简介：ObjectiveTostudytheeffectofsalicylateontheexpressionandfunctionofNMDAreceptorsinspiralganglionneurons(SGNs).MethodsThemRNAofNR1subunitofNMDAreceptorinmodiolustissuesweredetectedbyRealtimefluorescencequantitativePCR(FQ-PCR).NMDAreceptorwhole-cellcurrentswererecordedusingpatchclampinacuteisolatedSGNs.ResultsComparedwiththecontrolgroup,salicylatesignificantlyincreasedthemRNAlevelofNR1subunitinSGNs.NMDAofconcentrationsrangingfrom0.1mMto10mMevokednocurrentinSGNs.NMDA(0.1mMand0.5mM)appliedwithsalicylate(5mM),however,inducedinwardcurrents(212.6±15.2pA,n=5;607.9±44.3pA,n=5)inadose-dependentmanner,whichcouldbeinhibitedbyAPV.SalicylatealonedidnotproduceanycurrentinSGNs.ConclusionSalicylateincreasestheexpressionofNMDAreceptorsandfacilitatesthecurrentsmediatedbyNMDAreceptorsinSGNs.

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简介：Compactlysupportedradialbasisfunctioncanenablethecoefficientmatrixofsolvingweighlinearsystemtohaveasparsebandedstructure,therebyreducingthecomplexityofthealgorithm.Firstly,basedonthecompactlysupportedradialbasisfunction,thepapermakesthecomplexquadraticfunction(Multiquadric,MQforshort)tobetransformedandproposesaclassofcompactlysupportedMQfunction.Secondly,thepaperdescribesamethodthatinterpolatesdiscretemotioncapturedatatosolvethemotionvectorsoftheinterpolationpointsandtheyareusedinfacialexpressionreconstruction.Finally,accordingtothischaracteristicoftheunevendistributionofthefacemarkers,themarkersarenumberedandgroupedinaccordancewiththedensitylevel,andthenbeinterpolatedinlinewitheachgroup.Theapproachnotonlyensurestheaccuracyofthedeformationoffacelocalareaandsmoothness,butalsoreducesthetimecomplexityofcomputing.

简介：InthisarticleweintroducethedifferencesequencespacesW0[f,Δm],W1[f,Δm],W∞[f,Δm]andS[f,Δm],definedbyamodulusfunctionf.WeobtainarelationbetweenW1[f,Δm]∩l∞[f,Δm]andS[f,Δm]∩l∞[f,Δm]andprovesomeinclusionresults.

简介：MakinguseofWrightoperatorweintroduceanewclassofcomplex-valuedharmonicfunctionswithrespecttosymmetricpointswhichareorientationpreserving,univalentandstarlike.Weobtaincoefficientconditions,extremepoints,distortionbounds,andconvexcombination.

简介：Thisstudyinvestigatedtheeffectofcatheter-basedrenalsympatheticdenervation(RD)onleftventricularhypertrophy(LVH)andsystolicanddiastolicfunctioninpatientswithresistanthypertension.LVHanddiastolicdysfunctionareassociatedwithelevatedsympatheticactivityandincreasedmorbidityandmortality.TheeffectofRDonLVHandLVfunctionisunclear.MethodsandResultsForty-sixpatientsunderwentbilateralRD,and18patientsservedascontrols.Transthoracicechocardiographywasperformedatbaseline,andafter1monthand6months.Besidesreductionofsystolicanddiastolicbloodpressure(-22.5/-7.2mmHgat1monthand-27.8/-8.8mmHgat6months,P<0.001ateachtimepoint),RDsignificantlyreducedmeaninterventricularseptumthicknessfrom14.1±1.9mmto13.4±2.1mmand12.5±1.4mm(P=0.007),andLVmassindexfrom53.9±15.6g/m(2.7)(112.4±33.9g/m(2))to47.0±14.2g/m(2.7)(103.6±30.5g/m(2))and44.7±14.9g/m(2.7)(94.9±29.8g/m(2))(P<0.001)at1monthand6months,respectively.ThemitralvalvelateralE/E'decreasedafterRDfrom9.9±4.0to7.9±2.2at1monthand7.4±2.7at6months(P<0.001),indicatingreductionofLVfillingpressures.Isovolumicrelaxationtimeshortened(baseline109.1±21.7msvs.85.6±24.4msat6months,P=0.006),whereasejectionfractionsignificantlyincreasedafterRD(baseline:63.1±8.1%vs.70.1±11.5%at6months,P<0.001).Nosignificantchangeswereobtainedincontrolpatients.ConslusionsBesidestheknowneffectonbloodpressure,ourstudyshowedforthefirsttimethatRDsignificantlyreducesLVmassandimprovesdiastolicfunction,whichmighthaveimportantprognosticimplicationsinpatientswithresistanthypertensionathighcardiovascularrisk.

简介：Inthispaper,theenergy,equilibriumgeometry,andharmonicfrequencyofthegroundelectronicstateofPO2arecomputedusingtheB3LYP,B3P86,CCSD(T),andQCISD(T)methodsinconjunctionwiththe6-311++G(3df,3pd)andcc-pVTZbasissets.AcomparisonbetweenthecomputationalresultsandtheexperimentalvaluesindicatesthattheB3P86/6-311++G(3df,3pd)methodcangivebetterenergycalculationresultsforthePO2molecule.ItisshownthatthegroundstateofthePO2moleculehasC2vsymmetryanditsgroundelectronicstateisX2A1.TheequilibriumparametersofthestructureareRPO=0.1465nm,∠OPO=134.96°,andthedissociationenergyisEd=19.218eV.Thebentvibrationalfrequencyν1=386cm-1,symmetricstretchingfrequencyν2=1095cm-1,andasymmetricstretchingfrequencyν3=1333cm-1areobtained.Onthebasisofatomicandmolecularreactionstatics,areasonabledissociationlimitforthegroundstateofthePO2moleculeisdetermined.ThentheanalyticpotentialenergyfunctionofthePO2moleculeisderivedusingmany-bodyexpansiontheory.ThepotentialcurvescorrectlyreproducetheconfigurationsandthedissociationenergyforthePO2molecule.

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简介：BasedonthesolutionsoftheGreen'sfunctionforasaturatedporousmediumobtainedbytheauthors,andusingtransformationofaxisymmetriccoordinates,Sommerfeldintegralsandsuperpositionoftheinfluencefieldonafreesurface,theauthorshaveobtaineddisplacementsolutionsofasaturatedporousmediumsubjectedtoatorsionalforceinahalf-space.Therelationshipcurvesofthedisplacementsolutionsandvariousparameters(permeability,frequency,etc.)underactionofaunitoftorquearealsogiveninthispaper.TheresultsareconsistentwithpreviousReissner'ssolutions,whereatwo-phasemediumdecaystoasingle-phasemedium.Thesolutionisusefulinsolvingrelevantdynamicproblemsofatwophasesaturatedmediuminengineering.

简介：Thepurposeofthestudyistomeasurethe"growthdrag"accordingtothecharacteristicofChineselandresource.Romermodel(2001)holdsthateverycountryisinevitablyaffectedbythe"growthdrag"duetothelimitationoflandresource.Soit’sofprofoundstrategicsignificancetomeasurethe"growthdrag"accordingtothecharacterofChineselandresource.Modifiedtwo-levelCESproductionfunctionwasemployed,andthispapermodifiedthehypothesisofthemodel.TheresultindicatesthatthelimitationofChineselandresourcecastsshadowovertheeconomicdevelopmentofChina,andthegrowthrateis0.4618%lowerthanthatwithoutthelimitationoflandresource.Throughimplementingthelandresourceprotectionpolicyalongwiththetechnologyimprovementandthesubstituteeffectofotherfactorstothelandresource,Chinawillkeepasteadyandbalancedeconomicgrowth.

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简介：BackgroundTotheeffectofpercutaneouscoronaryintervention(PCI)onplasmalevelofN-terminalpro-Btypenatriureticpeptide(NT-proBNP)inpatientswithcoronaryheartdisease(CHD)andnormalleftventricularfunction.MethodsOnehundredandfivepatientswithCHDandnormalventricularfunctionwereenrolled.BloodsamplesforassessmentofNT-proBNPandcTn-TwerecollectedbeforeandafterPCI.ResultsThemeanleftventricularejectionfractionwas60.3±5.3%.Afterrevascularization,theleveloflgNT-proBNPwassignificantlyreduced(2.40±0.44vs2.23±0.43,P<0.001).SubgroupanalysisshowedthattheleveloflgNT-proBNPwasconsistentlydecreasedindifferentclinicalclassifications(stableangina45,unstableangina31andacutemyocardialinfarction29)andtarget-vesselrevascularization(leftanteriordescendingartery30,leftcircumflexartery26andrightcoronaryartery49),andin99patientswithoutelevationofpost-proceduralcTnT,butitshowedatrendofnon-significantincreasein6patientswithelevatedcTn-T.ConclusionsOurstudydemonstratesthatsuccessfulPCIreducesplasmaNT-proBNPconcentrationinpatientswithCHDandnormalventricularfunction.ThisimplicatesthattheimpactofPCIshouldbeconsideredintheinterpretationofNT-proBNPchangeinclinicalpractice,andfurtherstudiesarenecessarytoinvestigatethedirectand/orindirecteffectofmyocardialischemiaonBNP/NT-proBNP.