简介：

简介：AbstractObjective:The treatments and prognoses of high-risk and low-risk basal cell carcinomas are quite different. This study aimed to examine the dermoscopic features of basal cell carcinomas and assess the association between the features and basal cell carcinomas recurrence risks in a Chinese population.Methods:Patients with histopathologically confirmed basal cell carcinomas examined from March 2016 to April 2020 were enrolled. The dermoscopic features were evaluated, and the correlations between these features and the histological types and recurrence risks were assessed.Results:The study cohort comprised 119 Chinese patients with a total of 119 skin lesions. The most common dermoscopic feature of basal cell carcinomas was the absence of a pigment network (119/119, 100%), followed by shiny white streaks (105/119, 88.24%), blue-gray ovoid nests (99/119, 83.19%), multiple blue globules (78/119, 65.55%), and arborizing vessels (78/119, 65.55%); yellow-white structures were present in 29/119 lesions (24.37%). Leaf-like and spoke-wheel areas were significantly associated with superficial basal cell carcinomas (P < 0.001), while arborizing vessels (P < 0.001), blue-gray ovoid nests (P < 0.001), and ulceration (P < 0.05) were significantly associated with nonsuperficial basal cell carcinomas subtypes. The dermoscopic features of the high-risk and low-risk groups exhibited considerable overlap; however, the respective independent predictive factors for a high and low risk of basal cell carcinomas recurrence were short fine telangiectases (P < 0.05) and blue-gray ovoid nests (P < 0.05).Conclusion:Dermoscopy provides important information about basal cell carcinomas and is helpful in differentiating superficial basal cell carcinomas from other subtypes. The dermoscopic vascular structures and blue-gray ovoid nests play a crucial role in evaluating the basal cell carcinomas risks preoperatively.

简介：无

简介：AbstractObjective:To clarify whether the serum squamous cell carcinoma antigen (SCCA) levels of patients with inverted papilloma (IP) are different from patients with nasal polyps (NP) and rhinitis.Materials and methods:Serum SCCA levels were measured in 30 patients with IP and 30 patients with NP at one day before surgery and seven days after surgery and measured in 28 patients with rhinitis.Results:Elevated serum SCCA levels (>1.5 ng/ml) were found in 80.0% of patients in the IP group, 6.7% of patients in the NP group and 14.3% of patients in the rhinitis group, which was a significant difference. The medians of serum SCCA levels in the IP, NP and rhinitis groups were 3.9, 0.8 and 1.1 ng/ml, respectively, which was a significant difference. The SCCA level in IP group was not significantly correlated according to Krouse Staging. There was a significant difference in serum SCCA levels between the pre- and postoperative stages in the IP group, at 3.9 and 0.8 ng/ml, respectively, while in the NP group the levels were 0.8 and 1.0 ng/ml, not significantly different. With regard to the IP diagnosis in the IP and NP group based on the SCCA level (>1.5 ng/ml), sensitivity and specificity was 80.0% and 93.3%, respectively.Conclusions:The serum SCCA level in patients with IP was elevated and then it decreased after surgery. This was different from NP and rhinitis patients who mostly had normal levels, which did not change.

简介：

简介：Extrapulmonarysmallcellcarcinoma(EPSCC)isarareneoplasmcomprising2.5%to5%ofsmallcellcarcinomas(SCCs).BladderSCCisthemostcommonsiteofgenitourinarytract.PrimaryrenalSCCisextremelyrare.WereportacaseofprimarySCCofthekidneywhichisrarelyreportedintheurinarytractandpresentsanaggressiveclinicalpicture.A59-year-oldfemalevisitedaurologicclinicwithcomplaintofpersistentleftflanksoreness10yearsafterundergoingrenaltransplantation.Abdominalcomputedtomographyshowedaleftrenalpelvistumor.Afterthepatientreceivedleftnephroureterectomywithbladdercuffresection,herpathologyresultsshowedSCC.Aftersurgery,shereceivedadjuvantsystemicchemotherapy,andherrecoveryhasbeenuneventfulasof8months.PrimaryrenalSCCpresentswithanadvancedtumorstageandashortmediansurvivalperiod,thereforeearlyinterventionandclosefollow-uparerecommended.

简介：Objective:Oralsquamous-cellcarcinoma(OSCC)accountsfor>90%oforalcancersaffectingadultsmostlybetweenthefourthtoseventhdecadesoflife.ThemostcommonOSCCtreatmentisconcomitantchemoradiotherapy(CCRT)havingbothlocoregionalanddistantcontrol,butCCRThasacuteandchronictoxiceffectsonadjacentnormaltissue.ThisstudyaimedtodeterminethesideeffectsofCCRTontheoralmucosaandtocharacterizetheclinicopathologyoforallesionsinpatientswithOSCC.Methods:Thisdescriptive,cross-sectionalstudywascertifiedbytheEthicalReviewCommittee(UHS/Education/126-12/2728)oftheUniversityofHealthSciences,Lahore,Pakistan.OSSCpatients(n=81)withvarioushistologicalsubtypes,grades,andstageswererecruited,andfindingsontheiroralexaminationwererecorded.Thesepatientsreceived70,90,and119Gyofradiotherapydosagesincombinationwiththechemotherapydrugscisplatinand5-fluorouracil.DatawereanalyzedusingSPSS20.0.Results:ThemostcommonpresentationofOSCCwasanonhealingulcer(63%)involvingtongue(55.6%).Clinicalfindingsincludedmucositis(92.6%)andxerostomiaofmild,moderate,andseveredegreesin11.1%,46.9%,and35.8%cases,respectively.Ulcers(87.7%),palpablelymphnodes(64.2%),limitedmouthopening(64.2%)andfistula(40.7%)werealsoobserved.Infemales,theassociationofradiotherapydosagewithlimitedmouthopening,xerostomia,andhistologicalgradingwasstatisticallysignificant(P<0.05).Theassociationofchemotherapydrugswithxerostomia(P=0.003)wasalsostatisticallysignificant.Conclusions:CCRTinducedmucositis,xerostomia,andtrismusinpatientswithOSCC.

简介：

简介：MicroRNAs(米尔)是被报导了正在答应诊断工具的小noncodingRNA。我们使用了量的即时反向的抄写PCR(RT-qPCR)分析在前列腺肿瘤的表示miRNAs取样决定它的预示的价值的差别。从2007～2009，肿瘤纸巾从73个激进的前列腺切除术标本被获得。差别表示了miR-96，-145和-221被TaqManRT-qPCR用所有73纸巾验证。预示的价值用Kaplan-Meier和考克斯回归分析以生物化学的复发被估计。为我们的耐心的队，吝啬的年龄是64.7年(50-76年)，吝啬的前列腺特定的抗原(PSA)是7.5 ；ngml−1。在后续时期期间(平均数，19.4个月)，73中的14个(19.2%；)病人们发展了生物化学的复发。miR-96，-145和-221的表示与对方一起强烈相关，但是在miRNA表示和clinicopathologic参数之间没有关联。用木头等级测试的Kaplan-Meier幸存曲线与病理学的舞台显示出减少的生物化学的没有复发的间隔(P<；0.001)。另外，有超过8的格利森分数的病人，6与格利森一起与那些相比得分，在Kaplan-Meier分析(P=0.001)显示出减少的生物化学的没有复发的间隔。然而，miR-96，-145和-221的表示没用考克斯在Kaplan-Meier幸存曲线或由multivariate分析与生物化学的复发间隔相关比例的危险回归模型也。在结论，我们没观察在miR-96，-145和-221和clinicopathologic参数的表达式之间的重要关联。为了在临床的实践作为一个诊断工具利用miRNA，更多的研究被需要理解miRNA机制，识别miRNA目标，并且进一步描绘miRNA，工作。

简介：SerumALD-Aof57patientswithHCCand43ofotherdiseasesweremeasuredbyALD-A-McAblinkedwith425I-staphylococcusAprotein.TheresultsshowedthattheALD-AinpatientwithHCCwassignificantlyelevatedascomparedwithcontrolsandthatinpatientswithcholangiocarcinoma,gastrointestinalcancerwithouthepaticmetastasis,cirrhosis.CAHandbenignGIdiseases.TherewasnostatisticaldifferencebetweenALD-AinpatientswithHCCandthatincasesofcirrhosiswithliverfailureandthatincasesofmetastaticlivercarcinoma.ItwasnotedthatdiagnosticsensitivityofALD-AinAFP(+)HCCwas73.9%andthatinAFP(-)HCCwas81.8%1-6patientswithHCCweretreatedbyhepaticarterialembolizationcombinedwithchemotherapy.ALD-Ainpatientsafterthetreatmentdecreasedsignificantlythanthatbeforetreatment,furthermore,advantagesofthemethodarediscussed.

简介：AbstractIntroduction:Erosive pustular dermatosis of the scalp (EPDS) is an uncommon condition with unknown etiology. The clinical exclusive diagnosis needs to be differentiated from similar diseases.Here, we present a case of EPDS after surgical treatment of scalp squamous cell carcinoma.Case presentation:A 68-year-old woman presented with an eight-month history of a chronic scalp eruption. She had been diagnosed as squamous cell carcinoma by biopsy nine months ago, and had been treated by surgical excision and skin grafting. One month later, she was referred for evaluation of the newly enlarged lesion which was observed at the skin grafting site. She was diagnosed of EPDS based on characteristics of lesions, clinicopathological findings and laboratory data. The condition had clinically improved with systemic steroid therapy and topical tacrolimus for two weeks. Relapses occurred after complete withdrawal of both treatments. After repeating the above therapy and applying topical tacrolimus as maintenance therapy, the condition was well controlled at the one-year follow-up.Discussion:EPDS is an uncommon inflammatory dermatosis with main incidence rate of elderly patients and female predominance. The diagnosis of EPDS cant be made only by histopathological examination, which is helpful for differential diagnosis. Microbiological investigations commonly remain negative. For the high risk of relapse, it is important for clinicians to be aware of maintenance treatment and a long-term management.Conclusion:It should be recognized by clinicians that EPDS is an uncommon and relapse disease, leading to serious cosmetic problems. The treatment lacks evidence-based medicine data, clinician should choose the appropriate therapy according to the condition of patients.

简介：ＴＨＥＲＯＬＥＯＦＭＲＩＩＮＴＨＥＩＬＬＵＳＴＲＡＴＩＯＮＯＦＭＥＴＡＳＴＡＴＩＣＬＹＭＰＨＡＴＩＣＰＡＴＨＷＡＹＳＡＮＤＣＬＩＮＩＣＡＬＮＳＴＡＧＩＮＧＯＦＮＡＳＯＰＨＡＲＹＮＧＥＡＬＣＡＲＣＩＮＯＭＡＷｅｉＸｉｏｎｇ韦雄ＬｉＪｉａｎｊｕｎ李建军...

简介：瞄准：在根据操作特征(巨鸟)曲线分析的接收装置预言胰腺的癌的体面评估浆液CA19-9层次的临床的价值。方法：浆液CA19-9层次与可能根据成像是resected的胰腺的癌症在104个病人被测量。巨鸟曲线为CA19-9层次被阴谋。最近到图的上面的左边的角落的点被选择为截止的点。敏感，特性，在这个截止的点的CA19-9的积极、否定的预兆的价值被计算。结果：可切除的胰腺的癌症在58被检测(55.77%)病人和unresectable胰腺的癌症在46被检测(44.23%)病人。在ROC曲线下面的区域是0.918和95%CI是0.843-0.992。CA19-9水平是353.15U/mL，和敏感，在这个截止的点的CA19-9的特性分别地是93.1%和78.3%。积极、否定的预兆的价值分别地是84.38%和90%。结论：外科手术前的浆液CA19-9水平是为进一步评估胰腺的癌症的将切除能力的一个有用标记。CA19-9的显然增加的浆液层次(>353.15U/mL)能为unresectable被认为是一个辅助参数胰腺的癌症。

简介：Renalcellcarcinoma(RCC)accountsforapproximately3%ofallcancercases.RCCsusuallymetastasizetothelungs,bones,liver,orbrain.Only<1%ofpatientswithbonemetastasesmanifestedclavicularRCCmetastases.Thus,clavicularmetastasisastheinitialpresentationofRCCisextremelyrare.WereportapatientwithRCCmetastasistotheleftclavicle,whichwasfirstpresentedwithpaincausedbyapathologicalfracture.Magneticresonanceimagerevealedarenaltumor,andtechnetium-99m–methylenediphosphonatebonescintigraphyshowedmultipleosseousmetastases.Thepatienteventuallyunderwentsurgerytoremovethelateralendoftheleftclavicleandrightkidney.Histopathologyrevealedrenaltumorandclearcellcarcinomaintheclavicle.Finally,wereview17casesofclavicularmetastasesoriginatingfromdifferentmalignancies.

简介：对不完全的肠的阻塞的评估的主要诊断挑战是在传染、恶意的病原学之间区分。我们在场抱怨伴有恶心的腹的疼痛并且呕吐的一个老女人的一个案例，和到通行证气体或凳子的失败。反肺结核药被用来减轻她的腹的疼痛，并且腹洞的针活体检视显示出腹膜(PSCP)的主要的乳突的浆液的癌的证据。这是对在PSCP的背景的肺结核的稀罕描述。这份报告为恶意与风险因素说明恶意的潜在的复杂性质，并且强调需要在病人考虑恶意和感染的共存，特别在那些与抗菌素治疗失败。

简介：

简介：无

简介：TheaimofthepresentstudywastodeterminetheefficacyofimmunotherapywithdendriticcellstoelicitEBV-specificCTL-immunityinadvancedcasesofEBV-positivepatientswithnasopharyngealcarcinoma(NPC)andtodeterminethesafetyandtoxicityofthispreparation.NinecasesofhistologicallyconfirmedpatientswithNPCundergoingtreatmentwithradiologicaltherapywereenrolledinthisstudy.Dendriticcells,generatedinvitrofrombloodmonocytesofpatientswereculturedandmaturedwithcytokinesandtheninfectedwithrecombinantadenovirusvaccinecontainingEBV-latentmembraneprotein-2(Ad-LMP2).On9days'cultivationofcells,thematuredDCswereharvested,irradiatedwithCoandtheninjectedintradermallytopatientswithNPC.Theinjectionswereperformed3timestotally.Afterimmunization,theCTLresponseswereassayedbymeansofcytotoxicityandepitope-specificIFN-γproduction.Theresultsofthistrialshowedthatallpatientscouldtoleratethiskindoftreatmentwithoutanysideeffect,duringwhichmarkedincreaseofLMP2-specificCTL-responsescouldbedemonstratedin5patientsofthisgroup.AndthelevelofIgA/VCAantibodydecreasedin8of9patients,thusaccountingforabetterprognosisforthesepatients.Allpatientswillbefollowedupforanotheroneyear.Atleast,thepresentworkshowsthatintradermalvaccinationwithautologousDCsinfectedwithrecombinantAd-LMP2adenovirusisasafeprocedureinNPCpatients,inwhichthisprocedurecanenhancetheLMP2-specificCTLresponsesinpatients.Thesedataareencouragingtodevelopmoreeffectivevaccinestrategiesforthetreatmentofnasopharyngealcarcinoma.

简介：

简介：AbstractIntroduction:Nevoid basal cell carcinoma syndrome is an autosomal dominant disorder characterized by developmental malformations and carcinogenic activity. Multi-systemic anomalies may occur in this syndrome, such as odentogenic keratocysts of the mandible and postnatal tumors, especially multiple basal cell carcinoma.Case presentation:A 60 year old man presented with systemic plaques and nodules for more than 30 years. Cutaneous examination revealed that invasive erythema and black papules scattered on the face, trunk and limbs. He underwent extended surgical excision of lesions at multiple sites. No new lesions were found in the treated areas during a 3-year follow-up. Topical 5-aminolevulinic acid-mediated photodynamic therapy (ALA-PDT) was given as a palliative treatment for ulcerated tumors on the right lower eyelid and bleeding of the right temporal lesion. After application of ALA-PDT, the ulcers almost healed and the recurring hemorrhage ceased.Discussion:The management of multiple tumors in patients with nevoid basal cell carcinoma syndrome is extremely difficult, especially in the face. Surgical excision is the standard method, but the procedure can be applied in limited sites and may result in significant disfigurement and the difficulty of wound recovery. PDT can play a significant role in combination therapy for tumors that are extremely difficult to remove completely by surgical excision.Conclusion:We present a rare case manifested as multiple basal cell carcinoma and palmar pits who treated by surgery combined with topical 5-aminolevulinic acid-mediated photodynamic therapy. The combined therapy plays a complementary role in the treatment of nevoid basal cell carcinoma syndrome.