简介:目的探讨ST—T改变的鉴别方法及诊断意义。方法对210例患者除作心电图(ECG)外井做血生化(血脂、血糖、肝肾功能、心肌酶谱、甲状腺功能测定系列等)、超声心动图、心脏X线等检查,随机抽取54例行试验性治疗,即给予50%G.S250ml加复方丹参注射液20ml,生脉注射液100ml均1/d,10d。再规律休息1w后对比治疗前后ECG。结果54例治疗前后ECG比较无明显变化,并随访3—12个月无一例发生心脏事件,随机抽取32例ECG并做多帧前后比较差异无统计学意叉。结论本组病倒经临床检查排除药物影响、器质性心脏病及继发性心脏病。试验性治疗ST—T无改变,提示此组人群中ST—T改变为非特异性的。
简介:近日,美国食品药品监督管理局(FDA)批准诺华的CAR—T疗法Kymriah(tisagenlecleucel)上市,用于治疗急性淋巴细胞白血病(ALL),
简介:Itiswell-knownthatidiopathicthrombocytopenicpurpura(ITP)isanacquiredorgan-specificautoimmunehemorrhagicdiseaseanddysfunctionalcellularimmunityisconsideredimportantinthepathophysiologyofITP.However,polarizationpatternsandapoptosisprofilesofTlymphocytesremainunclear.Inthisstudy,weinvestigatedthepolarizationofTcellsubsets,theexpressionsofapoptoticproteinsFas/FasLonthesubsetsandthelevelofanti-apoptoticgenebcl-2andbaxmRNA.ItwasdemonstratedthattheratiosofTh1/Th2andTc1/Tc2inITPchildrenwereincreasedobviouslyandthattheaveragepercentageswereincreasedclearlyforTh1andTh2,butnotforTc1andTc2.InITPchildren,theenhancingexpressionsweredetectedforFasLonTh1andTc1andforFasonTh2andTc2.Withincreasinglevelofbcl-2mRNAanddecreasingexpressionofbaxmRNAinITPchildren,theratioofbcl-2/baxmRNAwasimprovedobviously,whichwaspositivecorrelatedwiththeratioofTh1/Th2.Takentogether,ourfindingsindicatethatITPisaTh1predominantdisease.ThispolarizationpatternofTcellsubsetsmightberelatedtothehighratioofbcl-2/baxmRNAandtheabnormalexpressionsofFasandFasLonTcellsubsets.Cellular&MolecularImmunology.
简介:摘要对农村50例带T管患者采用口头宣教、健康讲座、宣传手册、宣传栏、电话随访等方式进行T管护理、饮食护理、心理护理、生活护理、自我观察等方面进行健康指导。农村带T管患者得到了有效的家庭护理知识,尤其是提高了对T管护理不当可发生严重的并发症-胆汁性腹膜炎、胆漏等认识,减少了并发症的发生,提高生活质量,促进康复。
简介:摘要目的分析本院门诊和住院病人中100例心电图高耸T波的临床意义。方法诊断标准(1)肢体导联>0.5mv;(2)T波>QRS电压。胸壁导联>1.0mv,但有些正常人可高达1.5mv。因此,高耸T波的动态改变更有意义。结果急性缺血性高耸T波22例(22%),高钾血症6例(6%),主动脉瓣关闭不全3例(3%),早期复极40例(40%),完全性左束支传导阻滞5例(5%),脑血管意外2例(2%),迷走神经张力增高2例(2%),正常变异15例(15%),二尖瓣病变3例(3%)。结论高耸T波是较为常见的心电图现象,病因不同其治疗和预后并不完全相同,应与临床结合,特别是动态观察T波变化,及时对高耸T波作出准确判断。
简介:IncreasedexpressionofFasbyhematopoieticprogenitorsinaplasticanemia(AA)suggeststhatFas/Fasligand(FasL)systemplaysakeyroleintheformationofseverepancytopenia.Tofurtherconfirmtheabovehypothesis,Tcellsfrom8patientswithAAweresystematicallystudiedfortheirFasL'sdistributionpattern,releasingmannerandproapoptoticactivity,comparedwithnormalrestingTcellsandartificiallyactivatedTcellblasts.TheresultsdemonstratedthatAATcellsabnormallyexpressedlowlevelsofmembrane-boundFasLandcontainedhighlevelsofintracellularFasLwhichcouldbetriggeredtoreleasebyhigh-dosephytohemagglutinin(PHA)pulse-stimulation.ThesupernatantsfromthePHA-stimulatedAATcellshadapparentcytotoxicityagainstFasL-sensitiveJurkatcells,whichcouldbesignificantlyinhibitedbymonoclonalantibodyagainstFasLinadose-dependentmanner,ornearlycompletelyabrogatedbyultracentrifugation.TheabovephenomenaalsoappearedonartificiallyactivatedTcellblasts,butthiswasnotthecaseonnormalrestingTcells.TheseresultsindicatethatAATcellisatypeof'preactivated'Tlymphocyte,characterizedbyoverexpressionofFasL,especiallyintracellularFasLwhichcanbestimulatedtoreleaseinbioavtiveexosomesboundform.Takentogether,ourdataprovidefurtheranddirectevidenceforthehypothesisthatTcellsmightmediatethedestructionofhematopieticprogenitorinAAthroughFas/FasLsystem.