学科分类
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8 个结果
  • 简介:AIM:Toevaluatetheinterchangeabilityofkeratometricandasphericitymeasurementsprovidedbythreemeasurementsystemsbasedondifferentopticalprinciples.METHODS:Atotalof40eyesof40patientswithameanageof34.1ywereincluded.Inallcases,acornealcurvatureanalysiswasperformedwithIOL-Master(IOLM),iDesign2(ID2),andSiriussystems(SIR).Differencesbetweeninstrumentsforflattest(K1)andsteepest(K2)keratometricreadings,aswellasformagnitudeandaxisofcornealastigmatismwereanalyzed.Likewise,differencesinasphericity(Q)betweenSIRandID2werealsoevaluated.RESULTS:MeandifferencesbetweendevicesforK1were0.20±0.21(P<0.001),-0.12±0.36(P=0.046)and-0.32±0.36D(P<0.001)forthecomparisonsIOLM-SIR,IOLM-ID2andSIR-ID2,respectively.Therangesofagreementforthesecomparisonsbetweeninstrumentswere0.41,0.70,and0.70D.ForK2,meandifferenceswere0.31±0.33(P<0.001),-0.08±0.43(P=0.265)and-0.39±0.38D(P<0.001),withrangesofagreementof0.65,0.84,and0.74D.Concerningmagnitudeofastigmatism,rangesofagreementwereinthelimitofclinicalrelevance(0.49D,P=0.011;0.55D,P=0.386;0.43D,P=0.05).Incontrast,rangesofagreementwereclinicallyrelevantforastigmaticaxis(26.68o,33.83oand18.37o,P≥0.121)andforQbetweenSIRandID2(0.16,P<0.001).CONCLUSION:Thekeratometriccornealpower,astigmaticaxisandasphericitymeasurementsprovidebythethreesystemsevaluatedcannotbeconsideredasinterchangeable,whereasmeasurementsofcornealastigmatismobtainedwithSIRandID2canbeconsideredasinterchangeableforclinicalpurposes.

  • 标签: ASTIGMATISM CORNEAL TOPOGRAPHY KERATOMETRY CORNEAL ASPHERICITY
  • 简介:·AIM:Toevaluateandcomparetheefficacyandstabilityofintrastromalcornealringsegment(ICRs)implantationwithcross-linking(CXL)usingdifferentsequenceandtiming.·METHODS:Inthissingleretrospectivestudy,86keratoconiceyessubjectedtheICRsimplantation.Weanalyzedonly41eyesthathadcompletefollow-ups.Theyweredividedintothreegroups:ICRsimplantationwasappliedonly(groupnormal),ICRsfirstfollowedbyCXLimmediately(groupCXL-S),CXLfirstfollowedbyICRslongafter(groupCXL-B).Thevisualacuity,refractiveresults,keratometrywerecomparedpreoperativelyand1ypostoperatively.Theirdifferencesamongthethreegroupswerealsoanalyzed.·RESULTS:Groupnormalcomprised25eyes,groupCXL-S8eyes,andgroupCXL-B8eyes.Therewereimprovementsinthemeanuncorrecteddistancevisualacuity(UDVA)andthemeancorrecteddistancevisualacuity(CDVA)comparedpreoperativelyand1ypostoperatively[UDVA:0.31(P=0.030)logarithmicminimumangleofresolution(logMAR)groupnormal,0.4(P=0.020)groupCXL-S,0.45(P=0.001)groupCXL-B;CDVA:0.21logMAR(P=0.013)groupnormal,0.30(P=0.036)groupCXL-S;0.26(P=0.000)groupCXL-B].Therefractiveandtopographicoutcomesalsoshowedimprovements.Intermsofcomparisonsamongthethreegroups,allthePvalueswereabove0.05,showingnosignificantdifference.ButonlygroupCXL-BhadimprovementinUDVAandCDVAforallthepatients.·CONCLUSION:Withsafetyandgoodvisualoutcomes,ICRsimplantationisaviablealternativeforkeratoconus.Nosignificantdifferencewasfoundamongthesethreegroups.

  • 标签: KERATOCONUS intrastromal CORNEAL RING SEGMENT cross-linking
  • 简介:P75神经营养受体是最早发现的神经营养因子受体,既往认为其主要作为高亲和力受体的辅助受体间接发挥作用.近年来研究表明,P75神经营养受体在神经系统的发育中有诱导细胞凋亡作用.现阐述其在视网膜神经细胞生长,分化以及逆向运输神经营养因子等方面的作用.

  • 标签: P75神经营养受体 视网膜细胞 细胞凋亡 神经营养因子 信号传递
  • 简介:目的:观察tumstatin肽对体外培养的视网膜微血管内皮细胞迁移及P38MAPK蛋白表达的影响,初步探讨tumstatin肽抗视网膜内皮细胞迁移的机制。方法:采用细胞划痕实验测定tumstatin肽(T8肽)对血管内皮生长因子(VEGF)诱导下RF/6A细胞(恒河猴视网膜微血管内皮细胞)迁移的影响;Westernblotting检测T8肽对VEGF刺激后15,30,45,60min的RF/6A细胞P38MAPK蛋白水平的变化。结果:Tumstatin肽对RF/6A细胞迁移具有抑制作用,且可抑制VEGF对RF/6A细胞的促迁移作用,呈剂量依赖性。正常情况下,RF/6A细胞无P38MAPK蛋白的表达,但VEGF可诱导其表达P38MAPK蛋白,而tumstatin可抑制VEGF诱导的RF/6A细胞P38MAPK蛋白的表达(加入20mg/LT8肽30,45,60min时蛋白表达受到显著抑制,差异有显著性意义,P〈0.01)。结论:Tumstatin抑制视网膜微血管内皮细胞的迁移,其作用可能与P38MAPK通路有关。

  • 标签: TUMSTATIN 视网膜微血管内皮细胞 迁移 P38MAPK
  • 简介:目的:探讨眼附属器B细胞非霍杰金淋巴瘤(B—cellnon-Hodgkinlymphoma,NHL)中Skp2,p27和PTEN的表达。方法:收集1995年到2011年青岛大学附属医院眼科石蜡包埋标本,用免疫组化法分别检测眼附属器B细胞NHL(n=30)标本中Skp2,p27和PTEN的表达,以眼部反应性淋巴组织增生(n=10)作为对照组。以患者的年龄、性别、发病部位,病理类型作为眼附属器B细胞NHL的的分类标准。结果:Skp2,p27和PTEN的表达与患者的年龄、性别、发病部位无关,而与病例类型有关。眼附属器B细胞NHLSkp2表达率与眼部反应性淋巴组织增生相比显著增高。p27,PTEN表达率与反应性淋巴组织增生相比显著降低。随眼附属器B细胞NHL病理分级的提高,Skp2的表达显著增高,p27和PTEN的表达显著降低。在黏膜相关淋巴组织结(mucosa—associatedlymphoidtissue,MALT)外边缘区B细胞淋巴瘤(diffuselargeB—celllymphoma,DLBCL)中,Skp2分别与p27,VFEN成负相关,p27和PTEN成正相关。结论:Skp2的表达升高,p27,PTEN蛋白的缺失以及可能与眼附属器B细胞NHL的发生有关;其中在MALT外边缘区DLBCL中,三种蛋白存在相关性。联合三种蛋白的检测眼附属器B细胞NHL的不同病理类型有重要意义。

  • 标签: 眼附属器 非霍杰金淋巴瘤 SKP2 p27kip PTEN 免疫组织化学检验
  • 简介:AIM:ToidentifythegeneticdefectinaChinesefamilywithbilateralprogressivechildhoodposteriorcataract.METHODS:Atwo-generationfamilywasrecruitedinthisstudy.Familyhistoryandclinicaldatawererecorded.AllreportedcandidategenesassociatedwithcongenitalposteriorcataractwerescreenedbydirectDNAsequencing.·RESULTS:Allaffectedindividualspresentedposterioropacitiesinthelens.Directsequencingofthecandidategenesshowedaheterozygousc.2668C>TvariationinEPHA2gene,whichresultedinthereplacementofargininebycysteineatcodon890(p.R890C).Thismutationwasfoundintwoaffectedindividuals,butwasnotobservedin200normalcontrols.·CONCLUSION:Wereportanovelmutation(p.R890C)intheEPHA2receptortyrosinekinasegene.ThefindingexpandsthemutationspectrumofEPHA2inassociationwithposteriorcataract.

  • 标签: EPHA2 gene MUTATION POSTERIOR CATARACT