简介：我们分析了表示的基因(transcriptomes)和翻译的蛋白质(专业版--teomes)在肌肉纸巾和激活的CD4+和五种类型的CD8+T淋巴细胞(T房间)，2糖尿病(T2DM)用Affymetrix微数组和集体spectrometry使遭到，并且把他们与匹配的非糖尿病的控制作比较。胰岛素受体(INSR)的基因表达，维生素D受体，胰岛素降级酶，Akt，胰岛素受体substrate-1(IRS-1)，IRS-2，葡萄糖transporter4(GLUT4)，并且glycolytic小径的酶被减少至少50%在T2DM比在控制。然而，有比在血浆房间glycoprotein-1的规定上面的双重的基因大，肿瘤坏死因素(在T2DM的TNF，和gluconeogenic酶比在控制。为INSR或TNF的基因silencing分别地导致了GLUT4的抑制或刺激。相应于上述翻译transcriptomes的分子的重量的Proteome侧面显示出在T2DM和控制之间的变化的不同模式。同时，在在肌肉和T2DM的激活的T房间之间的transcriptomes和proteomes的变化是可比较的。激活的T房间，类似于肌肉房间，表示胰岛素发信号和葡萄糖新陈代谢基因和基因产品。在结论，在T2DM的T房间和肌肉相对非糖尿病的控制在某些基因和基因产品的表示展出了差别。在transcriptomes的这些改变和在T2DM的proteomes可以涉及胰岛素抵抗。

简介：Inthisresearch,fiveNitrariasibiricaprovenancessuchasDayiluwereselectedtodoexperimentofsalt-resistance,combiningfixedplotstestwithtypicalplotinvestigation,measuringsurvivalrateandgrowthasmainindicators.TheexperimentsofmainculturaltechnologyweredoneonNitrariasibiricain4typesofsitepreparation,3typesofplanting,3designsforplantingdensity.TheNitrariasibiricaexperimentsfortheeffectsofcurbingsaltandimprovingsoilweredonebytestingsoilnutrients,saltcontent,soilphysicalpropertiesasfocalpointsintypicalsiteof3-4yearswoods.TheexperimentresultsshowedthattheNitrariasibiricacouldsurvivewellwithsoilsaltcontentof0.6%,andthatsurvivalratedeclineddistinctivelyassoilsaltcontentexceeded0.8%.However,highsoilsaltcontentdidnotinfluencegrowthintheyearofplanting.Therewereobviousdifferencesinsalt-toleranceamongNitrariasibiricaprovenances;Dayiluwasthebestonsalt-tolerance,theother4provenanceshadnodifferences,andobviouslyinferiortoDayilu.Thedifferenttypesofsitepreparationclearlyinfluencedplantingsurvivalrate,conservingrateandgrowth.Themethodoftwo-ploughing-two-harrowingwasthebestamongall4typesofsitepreparation.Seedforestationwaslargelylimited,bared-rootedseedlingforestationmaybepopularisedwhensoilsaltcontentwaslessthan1%andsoilmoisturecontentwasbetterinspring.Forestationwithcontainerseedlingwassuitedtocoastalsalinesoilinrainyseason.TheoptimumplantingdensityofNitrariasibiricawas2505/haintheYellowRiverDeltaareainviewofcoveragerate,yieldoffruitsandcostofplanting.Generallyspeaking,Nitrariasibiricacouldeffectivelyrefrainsoilfromaccumulationofsaltinthesurfacesoil,decreasesaltcontentandincreasesoilnutrient,andheightensoilcapillaryporerate.

简介：TheChineseAnti-JapaneseWarwasabattlebetweenhumanrightsprotectionsandabuses,betweencivilizationandbrutality,andbetweenjusticeandevil.Duringthewar,thehumanrightsofChinesepeoplewerecompletelyviolatedbytheJapaneseaggressors,causinganunprecedentedhumanrightscatastrophe.Atthesametime,Chinesepeoplevigorouslyresistedtheaggressioninordertodefendthenationalsurvivalrightandsafeguardthehumanpeaceagainstwar.Thehistoryofhumanrights’victoryoverhumanrightsabusestellsus:aggressivewarsarethemostseriousviolationsofhumanrights.Wemustprotectpeople’srighttopeaceforeverycountryintheworld.Inordertoavoidviolationsofhumanrightsbywaronceagain,wemustsafeguardtheinternationalpostwarorderandpreventtherevivaloffascism,whoseessencesarecontemptforandtrampleonhumanrights.Thereforewehavetorespectandprotecthumanrightsanddefendboththecollectiverightsofeverynationandtheindividualrightsofeverypersonintheworld.

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简介：洋红蜘蛛螨，Tetranychuscinnabarinus(Boisduval)和twospotted搜寻螨，TetranychusurticaeKoch，是草莓和许多另外的园艺的庄稼的严肃的害虫。这些害虫的控制重重地依赖于化学杀螨剂。这研究的目的是决定这的抵抗地位二害虫种到在一个整年的集中的园艺的生产区域的草莓上的通常使用的杀螨剂。而那为成年twospotted蜘蛛螨是24%最高的标签率，为成年洋红蜘蛛螨的abamectin的LC90是4%。spiromesifen，etoxazole，hexythiazox和bifenazate的LC90s是为洋红蜘蛛螨鸡蛋的0.5%他们的各自的最高的标签率，0.5%，1.4%和83%，为美女的0.7%他们的各自的最高的标签，2.7%，12.1%和347%率。spiromesifen，etoxazole，hexythiazox和bifenazate的LC90s是为twospotted蜘蛛螨鸡蛋的4.6%他们的各自的最高的标签率，11.1%，310%和62%，为美女的3%他们的各自的最高的标签，13%，432,214%和15%率。我们的结果建议那T。cinnabarinus开发了抵抗到bifenazate并且T。urticae开发了抵抗到hexythiazox。这些结果强烈强调需要在这个区域开发抵抗管理策略。

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简介：Immatureembryosofricevarieties“Xiushui11”and“Chunjiang11”preculturedfor4dwereinfectedandtransformedbyAgrobacteriumtumefaciensstrainEHA101/pExT7(containingthespiderinsecticidalgene).Theresistantcalliweretransferredontothedifferentiationmediumandplantswereregenerated.Thetransformationfrequencyreached56%～72%measuredasnumbersofGeneticin(G418)-resistantcalliproducedand36%～60%measuredasnumbersoftransgenicplantsregenerated,respectively.PCRandSouthernblotanalysisoftransgenicplantsconfirmedthattheT-DNAhadbeenintegratedintothericegenome.InsectbioassaysusingT1transgenicplantsindicatedthatthemortalityoftheleaffolder(Cnaphalocrasismedinalis)after7dofleaffeedingreached38%～61%andthecorrectedmortalityofthestripedstemborer(Chilosuppressalis)after7dofleaffeedingreached16%～75%.Theinsectbioassayresultsdemonstratedthatthetransgenicplantsexpressingthespiderinsecticidalproteinconferredenhancedresistancetothesepests.

简介：Inthiswork,amethodbasedonscanningKelvinprobemicroscopyisproposedtoseparatelyextractsource/drain(S/D)seriesresistanceinoperatingamorphousindium–gallium–zinc–oxide(a-IGZO)thin-filmtransistors.TheasymmetrybehaviorofS/Dcontactresistanceisdeducedandtheunderlyingphysicsisdiscussed.ThepresentresultssuggestthattheasymmetryofS/DcontactresistanceiscausedbythedifferenceinbiasconditionsoftheSchottky-likejunctionatthecontactinterfaceinducedbytheparasiticreactionbetweencontactmetalanda-IGZO.Theoverallcontactresistanceshouldbedeterminedbyboththebulkchannelresistanceofthecontactregionandtheinterfacepropertiesofthemetalsemiconductorjunction.

简介：AbstractBackground:Rapid and accurate detection of drug resistance in Mycobacterium tuberculosis is critical for effective control of tuberculosis (TB). Herein, we established a novel, low cost strategy having high accuracy and speed for the detection of M. tuberculosis drug resistance, using gene splicing by overlap extension PCR (SOE PCR).Methods:The SOE PCR assay and Sanger sequencing are designed and constructed to detect mutations of rpoB, embB, katG, and inhA promoter, which have been considered as the major contributors to rifampicin (RFP), isoniazid (INH), and ethambutol (EMB) resistance in M. tuberculosis. One hundred and eight M. tuberculosis isolates came from mycobacterial cultures of TB cases at Chongqing Public Health Medical Center in China from December 2018 to April 2019, of which 56 isolates were tested with the GeneXpert MTB/RIF assay. Performance evaluation of the SOE PCR technique was compared with traditional mycobacterial culture and drug susceptibility testing (DST) or GeneXpert MTB/RIF among these isolates. Kappa identity test was used to analyze the consistency of the different diagnostic methods.Results:We found that the mutations of S531L, S315T and M306V were most prevalent for RFP, INH and EMB resistance, respectively, in the 108 M. tuberculosis isolates. Compared with phenotypic DST, the sensitivity and specificity of the SOE PCR assay for resistance detection were 100.00% and 88.00% for RFP, 94.64% and 94.23% for INH, and 68.97% and 79.75% for EMB, respectively. Compared with the GeneXpert MTB/RIF, the SOE PCR method was completely consistent with results of the GeneXpert MTB/RIF, with a concordance of 100% for resistance to RFP.Conclusions:In present study, a novel SOE PCR diagnostic method was successfully developed for the accurate detection of M. tuberculosis drug resistance. Our results using this method have a high consistency with that of traditional phenotypic DST or GeneXpert MTB/RIF, and SOE PCR testing in clinical isolates can also be conducted rapidly and simultaneously for detection of drug resistance to RFP, EMB, and INH.

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简介：Whitebackedplanthopper(WBPH)-resistanceinajaponica/indicadoubledhaploid(DH)ricepopulationestablishedfromacrossbetweenWBPH-resistantjaponicaChunjiang06andsusceptibleindicaTN1,wascomparativelyevaluatedthroughafieldexperimentbasedontheWBPHimmigrantdensityandstandardizedseedboxscreeningtest(SSST).AllthesusceptibleDHlinesinthefieldexperimentbehavedaccordinglyinSSST.However,35ofresistant66lines(53%)inthefield,werecategorizedtosusceptiblegroupsinSSST.Likewise,therewerenosignificantdifferencesinWBPHimmigrantdensitiesamong70DHlinesthatwerehighlyresistanttosusceptibleinSSST.TheresultsrevealedthatSSSTcouldnotevaluateproperlyWBPHresistanceintheDHlines.FourQTLsforWBPH-resistancephenotypedbytheimmigrantdensityweredetectedonchromosomes2,3,4,and11.Ofthem,theQTLonchromosome4wasthemosteffective(LOD21.8,variance78%).FiveQTLsassociatedwithseedlingmortalityweremappedonchromosomes2,3,4,5and6.InadditiontotheQTL(LOD10.5,variance68%)onchromosome4,therewasanothermajorQTL(LOD12.7,variance71%)locatedonchromosome5,whichwasSSST-specificbutmightbeirrespectiveoftheWBPHresistancetraits.

简介：TheultrafineWC—Cocompositepowderwassynthesizedbyanewlydevelopedrapidroutebasedoninsitureactions.Byusingtheas-synthesizedcompositepowder,thegranulationprocessingwasthencarriedouttopreparetheultrafine-structuredthermalsprayingfeedstock.Theinfluencesoftheheat-treatmentprocessondensityofthefeedstockpowder,phaseconstitutionandwearresistanceoftheresultantWC—Cocoatingsfabricatedbyhighvelocityoxy-fuel(HVOF)wereinvestigated.Theresultsshowedthatincreasingtheheatingtemperatureandextendingtheholdingtimeleadedtoremarkableincreaseinthedensityandflowabilityofthefeedstockpowder.Asaresult,thedecarburizationofthein-flightparticlescouldbedecreasedandthewearresistanceofcoatingwassignificantlyenhanced.Thepresentstudydemonstratedthatthedevelopedtechniquesfortheultrafinepowderanditsthermal-sprayedcoatingshadverypromisingapplicationsinscalinguptoproduceultrafine-structuredcermetcoatingswithexcellentperformance.

简介：Mg–9Li–3Al–1.6Yalloyswerepreparedthroughmixturemethod.Themicrostructure,mechanicalproperties,andcorrosionresistanceoftheas-castandasextrudedalloyswerestudiedbyopticalmicroscopy（OM）,scanningelectronicmicroscopy（SEM）,X-raydiffraction（XRD）,mechanicalpropertiestesting,andelectrochemicalmeasurement.Theas-castMg–9Li–3Al–1.6Yalloywiththeaveragegrainsizeof325lmiscomposedofb-Limatrix,blocka-Mg,andgranuleAl2Yphases.Afterextrusion,thegrainsizeoftheas-castalloyisobviouslyrefinedandreachesto75lm;thestrengthandelongationoftheextrudedalloyareenhancedby17.20%and49.45%,respectively,owingtotheirfinemicrostructureandreductionofcastingdefects.Theas-extrudedalloyshowsbettercorrosionresistancecomparedtotheas-castone,whichmayberelatedtothelowstoredenergyanddislocationdensityintheextrudedalloy,alsothehomogenizationtreatmentbeforeextrusion.

简介：Inordertoanalyzetheice-goingship’sperformanceunderthepackiceconditions,syntheticicewasintroducedintoatowingtank.Abarrierusingfloatingcylinderinthetowingtankwasdesignedtocarryouttheresistanceexperiment.Thetestresultsindicatedthattheencounteringfrequencybetweentheshipmodelandthepackiceshiftstowardsahigh-velocitypointastheconcentrationofthepackiceincreases,andthisencounteringfrequencycreatesanunstableregionoftheresistance,andtheunstableregionshiftstothehigherspeedwiththeincreasingconcentration.Theresultsalsoshowedthatforthesamespeedpoints,theratioofthepackiceresistancetotheopenwaterresistanceincreaseswiththeincreasingconcentration,andforthesameconcentrations,thisratiodecreasesasthespeedincreases.Motioncharacteristicsshowedthatthemeanvalueoftheheavemotionincreasesasthespeedincreases,andthepitchmotiontendstoincreasewiththeincreasingspeed.Inaddition,thetotalresistanceofthefullscalewaspredicted.

简介：CuNi10Fe1Mnalloybilletunderrotatingelectromagneticfield(REF)wascharacterizedinthiswork.ThechangeofthecrystalorientationwasfirstexploredbyX-raydiffraction(XRD)andscanningelectionmicroscope(SEM);thecorrosionresistancewasdonebythreeelectrodessystem,andthenaturalseawaterwasusedascorrosionmedium.Theresultsdemonstratethatthestrongestcrystalorientationistransformedfromcrystalplane(200)to(111);moreover,thecrystalplane(111)whoseintensityisthe...

简介：ObjectiveToprovethehypothesisthatthereareassociationsbetweenbodyweightandinsulinresistanceinessentialhypertension,X-syndromesandtype-2diabetes.MethodsWeexaminedthebodymassindex(BMI)andinsulinsensitveindex(ISI)among70hypertensives,39X-syndromes,33type-2diabetesand46controls.ToobservetherelationsbetweenthedegreesofobesityandLSIinallstudygroups.Seventypatientswithhypertension[70hypertensives,48menand22women,meanage(69.3+6.7)years],39X-syndromes[27menand12women,meanage(66.4+6.2)years],33type-2diabetes[21menand12women,meanage(68.7±7.3)years],and46healthycontrols[36menand10women,meanage(66.1+6.6)years].Duringstudyperiod,nopatientsdied.ResultsAllpatientsofhypertensives,X-syndromesandtype-2diabeteshaveinsulinresistance,BMIinallpatientswassingnificantlyhigherthanincontrols.Thelevelsofbloodglucoseandinsulinweresignificantlyhigherinobesehypertensive

简介：Normally,itisdifficulttodirectlymeasurethebandgapsofperovskitebasedonmethylammonium（MA）orformamidinium（FA）athightemperaturesduetomaterialdecomposition.Wepreventthedecompositionbykeepingthesynthesizedperovskitefilms（MAPbI3andMAPbI3）inorganiciodidevapors,thenmeasurethein-situresistanceofthefilmsatvariedtemperatures,andfurtherevaluatethebandgapsofthesetwomaterials.Theevaluatedbandgapsareconsistentwiththeresultsfromultraviolet-visible（UV-vis）absorptionspectrum.ThebandgapofMAPbI3decreaseswithtemperatureabove95℃,whereasthatofFAPbI3firstincreaseswithtemperaturefrom95℃to107℃andthendecreaseswithtemperatureabove107℃.

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简介：Thispaperdealswiththedesignofanoutputfeedbackpredictivecontrollerforinductionmotors.Thefundamentalinterestoftheproposedcontrolleristhecapabilityofdecouplingthemechanicalspeedandtherotorfluxes,withoutdegradationagainstthevariationofrotorresistanceandloadtorque.Hence,thecontributionistoapplytwoestimationproceduresinordertoachievethisgoal.Namely,anunknowninputobserver（UIO）isusedfortheconstanttimeestimationwhereasaheuristicsolutionisexploitedfortheloadtorqueupdate.Moreover,rotorfluxcomponentsarerecoveredasanunavailablestateofthesystem.Effectivenessoftheproposedobserversandtheperformanceofthecontrollerareconfirmedbysimulationresults.

简介：Race-specificresistanceandfieldresistanceof30riceblastresistancemonogeniclinesderivedfromdifferentresourceswereevaluated.Thespectraofresistanceto163MagnaporthegriseaisolatescollectedfromindicariceinGuangdongProvince,Chinarangedfrom0.6%to89.6%.Mostofthemonogeniclinesshowedanarrowresistancespectrumandhighsusceptibilityinriceblastarea,whereasthelineswithPikhandPi1(t)hadthebroadresistancespectraof89.6%and82.2%respectively,showingahighandstableblastresistanceinfields.Accordingtotheclusteranalysisofspecificresistanceto163blastisolatestested,the30monogeniclinesweredividedinto15groups,andbasedontheprincipalfactoranalysis,ninekindsofrace-specificresistancewereidentified.Pik,Piz5,Pi9andPishcanbeusedascandidateresistancegenesforricebreedingsincetheirspecificresistancedifferedfromthoseofthebackboneparentsinGuangdong,China.GenepyramidingofPikh[orPi1(t)],Pi9(orPiz5)andPish(orPita2)willbeeffectivetoobtainbroad-spectrumblastresistanceinricebreedingprograminGuangdong,China.Thestrategiesforstudyingandapplicationofriceblastresistancegeneswerediscussed.