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简介：AbstractBackground:Hasner valve incision has been recently introduced as a new treatment for ophthalmic patients with epiphora symptoms. The aim of this study was to examine whether surgical outcomes of Hasner valve incision for inferior nasolacrimal duct obstruction were different between pediatric and adult patients.Methods:A total of 53 eyes of 52 patients who underwent Hasner valve incision in the Beijing Tongren Hospital from October 2016 to November 2019 were retrospectively observed. Patients were divided into two groups, including pediatric group (23 eyes of 22 patients, <18 years old) and adult group (30 eyes of 30 patients, ≥18 years old). Success rate of surgery was determined by both subjective measure (complete resolution of epiphora) and objective measure (lacrimal passage irrigation and tear meniscus height). Fisher exact test was conducted.Results:By conducting Fisher exact test and comparing complete resolution of epiphora (P = 0.627), lacrimal passage irrigation (P = 0.663), measurement of Tear Meniscus Height (P = 0.561), and appearance of complication (P = 0.339), there was no statistically significant difference of surgical outcomes between pediatric and adult patients (P > 0.05).Conclusion:Hasner valve incision was effective for both adult and children with inferior nasolacrimal duct obstruction, with no difference in surgical outcomes between the two groups.

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简介：AbstractBackground:Fecal incontinence (FI) has been shown to be a common symptom in Western countries; however, there is few researches focusing on its epidemic condition in Chinese women. We conducted this national population-based epidemiology study to estimate the prevalence and risk factors of FI among adult Chinese women living in urban regions.Methods:This is a subgroup analysis of a national population-based epidemiology study of FI. Total 28,196 adult women from urban regions of six provinces and municipalities participated in this research from 2014 to 2015. They finished the questionnaire under the direction of trained interviewers. FI was defined as accidental leakage of flatus and/or liquid or solid stool at least once in the past. The FI prevalence trend and risk factors were identified by the Cochran-Armitage test, Chi-square test, and multivariable logistic regression.Results:The prevalence of FI in adult females in urban China was 0.43% (95% confidence interval: 0.35%-0.51%). Among women with FI, 42.96%, 82.96%, and 42.22% reported having leakage of solid, liquid stool, and gas, respectively. The overall FI prevalence and the incidence rate of solid stool/liquid stool/gas leakage increased with age. The mean Wexner score was 4.0% and 12.0% FI patients reported Wexner score ≥9. Body mass index ≥24 kg/m2, pelvic organ prolapses, chronic constipation, chronic cough, alcohol consumption, physical diseases including chronic bronchitis and cancer, gynecological diseases like gynecological inflammation are risk factors for FI. Vaginal delivery was the risk factor for FI in females with labor history.Conclusions:FI was not a common symptom in adult Chinese women living in urban areas and there were some potential modifiable risk factors.Trial Registration:Chinses Clinical Trial Registry: ChiCTR-OCS-14004675; http://www.chictr.org.cn/showproj.aspx?proj=4898

简介：AbstractOur study aimed to determine the effect of the neutrophil-lymphocyte ratio on the prognosis of adult patients with acute stroke. We searched the Web of Science, PubMed, Embase, Cochrane Library, and China National Knowledge Infrastructure databases and selected all of the potentially eligible studies. From the included studies, we extracted characteristics such as the stroke type and acquisition time until routine blood collection and the odds ratios across studies. The 95% confidence intervals and odds ratios were pooled to calculate the effect size for the neutrophil-lymphocyte ratio in acute stroke patients. We defined poor function outcomes according to the modified Rankin Scale ≥ 3 or Glasgow Outcome Scale< 3.Thirteen studies with 4443 patients were included in our analysis, including 7 ischemic and 6 hemorrhagic stroke studies. The pooled odds ratios for poor functional outcome at 3 months with a higher neutrophil-lymphocyte ratio in acute ischemic and hemorrhagic patients were 1.689 (95% CI = 1.184-2.409, p < 0.001) and 1.125 (95% CI = 1.022-1.239, p < 0.001), respectively, and the overall pooled odds ratio for poor functional outcome following stroke was 1.257 (95% CI = 1.146-1.379, p < 0.001). At the same time, the overall combined odds ratio for death at 3 months was 1.632 (95% CI = 1.155-2.306, p < 0.001).The neutrophil-lymphocyte ratio, an easily calculated marker, plays a predictive role in the short-term outcomes of adult patients (mean age ≥ 50 years) following acute ischemic and hemorrhagic stroke.

简介：BACKGROUND:Studieshaveshownthatneurogenesisinthedentategyrusplaysanimportantroleinlearningandmemory.However,studieshavenotdeterminedwhetherthesuperiorcervicalganglionorthesympatheticnervesysteminfluenceshippocampalneurogenesisorlearningandmemoryinadultrats.OBJECTIVE:Toobservedifferencesindentategyrusneurogenesis,aswellaslearningandmemory,inadultratsfollowingsuperiorcervicalganglionectomy.DESIGN,TIMEANDSETTING:Arandomized,controlled,animalstudywasperformedattheImmunohistochemistryLaboratoryoftheSchoolofLifeSciencesinLanzhouUniversityfromJuly2006toJuly2007.MATERIALS:DoublecortinpolyclonalantibodywasprovidedbySantaCruzBiotechnology,USA;avidin-biotin-peroxidasecomplexwaspurchasedfromZhongshanGoldenbrideBiotechnology,China;MorriswatermazewasboughtfromTaimengTechnology,China.METHODS:Atotalof20adult,male,Wistarratswererandomlydividedintosurgeryandcontrolgroups,with10ratsineachgroup.Inthesurgerygroup,thebilateralsuperiorcervicalganglionsweretransected.Inthecontrolgroup,thesuperiorcervicalganglionswereonlyexposed,butnoganglionectomywasperformed.MAINOUTCOMEMEASURES:Toexaminedistribution,morphology,andnumberofnewbornneuronsinthedentategyrususingdoublecortinimmunohistochemistryat36daysfollowingsurgicalprocedures.ToexamineabilityoflearningandmemoryinadultratsusingtheMorriswatermazeat30daysfollowingsurgicalprocedures.RESULTS:Doublecortinimmunohistochemicalresultsshowedthatareductioninthenumberofdoublecortin-positiveneuronsinthesurgerygroupcomparedtothecontrolgroup(P<0.05),whilethedistributionofdoublecortin-positiveneuronswasidenticalinthetwogroups.Thesurgerygroupexhibitedsignificantlyworseperformanceinlearningandspatialmemorytaskscomparedtothecontrolgroup(P<0.05).CONCLUSION:Superiorcervicalganglionectomyinhibitedneurogenesisinthedentategyrusanddecreasedlearningandmemorya

简介：我们分析了20化学感应的蛋白质(CSP)蚕Bombyxmori的基因。我们发现了在introns插入的retrotransposons的一个高数字。我们然后用量的即时聚合酶链反应(PCR)越过纸巾分析了20BmorCSP基因的表示。BmorCSPs的相对低的表示层次在内脏和胖身体纸巾被发现。我们因此在BmorCSP基因表示上测试了endectocyte杀虫药剂abamectin(B1a和B1bavermectins)的效果。量的即时PCR实验证明到杀虫药剂abamectin的单个简短暴露戏剧性地不仅在天线而且在大多数纸巾增加了CSP表示，包括内脏和胖身体。而且，我们的学习响应杀虫药剂以一种织物依赖者方式显示出CSP和新陈代谢的细胞色素P450酶的并列表示。CSP的功能仍然保持未知。基于我们的结果，我们在检测然后被细胞色素P450anti-xenobiotic酶除去的xenobiotics建议一个角色。

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简介：ObjectiveTo观察激活p21的kinase6(PAK6)在在成年rat.MethodsSprague-Dawley老鼠的针的绳索损害(SCI)以后的表示和它的可能的角色受到针的绳索损害。为了探索PAK6，表示模式和PAK6的分发的病理学、生理的意义，没被西方的污点观察，免疫组织化学和immunofluorescence.ResultsWestern污点分析证明PAK6蛋白质水平在白天2和白天4上是显著地起来调整的，然后减少了并且有到白天14为止的起来规定。免疫组织化学分析证明PAK6的表示显著地在与控制组相比的白天4上被增加。而且，染色的两倍immunofluorescence证明PAK6首先在控制组在神经原和星形细胞被表示。当时在损害以后，PAK6的表示在星形细胞显著地被增加，神经原，和星形细胞大部分被增殖。我们也检验了增殖的房间的表示原子抗原(PCNA)并且发现它的变化与PAK6的表示被相关。重要地，在在受伤针的绳索的PAK6的injury.ConclusionThe起来规定可以与glial增长被联系以后，染色的两倍immunofluorescence表明PCNA评估的房间增长在白天4上出现在许多PAK6-express-ing房间。

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简介：Ciliaryneurotrophicfactoristheonlyknownneurotrophicfactorthatcanpromotedifferentiationofhippocampalneuralprogenitorcellstoglialcellsandneuronsinadultrats.Thisprocessissimilartospontaneousdifferentiation.Therefore,ciliaryneurotrophicfactormaybeinvolvedinspontaneousdifferentiationofneuralstemcells.Toverifythishypothesis,thepresentstudyisolatedneuralprogenitorcellsfromadultmaleratsandculturedtheminvitro.Resultsshowedthatwhenneuralprogenitorcellswereculturedintheabsenceofmitogenfibroblastgrowthfactor-2orepidermalgrowthfactor,theyunderwentspontaneousdifferentiationintoneuronsandglialcells.Westernblotandimmunocytochemicalstainingshowedthatexogenousciliaryneurotrophicfactorstronglyinducedadulthippocampalprogenitorcellstodifferentiateintoneuronsandglialcells.Moreover,passage4adulthippocampalprogenitorcellsexpressedhighlevelsofendogenousciliaryneurotrophicfactor,andaneutralizingantibodyagainstciliaryneurotrophicfactorpreventedthespontaneousneuronalandglialdifferentiationofadulthippocampalprogenitorcells.Theseresultssuggestthatthespontaneousdifferentiationofadulthippocampalprogenitorcellsismediatedpartiallybyendogenousciliaryneurotrophicfactor.

简介：Researchindicatesthathighlevelsofsedentarybehavior(sittingorlyingwithlowenergyexpenditure)areadverselyassociatedwithhealth.Akeyfactorinimprovingourunderstandingoftheimpactofsedentarybehavior(andpatternsofsedentarytimeaccumulation)onhealthistheuseofobjectivemeasurementtoolsthatcollectdateandtime-stampedactivityinformation.OnesuchtoolistheactivPALmonitor.Thisthigh-worndeviceusesaccelerometer-derivedinformationaboutthighpositiontodeterminethestartandendofeachperiodspentsitting/lying,standing,andstepping,aswellassteppingspeed,stepcounts,andposturaltransitions.TheactivPALisincreasinglybeingusedwithinfield-basedresearchforitsabilitytomeasuresitting/lyingviaposture.WesummarisekeyissuestoconsiderwhenusingtheactivPALinphysicalactivityandsedentarybehaviorfield-basedresearchwithadultpopulations.ItisintendedthatthefindingsanddiscussionpointsbeinformativeforresearcherswhoarecurrentlyusingactivPALmonitorsorareintendingtousethem.Pre-datacollectiondecisions,monitorpreparationanddistribution,datacollectionconsiderations,andmanualandautomateddataprocessingpossibilitiesarepresentedusingexamplesfromcurrentliteratureandexperiencesfrom2researchgroupsfromtheUKandAustralia.

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简介：进行中的气候变化是对生物多样性的主要威胁。不管多么许多种类清楚地受不了进行中的气候变化，例如，其它由显示出范围扩大得益于它。然而，特定的特征哪个决定种类危险到气候变化？Phenotypic粘性，对环境变化被描述了为防卫的第一根线，可能在这里具有最大的重要性。对这个背景，我们这里在3铜蝴蝶种类在压力忍耐比较粘性，它在他们对气候变化的弱点可以证明不同。明确地，我们在成年阶段在acclimatization以后调查了热，寒冷和干燥抵抗到不同温度。我们证明在更高的温度的环境适应增加了热，但是减少冷忍耐和干燥抵抗。与我们的预言相反，种类没在压力抵抗显示出显著变化，尽管在温度的塑料能力强调抵抗确实越过种类变化了。总的来说，我们的结果似乎比speciesspecific模式反映populationrather。我们断定使用的人口的地理起源应该在比较研究被认为平。然而，我们的结果建议在这里学习的3种类，对气候变化的弱点没被压力抵抗首先在成年阶段决定。当昆虫学的研究仅仅实在太经常集中于成年人，当试着理解昆虫回答到环境变化时，我们主张更多的研究努力应该被奉献给另外的发展阶段。

简介：AbstractIntroduction:Langerhans cell histiocytosis (LCH), the most common histiocytic disorder, characterized by the abnormal over production of histiocytes that tend to infiltrate single or multiple organ systems leading to significant tissue damage.Here we report a case of an adult patient who was diagnosed with LCH presenting as multisystem involvement.Case presentation:We describe a 23-year-old man suffering from central diabetes insipidus, "hemorrhoids", progressive hearing loss and a surge in weight. Physical examination revealed lesion involvement of the skin and mucous membranes, including the perianal area, gingiva, and external auditory canal. He was diagnosed as LCH, who achieved remission following a chemotherapy regimen.Discussion:LCH is common in children, but it is not surprising to see it in adults. The clinical manifestations of LCH are highly variable and may involve multiple organs and systems. While, skin involvement is the most obvious symptom, and dermatologists should be familiar with it. Chemotherapy is the first-line treatment for multisystem or multifocal single system adult LCH.Conclusion:Characteristic features of LCH involving the perianal area was described in this case which helped the dermatologist to make quick judgments. We also emphasize that a global concept should be established confronting with a patient with multiple complaints.

简介：ObjectiveToinvestigatetheeffectsofselectivenitricoxidesynthase(NOS)inhibitorsondentategyrusneurogenesisafterdiffusebraininjury(DBI)intheadultratbrain.MethodsAdultmaleSDratsweresubjectedtodiffusebraininjury(DBI)model.Byusingsystemicbromodeoxyuridine(BrdU)tolabeldividingcells,wecomparedtheproliferationrateof

简介：在撒丁的岛上，鳞翅类的Papiliohospiton把阿魏属communis用作独占的主人植物。在Tavolara的小岛上，然而，成年女性在Seselitortuosum上生了鸡蛋，限制到岛的植物。当在Seseli上在监禁涨了时，仅仅很少幼虫在第一秒的中间形态以外成长了。lepidopterans的主人特性被女oviposition偏爱，而且由幼虫的食物接受决定，并且成年、幼虫的味道敏感可能与在两个盒子中的主人选择有关。这个工作的目的是：(i)将学习幼虫和ovipositing女性的味道敏感到阿魏属和Seseli的傻瓜；(ii)到crosscompare到两味道刺激的味觉的受体神经原(GRN)的尖铁活动；(iii)评估在二个傻瓜之间的区别能力并且决定神经code/sis/are使用了哪个。结果显示出那：(i)到两植物树液的成年女性的跗骨的GRN的尖铁回答不是不同的，因此，他们不能区别二植物；(ii)当反面发生时，幼虫的LlatGRN比阿魏属响应Seseli显示出一项更高的活动因为phagostimulant神经原，和幼虫可以借助于多重神经代码在二个傻瓜之间区别；(iii)在二家工厂上生的鸡蛋的数字是一样，但是幼虫的生长表演比Seseli在阿魏属上更好。味道敏感差别可以由幼虫由成年女性和工厂接受和生长性能解释在oviposition偏爱之间的一种积极关系的缺席。

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