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简介：PostedonJanuary4,2017byFDAVoiceThispastyearwasanothersuccessfulyearforthenewdrugsprograminFDA’sCenterforDrugEvaluationandResearch(CDER).CDERreviewedandapproved22noveldrugs,mostofwhichhavethepotentialtoaddsignificantclinicalvalue

简介：Wepresentthesolidmodeleditdistance(SMED),apowerfulandflexibleparadigmforexploitingshapesimilaritiesamongstCADmodels.ItisdesignedtomeasurethemagnitudeofdistortionsbetweentwoCADmodelsinboundaryrepresentation(B-rep).Wegivetheformaldefinitionbyanalogywithgrapheditdistance,oneofthemostpopulargraphmatchingmethods.Toavoidtheexpensivecomputationalcostpotentiallycausedbyexactcomputation,anapproximateprocedurebasedonthealignmentoflocalstructuresetsisprovidedinaddition.Inordertoverifytheflexibility,wemakeintensiveinvestigationsonthreetypicalapplicationsinmanufacturingindustry,anddescribehowourmethodcanbeadaptedtomeetthevariousrequirements.Furthermore,amultilevelmethodisproposedtomakefurtherimprovementsofthepresentedalgorithmonbotheffectivenessandefficiency,inwhichthemodelsarehierarchicallysegmentedintotheconfigurationsoffeatures.ExperimentresultsshowthatSMEDservesasareasonablemeasurementofshapesimilarityforCADmodels,andtheproposedapproachprovidesremarkableperformanceonareal-worldCADmodeldatabase.

简介：Thedevelopmentofcancernanotherapeuticshasattractedgreatinterestintherecentdecade.Cancernanotherapeuticshaveovercomeseverallimitationsofconventionaltherapies,suchasnonspecificbiodistribution,poorwatersolubility,andlimitedbioavailability.Nanoparticleswithtunedsizeandsurfacecharacteristicsarethekeycomponentsofnanotherapeutics,andaredesignedtopassivelyoractivelydeliveranti-cancerdrugstotumorcells.Weprovideanoverviewofnanoparticle-baseddrugdeliverymethodsandcancertherapiesbasedontumor-targetingdeliverystrategiesthathavebeendevelopedinrecentyears.

简介：试验性的调查被执行在在平静的水里进展的一个pentamaran模型的全部的抵抗上估计干扰性能的关系。为这动机，总数轮船拖为不对称的悬臂梁配置和壳分离的几价值被执行，在范围0.3-0.9改变弗鲁德数字。当波浪干扰可以发生时，我们的结果显示在抵抗的显著变化在横向的距离价值(壳分离)要求著名变化。另外，没有单个配置，一致地越过全部速度范围和最佳干扰因素超过另外的配置0.2与悬臂梁在S/L=0.33出现在0.45的一个弗鲁德数字外部位置：不对称为A3配置舷外。

简介：Inthiswork,thefactorsandparametersofatestmethodonabrasionresistanceatelevatedtemperatureswerediscussedandresearched.Firstofall,theprecisiontestsofthetestmethodonabrasionresistanceatelevatedtemperatureswereconductedin8laboratories.Theresultssuchasthestandarddeviationandreproducibilityshowgoodrepeatabilityandreliability.Therelationshipbetweenthestabilityofrefractoryperformanceandthestandarddeviationoftheirwearvaluewasanalyzed.ThentheimpactoftheheattreatmentconditionofunshapedrefractoriesandoxidationofSiCsandasabrasiveonthelostvolumeofthetestedspecimenswasresearched.

简介：PyriculariaoryzaeanamorphofMagnaportheoryzaeisoneofthemostnotoriousfungalpathogenscausingsevereeconomiclossinriceproductionworldwide.Variousmethods,viz.cultural,biologicalandmolecularapproaches,areutilizedtocounteractthispathogen.Moreover,sometolerantorresistantricevarietieshavebeendevelopedwiththehelpofbreedingprogrammes.Isolationandmolecularcharacterizationofdifferentblastresistancegenesnowopenthegatefornewpossibilitiestoelucidatetheactualallelicvariantsofthesegenesviavariousmolecularbreedingandtransgenicapproaches.However,thebehavioralpatternofthisfungusbreakupstheresistancebarriersintheresistantortolerantricevarieties.Thishost-pathogenbarrierwillbepossiblycounteredinfutureresearchbycomparativegenomicsdatafromavailablegenomesequencedataofriceandM.oryzaefordurableresistance.Presentreviewemphasizedfascinatingrecentupdates,newmolecularbreedingapproaches,transgenicandgenomicsapproaches(i.e.miRNAandgenomeediting)forthemanagementofblastdiseaseinrice.Theupdatedinformationwillbehelpfulforthedurable,resistancebreedingprogrammeinriceagainstblastpathogen.

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简介：ResistanceanalysisisanimportantanalyticalmethodusedtoevaluatethehydrodynamicperformanceofHighSpeedCraft(HSC).AnalysisofmultihullresistanceinshallowwaterisessentialtotheperformanceevaluationofanytypeofHSC.Shipsoperatinginshallowwaterexperienceincreasesinresistancebecauseofchangesinpressuredistributionandwavepattern.Inthispaper,theshallowwaterperformanceofanHSCdesignconcept,thesemi-SmallWaterplaneAreaTwinHull(semi-SWATH)form,isstudied.Thehullisinstalledwithfinstabilizerstoreducedynamicmotioneffects,andtheresistancecomponentsofthehull,hulltrimcondition,andmaximumwaveamplitudearoundthehullaredeterminedviacalmwaterresistancetestsinshallowwater.Thesecriteriaareimportantinanalyzingsemi-SWATHresistanceinshallowwateranditsrelationtoflowaroundhull.Theforefinangleisfixedtozerodegrees,whiletheaftfinangleisvariedto0o,5o,10o,and15o.Foreachconfiguration,investigationsareconductedwithdepthFroudenumbers(FrH)rangingfrom0.65to1.2,andtheresistancetestsareperformedinshallowwateratthetowingtankofUTM.Analysisresultsindicatethattheresistance,wavepattern,andtrimofthesemi-SWATHhullformareaffectedbythefinangle.Theresistanceisamplifiedwhereasthetrimandsinkagearereducedasthefinangleincreases.IncreasesinfinanglecontributetoseakeepingandstabilitybutaffectthehullresistanceofHSCs.

简介：多孔的媒介在生产和生活，以及在科技有大量应用。在多孔的媒介的流动抵抗的学习在工业、农业的生产上有大效果。通过一张20公里玻璃范围床的液体流动的流动抵抗试验性地被学习。在Ergun方程和试验性的数据之间有重要偏差，这被发现。一个蹒跚的毛孔喉咙模型被建立在随机包装的多孔的媒介调查流动抵抗。一个假设被做粒子在常规三角安排被蹒跚。在随机的多孔的媒介的流动抵抗的分析明确的表达被导出。在明确的表达没有实验常数，每个参数有一个特定的物理意思。明确的表达预言在对试验性的数据的好同意。偏差在25%的范围以内。这证明蹒跚的毛孔喉咙模型是讲理的并且被期望被更多的实验验证并且延长了到另外的多孔的媒介。

简介：Anewtypeofhybridweldingmethodcalledresistanceplugwelding(RPW)wasfirstlyadoptedtoachievetheconnectingofdissimilarsteel,mainlyasforthepoorweldingcharacteristicsofhighstrengthsteelproducedbyincreasingcarbon,manganese,silicon,etc.MicrostructuresandmechanicalpropertiesofRPWjointwereanalyzedbyopticalmicroscope,micro-hardnesstestandsheartensilemeasurement.ExperimentalresultsindicatethattheRPWjointhasaroundedrectanglenugget,andthesizeislargerthanellipticalnuggetofresistancespotwelding(RSW)joint;thehardnessvalueofRPWjointisevenlydistributed,accordinglythereisnohardbrittlephases;thesheartensilestrengthofRPWjointincreasesby20%incomparisonwithRSWjointunderthesameweldingconditions.

简介：Inearthquakeproneareas,understandingoftheseismicpassiveearthresistanceisveryimportantforthedesignofdifferentgeotechnicalearthretainingstructures.Inthisstudy,thelimitequilibriummethodisusedforestimationofcriticalseismicpassiveearthresistanceforaninclinedwallsupportinghorizontalcohesionlessbackfill.Acompositefailuresurfaceisconsideredinthepresentanalysis.Seismicforcesarecomputedassumingthebackfillsoilasaviscoelasticmaterialoverlyingarigidstratumandtherigidstratumissubjectedtoaharmonicshaking.Thepresentmethodsatisfiestheboundaryconditions.Theamplificationofaccelerationdependsonthepropertiesofthebackfillsoilandonthecharacteristicsoftheinputmotion.Theaccelerationdistributionalongthedepthofthebackfillisfoundtobenonlinearinnature.Thepresentstudyshowsthatthehorizontalandverticalaccelerationdistributioninthebackfillsoilisnotalwaysin-phaseforthecriticalvalueoftheseismicpassiveearthpressurecoefficient.Theeffectofdifferentparametersontheseismicpassiveearthpressureisstudiedindetail.Acomparisonofthepresentmethodwithothertheoriesisalsopresented,whichshowsthemeritsofthepresentstudy.

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简介：Thispaperstudiesconsensusofaclassofheterogeneousmulti-agentsystemscomposedoffirst-orderandsecond-orderagentswithintermittentcommunication.Forleaderlessmulti-agentsystems,weproposeadistributedconsensusalgorithmbasedontheintermittentinformationofneighboringagents.Somesufficientconditionsareobtainedtoguaranteetheconsensusofheterogeneousmulti-agentsystemsintermsofbilinearmatrixinequalities(BMIs).Meanwhile,therelationshipbetweencommunicationdurationandeachcontrolperiodissoughtout.Moreover,thedesignedalgorithmisextendedtoleader-followingmulti-agentsystemswithoutvelocitymeasurements.Finally,theeffectivenessofthemainresultsisillustratedbynumericalsimulations.

简介：为在期望的多搬运人信号隐藏的干扰，这份报纸建议新奇察觉和识别算法。算法不能仅仅由高顺序的cumulant检测单个搬运人的干扰(SCI)，而且基于光谱特性发现多搬运人信号。而且，算法能区分SCI的调整类型。算法不取决于任何优先的知识并且帮助数据，它对实际应用慈悲。分析和模拟结果证明建议算法是有效的。

简介：Thedispersioncharacteristicsandexcitationmechanismsoftheguidedwavesinmultilayeredplatesarestudiedinthispaper.Firstly,thedispersionequationisobtainedbythepropagatormatrixmethod.Then,thebisectiontechniqueisemployedtofindalltherootsofthedispersionequation.Thedispersioncharacteristicsoftheguidedwavesareinvestigatedandanalyzed.ForthemultilayeredplatesinwhichtheS-wavevelocityincreasesordecreasesfromtoptobottom,itisfoundthatthevelocitylimitsinhighfrequencyofthefirstandhighmodesareequaltotheRayleighwaveandS-wavevelocitiesofthelow-velocitylayer,respectively.ItisalsofoundthatthevelocitylimitsinthehighfrequencyofallmodesareequaltotheS-wavevelocityofthelow-velocitylayerfortheplatewithalow-velocitymiddlelayer.Thenormaldisplacementspectrumofallthemodesexcitedbythenormalforcesourcewithadefinitewidthonthesurfaceoftheplateisalsoinvestigated.ItisprovedthatthedominantmodeisthefirstmodewhentheS-wavevelocityincreasesfromtoptobottomlayerandthedominantmodeisdifferentindifferentfrequencyrangefortheplatewithalow-velocitymiddlelayer.

简介：Brownplanthopper(BPH)isaninsectspeciesthatfeedsonthevascularsystemofriceplants.ToexaminethedefencemechanismofriceplantsagainstBPH,thepathogenesis-relatedgenes(PR1a,PR2,PR3,PR4,PR6,PR9,PR10a,PR13,PR15andPRpha),signalingmoleculesynthesisgenes(AOS,AXR,ACOandLOX),antioxidant-relatedgenes(CAT,TRX,GSTandSOD)andligninbiosynthesis-relatedgenes(CHS,CHIandC4H)wereinvestigatedinaresistantricevariety.AOS,PR6,PR9andPR15genesshowedsignificantlyincreasedrelativeexpressionlevelsat24.38-,19.17-,14.71-,and12.74-foldcomparedtothecontrol.Moderateincreasedrelativeexpressionlevelsofligninbiosynthesis-relatedgene(C4H),pathogenesis-relatedgenes(PR4,PR10aandPRpha),andantioxidant-relatedgene(GST)werefound,whileCHI,LOX,SOD,TRX1andAXRshoweddecreasedrelativeexpressionlevels.Itwasthusclearlyshownthatwound-inducedresponsegeneswereactivatedinriceplantsafterBPHattacksthroughAOSactivation.JasmonicacidsignalingmoleculemayactivatePR6,PR15,GSTandCATsubsequentlyincreasingtheirexpressionforH2O2detoxification.PR6wereexpressedatthehighestrelativelevelamongthePRgenes.ThesegenesthereforehavealsoaconsiderablesynergisticrolewiththeothergenesagainstBPHbyinterferedtheirdigestiontractsystem.

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