简介：摘要甲状腺相关性眼病（TAO）是成年人最常见的眼眶疾病的一种，一般认为它属自身免疫性疾病或器官免疫性疾病，MicroRNA（miRNA）是具有调控功能的一类非编码小分子RNA，主要作用是参与基因转录后的表达调控，与眼部细胞的生长、发育、分化、凋亡及代谢功能的维持关系密切。近年来的研究显示，miRNA可能参与GO的发病。本文对近年来miRNA与GO的相关研究进行综述。

简介：Thecasepresentedhereoffersusanopportunitytodiscussanincreasinglycommonlyconfrontedclinicalchallenge.Twoissuesareraised:howbesttomanagethepatient’svalvularheartdisease,includingboththeindicationsforsurgicalinterventionandtheprostheticoptions,andhowbesttomanagehisaorticdilatation.Letustakethemoneatatime.Thepatienthassevereaorticregurgitationbutanormalejectionfraction.Althoughwedonothavehisventriculardimensions,hehasaclassIindicationforinterventiongivenhissymptoms.

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简介：AreviewarticlebyHaoetal.(JAmCollCardiol2017;69(24):2952–66)hashadhugerepercussionsamongthosefamiliarwithtraditionalChinesemedicine(TCM)intheinternationalacademiccommunity.ItevaluatedtheefficacyandsafetyofTCMforcardiovasculardiseaseandthepharmacologicaleffectofactiveTCMingredientsonthecardiovascularsystemandpotentialmechanisms.Wehaveseveralcomments:Firstly,wegiveabriefsummaryaddressingnonpharmacotherapyinTCM,includingacupuncture,moxibustion,Qigong,andTaiChi.Secondly,wehaveaddedtraditionalantiarrhythmicdrug–relatedrandomizedcontrolledtrialstomakethecoveragemorecomprehensive.Lastly,wesupporttheconceptthatresearchinto,developmentof,andapplicationofactiveingredientsispartofmodernTCM.

简介：Cardiovasculardiseaseistheleadingcauseofpregnancy-relateddeathsintheUnitedStates[1].Anestimated4%ofallpregnanciesintheUnitedStatesareaffectedbymaternalcardiovasculardisease,with80%ofthesecasesattributedtocongenitalheartdisease(CHD)[2–4].SecondarytoimproveddiagnosisandmanagementofCHD,morewomenwithCHDarereachingreproductiveage,andmanyofthesewomendesirepregnancy.WhilemanypregnantwomenwithCHDwillhaveanuncomplicatedpregnancyanddelivery,somewithmorecomplexcardiaclesionsorcomorbiditieswillhaveanincreasedriskofmaternalandneonatalmorbidityanddeath.Individualizedpreconception,antepartum,intrapartum.

简介：Thispaperdealswiththeissueofprioritysettinginhealthcareunderuncertaintiesabouttheseverityoftheillnessandtheeffectivenessofmedicaltreatment.Weexaminetheeffectofadiseaseuncertainty(atreatmentuncertainty)ontheallocationofhealthcareresourcesinthepresenceofatreatmentrisk(adiseaserisk)andidentifypreferenceconditionsunderwhichthesocialplannerallocatesmoreresourcestohigherriskpopulation.Weallowforthesimultaneouspresenceoftworisksandinvestigatethejointeffectoftwo-sourceuncertaintiesonhealthcareallocationwhenthetworisksareeithersmallorpositivelyquadrantdependent.Theeffectofinequalityaversiononhealthcareallocationisalsoanalyzedbyintroducinganequityweightingfunction.Ourworkextendsthepreviousmodelofhealthcareprioritytotwo-riskframeworkandprovidesnewinsightsintotheproblemofhealthcaredecisionmakingunderuncertainty.

简介：Dataontheprevalenceofdepressioninadultcongenitalheartdisease(ACHD)patientsdifferwidely.Weaimtosummarizethebestavailableinformationontheprevalenceofdepression,itsprognosticimpact,andpsychiatricinterventionsfordepressedACHDpatients.WereviewedreferencesinrelevantpublicationsuptoOctober17,2017.Forhomogeneityofdata,studiesinwhichdepressionwasindependentlyassessedinpatientsaged18yearsorolderorwithamean/medianageolderthan18yearswereincluded.Retrospectiveandpostoperativeevaluationstudieswereexcluded.Twentypublicationsmetthesecriteria.StudysamplesincludedACHDpatientsfollowedupatACHD-specializedhospitalsin13countries.Theprevalenceofdepressiondifferedwidely,rangingfrom6to69%.Depressionhasbeenshowntobeanindependentpredictorofadverseclinicaloutcomes.Itisalsofrequentlyassociatedwithotherprognosticvariables(i.e.,poorfunctionalclass,unfavorableperceivedhealthstatus,andlowqualityoflife).Currently,norandomizedclinicaltrialsonpsychiatricinterventionsinACHDareavailable.Insummary,depressionishighlyprevalentinACHDpatients,yetitisoftenunrecognizedanduntreated.Theadverseprognosticimpactofdepressioncallsforspecializedpsychiatricinterventions,forwhichmoreresearchisneededintheACHDpatientpopulation.

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简介：Withimprovementsintheirsurgicalandmedicalmanagement,thenumberofpatientswithcongenitalheartdisease(CHD)reachingadulthoodhasincreasedoverthelastdecade.AsthepopulationofadultCHDpatientscontinuestorise,anincreasingnumberofthesepatientswillrequireevaluationforhearttransplantation.ItisimportanttorecognizeadvancedheartfailureandotherassociatedcomplicationsearlyinthiscohortofcomplexpatientsforearlyreferraltoanadultCHDspecialist.Asthesepatientspresentwithuniquechallengesbecauseoftheirmultiplecomorbiditiesandcomplexanatomy,thereneedstobeacarefulselectionprocessfortransplantationtooptimizetheutilizationofdonororgans.

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简介：Congenitalheartdisease(CHD)-associatedpulmonaryarterialhypertension(PAH)includesaheterogeneouspatientpopulationthatcanbecharacterizedbytheunderlyingcardiacmalformation.CHD-associatedPAHhasanestimatedprevalenceof5–10%inadultpatients,withanincreasingnumberofpatientssurvivingtoadulthoodbecauseofadvancesinthesurgicalmanagementandthedevelopmentofpulmonaryarterialhypertension(PAH)-targetedpharmacotherapy.Althoughlimiteddataexist,targetedPAHpharmacotherapyhasproventobebeneficialinpatientswithCHD-associatedPAH,withobservedimprovementinfunctionalclass,increaseinexercisecapacity,andimprovementinqualityoflifeandcardiopulmonaryhemodynamics.Additionally,therehasbeenincreasinginterestinthe“treat-to-close”strategy.PAH-targetedpharmacotherapymaybeusedtooptimizecardiopulmonaryhemodynamicssoastoimprovepatients’operabilityinrepairingthecardiacdefect.Althoughtherehavebeensignificantadvancesinthemanagementofthisdiseasestateinthepast2decades,mortalityremainshigh,andongoingclinicaltrialsareneededtobetterunderstandthetreat-to-closestrategy.

简介：Asanadvancedprocessdetectiontechnology,electricalimpedancetomography(EIT)haswideapplicationprospectsandadvantagesinmedicalimagingdiagnosis.However,aseriesofissuesneedtobeaddressedbeforeapplyingEITforbedsidemonitoring.Medicaldiagnosisandbedsidemonitoringaredynamicmeasuringprocess,wherethepositionsofmeasuringelectrodesandtheshapeofthedetectedfieldarechangingdynamical.Duetotheinabilitytocopewiththechangeableelectrodepositionsandvariousdynamicfields,existingEITsystemsaremainlyusedforindustrialdetectioninconditionofstaticmeasurementandvisualization.Inthispaper,weinvestigatethedynamicmeasurementandvisualizationofhumanbreastinEITfield,describethedesignofthemeasuringsensorsystem,andexpoundthemeasuringprinciple.Themaincomponentofthehardwaresystemisabuiltinservoelectricalresistancetomographysensorwithcapacitiveslidingrod,whichcanadapttothecrowdofdifferentchestcontourandthechangeofchestshapeinthedynamicprocessofbreathing.Thecorrespondingmeasuringprincipleisextractingallreal-timepositionsofmeasuringelectrodes,thenobtainingthedynamicboundary,finallydividingthedetectionfieldrapidly.Experimentalresultsconfirmedthattheproposedsystemcanobtainreal-timelocationofboundarysensoranddynamicallysolvetheproblemofarbitrary-shapeboundarymeasurement.Theimagingresultsvalidatetheavailabilityofdesignedsensorsystemandtheeffectivenessofthecorrespondingmeasuringprinciple.

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简介：摘要目的研究在Graves甲亢患者中采取甲亢灵胶囊与减量法碘-131联合治疗的临床效果。方法本次分析目标是2015年7月至2017年7月期间纳入且研究的50例Graves甲亢患者，以随机数字表法进行分组，将常规一次性口服治疗应用在参照组，将甲亢灵胶囊与减量法碘-131联合治疗应用在实验组，比较两组Graves甲亢患者不同治疗的效果。结果数据显示，实验组Graves甲亢患者临床有效率计算值高于参照组指标，P＜0.05，具有统计学检验分析意义。虽然不良反应计算值低于参照组指标，但P＞0.05，无统计学差异。结论将甲亢灵胶囊与减量法碘-131联合治疗应用在Graves甲亢患者中具有显著的效果。

简介：维生素D作为维持机体钙磷代谢平衡的重要激素,对机体骨与矿物质盐代谢起着重要的调节作用.近年来研究发现Graves病患者体内维生素D水平偏低,这可能预示着Graves病患者机体内将出现一系列骨代谢紊乱的发生,测量Graves病患者体内维生素D水平,有助于Graves病相关骨质疏松的治疗和预防.此外,还有研究者发现维生素D缺乏可能参与Graves病的发生发展,而补充维生素D可能有助于Graves病的预防和治疗.本文将对维生素D与Graves病相关性及其可能存在的机制的研究新进展进行综述.

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