摘要
Themammalianliverhasaverystrongregenerationcapacityafterpartialhepatectomy(PH).Tofurtherlearnthegenesparticipatingintheliverregeneration(LR),551cDNAsselectedfromsubtractedcDNAlibrariesoftheregeneratingratliverwerescreenedbymicroarray,andtheirexpressionprofileswerestudiedbyclusterandgeneralizationanalyses.Amongthem,177geneswereidentifiedunreportedandup-ordown-regulatedmorethantwofoldatoneormoretimepointsafterPH,ofwhich62genesweredown-regulatedtolessthan0.5;99geneswereup-regulatedto2-10folds,and16geneswereeitherup-ordown-regulatedatdifferenttimepointsduringLR.ByusingBLASTandGENSCAN,thesegeneswerelocatedonresponsiblechromosomeswith131genesonthelongarmsofthechromosomes.Theclusterandgeneralizationanalysesshowedthatthegeneexpressionprofilesaresimilarin2and4,12and16,96and144hrespectivelyafterPH,suggestingthattheactionsofthegenesexpressedinthesameprofilesaresimilar,andthoseexpressedindifferentprofileshavelesssimilarity.However,thetypes,characteristicsandfunctionsofthe177genesremaintobefurtherstudied.
出版日期
2004年02月12日（中国期刊网平台首次上网日期，不代表论文的发表时间）
