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简介：客观fMLP-boanmycin(欺骗)的禁止的行动老鼠结肠癌和它的行动机制的生长上的联合被观察以便为在癌症的治疗与化疗在联合探查趋化性的调整的新奇政体提供试验性的证明。到肿瘤房间的BAM-fMLP联合的方法Cytotoxicity被MTT试金在vitro决定。BAM-fMLP联合的Antitumor活动皮下地在老鼠被估计移植冒号癌26。免除fMLP的superoxide阴离子的数量刺激了巨噬细胞被NBT决定试金。氮的氧化物的数量(没有)被Griess间接地决定方法。结果BAM-fMLP联合没在肿瘤房间上有synergistic效果(CDI>0.85)，但是在在有在集中20g/ml的fMLP的联合的10g/ml，30g/ml和100g/ml的剂量的欺骗面对巨噬细胞在肿瘤房间上展出了synergistic效果(CDI<0.75)。当它peritumorally在1mg/mouse的剂量被管理时，fMLP禁止了在50.0%的冒号癌26的生长。欺骗(intraperitoneally，三预定的1mg/kg)独自一个并且欺骗fMLP联合禁止了在38.6%和78.4%的结肠癌26的生长，分别地(CDI=0.71)在白天12上。数量免除了fMLP4.6?÷

简介：客观；在忍受肝癌症的老鼠调查鼠科的IL-12基因和HSV-TK基因治疗的synergistic反肿瘤效果。方法：老鼠肝癌症MM45T李(H-2d)房间是有包含IL-12基因或HSV-TK基因的retroviral向量的transfected插入修改基因的肝癌症房间，MM45TLi/IL-12和MM45TLi/TK，与IL-12和TK的稳定的表示被获得。Balb/c老鼠与2X105MM45T李房间皮下地被接种。当肿瘤到达了0.5鈥?.0厘米的一种尺寸时，MM45T.Li/TK房间的混合物照耀and60Co的MM45TLi/IL-12房间intratumoraly被注射。Ganciclovir(GCV)是注射ip(40mg.kg?1.d?1)为10天。Intratumoral注射照耀of60Co的MM45TLi/IL-12房间分开在一个星期内被重复两次。有远肿瘤的老鼠根据一样的协议被对待。怒气房间的CTL活动是测量by51Cr版本试金和由染色的immunohistochemical渗入淋巴细胞的肿瘤的显型。结果：在与MM45T对待的老鼠，Li/IL-12或MM45TLi/TK+GCV个别地在肿瘤生长，而是两个都不导致了中等减小能根除肿瘤完全，当时在加GCV与MM45TLi/IL-12和MM45TLi/TK细胞的混合物对待的60%老鼠，完全的肿瘤回归被观察，没有为二个月的肿瘤复发。远肿瘤的生长也在同样对待的老鼠显著地被禁止。大多数收到的老鼠加GCV联合了基因治疗有的丰富的CD4+，CD8+T淋巴细胞渗入。他们的CTL活动比在老鼠显著地高收到的单个基因治疗。有加GCV的IL-12基因和HSV-TK基因的结论联合治疗为老鼠肝癌症是有效的。

简介：Thisisareportofanonrandomizedcomparisonoftreatmentresultsof139patientswithstageIB,HAandproximalIIBcarcinomaoftheuterinecervixtreatedbyradiationaloneand113treatedwithacombinationofradiationandsurgery.Thefive-yeartumorfreeacturialsurvivalforthepatientswithstageIBeitherwithirradiationalone(RT)orcombinedwithsurgery(RS)wasapproximately87%.ForstageⅡthetumorfreeactuarialfive-yearsurvival79%withpatientsofRS,and76%withRT.Inthe113patientstreatedwithRStherewere18(16%).Inthe139patientstreatedbyRTtherewere18(13%)recurrencesofpelvic,4localrecurrences,11combinedwithparametrial,andfreeparametrialrecurrences.Therewasnosignificantdifferenceinthesurvivalandrecurrencerateofthepatientstreatedwitheithermethod.Majorcomplicationswerecomparableinbothgroups(RTapproximately25%andRSapproximately10%),but2/3ofthosecomplicationsrecoveredwithoutsequelae.Themostfrequentminor

简介：在分析hydrotreating催化的裂开联合处理的传统的残余的劣势以后，RIPP建议了集成与催化裂开对待的残余水疗院的一种双向联合技术叫了不推进的RICP再循环FCC在FCC单位内的重周期油(HCO)并且把HCO送到对待为并发地受到对待的水疗院的残余作为冲淡的油联合起来的残余水疗院在被用作FCC以前喂油。RICP技术能刺激与FCC轻精华的增加的收益一起通过HCO的利用对待反应的残余水疗院，导致提高的石油利用和精炼厂的经济好处。

简介：植物材料的使用作为土壤修正案是在在迦纳的主要耕作社区之中的一个不平常的惯例，尽管它为土壤富饶改进是必要的。土壤修正案的效果的考试是必要的鼓励under-utilized的使用在迦纳的器官的资源。因此，一个地实验用作为测试庄稼为西红柿的生长作为土壤修正案与鸡粪肥混合的8不同热带植物材料被进行。植物材料包括了Leucaenaleucocephala，Centrosemapubescens，Sesbaniasesban，Gliricidiasepium，Mucunapruriens，Puerariaphaseoloides，Azadirachtaindica，和Theobroma可可子。有二个另外的处理：有有没有化肥输入(控制)的化肥和其它的相等的数量的。植物材料与鸡粪肥被混合获得一致carbon-to-nitrogen(C:N)5:1的比率。除了没有化肥控制，所有处理收到了氮(N)的一样的数量。在土壤澄清植物材料的分解模式，一个孵化实验在地实验前用仅仅植物材料被进行。Gliricidia处理显著地在孵化实验比另外的植物材料释放了更多的矿物质N。然而，西红柿水果收益没在地实验在Gliricidia处理被提高。测试植物材料的已知的优秀参数例如全部的N，总计碳(C)，C:N比率，和全部的多酚，他们的矿化作用动力学上的有的最小的效果。Azadirachta通过显著地增加微生物引起的生物资源和水果西红柿产出的土壤与鸡肉粪肥显示出最好的synergistic效果。这结果在小规模的农业资源作为一个土壤修正案在联合向卓见提供进Azadirachta的可能的采纳鸡粪肥。

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简介：Thecombinationofdeepwetetchingandamagneto-rheologicalfinishing(MRF)processisinvestigatedtosimultaneouslyimprovelaserdamageresistanceofafused-silicasurfaceat355nm.ThesubsequentlydepositedSiO2coatingsareresearchedtoclarifytheimpactofsubstratefinishingtechnologyonthecoatings.Itisrevealedthatadeepremovalproceedingfromthesinglesideordoublesidehadasignificantimpactonthelaser-induceddamagethreshold(LIDT)ofthefusedsilica,especiallyfortherearsurface.Afterthedeepetching,theMRFprocessthatfolloweddoesnotactuallyincreasetheLIDT,butitdoesamelioratethesurfacequalitieswithoutadditionalLIDTdegradation.Thecombinationguaranteeboththeintegrityofthesurface’sfinishandthelaserdamageresistanceofthefusedsilicaandsubsequentSiO2coatings.

简介：AbstractBackground:Finding an optimal treatment strategy for adolescent idiopathic scoliosis (AIS) patients remains challenging because of its intrinsic complexity. For mild to moderate scoliosis patients with lower skeletal growth potential (Risser 3-5), most clinicians agree with observation treatment; however, the curve progression that occurs during puberty, the adolescent period, and even in adulthood, remains a challenging issue for clinicians. The aim of the study is to investigate the efficacy of Schroth exercise in AIS patients with lower skeletal growth potential (Risser 3-5) and moderate scoliosis (Cobb angle 20°-40°).Methods:From 2015 to 2017, data of 64 patients diagnosed with AIS in Peking University Third Hospital were reviewed. Forty-three patients underwent Schroth exercise were classified as Schroth group, and 21 patients underwent observation were classified as observation group. Outcomes were measured by health-related quality of life (HRQOL) and radiographic parameters. HRQOL was assessed using the visual analog scale (VAS) scores for back, Scoliosis Research Society-22 (SRS-22) patient questionnaire. Radiographic spinopelvic parameters were obtained from anteroposterior and lateral X-rays. The pre-treatment and post-treatment HRQOL and radiographic parameters were tested to validate Schroth exercise efficacy. The inter-rater reliability of the radiographic parameters was tested using the interclass correlation coefficient (ICC). The paired t test was used to examine HRQOL and radiographic parameters. Clinical relevance between C2-C7 sagittal vertical axis (SVA) and thoracic kyphosis was analyzed using Spearman correlation.Results:In Schroth group, VAS back score, SRS-22 pain, and SRS-22 self-image domain were significantly improved from pre-treatment 3.0 ± 0.8, 3.6 ± 0.5, and 3.5 ± 0.7 to post-treatment 1.6 ± 0.6 (t = 5.578, P = 0.013), 4.0 ± 0.3 (t = -3.918, P = 0.001), and 3.7 ± 0.4 (t = -6.468, P < 0.001), respectively. No significant improvements of SRS-22 function domain (t = -2.825, P = 0.088) and mental health domain (t = -3.174, P = 0.061) were observed. The mean Cobb angle decreased from 28.9 ± 5.5° to 26.3 ± 5.2° at the final follow-up, despite no statistical significance was observed (t = 1.853, P = 0.102). The mean C2-C7 SVA value decreased from 21.7 ± 8.4 mm to 17.0 ± 8.0 mm (t = -1.224 P = 0.049) and mean T1 tilt decreased from 4.9 ± 4.2 ° to 3.5 ± 3.1° (t = 2.913, P = 0.011). No significant improvement of radiographic parameters and HRQOL were observed in observation group.Conclusions:For AIS patients with a Risser 3-5 and a Cobb angle 20°-40°, Schroth exercises improved HRQOL and halted curve progression during the follow-up period. Both cervical spine alignment and shoulder balance were also significantly improved after Schroth exercises. We recommend Schroth exercises for patients with AIS.

简介：摘要ObjectiveThis study aimed to evaluate the effect of different combinations of rTMS and cognitive training (rTMS-COG) on PSCI and identify the optimal combination protocol.MethodsA cerebral infarction rat model was established by transient middle cerebral artery occlusion (tMCAO). The Morris water maze test was conducted to assess the cognitive function of rats. RNA sequencing and bioinformatics analysis were employed to study the underlying mechanisms.ResultsrTMS, COG and rTMS-COG all had beneficial effects on PSCI, while cognitive training immediately after rTMS (rTMS-COG0h) achieved a better effect than cognitive training 1 h and 4 h after rTMS, rTMS and COG. We identified 179 differentially expressed genes (DEGs), including 24 upregulated and 155 downregulated genes, between the rTMS-COG0h and rTMS groups. GO analysis revealed that the major categories associated with the DEGs were antigen procession and presentation, regulation of protein phosphorylation and axoneme assembly. KEGG analysis showed that the DEGs were enriched in processes related to phagosome, circadian entrainment, dopaminergic synapse, apelin signaling pathway, long-term depression, neuroactive ligand-receptor interaction, axon guidance and glucagon signaling pathway. PPI analysis identified Calb2, Rsph1, Ccdc114, Acta2, Ttll9, Dnah1, Dlx2, Dlx1, Ccdc40 and Ccdc113 as related genes.ConclusionsThese findings prompt exploration of the potential mechanisms and key genes involved in the effect of rTMS-COG0h on PSCI.

简介：Endoscopicultrasonography-guidedfine-needleaspiration（EUS-FNA）hasbeenappliedtopancreaticobiliarylesionssincethe1990sandisinwidespreadusethroughouttheworldtoday.Weusedthismethodtoconfirmthepathologicalevidenceofthepancreaticobiliarylesionsandtoperformsuitabletherapies.ComplicationsofEUS-FNAarequiterare,butsomeofthemaresevere.OperatorsshouldmasterconventionalEUSobservationandexperienceaminimumof20-30casesofsupervisedEUS-FNAonnon-pancreaticandpancreaticlesionsbeforeattemptingsoloEUSFNA.StudiesconductedonpancreaticobiliaryEUSFNAhavefocusedonselectionofsuitableinstruments（e.g.,needleselection）andsamplingtechniques（e.g.,fanningmethod,suctionlevel,withorwithoutastylet,optimumnumberofpasses）.Today,thediagnosticabilityofEUS-FNAisstillimproving;thedetectionofpancreaticcancer（PC）currentlyhasasensitivityof90%-95%andspecificityof95%-100%.InadditiontoPC,avarietyofrarepancreatictumorscanbediscriminatedbyconductingimmunohistochemistryontheFNAmaterials.Aflexible,largecaliberneedlehasbeenusedtoobtainalargepieceoftissue,whichcanprovidesufficienthistologicalinformationtobehelpfulinclassifyingbenignpancreaticlesions.EUSFNAcansupplyhighdiagnosticyieldsevenforbiliarylesionsorperi-pancreaticobiliarylymphnodes.ThisreviewfocusesontheclinicalaspectsofEUS-FNAinthepancreaticobiliaryfield,withtheaimofprovidinginformationthatcanenablemoreaccurateandefficientdiagnosis.

简介：Frequency-doubledantireflectioncoatingssimultaneouslyeffectiveat1064nmand532nmweredepositedonthelithiumtriborate(LiB3O5orLBO)crystalsusingtheelectronbeamevaporationmethod.Comparingwiththesamplewithoutbufferlayer,itisfoundthattheadhesionofthesamplewithbufferlayerofSiO2betweencoatingandLBOsubstrateisimprovedsignificantlyfrom137.4mNtogreaterthan200mN.Andthelaser-induceddamagethresholdisincreasedby20%from15.1J/cm2to18.6J/cm2.ThestrengtheningmechanismofadhesionofthebufferlayerofSiO2isdiscussedbyconsideringfullplasticindentationandsheartheory.

简介：PurdueUniversityresearchershavefoundamethodofidentifyingbiologicalmarkersinsmallamountsofbloodthattheybelievecouldbeusedtodetectamyriadofdiseases,infectionsanddifferentmedicalconditionsatearlystages.Apiezoelectricallyactuatedpipettesystemisusedasaninexpensivemeanstodetectbiologicalmoleculesassociatedwithspecificdiseases,infectionorother

简介：Background:Activevideogames(AVGs)encouragewholebodymovementstointeractorcontrolthegamingsystem,allowingtheopportunityforskilldevelopment.Childrenwithautismspectrumdisorder(ASD)showdecreasedfundamentalmovementskillsincomparisonwiththeirtypicallydeveloping(TD)peersandmightbenefitfromthisapproach.ThispilotstudyinvestigateswhetherplayingsportsAVGscanincreasetheactualandperceivedobjectcontrol(OC)skillsof11childrenwithASDaged6–10yearsincomparisonto19TDchildrenofasimilarage.Feasibilitywasasecondaryaim.Methods:Actual(TestofGrossMotorDevelopment)andperceivedOCskills(PictorialScaleofPerceivedMovementSkillCompetenceforYoungChildren)wereassessedbeforeandaftertheintervention(6×45min).Results:Actualskillscoreswerenotimprovedineithergroup.TheASDgroupimprovedinperceivedskill.Allchildrencompletedtherequireddoseandparentsreportedtheinterventionwasfeasible.Conclusion:TheuseofAVGsasaplay-basedinterventionmaynotprovideenoughopportunityforchildrentoperformthecorrectmovementpatternstoinfluenceskill.However,playofsuchgamesmayinfluenceperceptionsofskillabilityinchildrenwithASD,whichcouldimprovemotivationtoparticipateinphysicalactivities.

简介：A2D-directionofarrivalestimation(DOAE)formultiinputandmulti-output(MIMO)radarusingimprovedmultipletemporal-spatialsubspacesinestimatingsignalparametersviarotationalinvariancetechniquesmethod(TS-ESPRIT)isintroduced.InordertorealizetheimprovedTS-ESPRIT,theproposedalgorithmdividestheplanararrayintomultipleuniformsub-planararrayswithcommonreferencepointtogetaunifiedphaseshiftsmeasurementpointforallsub-arrays.TheTS-ESPRITisappliedtoeachsub-arrayseparately,andinthesametimewiththeotherstorealizetheparallellytemporalandspatialprocessing,sothatitreducesthenon-linearityeffectofmodelanddecreasesthecomputationaltime.Then,thetimedifferenceofarrival(TDOA)techniqueisappliedtocombinethemultiplesub-arraysinordertoformtheimprovedTS-ESPRIT.Itisfoundthattheproposedmethodachieveshighaccuracyatalowsignaltonoiseratio(SNR)withlowcomputationalcomplexity,leadingtoenhancementoftheestimatorsperformance.

简介：AIM:Toevaluatethelong-termresponsetothefixedcombinationofdorzolamide/timololinpatientswithprimaryopenangleglaucoma(POAG)andtheadditionofotherintraocularpressure(IOP)loweringmedicationssuchasprostaglandinanalogsandbrimonidine.METHODS:Aretrospective,non-randomized,anddescriptiveclinicalstudywasperformedwith182eyesdiagnosedwithPOAG.Patientsweredividedintothreegroups:agroupwithfixedcombinationofdorzolamide/timololonly,asecondgroupwithprostaglandinanalogsplusfixedcombinationofdorzolamide/timolol,andathirdgroupwiththeadditionofbrimonidinetothesamefixedcombination.IOPdataweregatheredretrospectivelyandthedifferencesbetweengroupswerecalculated.RESULTS:IOPwasreducedsatisfactorilyinallthreegroups;however,aprogressiveIOPreductionwasnotedinthegroupwiththefixedcombinationplusprostaglandinanalogs.Inthisgroup,aprogressive,significantandmorehomogeneousresponseofthereductionwasnotedincomparisonwiththeothergroups.CONCLUSION:IOPreductionwasefficaciousinallthreegroups.TheadditionofprostaglandinanalogsshowedprogressiveIOPreduction,progressiveresponseandabsenceoflong-termdrift.Brimonidinedidnotshowasignificantadditiveeffect.

简介：Thealternatecombinationalapproachofgeneticalgorithmandneuralnetwork(AGANN)hasbeenpresentedtocorrectthesystematicerrorofthedensityfunctionaltheory(DFT)calculation.IttreatstheDFTasablackboxandmodelstheerrorthroughexternalstatisticalinformation.Asademonstration,theAGANNmethodhasbeenappliedinthecorrectionofthelatticeenergiesfromtheDFTcalculationfor72metalhalidesandhydrides.ThroughtheAGANNcorrection,themeanabsolutevalueoftherelativeerrorsofthecalculatedlatticeenergiestotheexperimentalvaluesdecreasesfrom4.93%to1.20%inthetestingset.Forcomparison,theneuralnetworkapproachreducesthemeanvalueto2.56%.Andforthecommoncombinationalapproachofgeneticalgorithmandneuralnetwork,thevaluedropsto2.15%.Themultiplelinearregressionmethodalmosthasnocorrectioneffecthere.

简介：AbstractBackground:The screening of periprosthetic joint infection (PJI) in patients with inflammatory diseases before revision arthroplasty remains uncertain. Serum C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), plasma fibrinogen (FIB), monocyte/lymphocyte ratio, and neutrophil/lymphocyte ratio (NLR) can help screening PJI, but their values in patients with inflammatory diseases have not been determined.Methods:Patients with inflammatory diseases who underwent revision hip or knee arthroplasty at West China Hospital, Sichuan University, from January 2008 to September 2020 were divided into infected and non-infected groups based on the 2013 International Consensus Meeting criteria. Sensitivity and specificity of the tested biomarkers for diagnosing infection were determined based on receiver operating characteristic (ROC) curves, and optimal cutoffs were determined based on the Youden index. The diagnostic ability of these biomarkers was re-assessed after combining them with each other.Results:A total of 62 patients with inflammatory diseases were studied; of them 30 were infected. The area under the ROC curve was 0.813 for CRP, 0.638 for ESR, 0.795 for FIB, and 0.656 for NLR. The optimal predictive cutoff of CRP was 14.04 mg/L with a sensitivity of 86.2% and a specificity of 68.7%, while FIB had a sensitivity of 72.4% and a specificity of 81.2% with the optimal predictive cutoff of 4.04 g/L. The combinations of CRP with FIB produced a sensitivity of 86.2% and specificity of 78.1%.Conclusion:CRP with a slightly higher predictive cutoff and FIB are useful for screening PJI in patients with inflammatory diseases, and the combination of CRP and FIB may further improve the diagnostic values.Trial Registration:ChiCTR.org.cn, ChiCTR2000039989

简介：Apioneeringself-optimizingteachingmethodinstudent-centricseminarswasintroducedinthispaper,inwhicheachstudentwillestablishpreferredengineeringdrawingprocessdirectedbyeducatorsandnecessaryprinciples.Wepresentedtheworking-memorycenteredmechanisminmentalaspecttoexplainthephenomena.Thetheoreticalmechanismisbasedonthetypicaltranslationbetweenorthographicprojectionimageandperspectiveimage.Thefirstisbondingobjectintoawholesolid.Thesecondissplicingtheselectedsurfacesofobjectsandtailoredthemtogether.Twostudygroupsweredetermined:anexperimentalgroup,whoweredirectedtocombinetheobject-basedandsurface-basedconstructionmethodsinthepresentations,andacontrolgroup,wholearnedthroughregularpresentationsmadebyanexperiencedteacherduringthesameperiod.Theresultsshowedthatasignificantenhancementinaveragescoreshasbeenachievedinthetestamongtheexperimentalgroupincomparisonwiththecontrolgroup.Thevarianceofthescoresisobviouslyreducedthroughtheself-optimizinglearningstrategy,indicatingasignificantadvantageonfillinguptheabilitygapsamongstudents.Infact,theresultsalsoindicatedthattheeducatordidkeepthelessoninhighquality.Butitisworthyofmoreattentionthatthedifferenceofmentalmanipulationhabitsbetweensomestudentsandeducatormayleadtoapolarizationinscoredistribution.Sotheseminarisapromisingmethodtohelpthestudentstocombinetheobject-basedandsurface-basedconstructionmethods.

简介：InGaAsP/InPmultiplequantumwellswithquantumwellintermixinghavebeenpreparedbyimpurity-freevacancydisordering.Theluminescentcharacteristicswereinvestigatedusingphotoluminescenceandphotoreflectance,fromwhichthebandgapblueshiftwasobserved.Si3N4,SiO2andSOGwereusedforthedielectriclayertoenhanceintermixingfromtheoutdiffusionofgroupIIIatoms.Allsampleswereannealedbyrapidthermalannealing.Theresultsindicatethatthebandgapblueshiftvarieswiththedielectriclayersandtheannealingtemperature.TheSiO2cappingwithanInGaAscladdinglayerwassuccessfullyusedtoinducelargerbandtuningeffectintheInGaAsP/InPMQWsthantheSi3N4cappingwithanInGaAscladdinglayer.Ontheotherhand,sampleswiththeSi3N4-InPcaplayercombinationalsoshowlargerenergyshiftsthanthatwithSiO2-InPcaplayercombination.