简介：瞄准：在与足够的胆汁的排水在胆汁郁积的病人减少胆管炎在以后决定ciprofloxacin的角色内视镜后退cholangiopancreatography(ERCP)。方法：A使随机化的、控制试用在Rajavithi医院在48个胆汁郁积的病人被执行(ERCP的第三级的工作分派中心：600个案例每年)。所有48个病人在开始任何过程前为30min收到了200mgciprofloxacin静脉注射，然后随机在二个组被划分。在学习的22个病人在ERCP以后组织不断地收到的ciprofloxacin直到48h。胆汁的阻塞的原因，胆汁和血的细菌学(在胆管炎)并且临床的胆管炎被记录。结果：48个病人被注册并且划分了成连续ciprofloxacin治疗组(n=22)并且不连续的ciprofloxacin治疗组(n=26)。在ERCP期间，石头在5个病人在22个病人，在24个病人的恶性病和另外的病理学的损害被发现。谁的22个病人的(4.5%)收到了ciprofloxacin，(6.3%)2在ERCP以后中止了ciprofloxacin的26个病人开发了胆管炎(相对风险=0.71；95%CI=0.14-3.65；P=0.88)。Bacterobilia在27被发现(56.3%)从48个病人。E。关口i和链球菌青绿色的ans是最普通的有机体。结论：在有在足够的胆汁的排水过程以后的胆汁郁积的病人的ciprofloxacin的不断的使用不在减少胆管炎起作用。

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简介：Thefibroblastgrowthfactorreceptor(FGFR)familyplaysimportantrolesinregulatingcellgrowth,proliferation,survival,differentiationandangiogenesis.DeregulationoftheFGF/FGFRsignalingpathwayhasbeenassociatedwithmultipledevelopmentsyndromesandcancers,andthustherapeuticstrategiestargetingFGFsandFGFRinhumancancerarecurrentlybeingexplored.However,fewstudiesontheFGF/FGFRpathwayhavebeenconductedinsarcoma,whichhasapooroutcomewithtraditionaltreatmentssuchassurgery,chemotherapy,andradiotherapy.Hence,inthepresentreview,weprovideanoverviewoftheroleoftheFGF/FGFRpathwaysignalinsarcomaandFGFRinhibitors,whichmightbenewtargetsforthetreatmentofsarcomasaccordingtorecentresearch.

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简介：ObjectivesToevaluatethechangesoftheplasmaendothelinlevelinpatientswithdilatedcardiomyopathy,andtoinvestigatetherelationshipbetweentheplasmaendothelinlevelandtheseverityofheartfailure,heartsize,leftventricularfunctionandwithornotwithpulmonaryarterialhypertension;thechangesoftheplasmaendothelinlevelbeforeandaftertreatment.MethodsTheplasmaendothelinlevelof30patientswithDCM,30healthycontrolsubjects,andtheirLVEF,PAP,heartsize,plasmaendothelinlevelbeforeandaftertreatmentweredetermined.ResultsTheplasmaendothelinlevelinDCMgroupwassignificantlyhigherthanthatincontrolgroup(135.93±70.65pg/mL)vs(43.65±12.07pg/mL),P<0.05;therewasacorrelationbetweenETlevelandheartsize(r=0.4580,P=0.0109);therewasasignificantnegativecorrelationbetweenLVEFofDCMandETlevel(r=-0.6922,P=0.0021);anditwasasignificantpositivecorrelationbetweenETlevelandpulmonaryarterialhypertension(r=0.8974,P<0.0005).Aftertreatment,theETleveldecreasedsignificantlythanbeforeinDCMgroup(129.15±43.93pg/mL)vs(63.12±22.20pg/mL),P<0.05.ConclusionsPlasmaETlevelmaybeanewparameterofevaluatingseverityofheartfailure,efficacyoftherapyandprognosis.

简介：BACKGROUND:Physiologicalconvulsivethresholdsdegradewhenthebrainisinsomepathologicstates;thus,alevelofstimulusthatcannotprovokeaconvulsionmayevokeaseizureorepilepticseizure.OBJECTIVE:Toinvestigatethechangesthatoccurinthebrainwhenthephysiologicalconvulsivethresholdbecomespathological,andtodeterminewhatdifferencesoccurinpathologicalandphysiologicalconvulsivethresholdsduringthedevelopmentofepilepsy.DESIGN:Arandomizedcontrolledanimalexperiment.SETTING:ResearchInstituteofEpilepsyofShanxiMedicalUniversity;DepartmentofNeurology,TheThirdHospitalofShanxiMedicalUniversity;ResearchInstituteofFunctionofShanxiMedicalUniversity.MATERIALS:Thirty-sixfemaleWistarratswereselectedforthisstudy.TheratswereobtainedfromtheexperimentalanimalcenterofShanxiMedicalUniversity.Alllaboratoryprocedurescompliedwithanimalethicalstandards.Theanimalswererandomlydividedintothreegroups:astrongcurrentgroup,aweakcurrentgroupandacontrolgroup,with12ratsineachgroup.AnautomaticdeterminatorofseizurethresholdwasmadeatShanxiMedicalUniversityandTaiyuanUniversityofTechnology.Twobipolarstainlesssteelstimulatingelectrodesandanelectrodeconnector(diameter1.2mm)weremadeatTaiyuanUniversityofTechnology.METHODS:ThisstudywasperformedinthelaboratoryofResearchInstituteoftheEpilepsyofShanxiMedicalUniversitybetweenDecember2005andAugust2006.Thethresholdoflocalizedseizureswasmeasuredbyperformingdirectcorticalstimulationinratsunderanesthesia.After1weekofpost-operativerecovery,electricstimulationwasstartedwiththreedifferentkindsofstimulation.Seizureactivitywasinducedbyaramp-shapedsingletrainofbiphasicpulses(50Hz,totalpulsedurationof2ms,increasingfrom0to2000μAin15seconds).Thethresholdoflocalizedseizures(TLS)hasbeendefinedastheminimumcurrentintensitynecessarytoprovokeconvulsionoftheforel

简介：AIM:Toanalyzethepotentialrelationshipbetweengastroesophagealrefluxdisease(GERD)andthedevelopmentofatrialfibrillation(AF).METHODS:Usingthekeywords'atrialfibrillationandgastroesophagealreflux','atrialfibrillationandesophagitis,peptic','atrialfibrillationandhernia,hiatal'thePubMed,EMBASE,CochraneLibrary,OVIDSP,WILEYdatabaseswerescreenedforrelevantpublicationsonGERDandAFinadultsbetweenJanuary1972-December2013.StudieswritteninlanguagesotherthanEnglishorFrench,studiesnotperformedinhumans,reviews,casereports,abstracts,conferencepresentations,letterstotheeditor,editorials,commentsandopinionswerenottakenintoconsideration.ArticlestreatingthesubjectofradiofrequencyablationofAFandtheconsecutivedevelopmentofGERDwerealsoexcluded.RESULTS:Twothousandonehundredsixty-onetitleswerefoundofwhich8articlesmettheinclusioncriteria.ThepresenceofAFinpatientswithGERDwasreportedtobebetween0.62%-14%,highercomparedtothosewithoutGERD.EpidemiologicaldataprovidedbytheseobservationalstudiesshowedthatpatientswithGERD,especiallythosewithmoresevereGERD-relatedsymptoms,hadanincreasedriskofdevelopingAFcomparedwiththosewithoutGERD,butacausalrelationshipbetweenGERDandAFcouldnotbeestablishedbasedonthesestudies.ThemechanismsofAFasaconsequenceofGERDremainlargelyunknown,withinflammationandvagalstimulationplayingapossibleroleinthedevelopmentofthesedisorders.TreatmentwithprotonpompinhibitorsmayimprovesymptomsrelatedtoAFandfacilitateconversiontosinusrhythm.CONCLUSION:AlthoughlinksbetweenAFandGERDexist,largerandomizedclinicalstudiesarerequiredforabetterunderstandingoftherelationshipbetweenthesetwoentities.

简介：Incomparisonwiththenormalpeoplegroup,valuesofbloodCD2+andCD4+inpa-tientswithmallgnanttumorstreatedwithradiotherapyandchemotherapyweresignificantlylowerandtheratioofCD助+andCD8+decreasedobviously（allP<0.001）;CD8+hadnoapparentchange（P>0.05）.Followingacupuncturaltreatment,valuesofCD2+,CD4+andtheratioofCD4+toCD8+increasedobviously（allP<0.001）;whilethoseofthemedicinalcontrolgrouphadnosignificantchangeaftertreatment（P>0.05）.ValuesofIgG,IgAandIgMinpatients’serumpresentedanabnormalde-creasingorincreasingtendency,andC3inminorityofpatientswereraised.ResultsindicatedthattherewasabiphasicregulatoryeffectofacupunctureonthedisturbanceofhumoralimmunityandcouldcorrectthedeviationofC3level;anditseffectwasbetterthanorsimilartothatofthemedicinecontrolgroup.Itdemonstratesthatacupuncturecanenhanceandregulate.theimmunefunctionofpa-tientstreatedwithradiotherapya

简介：AbstractBackground:Preeclampsia (PE) is a serious complication that affects maternal and perinatal outcomes. However, the mechanisms have not been fully explained. This study was designed to analyze longitudinal gut microbiota alterations in pregnant women with and without PE in the second (T2) and third trimesters (T3).Methods:In this nested case-control study, which was conducted at Nanjing Maternity and Child Health Care Hospital, fecal samples from 25 PE patients (25 fecal samples obtained in T2 and 15 fecal samples obtained in T3) and 25 matched healthy controls (25 fecal samples obtained in T2 and 22 fecal samples obtained in T3) were collected, and the microbiota were analyzed using 16S rRNA gene sequencing. The diversity and composition of the microbiota of PE cases and controls were compared.Results:No significant differences in diversity were found between the PE and control groups (P > 0.05). In the control group, from T2 to T3, the relative abundances of Proteobacteria (median [Q1, Q3]: 2.25% [1.24%, 3.30%] vs. 0.64% [0.20%, 1.20%], Z = -3.880, P < 0.05), and Tenericutes (median [Q1, Q3]: 0.12% [0.03%, 3.10%] vs. 0.03% [0.02%, 0.17%], Z= -2.369, P < 0.05) decreased significantly. In the PE group, the relative abundance of Bacteroidetes in T2 was lower than in T3 (median [Q1, Q3]: 18.16% [12.99%, 30.46%] vs. 31.09% [19.89%, 46.06%], Z= -2.417, P < 0.05). In T2, the relative abundances of mircrobiota showed no significant differences between the PE group and the control group. However, in T3, the relative abundance of Firmicutes was significantly lower in the PE group than in the control group (mean ± standard deviation: 60.62% ± 15.17% vs. 75.57% ± 11.53%, t= -3.405, P < 0.05). The relative abundances of Bacteroidetes, Proteobacteria, and Enterobacteriaceae were significantly higher in the PE group than in the control group (median [Q1, Q3]: 31.09% [19.89%, 46.06%] vs. 18.24% [12.90%, 32.04%], Z=-2.537, P < 0.05; 1.52% [1.05%, 2.61%] vs. 0.64% [0.20%, 1.20%], Z=-3.310, P < 0.05; 0.75% [0.20%, 1.00%] vs. 0.01% [0.004%, 0.023%], Z = -4.152, P < 0.05). Linear discriminant analysis combined effect size measurements analysis showed that the relative abundances of the phylum Bacteroidetes, class Bacteroidia and order Bacteroidales were increased in the PE group, while those of the phylum Firmicutes, the class Clostridia, the order Clostridiales, and the genus unidentified Lachnospiraceae were decreased in the PE group; and these differences were identified as taxonomic biomarkers of PE in T3.Conclusion:From T2 to T3, there was an obvious alteration in the gut microbiota. The gut microbiota of PE patients in T3 was significantly different from that of the control group.

简介：AIM:Todescribetheresultsof5consecutivecasesofclearlensextractioninangleclosurepatientsforthetreatmentofelevatedintraocularpressure(IOP).·METHODS:Retrospectiveobservationalcaseseries.Allangleclosurepatientswereontwoormoretopicalglaucomamedicationsandhadpriorlaseriridotomy.Eyesunderwentclearlensextractionbyphacoemu-lsificationwithintraocularlensimplantation.·RESULTS:Allfivepatientsinthiscaseseriescarriedthediagnosisofangle-closureglaucomaandhaduncontrolledIOPpriortosurgerydespitetopicalmedications.AfterclearlensextractionthreeofthecaseshadgoodIOPcontrol(IOP<22mmHg)withouttheneedfortopicalmedications.InonecasetheIOPwasbettercontrolledaftersurgery,however,topicalmedicationswererequired.ThedesiredIOPwasnotmetinonecasedespiterestartingmaximumtopicaltherapy.·CONCLUSION:Thiscaseseriessuggeststhattheremaybearolefortherapeuticclearlensextractioninselectcasesofangle-closureglaucoma.

简介：AIM:ToinvestigateFusobacteriumnucleatum（F.nucleatum）abundanceincolorectalcancer（CRC）tissuesanditsassociationwithCRCinvasivenessinChinesepatients.METHODS:Theresectedcancerandadjacentnormaltissues（10cmbeyondcancermargins）from101consecutivepatientswithCRCwerecollected.Fluorescentquantitativepolymerasechainreaction（FQ-PCR）wasappliedtodetectF.nucleatuminCRCandnormaltissues.ThedifferenceofF.nucleatumabundancebetweencancerandnormaltissuesandtherelationshipofF.nucleatumabundancewithclinicalvariableswereevaluated.Fluorescenceinsituhybridization（FISH）analysiswasperformedon22CRCtissueswiththehighestF.nucleatumabundancebyFQ-PCRtestingtoconfirmFQ-PCRresults.RESULTS:ThemedianabundanceofF.nucleatuminCRCtissues[0.242（0.178-0.276）]wassignificantlyhigherthanthatinnormalcontrols[0.050（0.023-0.067）]（P<0.001）.F.nucleatumwasover-representedin88/101（87.1%）CRCsamples.TheabundanceofF.nucleatumdeterminedby2-ΔCTwassignificantlygreaterintumorsamples[0.242（0.178,0.276）]thaninnormalcontrols[0.050（0.023,0.067）]（P<0.001）.Thefrequencyofpatientswithlymphnodemetastaseswashigherintheover-abundancegroup[52/88（59.1%）]thanintheunder-abundancegroup[0/13（0%）]（P<0.005）.NosignificantassociationofF.nucleatumwithotherclinico-pathologicalvariableswasobserved（P>0.05）.FISHanalysisalsofoundmoreF.nucleatuminCRCthaninnormaltissues(mediannumber6,25th3,75th10vs2,25th1,75th5)（P<0.01）.CONCLUSION:F.nucleatumwasenrichedinCRCtissuesandassociatedwithCRCdevelopmentandmetastasis.

简介：瞄准：在先进或变形的颜色加irinotecan+/-bevacizumab调查cape-citabine的功效和安全表面的癌症病人。方法：四十六个病人与以前未经治疗，局部地进展或变形颜色表面的癌症(mCRC)在未来的开标签的阶段II试用在2001-2006之间被招募，在德国基于社区的门诊病人诊所。病人们加bevacizumab(CAPIRI十亿电伏)加irinotecan(CAPIRI)或CAPIRI收到了标准capecitabine政体每3wk。剂量减小从在>等级2毒性的情况下的第一个周期是强制的。bevacizumab的治疗选择依据见解医生。主要端点是反应和毒性，第二等的端点包括了没有前进的幸存和全面幸存。结果：在CAPIRI组对CAPRI十亿电伏组，比男病人(47%对24%)有更多的女性，并且更多的病人与作为主要肿瘤地点(5.9%对20.7%)有S字形的冒号的更少病人一起作为主要肿瘤地点(58.8%对48.2%)有冒号。等级3/4毒性比CAPIRI十亿电伏与CAPIRI是更高的：82%对58.6%。部分反应率是29.4%和34.5%，并且肿瘤控制率分别地是70.6%和75.9%。没有完全的回答被观察。中部的没有前进的幸存分别地为CAPIRI和CAPIRI十亿电伏是11.4瞬间和12.8瞬间。为CAPIRI的中部的全面幸存是15瞬间(458d)并且为CAPIRI十亿电伏24瞬间(733d)。这些差别不是统计上不同的。在CAPIRI十亿电伏，组织，二个病人在治疗以后经历了完整的第二等的肿瘤切除术，而在CAPIRI组没有盒子经历了这个过程。结论：政体很好被容忍并且在这门诊病人设置为有效肿瘤提供了生长控制。严重胃肠的毒性和thromboembolic事件是稀罕的并且如果观察从来不是致命的。

简介：Objective:Theextremityinjurypatternafteramajorearthquakeisnotwellunderstoodbecausedataonthistypeofinjuryandmanagementarelimited.Theaimofthisstudywastoanalyzethedataoftraumapatientswithex-tremityinjuryintheearthquakeofBarnIran,registering6.6ontheRichterscale.Methods:Wereviewedmedicalrecordsof486patientsadmittedtohospitalsofTehranUniversityofMedicalSciences.Amongthem,274patientssustainedextremityinjuries.Thisgroupwascomposedof138females(50.4%)and136males(49.6%)and213cases(77.7%)wereunder40yearsofage.Results:Fracturewasthemajortypeofinjury(58.4%ofextremityinjuries).Themostcommonsitesofinjurywerelowerextremities(185patients,67.5%ofallvictims).Pelvic&ribfracturesandabdominalinjurieswerethemostfre-quentlyassociatedinjuries.ThemeanISSwas6.2±4.0,and61%ofthepatientshadISS≤7.Amputationanddeathoccurredin2.9%and2.5%ofcases,respectively.Conclusions:Specialattentionshouldbegiventodeal-ingwithorthopedicinjuriesinsimilardisastersinthefuture.

简介：AbstractThis study aimed to determine the clinical characteristics of patients diagnosed with the coronavirus disease 2019 (COVID-19). Clinical data of COVID-19 patients diagnosed between January 28, 2020 and February 23, 2020 at the Beijing You'an Hospital were summarized and analyzed. Overall, 45 (18 men and 27 women) patients were included in this study. The average age of patients was 58 years (range, 7–94 years). Furthermore, 21 patients (47%) experienced underlying chronic diseases, with another four patients (9%) having three or more chronic diseases simultaneously. The first symptoms appeared at the onset of illness onset include fever in 36 patients (80%), cough in 23 patients (51%), and expectoration in 15 patients (33%), respectively. Patients may experience hepatic and renal injury as well as abnormal myocardial enzymes in varying degrees. Senior patients (≥58) and accompanying chronic diseases were considered as independent predictors for developing a severe and critically ill population with increased mortality. Laboratory results regarding the NEU percentage, NLR, ALC, and C-reactive protein levels were considered significant in predicting clinically critical disease or for prognosis assessment and thus require further studies. COVID-19 may affect multiple organs of the human body. Glucocorticoid is considered effective in the treatment of patients diagnosed with severe COVID-19.

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简介：Objective:Toanalyzethecorrelationsamongcomorbidityandoverallsurvival(OS),biochemicalprogression-freesurvival(b-PFS)andtoxicityinelderlypatientswithlocalizedprostatecancertreatedwith125Ibrachytherapy.Methods:Elderlymen,aged≥65years,withlow-intermediateriskprostatecancer,weretreatedwithpermanent125Ibrachytherapyasmonotherapy.Comorbiditydatawereobtainedfrommedicalreportsusingage-adjustedCharlsoncomorbidityindex(a-CCI).Thepatientswerecategorizedintotwoagegroups(<75and≥75yearsold),andtwocomorbidityscoregroups(a-CCI≤3and>3).ToxicitywasscoredwithRadiationTherapyOncologyGroup(RTOG)scale.Results:FromJune2003toOctober2009,atotalof92elderlypatientsunderwentprostatebrachytherapy,including57men(62%)withlow-riskprostatecancer,and35men(38%)withintermediate-riskprostatecancer.Themedianageofpatientswas75years(range,65-87years).Forty-sevenpatients(51%)hada-CCI≤3and45patients(49%)a-CCI>3.Withamedianfollow-upperiodof56months(range,24-103months),the5-yearactuarialOSandb-PFSwere91.3%and92.4%respectively,withoutstatisticalsignificancebetweentwoCharlsonscoregroups.Toxicitywasmild.Noneofthepatientsexperiencedgastrointestinal(GI)toxicity,andonly4patiens(4%)experiencedlategenitourinary(GU)grade-3(G3)toxicity.NocorrelationbetweenacuteGUandGItoxicityandcomorbiditywasshowed(P=0.50andP=0.70,respectively).Conclusions:Ourdatasuggestthatelderlymenwithlow-intermediateriskprostatecancerandcomorbiditycanbeconsideredforaradicaltreatmentas125Ilow-doseratebrachytherapy.

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