简介：Codfishisakindofabyssalfishspecieswithagreatvalueinfoodindustry.However,theflavorofcodfish,especiallytheunpleasantodor,hascausedseriousproblemsinitsprocessing.Toaccuratelyidentifythevolatilecompoundsincodfish,acombinationofsolidphasemicro-extraction(SPME)methodandsimultaneousdistillationextraction(SDE)methodwasusedtoextractthevolatiles.Gaschromatography-massspectrometry(GC-MS)alongwithKovatsindices(KI)andauthenticstandardcompoundswereusedtoidentifythevolatiles.Theresultsshowedthatatotalof86volatilecompoundswereidentifiedincodfish,ofthem24wereextractedbySDE,69compoundsbySPME,and10compoundsbybothSDEandSPME.Seventyvolatilecompoundswerefoundtohavespecificodors,ofthem7typicalcompoundscontributedsignificantlytotheflavorofcodfish.Alcohols(i.e.,(E)-2-penten-1-oland2-octanol),esters(i.e.,ethylbutyrateandmethylgeranate),aldehydes(i.e.,2-dodecenalandpentadecanal)contributedthemosttofreshflavorwhilenitrogencompounds,sulphurcompounds,furans,aswellassomeketones(i.e.,2-hydroxy-3-pentanone)broughtunpleasantodor,suchasfishyandearthyodor.ItwasindicatedthatthecombinationofmultipleextractionmethodsandGC-MSanalysiscanenhancetheaccuracyofidentification,andprovideareferenceforthefurtherstudyonflavorofaquaticproducts.

简介：在有高地震的危险的地点的风汽轮机的宽推广导致了工程师考虑如此的结构的一个更全面的地震图案。汽轮机特定的指南通常使用简化方法并且认为许多假设把地震需求与完成这些结构的设计的另外的运作的负担相结合。当汽轮机在尺寸和能力增加，在地震负担和空气动力学的负担之间的相互作用变得甚至更重要。响应对能执行风和地震负担的联合模拟的一个计算工具的需要，一个地震模块为快代码被开发并且在这描述了研究。这个平台允许在这工业工作直接考虑在之间的相互作用的工程师地震并且为汽轮机的另外的环境负担。这篇论文详细说明这个平台的实际应用程序和理论并且为不同能力的使用提供例子。站台然后被用来与由估计适当负担因素的空气动力学的抑制的含蓄的考虑显示出合适的地震和运作的负担联合。

简介：Shingledmagneticrecording(SMR)caneffectivelyincreasethecapacityofharddiskdrives(HDDs).HostawareSMR(HA-SMR)isexpectedtobemorepopularthanotherSMRmodelsbecauseofitsbackwardcompatibilityandnewSMR-specificAPIs.However,anHA-SMRdriveoftensuffersperformancedegradationunderwrite-intensiveworkloadsbecauseoffrequentnon-sequentialwritesbufferedinthediskcache.Thenon-sequentialwritesmainlycomefromupdatewrites,smallrandomwritesandout-of-orderwrites.Inthispaper,weproposeahybridstoragesystemcalledROCOwhichaimstouseasolidstatedrive(SSD)cachetoimprovetheperformanceofanHA-SMRdrive.ROCOreordersout-of-orderwritesbelongingtothesamezoneandusestheSSDcachetoabsorbupdatewritesandsmallrandomwrites.WealsodesignadatareplacementalgorithmcalledCREAfortheSSDcache.CREAfirstconductszone-orientedhot/colddataidentificationtoidentifycold-cachedzonesandhot-cachedzones,andthenevictsdatablocksbelongingtocolderzoneswithhigherprioritiesthatcanbesequentiallywrittenorwrittenthroughhost-sideread-modify-writeoperations.Itgivesthelowestprioritytodatablocksbelongingtothehottest-cachedzonethathavetobenon-sequentiallywritten.ExperimentalresultsshowthatROCOcaneffectivelyreducenon-sequentialwritestotheHA-SMRdriveandimprovetheperformanceoftheHA-SMRdrive.

简介：Duetotheminiaturizationofmoderndevicesre-quirecomponentswithlightweight,highintegra-tionandtheabilitytostoreenergyinassmallvol-umeaspossible.Asaresult,energystoragedensitybecomesanimportantfigureofmeritforenergystor-agedevices.Inthispaper,firstly,wediscussedtheenergydensityinfine-grainedleadzirconatetita-nateglass-ceramicscompositewiththehelpofthe

简介：NiXinischiefphysician,professoranddoctoralsupervisor.HeisDirectorofBeijingChildren'sHospitalaffiliatedwithCapitalMedicalUniversity;DirectorofBeijingResearchInstituteofPediatrics;DeputyDeanofE.N.T.DepartmentinCapitalMedicalUniversity;ViceChairmanofSocietyofHeadandNeckSurgeryofChineseAnti-

简介：

简介：

简介：在病人作为首要或第二线的治疗评估paclitaxel，cisplatin和5-FU(PCF)的联合政体的功效和毒性与的目的进展胃并且在中国的esophagogastric连接(EGJ)腺癌。病人与paclitaxel被对待的方法d1上的150mg/m2；fractionatedcisplatin15mg/m2和连续注入5-FU600mg/(m2朠楬污映扩楲汬牡????????????М

简介：

简介：

简介：Recentadvancesinstemcelltechnologieshaveopenednewavenuesforthetreatmentofanumberofdiseasesstilllackingeffectivetherapeuticoptions.Celltransplantationhasemergedasamongthemostpromisingclinicalinterventionfordisorderssuchasinjuries,diabetes,liver

简介：

简介：

简介：在与有一致基因背景的植物的一个玉米领域里的黄麴毒素污染的关系的昆虫损坏的空间、时间的模式很好没被理解。在昆虫损坏和黄麴毒素在的空间模式的以前的考试以后预先收获玉米地，我们进一步与二采样检验了喂圆块、喂核的昆虫损坏，和黄麴毒素水平的空间、时间的模式在在2008和2009预先收获。由每ear/kernel-feeding昆虫的喂的损坏(即，丝绸/圆块上的玉米一种有害幼虫/秋天粟蚕损坏，和玉米核由的褪色坏透臭虫)并且玉米象鼻虫人口用五只耳朵在每个格子点被估计。采样数据在两年里处于昆虫损坏和黄麴毒素污染显示出域边效果。玉米象鼻虫比任何一个玉米一种有害幼虫更经常向聚集的分布趋于或坏透两年里的臭虫损坏。为黄麴毒素水平检测聚集的分发的频率是昆虫损坏评价的不到任何东西。坏透臭虫损坏和玉米象鼻虫数字更仔细比是玉米一种有害幼虫的与黄麴毒素水平被联系损坏。另外，空间时间的协会(χ)的索引证明玉米象鼻虫的数字被联系在之间第一(4个星期预先收获)并且秒(1个星期预先收获)所有地上的两年里的采样。相反，在来自Belflower农场上的地的第一和第二采样之间的玉米一种有害幼虫损坏，和黄麴毒素水平和玉米一种有害幼虫在Lang农场上从这块地损坏在2009被分裂。

简介：ElectronleakagestillneedstobesolvedforInGaN-basedblue-violetlaserdiodes(LDs),despitethepresenceoftheelectronblockinglayer(EBL).Toreducefurtherelectronleakage,anewstructureofInGaN-basedLDswithanInGaNinterlayerbetweentheEBLandp-typewaveguidelayerisdesigned.TheopticalandelectricalcharacteristicsoftheseLDsaresimulated,anditisfoundthattheadjustedenergybandprofileinthenewstructurecanimprovecarrierinjectionandenhancetheeffectiveenergybarrieragainstelectronleakagewhentheIncompositionoftheInGaNinterlayerisproperlychosen.Asaresult,thedeviceperformancesoftheLDsareimproved.

简介：AbstractObjective:Pancreatic cancer (PC) is a highly lethal malignancy with an immunosuppressive environment. Yet, current immune checkpoint inhibitor monotherapies have shown limited efficacy in PC, prompting the need for combination therapies. Herein, we hypothesized that combinations of Notch signaling inhibitor and anti-ligand programmed death-ligand 1 (PD-L1) antibody immunotherapy would show synergistic efficacy.Methods:The baseline expression of PD-L1 and HES1 was measured in PC cell lines, single-cell RNA-seq data of PC (GSA: CRA001160), and cBioPortal databases. In an in vitro study, MIA PaCa2 and SW1990 were used to explore the mechanism between Notch signaling and PD-L1. To study the effects in vivo, a subcutaneous tumor model was established using Pan02 cells treated with either anti-PD-L1 monoclonal antibody and/or Notch inhibitor DAPT. The study performed involving human samples was approved by the Ethics Committee of Peking Union Medical College Hospital (approval No. S-K460, approval date: April 23, 2018). Animal studies were approved by the Animal Research Ethics Committee of Peking Union Medical College Hospital (approval No. XHDW-2019-049, approval date: November 28, 2019).Results:The Notch signaling inhibitor upregulated PD-L1 expression in PC tumor cells both in vitro and in vivo. Notch effector HES1 knockdown produced PD-L1 upregulation in both MIA PaCa2 and SW1990 cells. Combined DAPT and anti-PD-L1 antibody treatment of Pan02 subcutaneous tumor model resulted in significantly reduced tumor weights compared to that with monotherapy, as well as significantly reduced Ki67 than that in the monotherapy group and control group. Flow cytometry analysis revealed significantly increased CD8+ T cell infiltration in tumors of the combination group compared with those of the monotherapy group.Conclusion:Notch signaling blockade might enhance the antitumor effect of anti-PD-L1 therapy in PC.

简介：

简介：Acupunctureiswidelyusedtotreatfunctionaldyspepsiawithsatisfactoryoutcomes.CombinationoftheHeandMuacupointsiscommonlyusedandhasasynergisticeffectonfunctionaldyspepsia;however,itsunderlyingmechanismsremainunclear.Therefore,arandomizedcontrolledparallelclinicaltrialiscurrentlyunderwayatChengduUniversityofTraditionalChineseMedicine,China.ThistrialisdesignedtoexploretheefficacyofandcentralresponsestotheHe-Mupointcombinationinpatientswithfunctionaldyspepsiausingfunctionalmagneticresonanceimaging.Atotalof105patientswithfunctionaldyspepsiawillbeallocatedinto3groups:thelow-Hepointgroup(puncturingatZusanli(ST36)),Mupointgroup(puncturingatZhongwan(CV12)),andHe-Mupointcombinationgroup(puncturingatST36andCV12).Everyparticipantwillreceive20sessionsofmanualacupuncturefor4weeks.Theneedleswillbeinsertedperpendicularlytoadepthof1to2cun.Theangleofrotationandtwistingwillrangefrom90to180degrees,whileliftingandthrustingwillrangefrom0.3to0.5cm.Thevariousmanipulationswillbeperformed60to90timesperminute.Theneedleswillremaininplacefor30minutes,duringwhichmanipulationwillbeappliedevery10minutes.Magneticresonanceimagingwillbeperformedbeforeandafter20sessionsofacupuncture.TheprimaryoutcomeissymptomimprovementaccordingtotheChineseversionoftheNepeanDyspepsiaIndex.SecondaryoutcomesincludetheLeedsdyspepsiaquestionnaire,Self-RatingAnxietyScale,Self-RatingDepressionScale,BeckAnxietyInventory,BeckDepressionInventory,andvisualanaloguescalescoresbeforeandafter10and20sessionsofacupuncture.Needlesensationandadverseeventswillbeusedtoassessthetherapeuticeffects.ThisstudywillpromotemorewidespreadawarenessofthebenefitsofacupointcombinationintheclinicalsettingandprovideafurtherexplanationoftheneuromechanismbywhichacupunctureattheHe-Mupointcombinationforfunctio

简介：Inthiswork,areliableandsensitivemethodfordetectingpolybrominateddiphenylethers(PBDEs)hasbeendevelopedbythecombinationofliquid–liquidextractionandgaschromatography–massspectrometry.PBDEswereextractedfromalargevolumeofwaterbyliquid–liquidextractionandpurifiedbysilicagelchromatography.Inordertoreducethedeviation,dibromobiphenylwasexploitedastheinternalstandardtominimizedifferencesamongtheinjections.Thequantificationwasperformedusinganexternalstandard.Goodlinearcorrelationcoefficients(>0.991)andawidelinearityrange(1.0–500.0ng/L)indicatedthesteadinessoftheproposedmethod.Moreover,thesatisfactoryrecovery(>75%)suggestedthatsuccessfuldeterminationofPBDEsinriverwaterhadbeenachieved.Furthermore,thedeductionbehaviorofPBDEsinriverwatercouldbeinferredaccordingtotheresults.

简介：Objective:Todeterminetheclinicalserumlevelsofcarcinoembryonicantigen(CEA)andcarbohydrateantigen19-9(CA19-9),individuallyandincombination,forthediagnosisof50healthysubjectsand150casesofesophageal,gastric,andcoloncancers.Methods:Thesensitivitiesofthetwomarkerswerecomparedindividuallyandincombination,withspecificitysetat100%.Receiveroperatingcharacteristic(ROC)curveswereplotted.Results:SerumCEAlevelsweresignificantlyhigherincancerpatientsthaninthecontrolgroup.ThesensitivityofCEAwasdetermined:inesophagealcancer,sensitivity=28%,negativepredictivevalue(NPV)=61.72%,andAUC=0.742(SE=0.05),withasignificancelevelofP<0.0001;ingastriccancer,sensitivity=30%,NPV=58.82%,andAUC=0.734(SE=0.05),withasignificancelevelofP<0.0001;incoloncancer,sensitivity=74%,NPV=79.36%,andAUC=0.856(SE=0.04),withasignificancelevelofP<0.0001.ThesensitivityofCA19-9wasalsoevaluated:inesophagealcancer,sensitivity=18%,NPV=54.94%,andAUC=0.573(SE=0.05),withasignificancelevelofP=0.2054.Ingastriccancer,sensitivity=42%,NPV=63.29%,andAUC=0.679(SE=0.05),withasignificancelevelofP<0.0011.Incoloncancer,sensitivity=26%,NPV=57.47%,andAUC=0.580(SE=0.05),withasignificancelevelofP=0.1670.ThefollowingwerethesensitivitiesofCEA/CA19-9combined:inesophagealcancer,sensitivity=42%,NPV=63.29%,SE=0.078(95%CI:0.0159-0.322);gastriccancer,sensitivity=58%,NPV=70.42%,SE=0.072(95%CI:-0.0866-0.198);andcoloncancer,sensitivity=72%,NPV=78.12%,SE=0.070(95%CI:0.137-0.415).Conclusion:CEAexhibitedthehighestsensitivityforcoloncancer,andCA19-9exhibitedthehighestsensitivityforgastriccancer.Combinedanalysisindicatedanincreaseindiagnosticsensitivityinesophagealandgastriccancercomparedwiththatincoloncancer.