简介：AbstractBackground:Substantial research is underway to develop next-generation interventions that address current malaria control challenges. As there is limited testing in their early development, it is difficult to predefine intervention properties such as efficacy that achieve target health goals, and therefore challenging to prioritize selection of novel candidate interventions. Here, we present a quantitative approach to guide intervention development using mathematical models of malaria dynamics coupled with machine learning. Our analysis identifies requirements of efficacy, coverage, and duration of effect for five novel malaria interventions to achieve targeted reductions in malaria prevalence.Methods:A mathematical model of malaria transmission dynamics is used to simulate deployment and predict potential impact of new malaria interventions by considering operational, health-system, population, and disease characteristics. Our method relies on consultation with product development stakeholders to define the putative space of novel intervention specifications. We couple the disease model with machine learning to search this multi-dimensional space and efficiently identify optimal intervention properties that achieve specified health goals.Results:We apply our approach to five malaria interventions under development. Aiming for malaria prevalence reduction, we identify and quantify key determinants of intervention impact along with their minimal properties required to achieve the desired health goals. While coverage is generally identified as the largest driver of impact, higher efficacy, longer protection duration or multiple deployments per year are needed to increase prevalence reduction. We show that interventions on multiple parasite or vector targets, as well as combinations the new interventions with drug treatment, lead to significant burden reductions and lower efficacy or duration requirements.Conclusions:Our approach uses disease dynamic models and machine learning to support decision-making and resource investment, facilitating development of new malaria interventions. By evaluating the intervention capabilities in relation to the targeted health goal, our analysis allows prioritization of interventions and of their specifications from an early stage in development, and subsequent investments to be channeled cost-effectively towards impact maximization. This study highlights the role of mathematical models to support intervention development. Although we focus on five malaria interventions, the analysis is generalizable to other new malaria interventions.

简介：Now most of the students do better in reading and writing English than in listening and speaking. They can read and write,Some students begin to read at once when he get a reading material,If a man is only good at listening and speaking

简介：

简介：在这份报纸，我们在在向陆近海的转变区域获得的地震信号上考察速度地震检波器(VG)和加速地震检波器(AG)和他们的效果之间的差别。我们在场新一代打压电的地震检波器(LPG)并且分析它的表演。我们的地实验证明我们的新LPG能被用来代替让VG以便消除不同地震检波器系统之间的差别通常在转变区域使用了的阶段，频率和精力。关键词转变区域-颤动系统-打压电的地震检波器-频率特征-数据获得工作被国家鈥檚鈥?赞助63鈥?工程(号码2001AA602018)。首先写作LvGonghe，教授，他在1984从长春地质学研究所的石油地球物理部门毕业了，得到了B。在在1996的中国的海洋大学的海洋地质学的C，和他的Ph。在Xi鈥檃n交通大学的工程师力学的D。他的研究兴趣在在复杂区域的地震探索技术，高分辨率的地震数据获得。现在他为国家鈥?鈥?负责关于在沙滩区域鈥的高精确的地震探索技术的63鈥?工程鈥渢he研究？

简介：(L减水乳酸)(PLLA)Poly，/pristine蛭石nanocomposites被准备由融化掺双轴的extruder，和热、机械的性质的蛭石分散状态的详细信息和蛭石的效果系统地被学习。当装载内容不超过3wt%时，结果证明在矩阵的蛭石的分散相当好。太古的蛭石能显然在nonisothermal结晶化期间改进融化结晶化温度。两结晶化时间跨度和PLLA的spherulitic尺寸由提高PLLA的主要成核在等温的结晶化状况下面与蛭石的增加的数量减少。并且增加的蛭石能也改进张力的模量和PLLA的Izod影响力量。为PLLA上的蛭石的起核心作用的效果的内在的机制被建议是在蛭石和PLLA之间的取向附生的结晶化和特定的相互作用。

简介：

简介：Inthispaper,wecombinethedirect-forcingfictitiousdomain(DF/FD)methodandthesharpinterfacemethodtoresolvetheproblemofparticledielectrophoresisintwodimensions.TheflowfieldandthemotionofparticlesaresolvedwiththeDF/FDmethod,theelectricfieldissolvedwiththesharpinterfacemethod,andtheelectrostaticforceontheparticlesiscomputedusingtheMaxwellstresstensormethod.Theproposedmethodisvalidatedviathreeproblems:effectiveconductivityofparticlecompositebetweentwoplanarplates,celltrappinginachannel,andmotionofparticlesduetobothconventionalandtravelingwavedielectrophoreticforces.

简介：Amlodipine/valsartan(Aml/Val)single-pillcombination(SPC)therapyhasbeenwidelyusedandstudiedinclinicalpracticeinrecentyears.ThisarticlereviewstheChineseandEnglishliteratureontheclinicaluseofAml/ValSPCtherapyinChinesehypertensivepatients.Accordingtofivestudiesconcerningtheefficacyandsafetyofthistreatment,Aml/ValSPCtherapywasmoreefficaciousthanmonotherapywithvalsartan,amlodipine,orthenifedipinegastrointestinaltherapeuticsystem.Thistreatmentshowedgreaterbloodpressure-loweringeffects,ahigherbloodpressurecontrolrate,andahigherresponserate.Aml/ValSPCtreatmentwaswelltolerated,withadverseeventratessimilartothoseofmonotherapywithvalsartanoramlodipineandsignificantlyrareradverseeventscomparedwiththenifedipinegastrointestinaltherapeuticsystem.Aml/ValSPCisahighlyefficaciousandwell-toleratedantihypertensivetreatmentinChinesehypertensivepatients.

简介：BACKGROUND:Withdevelopmentsoftissueengineeringandgeneticengineering,weaimtoculturemyoblasts,whicharecharacterizedbyhighpurity,highqualityandhighproduction,forwideapplicationinneuralregenerationresearches.OBJECTIVE:Tomodifytraditionaldissociationmethodinordertoobtainmyoblasts,whicharecharacterizedbyhighpurity,highqualityandhighproduction,andexplorethebiologicalpropertiesunderinvitroculture.DESIGN:Observationalstudy.SETTING:BasicInstituteofAcademyofMilitaryMedicalSciencesofChinesePLA.MATERIALS:FourneonatalWistarratsof5daysold,bothgendersandmeanbodymassof10gwereselectedinthisstudy.Themainreagentsanddevicesweredetailedasfollows:DMEMmedium(GibcoCompany),fetusbovineserum(FBS,HycolneCompany),collagenaseⅡ(SigmaCompany),trypsin(SigmaCompany),dispaseⅡ(SigmaCompany),desminantibody(FuzhouMaixinCompany),antibodyⅡandABCkit(WuhanBosterBiotechnologyCompany),deskcentrifuge(KUBATO,Japan),andinvertedphasecontrastmicroscope(LEICADMIRB,Germany).METHODS:TheexperimentwascarriedoutintheBasicInstituteofAcademyofMilitaryMedicalSciencesofChinesePLAfromJunetoOctober2006.Neonatalratsweresacrificedundersterileconditiontoobtainskeletalmusclesoflimbs,whichwerewashedwithcoldPBS(containingbenzylpenicillinandestreptomicina),andmusculartissuewasshearedintopieces.Then,thosemuscularpieceswereaddedwithmixeddigestiveenzyme(containing2g/LcollagenaseⅡ+5g/LdispaseⅡ+0.28g/LCaCl2)astwicevolumeaspieces,dealtwithmechanicalpipettingfor5minutesandculturedinCO2incubatorfor10minutes.Theoperationwasdoneforthreetimesandthemuscularpiecesweredigestedfor45minutesintotal.Moreover,cellsweresuspendedagaininordertoobtainmyoblastsfromskeletalmuscleofneonatalrats.Inaddition,myoblastswerepurifiedwithdifferentialattachmenttechniqueandenzymedigestionsoastoobservemorpho

简介：为了在摇晃识别模型结构参数，从地震反应搁置测试，特别从变化时间的反应记录，这份报纸由联合论述新方法论联机与外长的变量(ARX)的通过多重模型(AFMM)和离线的汽车回归的递归的适应忘记模型。首先，AFMM被采用当使遭到了到强壮的运动时，检测模型结构的反应是否时间不变或变化时间。第二，如果反应是时间不变的，形式的参数从全部反应记录被识别，例如用ARX模型的加速时间历史。如果反应是变化时间的，加速记录根据AFMM检测的精确的变化时间的点被划分成三个片断，并且参数被仅仅使用尾巴片断数据识别，它为由ARX模型的分析时间不变、适合。最后，在动态性质的变化用介绍方法论由于各种各样的强壮的运动被获得。方法的可行性和优点被鉴别一个12故事的形式的参数增强了水泥(RC)表明在摇晃的表格测试的框架结构。

简介：150casesofprolapseoflumbarintervetebraldiscwererandomlydividedintotreatmentandcontrolgroups.80casesintreatmentgroupweretreatedwithcombinationofacupuncture,oraladministrationofChinesemedicinalherbs,traction,point-injectionandintravenousdripofenergydehydrationmixture;70casesincontrolgroupweremanagedbycombinationofacupuncture,oraladministrationofherbalmedicines,traction,acupoint-injection(withoutenergydehydrationmixture).Theresultsshowedthatthecurativerateandthetotaleffectiverateofthetreatmentgroupwere91.25%and98.75%separately,whilethoseofthecontrolgroup62.86%and92.86%respectively.Comparisonofthecurativeratebetweenthe2groupsshowedaremarkablesignificance(P＜0.01).TheobservationdemonstratedthatcombinedtreatmentofprolapseoflumbarintervertebraldiscwithtraditionalChineseandWesternmedicineisaneffectiveapproach.

简介：A60-year-oldwomanwithsquamouscellcarcinomaintherightlungwassuccessfullytreatedwithfourcyclesofcombinationchemotherapyaftersurgery,andcompleteremissionwasachieved.However,thepatientdevelopedmyelodysplasticsyndrome(MDS)RAEB-2withmyelofibrosisafterremission,possiblybecauseofchemotherapyorDNAmethylation.Thepatientrespondedwelltodacitabine(Dacogen),suggestingthatDNAhypomethylationagentscanbeapromisingtherapytoretardtheprogressionofasecondtumororcarcinoma.

简介：目的：观察针药并用治疗非特异性急性腰扭伤的临床疗效。方法：将69例患者按就诊川页序随机分为针药并用组、针刺组和药物组。针刺组24例，采用针刺治疗，每日1次，共治疗5次；药物组20例，采用口服双氯芬酸钠治疗，50mg每次，每日2次，连服5日；针药并用纽25例采用与针刺组、药物组相同的针刺和药物治疗。以疼痛量表和下腰痛量表评价临床疗效。结果：三组患者治疗后在疼痛，活动度方面均有一定改善，但针药并用组疗效最佳，与针刺组、药物组比较，差异有统计学意义（P〈0．01）；针刺组与药物组比较，差异无统计学意义。结论：针药并用治疗急性腰扭伤疗效优于单纯针刺治疗或常规剂量双氯芬酸钠治疗。

简介：

简介：<正>FoundedonSeptember19,2012inBeijing,WorldTourismCitiesFederation(WTCF)isanon-profit,non-governmentalinternationalmassorganization.TheestablishmentofWTCFwasproposedbyBeijingandorganizedvoluntarilybytouristcitiesofallcountriesandregions,non-governmentalorganizations,associationsandenterprisesrelatedtotourism.Underthethemeof"TourismMakesCity

简介：BACKGROUND:Wehavepreviouslyreportedthatadultentericglia(EG)facilitatethegrowthoftransecteddorsalrootaxonsintotheuninjuredspinalcordtoformfunctionalconnectionswiththeirtargets.OBJECTIVE:ThepresentstudyinvestigatedtheeffectsofEGonspinalcordfunction,tissueinjury,andaxonalregenerationfollowingtransplantationintoinjuredratspinalcords,accordingtohistologicalandfunctionaloutcomes.DESIGN,TIMEANDSETTING:ArandomizedcontrolledanimalexperimentwasperformedatMcMasterUniversity,CanadafromJanuary2006toMarch2008.MATERIALS:EGwereisolatedfromratintestine.METHODS:Oneweekfollowingspinalcordcrush,femaleWistarratswereinjectedwithanEGsuspension(2μL,1×10~5/μL,n=10)orwiththesamevolumeoffreshculturemediumalone(controlanimals,n=11).Thethirdgroupdidnotreceiveanyinjectionfollowinglaminectomyandservedasthesham-operatedcontrols(n=5).MAINOUTCOMEMEASURES:Behaviorwastestedpriortotransplantationandweeklyfollowingtransplantation,withninebehavioralexaminationsintotal.Openfield,hindlimbplacementresponse,footorientationresponse,andinclinedplanetestwereutilized.Immediatelyfollowingthefinalbehavioralexamination,spinalcordT_9toL_1segmentswereharvestedforimmunohistochemicalandhematoxylin-eosinstainingtodetermineastroglialscarring,axonalregenerationandspinalcordlesionsize.RESULTS:RatswithEGtransplantationexhibitedsignificantlybetterlocomotorfunctionwithreducedtissuedamage,comparedwiththecontrolrats.Cysticcavitieswerepresent2monthsafterinjuryinspinalcordsfrombothcontrolgroups.Incontrast,ratsinjectedwithEGdidnotpresentwithcysticlesions.Inaddition,theinjurysiteconsistedofcellularmaterialandnervefibers,andaxonalregenerationwasapparent,withdenselabelingofneurofilament-positiveaxonswithintheinjurysite.Moreover,regeneratingaxonswereintimatelyassociatedwithtransplantedEGCONCLUSION:ThesedataindicatedthatEGenha

简介：AbstractObjective:There are few studies evaluating the impact of Aspirin-exacerbated respiratory disease (AERD) treatment on otologic symptoms. The aim of this study is to evaluate the effects of endoscopic sinus surgery (ESS) and aspirin desensitization (AD) on otologic symptoms in subjects with AERD.Methods:Retrospective chart review of adult patients diagnosed with AERD at our tertiary Care Academic Medical Center-Otorhinolaryngology Department. Charts of adult patients diagnosed with AERD who underwent ESS and ASA desensitization at our institution’s AERD Center from 2016 to 2019 were reviewed. Sino-Nasal Outcomes Test 22-item survey (SNOT-22) scores were evaluated for patients at various time points including: pre-surgery, post-surgery/pre-aspirin desensitization, and various times post-desensitization up to >12 months. Within the SNOT-22, otologic-specific subdomain scores were evaluated at similar time points. Patients on immunomodulatory medications other than corticosteroids were excluded from analysis.Results:SNOT-22 scores were analyzed for 121 patients. There was a significant improvement in overall SNOT scores from pre-surgery (44.62) to post surgery/pre-desensitization (23.34) (P < 0.0005). Similarly, SNOT-22 otologic-specific scores also improved after surgery prior to desensitization (3.19-2.04) (P = 0.005). Following AD, the improvement in the overall SNOT-22 continued to improve for up to 12 months (P < 0.005). While the otologic-specific SNOT-22 scores remained stable after surgery and ASA desensitization.Conclusion:ESS and AD reduce otologic-specific SNOT-22 scores and parallel trends in overall SNOT-22 scores. The effect of treatment is durable over the course of 12 months. Future work should aim to correlate otologic SNOT-22 scores with objective otologic data.

简介：波浪方程波浪地数字建模技术被用于深层成像在高速度的暗岩的屏蔽的层下面是困难的观察。三个简单高速度的暗岩模型根据暗岩形成特征被设计。低频率的地震信号能够两个都渗透薄高速度的暗岩层并且减少衍射噪音的地震信号精力表演由不平的表面引起了的深层的思考的分析。一个完全的2D暗岩模型的模拟实验证实低频率的信号能被用来在高速度的暗岩层下面增加深层的成像的质量并且在低通行证的过滤器处理实际数据完成好结果。

简介：Arraygainwouldbewellexploitedtoimprovepowercoverageifsomepowerfulmultipathcomponentsfromdifferentradiolinkscancoherentlycombineatthereceiver(Rx).Thus,inthispaper,analgorithmisproposedfortransmissioninsimulcastsystem,wherepartialchannelstateinformation(CSI)isneeded.Basedonmeasuredmultipathchannel,performanceoftheproposedalgorithmisevaluated.Accordingtosimulationresults,theproposedalgorithmoutperformsthedirectionsummation(DS)schemeandmultipathantennadiversity(MAD)algorithm,with2～4dBadvantageoverthelatters.Especiallyinlineofsight(LOS)scenario,theadvantageismoreobvious.Besides,theproposedalgorithmbringsmoregainwithincreasingnumberoftransmitantennaswithoutadditionalpower.Finally,robustnessoftheproposedalgorithmisexaminedwithimperfectCSI.

简介：