简介:InthispaperL^p-L^qestimatesforthesolutionu(x,t)tothefollowingperturbedhigh-erorderhyperbolicequationareconsidered,(ρπ--a△)(ρπ--b△)u+V(x)u=O,x∈R^n,n≥6,ρ1eu(x,O)=O,ρ^3eu(x,O)=f(x),(j=O,1,2).WeassumethattheotentialV(x)andtheinitialdataf(x)arecompactlysupported,andV(x)issufficientlysmall,thenthesolutionu(x,t)oftheaboveproblemsatisfiesthesameL^p-L^qestimatesasthatoftheunperturbedproblem.
简介:摘要目的探索α-L-岩藻糖苷酶1(FUCA1)对前列腺癌增殖、迁移的影响及其作用机制。方法使用肿瘤基因组图谱(TCGA)数据库比较2006年至2021年497例前列腺癌和52例正常前列腺组织中基因FUCA1的差异表达。将人源的前列腺癌细胞系22RV1和DU145分为对照组和实验组,分别转染空质粒和FUCA1质粒,转染2 d后,采用细胞计数试剂盒(CCK-8)、平板克隆形成实验、5-乙炔基-2’脱氧尿嘧啶核苷(EdU)染色实验验证细胞的增殖能力;采用划痕愈合实验和Transwell实验验证细胞的迁移能力,采用蛋白质印迹法探索阿霉素以及抑癌基因p53与FUCA1的靶向关系。两实验组间比较采用独立样本t检验,多实验组间比较采用方差分析。结果对照组细胞EdU着色细胞比例高于实验组[22RV1:(37.330±2.028)%比(16.000±2.646)%,t=6.400,P<0.05;DU145:(56.330±4.978)%比(27.330±2.404)%,t=5.246,P<0.05]、培养96h后吸光度高于实验组(22RV1:1.613±0.075比1.113±0.049,F=55.620,P<0.05;DU145:1.998±0.058比1.263±0.065,F=54.590,P<0.05)、克隆形成数高于实验组(22RV1:172.700±14.620比75.330±4.410,t=6.373,P<0.05;DU145:308.300±12.810比146.300±7.839,t=10.790,P<0.05)、划痕愈合率高于实验组[22RV1:(62.940±4.778)%比(25.700±4.948)%,t=5.414,P<0.05;DU145:(97.670±1.891)%比(38.430±2.727)%,t=17.860,P<0.05]、迁移细胞数高于实验组(22RV1:156.3±9.821比44.33±5.364,t=10.010,P<0.05;DU145:179±7.572比78.33±7.311,t=9.564,P<0.05)。抑癌基因P53过表达组FUCA1蛋白表达量高于对照组(22RV1:1.080±0.076比5.962±0.373,t=12.810,P<0.05;DU145:1.121±0.052比15.360±0.523,t=27.080,P<0.05)。结论DNA损伤能够促进前列腺癌中FUCA1的表达,同时,p53能够靶向FUCA1抑制前列腺癌细胞增殖和迁移从而抑制前列腺癌的进展。
简介:<正>InthispaperitisprovedthatforallcompletelydistributivelatticesL.thecategoryofL-fuzzifyingtopologicalspacescanbewmbeddedinthecategoryofL-topologicalspaces(stratifiedChang-Goguenspaces)asasimultaneouslybireflectiveandbicoreflectivefullsubcategory.
简介:WeconstructaclassofintegrablegeneralizationofTodamechanicswithlong-rangeinteractions.ThesesystemsareassociatedwiththeloopalgebrasL(Cr)andL(Dr)inthesensethattheirLaxmatricescanberealizedintermsofthec=0representationsoftheaffineLiealgebrasCr(1)andDr(1)andtheinteractionspatterninvolvedbearsthetypicalcharactersofthecorrespondingrootsystems.WepresenttheequationsofmotionandtheHamiltonianstructure.Thesegeneralizedsystemscanbeidentifiedunambiguouslybyspecifyingtheunderlyingloopalgebratogetherwithanorderedpairofintegers(n,m).Itturnsoutthatdifferentsystemsassociatedwiththesameunderlyingloopalgebrabutwithdifferentpairsofintegers(n1,m1)and(n2,m2)withn2<n1andm2<m1canberelatedbyanestedHamiltonianreductionprocedure.Forallnontrivialgeneralizations,theextracoordinatesbesidesthestandardTodavariablesarePoissonnon-commute,andwheneithernorm≥3,thePoissonstructurefortheextracoordinatevariablesbecomessomeLiealgebra(i.e.theextravariablesappearlinearlyontheright-handsideofthePoissonbrackets).Inthequantumcase,suchgeneralizationswillbecomesystemswithnoncommutativevariableswithoutspoilingtheintegrability.
简介:摘要 目的:讨论α-L-岩藻糖苷酶(AFU)、甲胎蛋白(AFP)两项指标联合检测在早期原发性肝癌中的诊断价值。方法:随机选取2022年9月-2023年2月岑巩县人民医院收治的早期原发性肝癌(PHC)患者30例作为肝癌组,30例酒精肝患者作为良性肝病变组,另选取同院同期体检的30例肝功能正常的健康人作为对照组。应用酶联免疫分析法检测三组研究对象血清甲胎蛋白与α-L-岩藻糖苷酶的水平,用F检验和卡方检验对检测结果进行统计分析。结果:肝癌组AFU、AFP表达水平明显高于健康人组和良性肝病变组,良性肝病变组略高于健康人组,差异性显著,有统计学意义(P<0.05)。三组研究对象的联合检测阳性率,肝癌组为93.33%,显著高于良性肝病变组存在差异性显著,具有统计学意义(P<0.05)。肝癌组的联合检测灵敏度是93.33%、准确率是85.56%;并且联合检测的灵敏度、准确率均高于单独检测的灵敏度、准确率,存在差异性显著,具有统计学意义(P<0.05);肝癌组的联合检测特异性为81.67%低于AFU的特异性为83.33%,差异不显著,不具有统计学意义(P>0.05)。结论:血清甲胎蛋白与α-L-岩藻糖苷酶联合检测可以提高诊断原发性肝癌的阳性率、灵敏度、准确率,可以为早期原发性肝癌的诊断提供一定的参考依据。
简介:Weconsiderforafixedμ,theclassofpolynomialsPn,μ,s:=P(z)=zsanzn-s+n-s∑j=μan-jzn-j-s;1≤μ≤n-sofdegreen,havingallzerosin|z|≤k,k≤1,withs-foldzerosattheorigin.Inthispaper,wehaveobtainedinequalitiesinthereversedirectionfortheaboveclassofpolynomials.Besides,extensionsofsomeTuran-typeinequalitiesforthepolarderivativeofpolynomialshavebeenconsidered.
简介:AnefficientroutetoprepareL-glucoseandL-galactoseisdescribed.TheL-sugarsareachievedbyusingthestrategyofswitchingthefunctionalgroupsatC1andC5ofD-glucoseandD-mannose.TheoxidationandreductionofthesilylenoletheratC1andthelead(IV)tetraacetatemediatedoxidativedecarboxylationatC5arethekeysteps.L-GlucoseandL-galactosearepreparedinaconvenientandinexpensiveway.
简介:Lp-LqdecayestimateofsolutiontoCauchyproblemofalinearthermoviscoelasticsystemisstudied.Byusingadiagonalizationargumentoffrequencyanalysis,thecoupledsystemwillbedecoupledmicrologically.Thenwiththehelpoftheinformationofcharacteristicrootsforthecoefficientmatrixofthesystem,Lp-LqdecayestimateofparabolictypeofsolutiontotheCauchyproblemisobtained.
简介:1.IntroductionInthispaperweconsiderCauchyproblemforaclassofnonhomogeneousNavier-Stokesequationsintheinfinitecylinderwith.Givensatisfyinginthedistributionsensediv,weseekasolutionvectorandapressurefunctionP(t,x)suchthatwhereisanonlinearvector-valuedfun...