简介：AbstractPlatelet-rich fibrin (PRF) is a second-generation platelet concentrate obtained from autologous blood. PRF is composed of abundant platelets, leucocytes, and a high concentration of various growth factors and fibrinogen. The composition and three-dimensional structure of PRF enable it to effectively make cells migrate and proliferate, playing an important role in tissue repair. Furthermore, the easy preparation and low cost of PRF make it a good treatment option. Numerous articles have been published about the application of PRF in clinical practice, however, the application of PRF in dermatology has not been comprehensively reviewed. The objective of this review article was to discuss various applications of PRF in dermatology, including healing chronic wounds, treating androgenic alopecia, skin rejuvenation, autologous fat transplantation, and treating vitiligo. PRF is a promising dermatologic treatment, but lacks a standardized protocol regarding its methods of attainment and use, which needs more investigations.

简介：AbstractObjective:Platelet-rich plasma (PRP) releases growth factors upon activation, which in turn accelerates healing and regeneration of the target tissue. However, PRP composition may vary according to the patient’s demographics, and wider applications of PRP warrant product standardization. The current study aimed to examine variables influencing the platelet-derived growth factor BB (PDGF-BB) concentration in PRP.Methods:This observational study was conducted in the Department of Pathology and Dentistry at Swami Rama Himalayan University, a tertiary care hospital in northern India from December 2016 to November 2017. PRP was prepared from 40 mL of whole blood from 35 individuals (22 women, 13 men). Platelet counts, platelet indices (platelet distribution width, mean platelet volume) and PDGF-BB levels were measured, and platelet yield, platelet dose, and growth factor dose in PRP were also calculated. All parameters were analyzed using Pearson’s correlation coefficient. The association between PDGF-BB and PRP platelet count was evaluated using logistic regression. This study was approved by the Ethics Committee of Swami Rama Himalayan University (SRHU/HIMS/ETHICS/2016/103) on September 7, 2016.Results:The mean platelet count, PDGF-BB concentration, platelet yield, platelet dose, and growth factor dose in PRP were 1317×109/L, 30±9.89ng/mL, 71.62±28.34%, 6.5±3.5×109, and 159.62±52.39ng/mL, respectively. Linear regression analysis indicated that PRP platelet counts were a good predictor for PGDF-BB (P<0.05; adjusted R2=0.96. PRP platelet count was significantly positively correlated with PDGF-BB concentration (r=0.74, P<0.001), platelet yield (r=0.80, P<0.001), platelet dose (r=1, P<0.001), and growth factor dose (r=0.74, P<0.001).Conclusions:PRP has wide clinical applications associated with its healing and regenerative properties, and both the quality and quantity of PRP thus need to be standardized as per the requirements. Evaluating variables affecting PRP will thus aid pathologists and clinical practitioners.

简介：AbstractObjective:Androgenetic alopecia (AA) is a progressive hair loss disorder mediated by systemic androgens and genetic factors. A variety of AA treatments have been investigated. Currently, there is emerging evidence and growing interest in the use of platelet-rich plasma (PRP) for AA. This study describes a single-center experience using PRP to treat AA in women.Methods:A retrospective observational study design was employed. The study cohort comprised 20 women >18 years of age who were diagnosed with AA. PRP was prepared using a commercially available PRP kit. Each patient received six PRP treatment sessions at 4-week intervals. The severity of alopecia tool (SALT) scoring system was used to measure the severity of alopecia, and a paired t-test was used to calculate significance levels.Results:The mean pre-intervention and post-intervention total SALT score was 27.5 ± 6.35 and 9.41 ± 3.71, respectively. The difference in the total mean SALT score was 18.33 ± 1.64 and the effect size was 3.52. The scalp area with the largest effect size was the vertex (Cohen d= 2.53). The effect size was similar across other scalp areas (Cohen d= 1.91-2.09). There were no serious adverse effects of the treatment; only mild transient adverse effects were reported.Conclusion:The present study demonstrated the efficacy and safety of PRP injections in treating AA in women. However, these findings require confirmation in well-designed studies using standardized treatment protocols and evaluation methods.

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简介：Background:Plateletrichplasma(PRP)therapyiswidelyusedinenhancingtherecoveryofskeletalmusclefrominjury.However,theimpactofintramusculardeliveryofPRPonhematologicandbiochemicalresponseshasnotbeenfullyelucidatedinexercise-inducedmuscledamage.ThepurposeofthisinvestigationtheeffectsofintramusculardeliveryofPRPonhematologicandbiochemicalresponsesandrecoverystrategymuscledamageinducedbyhighintensitymuscleexercise(exercise-inducedmuscledamage,EIMD).Methods:Moderatelyactivemalevolunteersparticipatedinthisstudyandwereassignedtoacontrolgroup(control,n=6)andPRPadministrationgroup(PRP,n=6).Thesubjectsperformedexercisewithaloadof80%onerepetitionmaximum(1RM)maximalvoluntarycontractionoftheelbowflexorsuntilpointofexhaustionofthenon-dominantarmwasreached.ThearmsweretreatedwithsalineorautologousPRPpost-24hEIMD.Venousbloodsampleswereobtainedinthemorningtoestablishabaselinevalueand1–4dayspost-exerciseandwereanalyzedforserumferritin,iron,ironbindingcapacity(IBC),creatininekinase(CK),lactatedehydrogenase(LDH),aspartateaminotransferase(AST),andalanineaminotransferase(ALT).Results:Thebaselinelevelsofplasmairon,ferritin,IBC,CK,LDH,AST,andALTweresimilarinboththecontrolandPRPgroups.However,24-hfollowingexerciseasignificantincreaseintheseparameterswasobservedinbothgroupsbetween1and4daysduringtherecoveryperiod.Interestingly,PRPadministrationdecreasedplasmaironlevelscomparedtothecontrolontheseconddaypost-exercise.PlasmaIBCincreasedinPRPgroupfromDays2to4post-exercisecomparedtothecontrolgroupwhilstPRPadministrationhadnoeffectonplasmaferritin,CK,AST,ALT,orLDH.Conclusion:Acuteexhaustiveexerciseincreasedmuscledamagemarkers,includingplasmairon,IBC,andferritinlevels,indicatingmuscledamageinducedbyexercise.PRPadministrationimprovesinflammationbyreversingtheincreaseintheironlevelspost-exercisewi

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简介：TheIndiancivilizationhasthusfarexperiencedthreephasesofancient,medievalandmodernstagesandisnowenteringsteadilytherealmodernstageinthetruesenseoftheterm.Afterfurtheradvancesinanotherfivetotendecades,theIndiancivilizationwillsurelyappearinanewvigorouslookofprosperityandstrength,boastingbothtraditionalsplendorandmodernwonders.

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简介：血浆nitrocarburizing和血浆氧化处理被执行改进wear和SKD61钢的腐蚀抵抗。血浆nitrocarburizing在生产epsilon-Fe2_3的氮，氢和甲烷空气在540°C为12h被进行(N，C)血浆nitrocarburising生产的phase.The混合物层主要由电子阶段组成，与gamma'-Fe4的一个小比例(N，C)复合的层和扩散层的phase.The厚度是大约10亩m和大约200/^m，respectively.Plasma柱子氧化为1h.The在500°C的经常的温度与各种各样的氧/氢比率在nitrocarburized样品上被执行在在复合的层上的厚度的1-2亩m的很薄的磁铁矿(Fe3O4)层被获得。阳极极化测试表明那个血浆nitrocarburizing过程贡献了SKD61钢的腐蚀抵抗的重要改进。然而，nitrocarburized混合物层的腐蚀特征被氧化处理败坏。

简介：为阐明β榄香烯的抗血小板作用，本文分别采用比浊法和放免法测定大鼠连续ｉｐ７ｄβ榄香烯乳６．２５～１２．５ｍｇ·ｋｇ－１·ｄ－１后对血小板聚集、血浆ｋｅｔｏＰＧＦ１α和ＴＸＢ２水平的影响。结果表明，本品分别使凝血酶、花生四烯酸和ＡＤＰ诱导血小板最大聚集率下降３８．３％～４２．６％，１４．７％～１９．１％和７．２％～１０．８％，血浆ＴＸＢ２从８８ｎｇ·Ｌ－１下降至７２ｎｇ·Ｌ－１，ｋｅｔｏＰＧＦ１α从１７．５ｎｇ·Ｌ－１增加至２０．９ｎｇ·Ｌ－１。提示ＴＸＢ２降低和ｋｅｔｏＰＧＦ１α值增加是其抑制血小板聚集的作用机制之一。

简介：AIM:Toinvestigatethediagnosticaccuracyofthemeanplateletvolumeandplateletdistributionwidthinacuteappendicitis.METHODS:Thisretrospective,case-controlledstudycompared295patientswithacuteappendicitis(Group?Ⅰ),100patientswithotherintra-abdominalinfections(GroupⅡ),and100healthyindividuals(GroupⅢ)betweenJanuary2012andJanuary2013.Theage,gender,andwhitebloodcellcount,neutrophilpercentage,meanplateletvolume,andplateletdistributionwidthvaluesfrombloodsampleswerecomparedamongthegroups.StatisticalanalyseswereperformedusingSPSSforWindows21.0software.Inaddition,thesensitivity,specificity,positiveandnegativepredictivevaluesandlikelihoodratios,anddiagnosticaccuracywerecalculated.RESULTS:Themeanagesofpatientswere29.9±12.0yearsforGroup?Ⅰ,31.5±14.0yearsforGroupⅡ,and30.4±13.0yearsforGroupⅢ.Demographicfeaturessuchasageandgenderwerenotsignificantlydifferentamongthegroups.Whitebloodcellcount,neutrophilpercentageandplateletdistributionwidthweresignificantlyhigherinGroup?Ⅰ?comparedtogroupsⅡandⅢ(P<0.05).Diagnostically,thesensitivity,specificityanddiagnosticaccuracywere73.1%,94.0%,and78%forwhitebloodcellcount,70.0%,96.0%,and76.0%forneutrophilpercentage,29.5%,49.0%,and34.0%formeanplateletvolume,and97.1%,93.0%,and96.0%forplateletdistributionwidth,respectively.ThehighestdiagnosticaccuracydetectedwasforplateletdistributionwidthbetweenGroup?Ⅰ?andGroupⅢ(P<0.01).CONCLUSION:Plateletdistributionwidthanalysiscanbeusedfordiagnosisofacuteappendicitiswithoutrequiringadditionaltests,thusreducingthecostandlossoftime.

简介：ObjectiveTrauma在在沙特阿拉伯的年轻年龄组之中是死亡和病态的领先的原因并且开发国家。这研究试图为临床的严厉作为一个潜在的预言者与创伤的大脑损害(TBI)在孩子评估血小板计数的秋天，outcome.MethodsTotally，有TBI的74个病人从开始2008年1月到目的进入我们的医院的小儿科的特别护理单位(PICU)2010年3月(27个月)。基线注册标准是很长时间12年，在在损伤事件以后的4个小时以内的承认，和缩短的损害规模(AIS)(或)，3.1；相对风险(RR)，2.15。接收装置操作特征(巨鸟)曲线和Youden索引证明PFP的最佳截止点在51.5%.ConclusionPFP与TBI的严厉被增加，它能也为它的结果作为一个重要独立预言因素被拿。

简介：Theβ-decaysofneutron-richcarbon,nitrogenandfluorineisotopeshavebeensys-tematicallystudiedusingtheOXBASHshellModel.Inthepsd,spsdandspsdpfmodelspace,weusetheWBPinteractiontocalculatethehalf-livesandneutronemissionprobabilitiesofneutron-richcarbonandnitrogenisotopes,respectively.WiththeUSD(W)andCWinteractions,wecalculatethehalf-livesandneutronemissionprobabilitiesofneutron-richfluorineisotopeinthesdmodelspace,respectively.Thecalculatedhalf-livesandneutronemissionprobabilitiesrepro-ducerecentexperimentaldataverywell.Itseemstoshowthattheparticlesoftheneutron-richcarbonandnitrogenisotopesaremainlyexcitedinthespsdspace.Theβ-decayof21Ntotheneutronboundstatesin21Oismostlythefirstforbiddentransitionwhichmakestheneutronemissionprobabilityincrease.Thetheoreticalcalculationofβ-decayof25Fto25NewithCWinteractionshowsthatCWinteractionisbetterthanUSDinteraction.

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简介：Al-richmetapelitesfromtheMashankhondaliteseriesarecharacterizedbytheassemblageSpl+Grt+Sil+Crd+Bt+Pl(An72)+Kfs+Quartz+graphite.Largeamountsofspinel+quartzassemblagesoccurasinclusionsingarnetandprismaticsillimaniteintheAl-richmetapelitesoftheMashancomplex,NEChina.ThechemicalcompositionofspinelischaracterizedbyZn-rich(XZn=0.33–0.40.XZn=Zn/Zn+Mg+Fe*)(Fe*=Fe2++Fe3+)andFe3+rich(upto0.31p.f.u.).ThecharacteristicchemicalcompositionandthemineralassociationindicatedthattheformationofspinelandquartzassemblagemaybeduetothebreakdownofZn-richstaurolite.ThegeothermobarometersstudiesshowthatthepeaktemperatureoftheMashancomplexisaround820℃andthepeakpressuresis8.0kbar.TheMashancomplexshowsatypicalorogenstyleP-Tpath.