活跃之物分子和压抑的分子的效果被考虑绑在allosteric酶的调整分子的heterotropic效果讨论。有heterotropic效果的allosteric酶的一个模型被介绍。在规定过程的cooperativity和anticooperativity被学习。
简介: IllustrationAllthedatainthiscatalogarechosenfromthe"PreliminarySeismologicalReportofChineseSeismicStations"(Itsabbreviationis"MonthlyReport").ThecatalogincludestheeventsofM≥4.7inandnearChinaandM≥6allovertheworld.The"MonthlyReport"ismonthlycompiledbvtheNinthSectionofInstituteofGeophysics,CSB.……
简介: Illustration Allthedatainthiscatalogarechosenfromthe"PreliminarySeismologicalReportofChineseSeismicStations"(Itsabbreviationis"MonthlyReport").……
简介:EuphorbiakansuiisacommonlyusedtraditionalChinesemedicineforthetreatmentofedema,pleuraleffusion,andasthma,etc.Accordingtothepreviousresearches,terpenoidsinE.kansuipossessvariousbiologicalactivities,e.g.,anti-virus,anti-allergy,antitumoreffects.Inthiswork,twentyfiveterpenoidswereisolatedfromE.kansui,includingthirteeningenane-andeightjatrophane-typediterpenoids(withtwonewcompounds,kansuininPandQ)andfourtriterpenoids.EighteenofthemwereanalyzedbyMTSassayforinvitroanticanceractivityinfivehumancancercelllines.Structure-activityrelationshipfor12ingenane-typediterpenoidsincolorectalcancerColo205cellswerepreliminarystudied.Significantanti-proliferationactivitieswereobservedinhumanmelanomacellsbreastcancerMDA-MB-435cellsandColo205cells.Morethanhalfoftheisolatedingenane-typediterpenoidsshowedinhibitoryactivitiesinMDA-MB-435cells.Eightingenane-andonejatrophane-typediterpenoidspossessedmuchlowerIC_(50)valuesinMDA-MB-435cellsthanpositivecontrolstaurosporine.Preliminarystructure-activityrelationshipanalysisshowedthatsubstituentonposition20wasimportantfortheactivityofingenane-typediterpenoidsinColo205cellsandsubstituentonposition3contributedmoresignificantbiologicalactivityofthecompoundsthanthatonposition5inbothMDA-MB-435andColo205cells.
简介:温室实验被进行在在正常、含硒的土壤上种的二个米饭变化(PR116和PusaBasmati1121)调查硒累积和它的抗氧化剂反应。植物生长在早发展的阶段被减少,flowering被10d的一个时期在含硒的土壤上推迟。3–20和13–14增加的硒累积在叶子合拢,在从PusaBasmati1121和PR116变化的谷物的18和3褶层分别地。在从在含硒的土壤上种的大米植物的叶子的硒累积导致了叶绿素内容,氢过氧化物,脯氨酸,免费氨基酸,全部的酚和丹宁内容的重要增加。而过氧化氢酶活动显示出一个反向的趋势,在叶子的类脂化合物peroxidation层次和peroxidase活动增加了。硒累积减少了,这被结束在在庄稼期间,开发而是这些种的米饭的干燥的事内容能由在他们的防卫系统导致改变与硒毒性作斗争。
简介:Zygosaccharomycesrouxiiisasalt-tolerantyeastspeciescapableofremovingcadmium(Cd)pollutantfromaqueoussolution.Presently,thephysiologicalcharacteristicsofZ.rouxiiunderthestressofsodiumchloride(NaCl)andCdarepoorlyunderstood.ThisstudyinvestigatedtheeffectsofNaClandCdonthegrowth,oxidativestressandantioxidantenzymeactivitiesofZ.rouxiiafterstresstreatmentfor24h.ResultsshowedthatNaClorCdalonenegativelyaffectedthegrowthofZ.rouxii,butthegrowth-inhibitingeffectofCdonZ.rouxiiwasreducedinthepresenceofNaCl.FlowcytometryassayshowedthatunderCdstress,NaClsignificantlyreducedtheproductionofreactiveoxygenspecies(ROS)andcelldeathofZ.rouxiicomparedwiththoseintheabsenceofNaCl.Theactivitiesofsuperoxidedismutase(SOD),catalase(CAT),andperoxidase(POD)ofZ.rouxiiweresignificantlyenhancedby2%–6%NaCl,whichlikelycontributedtothehighsalttoleranceofZ.rouxii.ThePODactivitywasinhibitedby20mgL-1CdwhiletheSODandCATactivitieswereenhancedby8mgL-1Cdandinhibitedby20mgL-1or50mgL-1Cd.Theinhibitoryeffectofhigh-levelCdontheantioxidantenzymeactivitiesofZ.rouxiiwascounteractedbythecombineduseofNaCl,especiallyat6%.ThisprobablyaccountedforthedecreaseinCd-inducedROSproductionandcelldeathofZ.rouxiiafterincubationwithNaClandCd.OurworkprovidedphysiologicalcluesastotheuseofZ.rouxiiasabiosorbentforCdremovalfromseawaterandliquidhighlysaltyfood.
简介:Theeffectsofpolishingonproximatecompositions,physico-chemicalcharacteristics,mineralcompositionsandantioxidantpropertiesofthericefloursobtainedfromthreedifferentpigmentedricevarieties(Chak-haoAngangba,Chak-haoAmubiandChak-haoPoireiton)wereinvestigated.Thericevarietiesweresignificantly(P<0.05)differentinthecontentsofthetestcharacteristics.Lipids,ash,minerals,phytochemicals(phenolicacidsandflavonoids)and2,2-diphenyl-1-picrylhydrazyl(DPPH)activityofricefloursweredecreasedafterpolishing(9%degreeofmilling),whileamylosecontentandlightnesswereincreased.X-raydiffractionpatternofricefloursexhibitedA-typecrystallinepatternwithreflectionsat15.1o,17.1o,18.2oand23.0o.Pastingpropertiesandtransitiontemperaturesweredecreasedafterpolishingtreatment.Polishingresultedinchangesinthecrystallinity,enthalpyandmorphologyofriceflours.
简介:Presentstudywasconductedtocharacterisetenrice(OryzasativaL.)cultivarsviz.IET-23466,Dhan-201,IET-23448,MAS-946,IET-23445,IET-23463,IET-23455,PR-123,PR-115andIET-23449basedonantioxidants(totalphenolics,flavonolsandtannins),bioactivecompounds(phyticacid,gammaaminobutyricacid,tocopherolandreducedascorbate)andantioxidantactivity(1,1-diphenyl-2-picrylhydrazylradicalscavengingactivity,hydroxylradicalscavengingactivity,freeradicalantioxidantpowerandtotalreducingpower)withanaimtoidentifycultivarscontaininghigherhealthpromotingcomponentsaftergermination.ThreecultivarsIET-23466,IET-23463andPR-123performedbetterasrevealedbyhigherlevelofantioxidants,bioactivecompoundsandantioxidantactivitybeforeandaftergermination.ThreecultivarsMAS-946,IET-23445andIET-23449hadmoderatelevelofantioxidants,bioactivecompoundsandantioxidantactivity.FourcultivarsDhan-201,IET-23448,IET-23455andPR-115performedintermediately.Strongpositivecorrelationwasobservedamongtotalphenolicsandtheantioxidantactivity.Phyticacidwasfoundtobenegativelycorrelatedtotheantioxidantactivity.OurresultshighlightedthatcultivarsIET-23466,IET-23463andPR-123holdgreatpotentialaftergerminationandwouldopenupausefulopportunityforthefunctionalfoodindustry,andconsumptionofthesecultivarsaftergerminationwouldaffordhealthbenefitstoconsumerssincetheycontainhigherlevelofantioxidants.
简介:瞄准:为了在streptozotocin(STZ)的阴囊的组织每氧化(LPO)和抗氧化剂酶的活动在类脂化合物上检验melatonin治疗的效果,导致了糖尿病的老鼠。方法:26只雄的老鼠随机如下被划分成三个组:组我,控制,非糖尿病的老鼠(n=9);组II,导致STZ的、未经治疗的糖尿病的老鼠(n=8);组III,导致STZ,对待melatonin(10mg/kg的剂量。白天)糖尿病的老鼠(n=9)。后面的8星期的melatonin处理,所有老鼠被使麻木然后被打死把睾丸从阴囊移开。结果:作为与组相比我,在老鼠组II的阴囊的纸巾,malondialdehyde(MDA)的增加的层次(P<0.01)并且超级氧化物歧化酶(草皮)(P<0.01)象过氧化氢酶(猫)的减少的层次一样(P<0.01)并且谷胱甘肽过氧化物酶(GSH-Px)(P>0.05)被发现。相反作为与组II相比,在老鼠组III的阴囊的纸巾,MDA的层次减少了(但是这减少不是重要的,P>0.05)并且草皮(P<0.01)象猫一样(P<0.05)增加。GSH-Px没被任何处理影响。Melatonin显著地没影响糖尿病的组的提高的葡萄糖集中。在学习的结束,借助于身体和阴囊的重量在对待melatonin的组和未经治疗的组之间没有有效差量。结论:糖尿病增加氧化应力,melatonin每氧化和力量禁止类脂化合物调整糖尿病的老鼠睾丸的抗氧化剂酶的活动。