简介:摘要新型冠状病毒(2019-nCoV)引发的COVID-19已蔓延至全世界,升级为国际突发公共卫生事件。COVID-19患者主要表现为呼吸系统症状,重症患者还可合并肺外多器官功能损伤。人体免疫系统可有效抵御病毒入侵,然而多项临床现象和病理解剖提示COVID-19患者病程中存在免疫应答失衡。免疫失衡和过度的炎症激活与COVID-19患者的疾病进展、不良预后密切相关。本文从机体固有免疫、适应性免疫、细胞因子风暴等角度综述了COVID-19患者发病过程中的免疫特征,以期阐述COVID-19免疫相关的发病机制,为临床预防及治疗COVID-19提供理论依据。
简介:摘要The present global pandemic of COVID-19 has brought the whole world to a standstill, causing morbidity, death, and changes in personal roles. The more common causes of morbidity and death in these patients include pneumonia and respiratory failure, which cause the patients to require artificial ventilation and other techniques that can improve respiratory function. One of these techniques is chest physiotherapy, and this has been shown to improve gas exchange, reverse pathological progression, and reduce or avoid the need for artificial ventilation when it is provided very early in other respiratory conditions. For patients with COVID-19, there is limited evidence on its effect, especially in the acute stage and in patients on ventilators. In contrast, in patients after discharge, chest physiotherapy in the form of respiratory muscle training, cough exercise, diaphragmatic training, stretching exercise, and home exercise have resulted in improved FEV1 (L), FVC (L), FEV1/FVC%, diffusing lung capacity for carbon monoxide (DLCO%), endurance, and quality of life, and a reduction in anxiety and depression symptoms. However, there are still controversies on whether chest physiotherapy can disperse aerosols and accelerate the rate of spread of the infection, especially since COVID-19 is highly contagious. While some authors believe it is possible, others believe the aerosol generated by chest physiotherapy is not within respirable range. Therefore, measures such as the use of surgical masks, tele-rehabilitation, and self-management tools can be used to limit cross-infection.
简介:目的探讨浮肩损伤的临床特征及治疗方法。方法回顾分析2000年4月至2006年7月收治的,经手术治疗的19例浮肩损伤患者的临床资料。患者均有不同程度的合并损伤,其中肋骨骨折、血气胸和(或)肺挫伤占89.5%。受伤至手术时间3~42d,平均10.2d。术后3个月对患者肩关节功能根据Herseovici标准进行评定,并对浮肩损伤的临床特征和治疗进行总结。结果术后随访3~50个月,平均16.2个月。肩胛颈骨折在目标区上均获解剖复位,锁骨和肩胛骨均愈合。根据Herscovici标准进行评定,优15例(78.9%),良3例(15.8%),可1例(5.3%)。结论浮肩损伤多南高能量直接暴力所致,常伴有合并损伤。切开复位内固定能恢复肩关节的动力平衡及稳定性,可早期进行功能锻炼,是一种较好的治疗方法。
简介:Aseriesof96-htyphoontrackpredictionexperimentswerecarriedoutusingmediumrangeforecastingsystemofNMCbyaddingBOGUStyphoon(simplifiedasB-TC)intothefirstguessfieldortheanalysisfieldinordertoprovidelongertimetyphoontrackforecast.TheresultsshowthatT106L19couldprovideabetterforecasttotyphoontrackswhentheB-TCwasadded,especiallywhenthetyphoonvortexisevenweaker.ThesensitiveexperimentsonwheretoaddtheB-TCshowthattheresultsfromaddingtheB-TCintothefirstguessfieldarebetter.TheresultsalsoshowthattheinitializationsmoothestheB-TCalotandthiswillaffectthetyphoontrackprediction.
简介:摘要目的总结手足口病并发脑干脑炎患儿的临床特征,为手足口病并发脑干脑炎的诊断和治疗提供依据。方法收集我院2016年6月-2017年10月诊断为手足口病并发脑干脑炎患儿的临床资料,分析临床表现、实验室检查、神经电生理检查、影像学检查、治疗及转归等特征。选择同期诊断为手足口病并发病毒性脑炎的患儿作为对照组,进行脑干脑炎危险因素进行分析。结果19例手足口病并发脑干脑炎患儿进入分析。临床表现19例患儿均有发热和皮疹;15例神经系统症状多见于肢体震颤,12例眼球异常运动(游动或上翻),8例患儿烦躁和惊恐,14例脑神经损害多见于单侧脑神经损害,9例舌咽和迷走神经麻痹。15例出现呼吸衰竭,3例出现肺出血。结论手足口病患儿如出现肢体震颤、眼球异常运动(游动或上翻)等症状,应警惕脑干脑炎的发生。BAEP检查对脑干损伤有较好的诊断价值。及时和规范治疗后大多数患儿的预后良好。
简介:AbstractImportance:Within the coronavirus disease 2019 (COVID-19) global pandemic, more attention is warranted for whether this new infectious disease has unique manifestations in children.Objective:To retrospectively determine the epidemiological and clinical characteristics of 35 children with COVID-19 in Beijing, China.Methods:We collected data for 35 children diagnosed with COVID-19 who were admitted to Beijing Ditan Hospital from January 2020 to June 2020, and analyzed their epidemiological characteristics, clinical manifestations, laboratory examinations, chest imaging findings, treatments, and outcomes.Results:The children comprised 18 boys (51.4%) and 17 girls (48.6%) aged 6 months to 15 years. All patients had clear epidemiological history, with family clusters accounting for 28 cases (80.0%) and clear tracing of exposure to high epidemic areas in the remaining 7 cases (20.0%). Four (11.4%) patients were classified as asymptomatic, 17 (48.6%) as acute upper respiratory infection, and 14 (40.0%) as mild pneumonia, with no severe or critical cases. Clinical manifestations were mild, including fever in 18 (51.4%), cough in 14 (40.0%), and nausea and diarrhea in 7 (20.0%) patients. White blood cell count was mostly normal (26 cases, 74.3%) or decreased (7 cases, 20.0%); lymphocyte percentage was increased in 24 (68.7%); neutrophil percentage was decreased in 25 (71.4%); alanine aminotransferase was increased in 3 (8.6%); and serum potassium was decreased in 4 (11.4%). Time to negative viral nucleic acid testing was 2-42 days (mean: 14.0 ± 9.4 days). Chest imaging examination revealed that 20 patients (57.1%) had different forms of lung inflammation. Treatment was mainly isolation and nutritional support. Eleven patients were treated with interferon atomization inhalation. No patients required oxygen therapy. All 35 children were cured and discharged. Length of hospital stay was 9-54 days (mean: 25.4 ± 13.8 days). During regular follow-up after discharge, 5 children showed positivity again in the viral nucleic acid test and were re-hospitalized for observation and treatment. The mean length of re-hospitalization stay was 10.8 days.Interpretation:Children with COVID-19 mainly become infected within their family, and children of all ages are generally susceptible. The disease in children is mostly mild and the prognosis is good. Nucleic acid tests in some patients become positive again after discharge, suggesting that it is of great significance to carry out centralized isolation medical observations and active nucleic acid tests in close contacts for early detection of patients and routine epidemic prevention and control.
简介:摘要目的探讨分析十二指肠损伤的临床治疗方式及疗效。方法19例患者全部属于闭合性损伤,其中14例是车祸引发的损伤,2例由于上腹挤压造成损伤,其余3例被钝器所伤。19例患者十二指肠发生损伤的部位如下9例降部,2例球部,4例水平部,2例升部,2例多发性损伤。5例合并脾脏破裂,4例合并肝损伤,1例合并结肠损伤,1例合并胰腺损伤,3例合并空肠损伤,2例合并肾脏损伤。结果接受手术治疗之后,18例获得治愈,占总数的94.7%;1例死亡,占总数的5.3%。6例患者在术后引发不同的并发症,其中2例肠瘘,1例胰瘘,1例腹腔脓肿,2例多器官功能衰竭。导致1例死亡的原因是患者存在肠瘘,最终使多器官功能发生衰竭。讨论十二指肠的生理学特点、发生损伤的部位、解剖位置等都存在显著的特殊性。医护人员要时刻保持谨慎的态度,尽最大的努力降低漏诊的机率。十二指肠存在损伤将会对患者全身产生较大的影响,所以在接受手术治疗之后,必须要进行高效的综合治疗,避免出现术后感染并及时补充肠内营养,只有这样才能获得令人满意的临床疗效。