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简介：Ithasbeenknownforsometimethatstraininjuriesoccurthroughtheexcessivelengtheningofamuscle.~(1–3)However,theprecisemechanismforstraininjuryremainselusiveandhasbeenthesubjectofrecentdebateintheJournalofSportandHealthScience,~(4–9)butitseemssensibletoconsidermechanismsatthelevelofthemusclefiber.Itwaspreviouslybelievedthatdamagewastheresultofnon-uniformstretchingofsarcomeres

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简介：Softand3D-printedmicromachinescanbeimplantedinthebodytodeliverdosesofachemodrug.Thisstrangenewbiobotusesneitherbatterynorwires,andcanbecontrolledfromoutsidethebodytodeliveradoseoncommand.It’sagadgetwellsuitedforthisneweraofpersonalizedmedicine.

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简介：Age-relatedmaculardegeneration(AMD)causesirreversiblelossofcentralvisionforwhichthereisnoeffectivetreatment.IncipientpathologyisthoughttooccurintheretinaformanyyearsbeforeAMDmanifestsfrommidlifeonwardstoaffectalargeproportionoftheelderly.Althoughgeneticaswellasnon-genetic/environmentalrisksarerecognized,itscomplexaetiologymakesitdifficulttoidentifysusceptibility,orindeedwhattypeofAMDdevelopsorhowquicklyitprogressesindifferentindividuals.HerewesummarizetheliteraturedescribinghowtheAlzheimer's-linkedamyloidbeta(Aβ)groupofmisfoldingproteinsaccumulateintheretina.ThediscoveryofthiskeydriverofAlzheimer'sdiseaseinthesenescentretinawasunexpectedandsurprising,enablinganaltogetherdifferentperspectiveofAMD.WearguethatAβfundamentallydiffersfromothersubstanceswhichaccumulateintheageingretina,anddiscussourlatestfindingsfromamousemodelinwhichphysiologicalamountsofAβweresubretinally-injectedtorecapitulatesalientfeaturesofearlyAMDwithinashortperiod.OurdiscoveriesaswellasthoseofotherssuggestthepatternofAβaccumulationandpathologyindonoraged/AMDtissuesarecloselyreproducedinmice,includinglate-stageAMDphenotypes,whichmakesthemhighlyattractivetostudydynamicaspectsofAβ-mediatedretinopathy.Furthermore,wediscussourfindingsrevealinghowAβbehavesatsingle-cellresolution,andconsiderthelong-termimplicationsforneuroretinalfunction.WeproposeAβasakeyelementinswitchingtoadiseasedretinalphenotype,whichisnowbeingusedasabiomarkerforlatestageAMD.

简介：PurdueUniversityresearchershavefoundamethodofidentifyingbiologicalmarkersinsmallamountsofbloodthattheybelievecouldbeusedtodetectamyriadofdiseases,infectionsanddifferentmedicalconditionsatearlystages.Apiezoelectricallyactuatedpipettesystemisusedasaninexpensivemeanstodetectbiologicalmoleculesassociatedwithspecificdiseases,infectionorother