简介:Gingivaladenoidcysticcarcinoma(ACC)isararemalignancy.Wedescribethediagnosisandtreatmentofa43year-oldwomanwhopresentedwithapersistentoralulcerforapproximately1year,andsubsequentpainintheleftposteriormaxillaryregion.Clinicalexaminationrevealedanulcerintheleftuppermolargingiva,withswellingintheregionfromthesecondpremolartothethirdmolar.X-rayimagesdemonstratedtheinvolvementofthemaxillaryalveolarbone.ThehistopathologicalandimmunohistochemicalfeatureswerediagnosticofACC.ACCisoftenpresentedasagingivallesion;thus,itmayeasilybeneglectedbypatients.Theidentificationofthistumorusingspecificpathologicalanalysespreventsmisdiagnosisandenablesclinicianstodeterminetheappropriatetreatment.Inthiscase,norecurrenceordistantmetastasiswasobservedafter2yearsoffollow-up.
简介:Haemangiopericytoma(HPC)isararevasculartumorwithborderlinemalignancy,considerablehistologicalvariability,andunpredictableclinicalandbiologicalbehavior.HPCcanpresentadiagnosticchallengebecauseofitsindeterminateclinical,radiological,andpathologicalfeatures.HPCgenerallypresentsinadulthoodandisequallyfrequentinbothsexes.HPCcanariseinanysiteinthebodyasaslowlygrowingandpainlessmass.TheprecisecelltypeoriginofHPCisuncertain.OnethirdofHPCsoccurintheheadandneckareas.Exceptionalcasesofhemangioblastomaarisingoutsidetheheadandneckareashavebeenreported,butlittleisknownabouttheirclinicopathologicandimmunohistochemicalfeatures.Thisstudyreportsonacaseofalargesacro-anteriorHPCina65-year-oldmale.
简介:ADULTMESENCHYMALHAMARTOMAOFTHELIVER:ACASEREPORTWangXianghui王湘辉ChaiFulu柴福录DongLiang董亮LanzhouGeneralHospitalofPLA,Lanzhou730050...
简介:ADENOSQUAMOUSCARCINOMAOFTHENASOPHARYNXCONTAININGEBVIRUS,APROPOSOFACASEZhangFeng张锋;ZhangChangqing张昌卿;ZhangJinxia张锦霞;ZongYongsh...
简介:Littoral-cellangioma(LCA),aprimaryangiomawhichclinicallybelongstosplenichemangioma,canbemostlyfoundinnormalspleenredsinusshorecellsofreticuloendothelialcellsystem.ThecellsofLCAstronglyexpressendothelialandtissuecellassociatedantigensthatindicateadualdifferentiationcharacteristic;whereasonlyendothelialcellmarkersarepositiveinnormalspleenredsinusshorecells.DiagnosisofLCAreliesonhistopathology.Regularfollow-upisneededtomonitorrecurrenceandmetastasis.
简介:Hepaticinvolvementinaggressivesystemicmastocytosis(ASM)isrelativelycommon,andthemainclinicalfeaturesofthisdiseaseincludehepatomegaly,portalhypertension,ascites,andfibrosis.CirrhosisisarareASMsymptom.WereportanASMcasethatinitiallymimickedcirrhosisbasedonclinicalandradiographicanalyses.Theportaltractwasexpandedbymononuclearinflammatorycells,andanincreaseincollagenamountwasobservedinroutinehistologicalsectionsofthebiopsiedliver.Adiagnosisofsystemicmastocytosis(SM)wasmadeafterancillarytestsformastcellsusingbonemarrowaspirates.Extensiveinvolvementoftheliverandgastrointestinaltractwasobserved.CliniciansandpathologistsneedtoconsiderASMasadiagnosisordifferentialdiagnosisinaclinicalcaseofcirrhosiswithunknownetiology.Thediagnosiscanbeconfirmedordisregardedbyimmunohistochemicalstainingandmolecularanalysis.
简介:ELEMENTALSTUDYOFGENETHERAPYWITHTHROMBOPOIETINLuChengrong陆承荣ZhaoJianzeng赵建增WangXiaoping王小平Liuli刘丽ResearchCenterofMolecularBiol...
简介:Splenicmetastasisisgenerallynotacommonclinicalevent.However,metastasistothespleenfromadrenalpheochromocytomaisextremelyrareandhasnotbeenreportedinliterature.Thisreportpresentsacaseofa58year-oldmalepatientwhodevelopedspleen-onlymetastasesinJuly2007.ThepatienthadaprevioushistoryofleftepinephroectomyforadrenalpheochromocytomainJanuary2003.Abdominalcomputedtomographydemonstratedmultipleenhancinglesionssuggestiveofmetastases;thussplenectomywasperformed.Pathologicalexaminationsconfirmedthediagnosisofsplenicmetastasesfrompheochromocytoma.Thepatientwasalivewithoutrecurrence48monthsaftersplenectomy.Thisstudyisthefirstreportonsplenicmetastasisfrompreviousadrenalpheochromocytoma,andlong-termsurvivalwasachievedbysplenectomy.Ahistoryofmalignancyindicatesahighindexofsuspicionforsplenicmetastasis,andlong-termsurvivalcanbeachievedbysplenectomyforspleen-onlymetastasis.
简介:Anewcaseofepithelioidhemangioendotheliomaisreportedtohaveoccurredtoa67-year-oldpatientwhoconsultedforrightsidedchestpain.Thework-upshowedmultiplerightpulmonarylesionsassociatedwithbilateralmoderatepleuraleffusionandleft-sidedpleuralthickeningandthreehypodensenodulesintherightlobeoftheliver,peritonealthickening,ascites,andmultiplevertebrallyticlesions.Thediagnosisofanepithelioidhemangioendotheliomawasconcludedthroughahistologicalexaminationofacomputedtomographyscanguidedbiopsyoftheliver.Thepatientreceivedaprimarymono-chemotherapywithAdriamycin(75mg/m~2everythreeweeks)andintravenousbisphosphonateswithoutresponseandgeneralstatusimpairment.Thepatientdiedafter16monthsoffollow-up.
简介:Gastrointestinalmetastasisfromprimarylungcancerisrare.Inthepresentstudy,wereportthecaseofa78-year-oldmalewhowasadmittedtotheemergencydepartmentwithacutebleedingofthedigestivetract.Duringevaluation,hewasfoundtohavelungadenocarcinomametastasisinthesmallbowelleadingtohemorrhage.Ajejunumwedgeresectionwascarriedoutandbleedingwascontrolled.However,2monthsaftertheoperation,thepatientthedfromseverepulmonaryinfection.Wealsoreviewthepublishedliteratureofprimarylungcancerwithgastrointestinalmetastasis.
简介:Sarcoidosisisabenignsystematicgranulomatousdisorderofunknownetiologyandisassociatedwithvariousmalignancies.However,granulomatousandmetastaticlymphnodelesionsaredifficulttodistinguishevenwhenusingpreciseandmoderndiagnosticmethods,suchaspositronemissiontomography.Thus,histologicalverificationistheonlymethodthatcanbeusedtoaccuratelydescribethenatureofthisdisease.Inthisarticle,wereportacaseofnon-luminalHER-2/neu-positivebreastcancerinapatientwithouthistoryofsarcoidosisandsuspectedtohavemetastaticdisease.
简介:Autoimmunehepatitis(AIH)hasrarelybeendescribedasanautoimmuneparaneoplasticsyndromeofthymoma.ThiscaseistheseventhcaseofAIHrevealedbycholestasisfewyearsafterthediagnosisofthymomaandthefirstcasetreatedwithchemotherapyalone.Wereportinthispaperanewapproachtothisrareseverecondition.A29year-oldmanpresentedwithchestpainanddyspneawithahistoryofthymomasurgicallyremoved4yearsago.CTscanshowedtherecurrenceofananteriormediastinalmass.Biologyshowedelevatedliverenzymesandprofoundcholestasis.Nosignofviralortoxichepatitisorbileductabnormalitieswereobserved.Autoimmuneantibodies,exceptfortheanti-nuclearantibody,werenegative.LiverbiopsyshowedactivechronicAIH.ThepatientwasdiagnosedwithrecurrentthymomawithAIHandunderwent6cyclesofchemotherapy.Acompleteresponseonthymomaandcholestasiswasobtainedafter10monthsoffollow-up.SteroidsandimmunosuppressorsarethestandardtreatmentforAIH.Theeffectofchemotherapyasaspecifictreatmentofthisparaneoplasticsyndromeneedstobeconsidered.
简介:Spindlecellcarcinomaofthebreastisararetumor.Thistumorcanproliferaterapidlyandcausecysticchangesbecauseofinternaltissuenecrosis.Weevaluateda54-year-oldwomanwithrightbreastlump.Mammographyshowedacategoryfourmasswithadiameterof2.5cm.Ultrasonography(US)revealedacomplexcysticlesion,andfine-needleaspiration(FNA)cytologydemonstratedbloodyfluidandmalignantcells.Partialbreastresectionandsentinellymphnodebiopsywereperformed.Immunohistologyrevealedspindlecellswithpositiveresultsforcytokeratin(AE1/AE3)andvimentin,partiallypositiveresultsfors-100,andnegativeresultsfordesminandα-actin.ThepathologicalstagewasIIA,andbiochemicalcharacterizationshowedthatthetumorwastriplenegative.SixcoursesofFEC-100chemotherapy(5-fluorouracil500mg/m2,epirubicin100mg/m2,andcyclophosphamide500mg/m2)wereadministered.Radiotherapywasperformed.Thiscaseisdiscussedwithreferencetotheliterature.
简介:THESTUDYOFESTROGENANDPROGESTERONERECEPTORINNASOPHARYNGEALCARCINOMAZhengTianrong郑天荣;LiJiancheng李建成;LiuXiuying刘秀英;(Departmentof...
简介:Non-parasitichepaticcystswithbiliarycommunicationarerare.Theclinicalsymptomsinvolvedarenotspecifictothiscondition,therebymakingdiagnosisdifficultandtreatmentcontroversial.Here,wereportacaseof70-year-oldwomancomplainingofabdominalsatiety,combinedwithnon-specificpainintherightupperquadrant.Theabdominalcontrast-enhancedMRI-scanrevealedalargeandthick-walledseptuscysticlesionintheliver.Duringoperation,thebiliaryfistulawasconfirmedinthecystcavity.Asilicageltubewasinsertedviathecysticductforcholangiography,whichdemonstratedcommunicationbetweenthecystandbiliarytract.Weperformedwide-scalecystwallresection;thebiliaryfistulawascompletelyrepairedbytheclosureofcommunicatedbileducts.Thepostoperativecoursewasuneventful,andthepatientwasdischargedwithnosignofcholangitisoranyothersymptoms.Thenovelsurgicalmanagementviawideresectionofthecystwallandclosureofbiliarycommunicationprovedtobeanadequateandeffectiveprocedurefortreatingnonparasitichepaticcystswithbiliarycommunication.