简介：Qidong(Jiangsu,China)hasbeenofinteresttocancerepidemiologistsandbiologistsbecause,untilrecently,itwasanendemicareaforlivercancer,havingamongstthehighestincidenceratesintheworld.TheestablishmentoftheQidongCancerRegistrytogetherwiththeQidongLiverCancerInstitutein1972haschartedthepatternsoflivercancerincidenceandmortalityinastablepopulationthroughoutaperiodofenormouseconomic,social,andenvironmentalchangesaswellasofimprovementsinhealthcaredelivery.UpdatedincidencetrendsinQidongaredescribed.Notably,theChinaage-standardizedincidencerateforlivercancerhasdroppedbyover50%inthepastseveraldecades.MolecularepidemiologicandgenomicdeepsequencingstudieshaveaffirmedthatinfectionwithhepatitisBvirusaswellasdietaryexposuretoaflatoxinsthroughcontaminationofdietarystaplessuchascorn,andtomicrocystins–blue-greenalgaltoxinsfoundinditchandpondwater–werelikelyimportantetiologicfactorsthataccountforthehighincidenceoflivercancerinthisregion.PublichealthinitiativestofacilitateuniversalvaccinationofnewbornsagainstHBVandtoimprovedrinkingwatersourcesinthisruralarea,aswellaseconomicandsocialmandatesserendipitouslyfacilitatingdietarydiversity,haveledtoprecipitousdeclinesinexposurestotheseetiologicfactors,concomitantlydrivingsubstantivedeclinesinthelivercancerincidenceseennowinQidong.Inthisregard,Qidongservesasatemplatefortheglobalimpactthatapackageofinterventionstrategiesmayexertoncancerburden.

简介：Aratmodelofchronictympanicmembraneperforationwasdevelopedtobeusedinthesearchofnewmaterialsforthesealingoftheseperforations.AlongitudinalstudywascarriedoutinratssubjectedtoincisionalmyringotomyfollowedbytheapplicationofmitomycinCaloneorwithdexamethasone.Ratswerecheckedatdays3,7,10,14andweeklythereafteruntilperforationclosure,forupto6months.Theadditionofdexamethasoneisakeycomponentinordertoobtainachronicopening.Myringotomiestreatedwithsalinehadameanhealingtimeof8.5days.At8weeks,between62.5%and77.7%oftympanicmembranestreatedwithmitomycinCanddexamethasoneremainedperforatedandat6monthsthisnumberfellto21.4%.Thistechniqueisabletomaintainmosttympanicmembraneperforationspatentforatleast8weeks.Thisratmodelisadequateforitsuseinpreclinicalortranslationalresearch.

简介：Inthecurrenteraofcardiovasculardisease,thediagnosisofheartfailurewithpreservedejectionfraction(HFpEF)isawell-recognizedclinicalentitythatisequallyprevalentbutdistinctlydifferentfromheartfailurewithreducedejectionfraction(HFrEF).DespitenormalEFpatientswiththisdiseasehavesimilarmorbidityandmortalityratescomparedwithHFrEF,aswellasarisingrateofhospitalizations.ThepathophysiologyofHFpEFisincompletelyunderstood.Thenumberoftherapieswithprovenefficacyatimprovinglongtermcardiovascularoutcomesislimited.Womenwithheartfailuresyndromes,particularlytheelderly,aremuchmorelikelytohaveaHFpEFphenotypeatthetimeoftheirdiagnosis.Thepurposeofthispaperistoreviewtheepidemiology,pathophysiology,clinicalfeatures,andcurrentmanagementstrategiesinHFpEF,especiallyasitpertainstowomen.

简介：On26thOctober2015,anMw7.5earthquakestrucknorthernPakistan,withitsepicenterlocated45kmsouthwestofJarmintheHinduKushregionofAfghanistan.Theearthquakeresultedfromreversefaultingatadepthof210km,resultingin280fatalitiesandsubstantialdamagetosome109,123buildings.Regionalseismicity,characteristicsofrecordedstrongmotions,damagestatistics,andbuildingperformanceobservationsarepresented.Earthquakedamagewasmostlyconstrainedtoseismic-deficientunreinforcedmasonry(URM)buildings.Typicalfailuremodesincludedtoppledminarets,partialorcompleteoutofplanecollapseofURMwalls,diagonalshearcrackinginpiers,flexuralcrackinginspandrels,cornerdamage,poundingdamage,anddamageduetogroundsettlement.ThemajorityofhumanlossresultedduetofailureofURMwallsandsubsequentroofcollapse.URMbuildingslocatedinruralhillyareasclosertotheepicentersufferedmoreintenseandfrequentdamagethanurbanURMbuildingslocatedfartherawayinlargercities.

简介：Theloadandcorrosioncausedbytheharshmarineenvironmentleadtotheseveredegradationofoffshoreequipmentandtotheircompromisedsecurityandreliability.Inthequantitativeriskanalysis,thefailuremodelsaredifficulttoestablishthroughtraditionalstatisticalmethods.Hence,thecalculationoftheoccurrenceprobabilityofsmallsampleeventsisoftenmetwithgreatuncertainty.Inthisstudy,theBayesianstatisticalmethodisimplementedtoanalyzetheoilandgasleakagesofFPSOinternalturret,whichisatypicalsmallsampleriskbutcouldleadtoseverelosses.Accordingtothecorrespondingfailuremechanism,twoBayesianstatisticalmodelsusingtheWeibulldistributionandlogarithmicnormaldistributionasthepopulationdistributionareestablished,andtheposteriordistributionofthecorrespondingparametersiscalculated.TheoptimalBayesianstatisticalmodelisdeterminedaccordingtotheBayesianinformationcriterionandAkaikecriterion.Onthebasisofthedeterminedoptimalmodel,thecorrespondingreliabilityindexissolvedtoprovidebasicdataforthesubsequentriskassessmentsofFPSOsystems.

简介：Nitrogen(N)applicationmayleadtonichesegregationofsoilammonia-oxidizingarchaea(AOA)andbacteria(AOB),therebyreducingthecompetitiveinteractionsbetweenAOAandAOBduetohigherammoniumsubstrateavailability.However,theadaptivemechanismsofAOAandAOBunderNenrichmentremainpoorlyunderstood.Stableisotopeprobing(SIP)microcosmincubationwasemployedtorevealcommunitychangesofactiveAOAandAOBinaloesssoilfromafieldexperimentgrowingpotatoesthatreceivednoN(control,CK),lowN(LN,75kgNha-1),andhighN(HN,375kgNha-1).Theresultsshowedthatthesoilpotentialnitrificationrate(PNR)wasmeasuredbyculturingofthesoilsamplesfromthefieldexperiment.SoilPNRwassignificantlyincreasedinHNby87.5%and67.5%comparedwithCKandLN,respectively.ComparedwithCK,the13C-amoAgenesofsoilAOAandAOBinHNhad2.58×104and1.55×106copies,representing1.6-and16.2-foldincreaserespectively.ItwasindicatedthatAOBdominatedsoilammoniaoxidation.Aphylogeneticanalysisofthe13C-amoAgeneshowedthatNapplicationsignificantlyincreasedtheproportionof54d9-likeAOAupto90%inHN,whiletheNitrososphaeragargensis-likeandNitrososphaeraviennensis-likeAOAwereinhibitedandcompletelydisappeared.NitrogenapplicationalsoresultedinthecommunityshiftofactiveAOB-dominantgroupfromNitrosospirabriensis-liketoNitrosospirasp.TCH711-like.OurstudyprovidescompellingevidencefortheemergenceandmaintenanceofactivenitrifyingcommunitiesundertheintensifiedNinputtoanagriculturalecosystem.