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简介：Objective:Estimationofactivityaccumulatedintumorandorgansisveryimportantinpredictingtheresponseofradiopharmaceuticalstreatment.Inthisstudy,wesynthesized177Lutetium(177Lu)-trastuzumabironoxidenanoparticlesasadoubleradiopharmaceuticalagentfortreatmentandbetterestimationoforganactivityinanewwaybymagneticresonanceimaging（MRI）.Methods:177Lu-trastuzumab-ironoxidenanoparticlesweresynthesizedandallthequalitycontroltestssuchaslabelingyield,nanoparticlesizedetermination,stabilityinbufferandbloodserumupto4d,immunoreactivityandbiodistributioninnormalmiceweredetermined.Inmicebearingbreasttumor,liverandtumoractivitieswerecalculatedwiththreemethods:singlephotonemissioncomputedtomography（SPECT）,MRIandorganextraction,whichwerecomparedwitheachother.Results:Thegoodresultsofqualitycontroltests（labelingyield:61%±2%,meannanoparticlehydrodynamicsize:41±15nm,stabilityinbuffer:86%±5%,stabilityinbloodserum:80%±3%,immunoreactivity:80%±2%）indicatedthat177Lu-trastuzumab-ironoxidenanoparticlescouldbeusedasadoubleradiopharmaceuticalagentinmicebearingtumor.Resultsshowedthat177Lu-trastuzumab-ironoxidenanoparticleswithMRIhadtheabilitytomeasureorganactivitiesmoreaccuratethanSPECT.Conclusions:Co-conjugatingradiopharmaceuticaltoMRIcontrastagentssuchasironoxidenanoparticlesmaybeagoodwayforbetterdosimetryinnuclearmedicinetreatment.

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简介：Inthepresentanalysisontherelationshipsamongthedepthoflithospherebrittlefracture,seismotectonicsandgeothermalanomalousactiveinTibetanplateauwereinvestigatedusingtheseismicdadafromISCandChineseseismicnetandgeothermaldata.Theresultssuggestthattheregionofanomalouslygeothermalactivityalmostcoincideswiththatofthenormalfaultingtypeearthquake.Thegeothermalanomalyactivityregioncoincidesspatiallywiththatoftheeventsdeeperthan60kmaswellas.Thenormalfaultingearthquakesmaybemainlytectonicactivityregimesuntil110kmdeepinthethermalanomalyregion.ThestrikedirectionsofeventsarelikelytheN-Sdirection,coincidingwiththestrikeofthethermalanomalyactivebelts.Theearthquakesalignalongthenormalfaultsandfaulted-depressionzonewiththeN-Sdirection.Thethermalanomalyactivityalsodistributesalongthefaulted-depressionzone.Manyeventsdeeperthan60kmexistintheanomalouslygeothermalactivityregionintheplateau.Eventsextendtobottomofthelithosphereof110kmfromthesurface,likecolumnarseismiccrowd.ThelithosphereextendsalongtheE-WdirectionduetotheE-WextensionalstressinthecentralandsouthernTibetanplateau,altitudeoftheplateau.ThetensionalstressintheE-WresultsinthelithospherefracturesandthenormalfaultsstrikingN-Sdirection,grabensandfaulted-depressionzones.Thermalmaterialfromtheasthenospherewellsupwardtothesurfacealongdeepseismicfracturesandfaultsthroughthethickcrust.TheanomalouslythermalactivitiesareattributabletotheupwellingthermalmaterialfromthemantleinthealtitudeofTibetanplateau.

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简介：ByapplyinganewvortexdetectionmethodtotheECMWF40-yrreanalysis(ERA40)datafrom1985to2002,theclimatologyofsummervorticeshasbeeninvestigatedinfivesubtropicalregions,i.e.,thenorthwesternPacific,northeasternPacific,northwesternAtlantic,northeasternAtlantic,andAustralia-SouthPacific,followedbyvalidationwithNCEP/NCARreanalysisdata.Resultsareasfollows:(1)ThespatialdistributionsofERA40vortexactivities(VAC)werewellconsistentwiththoseofNCEP/NCARreanalysis(NRA)resultsinallregions,especiallyinnorthwesternPacific.(2)Becauseofdifferentmodelresolutions,boththenumberandintensityofvorticesobtainedfromNRAweresignificantlyweakerthanERA40's.(3)Vorticesmainlycruisedincoastsandtheadjacentseas,fromwheretothelandortheopenseavortexactivitiesweregraduallydecreased.(4)ThereweretwoactivecentersinthenorthwesternPacific:onewaslocatedinSouthChinaSeaandtheother,asthelargestcenterofthefiveregions,spreadfromtheeastsideofthePhilippinestoJapan.(5)OverthenorthwesternAtlantic,mostvorticesoccurredinPanamaanditswest-sideoffshore.(6)ThespatialdistributionsofvorticeswerealikebetweenthenortheasternPacificandnortheasternAtlantic,bothspreadingfromcoaststothewest-sideseaat5°-20°N.(7)IntheAustralia-SouthPacific,vorticeswerenotasactiveasthoseintheotherfourregions,andmostlytookplaceintheequator-sideofnearoceanareas.(8)ExceptthenorthwesternPacificandnorthwesternAtlantic,theVACinterannualvariationsintheotherthreeregionsweredifferentbetweenERA40andNRAdata.(9)InthenorthwesternPacificandnorthwesternAtlantic,theVACinterannualvariationcouldbeseparatedtoseveraldistinctstages.(10)Sincethemid1980s,meanvortexintensitywasgettingincreasedinthenorthwesternPacific,whichwasmostsignificantinthesubtropicalareasonaglobalbasis.InthewesternNorthAtlantic,therewasadecreasing(increasing)trendofthemeanvortexintensitybefo

简介：在allosteric酶和底层之间的有约束力的过程上的使活跃之物分子和压抑的分子的效果被考虑绑在allosteric酶的调整分子的heterotropic效果讨论。有heterotropic效果的allosteric酶的一个模型被介绍。在规定过程的cooperativity和anticooperativity被学习。

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简介：ＳｅｉｓｍｉｃａｃｔｉｖｉｔｙａｎｄａｃｔｉｖｅｆａｕｌｔｓｉｎＨｕａｉｌａｉｂａｓｉｎＰＥＩＤＥＷＡＮＧ（王培德）ＹＵＨＯＮＧＴＩＡＮ（田玉红）ＣＨＵＮＬＡＩＬＩ（李春来）ＹＵＮＴＡＩＣＨＥＮ（陈运泰）ＩｎｓｔｉｔｕｔｅｏｆＧｅｏｐｈｙｓ...

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简介：Fivenewcephalosporincompoundsweredesignedandsynthesized,andtheantibacterialactivitieswereevaluatedbythestandardserial2-foldagardilutionmethodinvitro.TheresultsshowedthattheactivitiesofthecompoundsⅠaandⅠbagainstESBLE.coliandK.pneumoniaearecomparabletothoseofCefepime.

简介：　　IllustrationAllthedatainthiscatalogarechosenfromthe"PreliminarySeismologicalReportofChineseSeismicStations"(Itsabbreviationis"MonthlyReport").ThecatalogincludestheeventsofM≥4.7inandnearChinaandM≥6allovertheworld.The"MonthlyReport"ismonthlycompiledbvtheNinthSectionofInstituteofGeophysics,CSB.……

简介：　　Illustration　　Allthedatainthiscatalogarechosenfromthe"PreliminarySeismologicalReportofChineseSeismicStations"(Itsabbreviationis"MonthlyReport").……

简介：EuphorbiakansuiisacommonlyusedtraditionalChinesemedicineforthetreatmentofedema,pleuraleffusion,andasthma,etc.Accordingtothepreviousresearches,terpenoidsinE.kansuipossessvariousbiologicalactivities,e.g.,anti-virus,anti-allergy,antitumoreffects.Inthiswork,twentyfiveterpenoidswereisolatedfromE.kansui,includingthirteeningenane-andeightjatrophane-typediterpenoids(withtwonewcompounds,kansuininPandQ)andfourtriterpenoids.EighteenofthemwereanalyzedbyMTSassayforinvitroanticanceractivityinfivehumancancercelllines.Structure-activityrelationshipfor12ingenane-typediterpenoidsincolorectalcancerColo205cellswerepreliminarystudied.Significantanti-proliferationactivitieswereobservedinhumanmelanomacellsbreastcancerMDA-MB-435cellsandColo205cells.Morethanhalfoftheisolatedingenane-typediterpenoidsshowedinhibitoryactivitiesinMDA-MB-435cells.Eightingenane-andonejatrophane-typediterpenoidspossessedmuchlowerIC_(50)valuesinMDA-MB-435cellsthanpositivecontrolstaurosporine.Preliminarystructure-activityrelationshipanalysisshowedthatsubstituentonposition20wasimportantfortheactivityofingenane-typediterpenoidsinColo205cellsandsubstituentonposition3contributedmoresignificantbiologicalactivityofthecompoundsthanthatonposition5inbothMDA-MB-435andColo205cells.

简介：温室实验被进行在在正常、含硒的土壤上种的二个米饭变化(PR116和PusaBasmati1121)调查硒累积和它的抗氧化剂反应。植物生长在早发展的阶段被减少，flowering被10d的一个时期在含硒的土壤上推迟。3–20和13–14增加的硒累积在叶子合拢，在从PusaBasmati1121和PR116变化的谷物的18和3褶层分别地。在从在含硒的土壤上种的大米植物的叶子的硒累积导致了叶绿素内容，氢过氧化物，脯氨酸，免费氨基酸，全部的酚和丹宁内容的重要增加。而过氧化氢酶活动显示出一个反向的趋势，在叶子的类脂化合物peroxidation层次和peroxidase活动增加了。硒累积减少了，这被结束在在庄稼期间，开发而是这些种的米饭的干燥的事内容能由在他们的防卫系统导致改变与硒毒性作斗争。

简介：Zygosaccharomycesrouxiiisasalt-tolerantyeastspeciescapableofremovingcadmium(Cd)pollutantfromaqueoussolution.Presently,thephysiologicalcharacteristicsofZ.rouxiiunderthestressofsodiumchloride(NaCl)andCdarepoorlyunderstood.ThisstudyinvestigatedtheeffectsofNaClandCdonthegrowth,oxidativestressandantioxidantenzymeactivitiesofZ.rouxiiafterstresstreatmentfor24h.ResultsshowedthatNaClorCdalonenegativelyaffectedthegrowthofZ.rouxii,butthegrowth-inhibitingeffectofCdonZ.rouxiiwasreducedinthepresenceofNaCl.FlowcytometryassayshowedthatunderCdstress,NaClsignificantlyreducedtheproductionofreactiveoxygenspecies(ROS)andcelldeathofZ.rouxiicomparedwiththoseintheabsenceofNaCl.Theactivitiesofsuperoxidedismutase(SOD),catalase(CAT),andperoxidase(POD)ofZ.rouxiiweresignificantlyenhancedby2%–6%NaCl,whichlikelycontributedtothehighsalttoleranceofZ.rouxii.ThePODactivitywasinhibitedby20mgL-1CdwhiletheSODandCATactivitieswereenhancedby8mgL-1Cdandinhibitedby20mgL-1or50mgL-1Cd.Theinhibitoryeffectofhigh-levelCdontheantioxidantenzymeactivitiesofZ.rouxiiwascounteractedbythecombineduseofNaCl,especiallyat6%.ThisprobablyaccountedforthedecreaseinCd-inducedROSproductionandcelldeathofZ.rouxiiafterincubationwithNaClandCd.OurworkprovidedphysiologicalcluesastotheuseofZ.rouxiiasabiosorbentforCdremovalfromseawaterandliquidhighlysaltyfood.

简介：Theeffectsofpolishingonproximatecompositions,physico-chemicalcharacteristics,mineralcompositionsandantioxidantpropertiesofthericefloursobtainedfromthreedifferentpigmentedricevarieties(Chak-haoAngangba,Chak-haoAmubiandChak-haoPoireiton)wereinvestigated.Thericevarietiesweresignificantly(P<0.05)differentinthecontentsofthetestcharacteristics.Lipids,ash,minerals,phytochemicals(phenolicacidsandflavonoids)and2,2-diphenyl-1-picrylhydrazyl(DPPH)activityofricefloursweredecreasedafterpolishing(9%degreeofmilling),whileamylosecontentandlightnesswereincreased.X-raydiffractionpatternofricefloursexhibitedA-typecrystallinepatternwithreflectionsat15.1o,17.1o,18.2oand23.0o.Pastingpropertiesandtransitiontemperaturesweredecreasedafterpolishingtreatment.Polishingresultedinchangesinthecrystallinity,enthalpyandmorphologyofriceflours.

简介：Presentstudywasconductedtocharacterisetenrice(OryzasativaL.)cultivarsviz.IET-23466,Dhan-201,IET-23448,MAS-946,IET-23445,IET-23463,IET-23455,PR-123,PR-115andIET-23449basedonantioxidants(totalphenolics,flavonolsandtannins),bioactivecompounds(phyticacid,gammaaminobutyricacid,tocopherolandreducedascorbate)andantioxidantactivity(1,1-diphenyl-2-picrylhydrazylradicalscavengingactivity,hydroxylradicalscavengingactivity,freeradicalantioxidantpowerandtotalreducingpower)withanaimtoidentifycultivarscontaininghigherhealthpromotingcomponentsaftergermination.ThreecultivarsIET-23466,IET-23463andPR-123performedbetterasrevealedbyhigherlevelofantioxidants,bioactivecompoundsandantioxidantactivitybeforeandaftergermination.ThreecultivarsMAS-946,IET-23445andIET-23449hadmoderatelevelofantioxidants,bioactivecompoundsandantioxidantactivity.FourcultivarsDhan-201,IET-23448,IET-23455andPR-115performedintermediately.Strongpositivecorrelationwasobservedamongtotalphenolicsandtheantioxidantactivity.Phyticacidwasfoundtobenegativelycorrelatedtotheantioxidantactivity.OurresultshighlightedthatcultivarsIET-23466,IET-23463andPR-123holdgreatpotentialaftergerminationandwouldopenupausefulopportunityforthefunctionalfoodindustry,andconsumptionofthesecultivarsaftergerminationwouldaffordhealthbenefitstoconsumerssincetheycontainhigherlevelofantioxidants.

简介：瞄准：为了在streptozotocin(STZ)的阴囊的组织每氧化(LPO)和抗氧化剂酶的活动在类脂化合物上检验melatonin治疗的效果，导致了糖尿病的老鼠。方法：26只雄的老鼠随机如下被划分成三个组：组我，控制，非糖尿病的老鼠(n=9)；组II，导致STZ的、未经治疗的糖尿病的老鼠(n=8)；组III，导致STZ，对待melatonin(10mg/kg的剂量。白天)糖尿病的老鼠(n=9)。后面的8星期的melatonin处理，所有老鼠被使麻木然后被打死把睾丸从阴囊移开。结果：作为与组相比我，在老鼠组II的阴囊的纸巾，malondialdehyde(MDA)的增加的层次(P<0.01)并且超级氧化物歧化酶(草皮)(P<0.01)象过氧化氢酶(猫)的减少的层次一样(P<0.01)并且谷胱甘肽过氧化物酶(GSH-Px)(P>0.05)被发现。相反作为与组II相比，在老鼠组III的阴囊的纸巾，MDA的层次减少了(但是这减少不是重要的，P>0.05)并且草皮(P<0.01)象猫一样(P<0.05)增加。GSH-Px没被任何处理影响。Melatonin显著地没影响糖尿病的组的提高的葡萄糖集中。在学习的结束，借助于身体和阴囊的重量在对待melatonin的组和未经治疗的组之间没有有效差量。结论：糖尿病增加氧化应力，melatonin每氧化和力量禁止类脂化合物调整糖尿病的老鼠睾丸的抗氧化剂酶的活动。

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