简介:摘要目的探讨CT引导下经皮肺穿刺活检对肺内肿块的诊断价值。方法13例肺部肿块患者,行CT引导下经皮肺穿刺活检,分别行组织学检查。以术后病理为标准,计算经皮肺穿刺活检的阳性率、成功率以及并发症的发生率。结果穿刺病理结果阳性率85%(11/13),病例穿刺成功率100%(13/13)。并发症气胸2例(15%),咯血1例(7.7%),均较轻微,无严重并发症。结论CT引导经皮肺穿刺活检是一种安全、快捷准确的诊断方法。
简介:AIM:Tocomparethetrabecularmeshwork(TM)andirisapoptosisoftreatedanduntreatedprimaryopenangleglaucoma(POAG)patients.METHODS:Eighttreatment-naive,newlydiagnosed(group1)and11medlcaiytreated(group2)patientswithPOAGwereincludedinthestudy.Eachpatientunderwentalimbus-basedtrabeculectomy.TheTMandperipheralirisspecimensweredissectedoutandweresnap-frozeninliquidnitrogenandstoredat-80tuntiltheywereassayed.ApoptosisineachgroupwasassesedbyTUNELmethod.RESULTS:Themeanpatientagewas60.6±5.8years(53-68years)vs58.9±8.9years(47-70years)ingroup1andgroup2(P=0.859).Themeantreatmenttimeingroup2was22.2±7.3months(12-34months).ApoptoticindexesinTMandirisweresignificantlyhigherinPOAGpatientsusingmedication(group2)comparedtotreatment-naivePOAGpatients(group1)(P=0.004,0.015;respectively).CONCLUSION:LongtermadministrationoftopicalantiglaucomamedicationscausesadditionaltoxiceffectsonTM.