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297 个结果
  • 简介:Thepaperdealswiththebackgroundfeatures,formationanddistributionofthechemicalel-ementsK,Na,Ca,Mg,Si,Fe,Mn,Cr,Ni,V,Co,Ti,Mo,Cu,Pb,Zn,As,Hg,Cd,Be,Li,Sr,B,F,Cl,BrandIinthegroundwaterintheregionofthemiddleandlowerreachesoftheYangtzeRiverandtheirrelationstothecompositionofthewater-bearingmedia,propertiesoftheoverly-ingrocksandsoils,redoxenvironment,andgroundwaterflowcondition,mineralizationandpHofgroundwater.

  • 标签: lower-middle reaches of the YANGTZE River
  • 简介:Self-affinefractalfeaturesofearthquaketimeseriesbeforeandaftermoderateearthquakesChang-HatLIU(刘长海),Yi-GaoLIU(刘义高)andJunZHANG(...

  • 标签: SELF-AFFINE FRACTAL local FRACTAL dimension value
  • 简介:Wepresentnewgeochemicaldatafortheuppermantleandcrustalsections(whole-rockmajorandtraceelementcompositions)aswellasmineralchemicaldata,fromtheNorthernCarbibbeanophiolitesintheHabana-MatanzasregioninWesternCuba.TheseophiolitesarepartoftheNorthernCubanOphioliticBelt(NCOB),extendingformorethan1000kmalongtheisland.Theuppermantleperidotitesarecomposedmainlyofrefractoryharzburgitewithtectonitetextures,andshowconvex-downwardpatternsdepletedinMREEnormalizedtochondritevalues(McDonoughandSun,1995).Thesegeochemicaltrendsarecharacteristicfordepletedmantlewedgeperidotitesmetasomatizedbyslab-derived,LREEenrichedmelts.TheNCOBalsoincludesabyssalperidotiteshavinglowerLREE/HREEratiosanddisplayingrelativelyhomogeneousandflatpatternsfromMREEtoHREE.Theseperidotitesrepresentfragmentsaccretedintothecontinentalmarginfromasubductedoceaniclithosphere.GabbroanddoleriteunitsintheNCOBaresystematicallydepletedinHighFieldStrengthElements(HFSE:Nb,Ta,Hf,Ti)andREEwithrespecttoN-MORB(<1XN-MORB).Theirmeltevolutionwasaffectedbysubductioninput.Spatiallyassociatedgraniticrockshaveavolcanicarcgeochemicalaffinity.SomemaficextrusiverockswithintheNCOBexhibitboniniticsignatures,andmayrepresenttheproductsofsubductioninitiationmagmatism,whereasotherextrusiverockoccurrencesdisplayN-MORBtoE-MORBgeochemicalfingerprints,slightlymodifiedbysubductionderivedfluids.Usingthesegeochemicaldataandconstraints,wepresentatectonomagmaticmodelfortheevolutionoftheNCOBwithintheframeworkoftheCaribbeangeology.

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  • 简介:UnderstandingthecouplingspecificitybetweenGprotein-coupledreceptors(GPCRs)andspecificclassesofGproteinsisimportantforfurtherelucidationofreceptorfunctionswithinacell.IncreasinginformationonGPCRsequencesandtheGproteinfamilywouldfacilitatepredictionofthecouplingpropertiesofGPCRs.Inthisstudy,wedescribeanovelapproachforpredictingthecouplingspecificitybetweenGPCRsandGproteins.ThismethodusesnotonlyGPCRsequencesbutalsothefunctionalknowledgegeneratedbynaturallanguagepro-cessing,andcanachieve92.2%predictionaccuracybyusingtheC4.5algorithm.Furthermore,rulesrelatedtoGPCR-Gproteincouplingaregenerated.Thecom-binationofsequenceanalysisandtextminingimprovesthepredictionaccuracyforGPCR-Gproteincouplingspecificity,andalsoprovidescluesforunderstandingGPCRsignaling.

  • 标签: GPCR G蛋白 耦合特异性 预测 序列特征 生物机能
  • 简介:BasedontheQuikSCATdata,thefeaturesofsurfacewinddistributionofthetyphoonVongfonglandfallprocessareanalyzed.WehavealsostudiedthevariancespectralconfigurationofthesurfacewindfieldusingDCT(DiscreteCosineTransform).Theconclusionsareasfollows:Thenear-surfacewindfieldishighlyasymmetric;thevariancecomponentsofasymmetricsurfacewindfielddependmainlyontheairflowdirectionofwavenumber1and2.Whenthetyphoonmoveswest,therearetwowavespectralcentersliningupinthezonaldirection,mainlytheairflowfromzonalwavenumber2andmeridionalwavenumber2;whenitmovesnorth,therearetwowavespectralcentersinameridionalarray,mainlytheairflowfromzonalwavenumber1andmeridionalwavenumber2.Theairflowforwavenumber1mainlycontributestothevarianceofthetangentialwindwhilethatforwavenumber2tothevarianceoftheradialwind.Theasymmetricaldistributionchangeswiththelarge-scaleenvironmentandself-rotatingcirculationaroundthetyphoon.Whenitapproachedland,theassociatedgaleappearsinfrontportionintheadvancingdirectionofthestorm.ItisineffectsimilartothemodelofChenLian-shoufortyphoon-relatedgales-NNWontheleftfrontportionandSEontherightfrontportion.

  • 标签: 离散余弦变换 地表风 台风 气流
  • 简介:Inaself-consistentmean-fieldtreatmentofthetwo-dimensionalt-t'-Jmodel,wetheoreticallyexaminethecouplingofin-planequasi-particlestotheantiferromagneticspinfluctuationsinhigh-Tcsuperconductors,whichrenormalizesthefermionicself-energy.Wereproducethecharacteristicpeak-dip-humpstructureobservednotonlyinangly-resolvedphotoemissionspectroscopy,butalsoinsuperconductor-insulator-normalmetalunctionsandscanningtunnellingmicroscopyexperiments.Weconsidertheevolutionofthisstructurewithdoping.Itisshownthatthiskindofcouplingcanaccountformanyanomalouspropertiesofhigh-Tcsuperconductorsinsuperconductingstates.

  • 标签: 高Tc超导电体 自旋涨落 准粒激发
  • 简介:Thedaily1°×1°dataoftheAviation(AVN)model,theblackbodytemperature(TBB)dataofcloudtop,andcloudimagesbygeostationarymeteorologicalsatellite(GMS)areusedtoidentifyadew-pointfrontneartheperipheryofthewesternPacificsubtropicalhigh(WPSH).Theresultsclearlydemonstratetheexistenceofthedew-pointfront,anditsthermodynamicanddynamicstructuralcharacteristicsareanalyzedindetail.Thedew-pointfrontisatransitionalbeltbetweenthemoistsouthwestmonsoonflowandthedryadiabaticsinkingflowneartheWPSH,manifestedbyalargehorizontalmoisturegradientinthemid-lowertroposphereandconjugatedwiththemei-yufronttoformapredominantdouble-frontstructureassociatedwithintenserainfallinthemei-yuperiod.Themei-yufrontislocatedbetween30°and35°N,verticallyextendsfromthegroundleveltotheupperlevelandshiftsnorthward.Thedew-pointfrontistothesouthofthemei-ynfrontandliesupagainsttheperipheryoftheWPSH.Generally,itislocatedbetween850hPaand500hPa.Onthedew-pointfrontside,thesouthwesterlyprevailsatthelowerlevelandthenortheasterlyattheupperlevel;thiswinddistributionisdifferentfromthatonthemei-yufrontside.Verticalascendingmotionexistsbetweenthetwofronts,andtherearedescendingmotionsonthenorthsideofthemei-yufrontandonthesouthsideofthedew-pointfront,whichformasecondarycirculation.Thedynamicsofthedoublefrontsalsohavesomeinterestingfeatures.Atthelowerlevel,positiveverticalvorticityandobviousconvergencebetweenthetwofrontsareclearlyidentified.Atthemid-lowerlevel,negativelocalchangeofthedivergence(correspondingtoincreasingconvergence)isoftenembeddedinthetwofrontsoragainstthemei-yufront.Mostcloudclustersoccurbetweenthetwofrontsandpropagatedownstreaminawave-likemanner.

  • 标签: 热动力 中国 梅雨 结构参数
  • 简介:Cancercellsarewelldocumentedtorewiretheirmetabolismandenergyproductionnetworkstosupportandenablerapidproliferation,continuousgrowth,survivalinharshconditions,invasion,metastasis,andresistancetocancertreatments.SinceDr.OttoWarburg’sdiscoveryaboutalteredcancercellmetabolismin1930,thousandsofstudieshaveshedlightonvariousaspectsofcancermetabolismwithacommongoaltofindnewwaysforeffectivelyeliminatingtumorcellsbytargetingtheirenergymetabolism.Thisreviewhighlightstheimportanceofthemainfeaturesofcancermetabolism,summarizesrecentremarkableadvancesinthisfield,andpointsoutthepotentialstotranslatethesescientificfindingsintolife-savingdiagnosisandtherapiestohelpcancerpatients.

  • 标签: 物质代谢 癌症患者 重编程 抗肿瘤治疗 疗法 抗癌
  • 简介:ThepaperdiscussesquantitativelytheinfluenceoftheYutianMS7.4earthquakeofMarch21,2008andWuqiaMS6.9earthquakeofOctober5,2008onregionalseismicityinXinjiang,andexplainsprimarilythepossiblereasonofearthquakeactivityfeatureinXinjiangaftertheYutianMS7.4earthquakebyanalyzingthestaticCoulombfailurestresschangeproducedbytheYutianMS7.4earthquakeandWuqiaMS6.9earthquake,andtheseismicityfeatureofMS≥3earthquakesinthepositiveCoulombstresschangeregionofKashi-Wuqiajointregion,thecentralsegmentofTianshanMountainandKalpinblock.TheresultshowsthattheYutianMS7.4earthquakeofMarch21,2008,mayencouragetheWuqiaMS6.9earthquakeofOctober5,2008,andtheYutianMS7.4earthquakeandWuqiaMS6.9earthquakemaychangetheseismicitystateinthecentralsegmentofTianshanMountain,KalpinblockandKashi-Wuqiajointregion,andencouragethesubsequentMS≥3earthquakes.

  • 标签: 地震活动特点 新疆地区 库仑破裂应力变化 原因 喀什地区 天山山区
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  • 简介:用为时期的NCEP/NCAR分析数据19572001,季节的转变在亚洲澳大利亚人的季风区域大规模垂直地综合的潮湿运输(VIMT)展示的climatological在这篇论文被调查。到夏天的从冬季的VIMT的季节的转变的基本特征是夏日的建立“大潮湿河”模式(说出GMR模式)并且它的东方扩大,与发生在“一些关键时期”的一系列climatological事件联系了,它在中间的5月在中间的三月,在在迟了的4月的斯里兰卡附近的低VIMT旋涡的活动,和华南海夏季风的发作在印度支那半岛上包括著名南方的VIMT的出现,在其它之中。在到冬季的从夏天的转变期间,然而,特征被建立主要展出在东方位于热带区域的VIMT带,由发生在“关键时期”的一些事件伴随了。当在季节的变化过程期间从西的VIMT的南方的迁居看了时,进一步的分析揭示印第安人和东方亚洲季风区域之间的大差别,根据哪个亚洲季风区域能容易沿着印度支那半岛的西方的方面被划分成二部分,它可以也表示在二个区域之间的不同形成机制。

  • 标签: 大尺度 水汽输送 亚洲-澳洲季风区 季节性变换
  • 简介:AIM:Todescribetheclinicalfeatures,systemicassociations,treatmentandvisualoutcomesinSaudipatientswithscleritis.·METHODS:AretrospectivechartreviewwasperformedforpatientswithscleritispresentingtotwotertiarycareeyehospitalsinRiyadh,SaudiArabia,from2001to2011.Datawerecollectedontheclinicalfeaturesofscleritis,subtypesofscleritis,associatedsystemicdisease,historyofpreviousocularsurgeryandmedicaltherapy,includingtheuseofimmunosuppressants.Treatmentoutcomeswereevaluatedbasedonbest-correctedvisualacuity(BCVA)andresponsetotreatment.·RESULTS:Ofthe52patientsincludedinthestudy,non-necrotizinganteriorscleritiswasthemostcommontypeofscleritisin22patients(42.3%),followedbyposteriorscleritisin14patients(26.9%).Themajorityofcases,31patients(59.6%),wereidiopathicinnature.Systemicassociationswerepresentin12patients(23.1%).Infectiousscleritiswasconfirmedin6patients(11.5%):3withbacterialscleritisafterpterygiumexcision,2patientswithscleritisrelatedtotuberculosisand1patientwithscleritisresultingfromherpessimplexinfection.Forthevarioussubtypesofscleritis,BCVAvaluesaftertreatmentandtimetoremissionsignificantlydiffered(P<0.05,allcases).Systemicimmunosuppressivetherapiesinadditiontosteroidswereadministeredto46.2%ofallpatients.TheT-signwaspresentonB-scanultrasonographyin9(64.3%)ofthe14posteriorscleritispatients.·CONCLUSION:Non-necrotizinganteriorscleritiswasthemostcommonsubtypeofscleritis.Finalvisualoutcomeandtimetoremissiondifferedamongthevariousscleritissubtypes.

  • 标签: 自体免疫 巩膜炎 scleromalacia episcleritis NECROTIZING 抑制免疫力的治疗
  • 简介:AIMThepreviousworkhasdemonstratedthatthepolysaccharidesofAngelicasinensis(Oliv.)Dielshavesignificantlyantitumoractivityandindicatedthattheactivityisstronglydependentontheirstructures.However,therelationshipsbetweenthestructureandtheactivitiesarestillambiguous.Thus,atpresent,moreeffortsarebeingexpendedinseekingtoisolatethepolysaccharidesfromAngelicasinensis(Oliv.)Diels,measuretheirstructuralfeaturesandantitumoractivities,andelucidatestructure-activityrelationshipsofpolysaccharides.METHODSTherootsofAngelicasinensis(Oliv.)DielswereextractedWithwater,separatedbySephacrylS-400andDEAE-sephadexA-25columnsandfurtherpurifledonSephadexG-100column.

  • 标签: 结构特征 抗癌作用 活动性 抗菌作用 六聚糖 当归
  • 简介:ThispapersummarisesthegeologicalfeaturesoftheLarderello-TravaleandMonteAmiataareas,wheretheworld'smostancientexploitedgeothermalfieldsarelocated.Inbothgeothermalareas,threeregionaltectonostratigraphicelementsaredistinguished,fromthetop:(a)LateMiocene-PlioceneandQuaternary,continentaltomarinesediments;(b)theLigurianandSub-Liguriancomplexes,whichincluderemnantsoftheJurassicoceanicrealmandofthetransitionalareatotheAdriaticmargin,respectively;(c)theTuscanUnit(TuscanNappe),composedofsedimentaryrocksrang-inginagefromLateTriassictoEarlyMiocene.Thesub-stratumoftheLarderelloandMonteAmiataareasisreferredtoastheTuscanMetamorphicComplex.Thisismainlyknownthroughdrillingofgeothermalwells.Thiscomplexiscomposedoftwometamorohicunits:theupperMonticiano-RoccastradaUnitandthelowerGneissComplex.TheMonticiano-RoccastradaUnitconsistsof(fromtoptobottom):theVerrucanoGroup,thePhyllite-QuartziteGroupandtheMicaschistGroup.TheGneissComplexconsistsonlyofpre-Alpinepoly-metamorphicgneiss.TheTuscanMetamorphicComplexisaffectedbycontactmetamorphismbyPlio-Quater-narygranitoidsandtheirdykeswarms.Hydrothermalphenomenastilloccurinbothgeothermalfields.TheLarderello-TravaleandMt.AmiatageothermalfieldsarelocatedintheinnerNorthernApennines,inanareathathasbeensubjecttoextensionsincethe?Early-Mid-dleMiocene.Twomainextensionaleventsarewellexpressedinthestructuresofthegeothermalareas.Thefirstextensionalevent(?Early-MiddleMiocene)deter-minedthetectonicdelaminationoftheLigurianUnitsandTuscanNappe.Thesecondextensionalevent(LateMiocene-Present)ischaracterizedbyhigh-anglenor-malfaultsboundingtheNeogenetectonicdepressionsofsouthernTuscany.

  • 标签: 地质特征 意大利 南部地区 地热学 Larderello-Travale TUSCANY
  • 简介:Objective:Toassesstheclinicalfeatures,survivalandprognosticfactorsofprimarytesticulardiffuselargeB-celllymphoma(DLBCL).Methods:Aretrospectivestudyof37patientswithprimarytesticularDLBCLwascarriedoutfromNovember2003toMay2012.Theirclinicalfeatures,survivalandprognosticfactorswereanalyzed.Results:Duringamedianfollow-upperiodof39.8months(5.4-93.0months),themedianprogression-freesurvival(PFS)was26.2months(95%CI:0-65months)andthe3-yearoverallsurvival(OS)ratewas78.4%.Withinthewholecohort,thefactorssignificantlyassociatedwithasuperiorPFSwerelimitedstage(stageI/II),lactatedehydrogenase(LDH)≤245U/L,internationalprognosticindex(IPI)≤1,primarytumordiameter<7.5cm,andpatientswhohadcompleteresponse(CR)andreceiveddoxorubicin-containedchemotherapy(P<0.05).Therewasatrendtowardsuperioroutcomeforpatientswhoreceivedcombinedtherapy(surgery/chemotherapy/radiotherapy)(P=0.055).PatientswhohadCR,primarytumordiameter<7.5cmandIPIscore≤1weresignificantlyassociatedwithlongerPFSatmultivariateanalysis.Conclusions:PrimarytesticularDLBCLhadpoorersurvival.CR,primarytumordiameterandIPIwereindependentprognosticfactors.Thecombinedtherapyoforchectomy,doxorubicin-containedchemotherapyandcontralateraltesticularradiotherapy(RT)seemedtoimprovesurvival.

  • 标签: B细胞淋巴瘤 临床特征 原发性 弥漫性 预后 睾丸
  • 简介:这份报纸处理从Hubin弹簧射出的气体的geochemical特征。Hubin弹簧地区,一个强壮的热排放地区,是在Tianchi火山口湖的北方边的locatedd。与不明确的爆发日期一起的很年轻的存款在Tianwenfeng的最高的区域上被发现,它可能在最近的爆发或千年爆发之一被形成了。从Hubin弹簧学习射出的气体的地球化学特征理解Tianchi火山的活动具有意义。系统地取样并且分析从Hubin弹簧射出并且讨论了他们的地球化学特征的气体的这份报纸。结果证明有深导出的气体的一个高内容,例如在Hubin弹簧地区的CO2,他,CH4和Ar。同位素的比率他躺在4之间。18和5。95Ra。平均披风导出从^4He/2^20Ne比率计算的煤气的内容并且他内容到达67.1%。Hubin触发的所有这些表演位于在高紧张和大规模释放的深气体的一条特殊的带。氦同位素的空间分发被凹度描绘,证明这个特殊区域可能与暴烈的大厦有关。释放气体从Tianchi火山代表最近的爆发的剩余气体样品,是高度可能的。然而,更多的详细研究被要求。

  • 标签: 地球化学特征 幔源气体 天池火山 湖滨 长白山 火山喷发
  • 简介:AbstractBackground:Due to development of magnetic resonance-based functional imaging, it is easier to detect micro-structural alterations of tumor tissues. The aim of this study was to conduct a preliminary evaluation of the correlation of non-Gaussian diffusion kurtosis imaging (DKI) parameters with expression of molecular markers (epidermal growth factor receptor [EGFR]; anaplastic lymphoma kinase [ALK]; Ki-67 protein) in patients with advanced lung adenocarcinoma, using routine diffusion-weighted imaging as the reference standard.Methods:Data from patients with primary lung adenocarcinoma diagnosed at Cancer Hospital, Chinese Academy of Medical Sciences (CHCAMS) from 2016 to 2019 were collected for retrospective analysis. The pathologic and magnetic resonance imaging data of 96 patients who met the inclusion criteria were included in this study. Specifically, the Kapp and Dapp parameters measured from the DKI model; apparent diffusion coefficient (ADC) value from the diffusion-weighted imaging model; and the EGFR, ALK, and Ki-67 biomarkers detected by immunohistochemistry and/or molecular biology techniques after biopsy or surgery were evaluated. The relations between quantitative parameters (ADC, Kapp, Dapp) and pathologic outcomes (EGFR, ALK, and Ki-67 expression) were analyzed by Spearman correlation test.Results:Of the 96 lung adenocarcinoma lesions (from 96 patients), the number of EGFR- and ALK-positive and high Ki-67 expressing lesions were 53, 12, and 83, respectively. The Kapp values were significantly higher among patients with EGFR-positive mutations (0.81 ± 0.12 vs. 0.66 ± 0.10, t = 6.41, P < 0.001), ALK rearrangement-negative (0.76 ± 0.12 vs. 0.60 ± 0.15, t = 4.09, P < 0.001), and high Ki-67 proliferative index (PI) (0.76 ± 0.12 vs. 0.58 ± 0.13, t = 4.88, P < 0.001). The Dapp values were significantly lower among patients with high Ki-67 PI (3.19 ± 0.69 μm2/ms vs. 4.20 ± 0.83 μm2/ms, t = 4.80, P < 0.001) and EGFR-positive mutations (3.11 ± 0.73 μm2/ms vs. 3.59 ± 0.77 μm2/ms, t = 3.12, P = 0.002). The differences in mean Dapp (3.73 ± 1.26 μm2/ms vs. 3.26 ± 0.68 μm2/ms, t = 1.96, P = 0.053) or ADC values ([1.34 ± 0.81] × 10-3 mm2/s vs. [1.33 ± 0.41] × 10-3 mm2/s, t = 0.07, P = 0.941) between the groups with or without ALK rearrangements were not statistically significant. The ADC values were significantly lower among patients with EGFR-positive mutation ([1.19 ± 0.37] × 10-3 mm2/s vs. [1.50 ± 0.53] × 10-3 mm2/s, t = 3.38, P = 0.001) and high Ki-67 PI ([1.28 ± 0.39] × 10-3 mm2/s vs. [1.67 ± 0.77] × 10-3 mm2/s, t = 2.88, P = 0.005). Kapp was strongly positively correlated with EGFR mutations (r = 0.844, P = 0.008), strongly positively correlated with Ki-67 PI (r = 0.882, P = 0.001), and strongly negatively correlated with ALK rearrangements (r = -0.772, P = 0.001). Dapp was moderately correlated with EGFR mutations (r = -0.650, P = 0.024) or Ki-67 PI (r = -0.734, P = 0.012). ADC was moderately correlated with Ki-67 PI (r = -0.679, P = 0.033).Conclusions:The Kapp value of DKI parameters was strongly correlated with different expression of EGFR, ALK, and Ki-67 in advanced lung adenocarcinoma. The results potentially indicate a surrogate measure of the status of different molecular markers assessed by non-invasive imaging tools.

  • 标签: Lung adenocarcinoma Magnetic resonance imaging Diffusion kurtosis imaging Epidermal growth factor receptor Anaplastic lymphoma kinase Ki-67 protein
  • 简介:AbstractBackground:The aim of this study was to retrospectively analyze our experience with the patients who underwent surgical treatment of posterior communicating artery (PComA) aneurysms originating from fetal posterior cerebral artery (fPCA) and analyze the risk factors for the postoperative radiological infarction and outcome.Methods:From 2011 to 2020, we retrospectively reviewed 74 PComA aneurysms originating from fPCA in terms of the clinical and radiological features and obtained the follow-up data from the Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University. The relationships between these features and follow-up data were assessed with the univariate and multivariate analysis.Results:In this series, 74 aneurysms were occurring at the origin of fPCAs. All the patients showed complete obliteration of their aneurysms. Full fPCA type tends to be a predictive factor for radiological infarction (univariate χ2 = 5.873, P = 0.027; multivariate OR = 0.264, P = 0.060). Postoperative radiological infarction (univariate χ2 = 12.611, P = 0.001; multivariate OR = 6.033, P = 0.043), rupture (univariate χ2 = 4.514, P = 0.047; multivariate OR = 57.966, P = 0.044), and hypertension (univariate χ2 = 5.301, P = 0.024; multivariate OR = 24.462, P = 0.029) tend to be the independent predictive factors for poor prognosis at 3 months after discharge.Conclusions:In conclusion, we report a series of patients harboring aneurysms originating from the fPCA. Surgical clipping is a reliable strategy. Full fPCA type is related to postsurgical infarction. Postoperative radiological infarction, rupture, and hypertension tend to be the independent predictive factor for poor prognosis at 3 months after discharge.

  • 标签: Aneurysm Fetal posterior cerebral artery Clinical features Outcome