简介：AbstractThroughout the past 2020, the pandemic COVID-19 has caused a big global shock, meanwhile it brought a great impact on the public health network. Trauma emergency system faced a giant challenge and how to manage trauma under the pandemic of COVID-19 was widely discussed. However, the trauma treatment of special population (geriatric patients and patients taking anticoagulant drugs) has received inadequate attention. Due to the high mortality following severe traumatic hemorrhage, hemostasis and trauma-induced coagulopathy are the important concerns in trauma treatment. Sepsis is another topic should not be ignored when we talking about trauma. COVID-19 itself is a special kind of sepsis, and it may even be called as serious systemic infection syndrome. Sepsis has been become a serious problem waiting to be solved urgently no matter in the fields of trauma, or in intensive care and infection, etc. This article reviewed the research progress in areas including trauma emergency care, trauma bleeding and coagulation, geriatric trauma and basic research of trauma within 2020.

简介：AbstractStroke is a devastating disease that occurs when a blood vessel in the brain is either blocked or ruptured, consequently leading to deficits in neurological function. Stroke consistently ranked as one of the top causes of mortality, and with the mean age of incidence decreasing, there is renewed interest to seek novel therapeutic treatments. The Scavenger Receptor Class B type 1 (SR-B1) is a multifunctional protein found on the surface of a variety of cells. Research has found that that SR-B1 primarily functions in an anti-inflammatory and antiatherosclerotic capacity. In this review, we discuss the characteristics of SR-B1 and focus on its potential correlation with the modifiable risk factors of stroke. SR-B1 likely has an impact on stroke through its interaction with smoking, diabetes mellitus, diet, physical inactivity, obesity, hypercholesterolemia, atherosclerosis, coronary heart disease, hypertension, and sickle cell disease, all of which are critical risk factors in the pathogenesis of stroke.

简介：摘要目的分析龈沟液中白细胞介素-8(IL-8)、钙结合蛋白S100A12型(以下简称S100A12)水平与年轻恒牙根尖周病变(IPL)患者牙髓血运重建术(PR)治疗效果的关系。方法前瞻性选择2018年9月至2020年9月河南神火集团职工总医院拟行牙髓PR治疗的128例年轻恒牙IPL患者作为研究对象，入院时测定龈沟液中IL-8、S100A12水平，完成牙髓PR后随访6个月评估治疗效果，比较不同治疗效果患者的基线资料和入院时龈沟液中IL-8、S100A12水平，分析入院时龈沟液中IL-8、S100A12水平与年轻恒牙IPL患者牙髓PR治疗效果的关系。结果经6个月随访发现，治愈74例，好转33例，共107例纳入有效组；无效21例，纳入无效组。无效组龈沟液中IL-8、S100A12水平高于有效组，差异有统计学意义(P<0.05)。经Logistic回归分析检验结果显示，龈沟液中IL-8、S100A12水平与年轻恒牙IPL患者牙髓PR治疗效果有关，龈沟液中IL-8、S100A12高表达可能是年轻恒牙IPL患者牙髓PR治疗无效的风险因子(OR>1，P<0.05)。结论龈沟液中IL-8、S100A12水平与年轻恒牙IPL患者牙髓PR治疗效果有关。龈沟液中IL-8、S100A12水平可用于预测年轻恒牙IPL患者牙髓PR治疗效果。

简介：AbstractBackground:Hepatitis B core-related antigen (HBcrAg) is a promising disease-monitoring marker for chronic hepatitis B (CHB). We investigated correlations between HBcrAg with antiviral efficacy and virological and histological variables.Methods:One hundred and forty-five CHB patients from the mainland of China between August 2013 and September 2016 who underwent liver biopsy received entecavir therapy and had paired liver biopsy at 78 weeks. We analyzed correlations between HBcrAg and virological and histological variables in hepatitis B e antigen (HBeAg)-positive and HBeAg-negative patients. We also explored the predictors of HBeAg loss after 78 weeks of antiviral therapy. Pearson correlation analysis and logistic forward stepwise regression were the main statistic methods.Results:HBeAg-positive patients (n = 93) had higher baseline HBcrAg (median 7.4 vs. 5.3 log10 U/mL P < 0.001) and greater HBcrAg declines (median 1.6 vs. 0.9 log10 U/mL P= 0.007) than HBeAg-negative patients after 78 weeks of therapy. At baseline, HBcrAg correlated with hepatitis B virus (HBV) DNA in both HBeAg-positive (r = 0.641, P < 0.001) and -negative patients (r = 0.616, P < 0.001), with hepatitis B surface antigen (HBsAg) in HBeAg-positive patients (r = 0.495, P < 0.001), but not with anti-hepatitis B virus core antibody (anti-HBc). Weak correlations existed between HBcrAg, histology activity index (HAI; r = 0.232, P= 0.025), and Ishak fibrosis score (r= -0.292, P= 0.005) in HBeAg-positive patients. At 78 weeks, significant correlations existed only between HBcrAg and anti-HBc in HBeAg-positive (r = -0.263, P = 0.014) and HBeAg-negative patients (r= -0.291, P= 0.045). Decreased HBcrAg significantly correlated with reduced HBV DNA (r= 0.366, P= 0.001; r= 0.626, P < 0.001) and HBsAg (r = 0.526, P = 0.001; r = 0.289, P = 0.044) in HBeAg-positive and -negative patients, respectively, and with reduced HAI in HBeAg-positive patients (r = 0.329, P = 0.001). Patients with HBeAg loss (n = 29) showed a larger reduction in HBcrAg than those without (median 2.3 vs. 1.3 log10 U/mL, P = 0.001). In multivariate analysis, decreased HBcrAg was an independent predictor of HBeAg loss (P = 0.005).Conclusions:HBcrAg reflects viral replication and protein production. Decreased HBcrAg could predict HBeAg loss after antiviral therapy.Trial registration:Clinical Trials.gov: NCT01962155; https://www.clinicaltrials.gov/ct2/show/NCT01962155?term=NCT01962155&draw=2&rank=1

简介：摘要探讨结直肠癌中S100P、环氧合酶-2（COX-2）、高尔基体磷蛋白3（GOLPH3）的表达情况及与肿瘤分期、侵袭深度的关系。研究发现直肠癌患者的S100P阳性表达量、COX-2、GOLPH3表达水平显著高于对照组；不同侵袭深度、临床分型、DUKE分期患者的S100P、COX-2、GOLPH3表达水平存在统计学意义。结直肠癌中S100P、COX-2、GOLPH3的表达情况及与肿瘤分期、侵袭深度的呈现正相关关系，可以作为临床效果评估依据之一。

简介：AbstractChronic hepatitis B virus (HBV) infection remains a global health burden. Timely and effective antiviral therapy is beneficial for patients with HBV infection. With existing antiviral drugs, including nucleos(t)ide analogs and interferon-alfa, patients can achieve viral suppression with improved prognosis. However, the rate of hepatitis B surface antigen loss is low. To achieve a functional cure and even complete cure in chronic hepatitis B patients, new antivirals need to be developed. In this review, we summarized the advantages and disadvantages of existing antiviral drugs and focused on new antivirals including direct-acting antiviral drugs and immunotherapeutic approaches.

简介：AbstractGroup B streptococcus (GBS) is a leading cause of neonatal infection. Maternal vaginal-rectal colonization with GBS during the intrapartum period is a prerequisite for GBS early-onset disease (EOD). The obstetric measures for effective prevention of GBS EOD include universal prenatal screening by vaginal-rectal culture, correct specimen collection and processing, appropriate implementation of intrapartum antibiotic prophylaxis, and coordination with pediatric care providers. It is now recommended to universal screen GBS between 360/7 and 376/7 weeks of gestation and to identify groups of women who are eligible for intravenous intrapartum antibiotic prophylaxis as a means of preventing GBS EOD.

简介：目的：探究妇产科急腹症联合应用腹部B超和阴道B超的诊断效果。方法：研究时限2021年6月到2022年7月，研究患者共160例，从我院妇产科随机抽选，组别划分如下：对照组（女性患者80例，行腹部超声检查）；联合组（患者80，行腹部B超、阴道B超联合检查），比对检出率和准确率。结果：联合检验组检出率与病理检查结果相比较仅有3例误诊，确诊（87.50%）和延诊（8.75%）率更，诊断准确率也优于对照组，P＜0.05；对照组各项妇产科急腹症检出率均低于联合组，除宫颈粘连1项其余检出率对比P＜0.05（有统计学意义）。结论：腹部和阴道超声联合检查诊断准确率更高，可以有效避免延诊和漏诊，给妇产科疾病治疗提供科学依据。

简介：AbstractObjectives:Describe the h index as a bibliometric that can be utilized to objectively evaluate scholarly impact. Identify which otolaryngology subspecialties are the most scholarly. Describe if NIH funding to one’s choice of medical school, residency, or fellowship has any impact on one’s scholarly output. Determine other factors predictive of an academic otolaryngologist’s productivity.Study design:Analysis of bibliometric data of academic otolaryngologists.Methods:Active grants from the National Institutes of Health (NIH) to otolaryngology departments were ascertained via the NIH Research Portfolio Online Reporting Tools Expenditures and Reports database. Faculty listings from these departments were gleaned from departmental websites. H index was calculated using the Scopus database.Results:Forty-seven otolaryngology programs were actively receiving NIH funding. There were 838 faculty members from those departments who had a mean h index of 9.61. Otology (h index 12.50) and head and neck (h index 11.96) were significantly (P < 0.0001) more scholarly than the rest of subspecialists. H index was significantly correlative (P < 0.0001) with degree of NIH funding at a given institution. H index was not significantly higher for those that attended medical school (P < 0.18), residency (P < 0.16), and fellowship (P < 0.16) at institutions with NIH funding to otolaryngology departments.Conclusions:H index is a bibliometric that can be used to assess scholarly impact. Otology and head and neck are the most scholarly subspecialists within otolaryngology. NIH funding to an individual’s medical school, residency, or fellowship of origin is not correlative with one’s scholarly impact, but current institutional affiliation and choice of subspecialty are.

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简介：AbstractObjective:Scoping review of published literature to establish clinical characteristics and audiologic outcomes in patients diagnosed with Susac’s Syndrome(SS) who have undergone cochlear implantation (CI).Data sources:All published studies of CI in SS and contribution of two of our own patients who have not been reported previously.Methods:A comprehensive search of MEDLINE (via PubMed) was carried out in March 2020 using the following keywords and related entry terms: Susac’s Syndrome, Cochlear Implantation. Results: Our search identified a total of five case reports of CI in SS. With the addition of our two patients reported here, we analyzed characteristics and outcomes in seven patients. Mean age at implantation was 30 years old (range 19-46), with six women and one man implanted. Mean time from onset of hearing loss to implantation was 17 months (range three months to four years). Best reported postoperative speech understanding was reported via different metrics, with six of seven patients achieving open set speech scores of 90% or better, and one subject performing at 68%. Vestibular symptoms were present preoperatively in four of seven patients (57%), with vestibular testing reported in two patients, and showing vestibulopathy in one patient. No complications were reported following cochlear implantation.Conclusion:Cochlear implantation is a viable option for hearing rehabilitation in patients with SS, with levels of attainment of open set speech comparable to other populations of CI candidates.

简介：AbstractThe main treatments for Parkinson’s disease (PD) currently include surgery, rehabilitation, and most commonly, drug therapy. However, the drugs that are currently used to treat PD provide only symptomatic relief and delayed disease progression but have no curative effect and cause many adverse reactions. When considering pathogenic factors and metabolic regulation, PD and type 2 diabetes have a high rate of comorbidity; this provides a theoretical basis for the treatment of PD with first-line antidiabetic drugs. Among these agents, metformin reduces neuronal damage in the brains of PD patients via neuroprotection and the inhibition of oxidative stress and inflammatory responses, thus providing a novel strategy for the clinical treatment of PD. Here, we present the current state of knowledge about the use of metformin to treat PD and discuss its clinical prospects.

简介：摘要目的探讨完全后腹腔镜经膀胱外途径规范化直视下(P.R.E.S.S.)膀胱袖套状切除术的操作要点和疗效。方法回顾性分析2017年8月至2020年12月收治的95例上尿路尿路上皮癌(UTUC)患者的病例资料，分别为海军军医大学长征医院30例，北京大学第一医院21例，烟台毓璜顶医院20例，大连医科大学附属第二医院21例，东部战区总医院3例。男57例，女38例。平均年龄(67.7±10.0)岁。中位肿瘤最大径3.0 cm。95例均行单次体位全程后腹腔镜肾输尿管全长切除联合P.R.E.S.S.技术膀胱袖套状切除术，根据术者手术习惯和经验分别采用四孔法(36例)和五孔法(59例)套管布局完成手术。四孔法组和五孔法组的年龄[(66.3±11.2)岁与(68.6±9.1)岁]、性别(男/女：25/11例与32/27例)、体质指数[(25.0±3.0)kg/m2与(24.8±3.4)kg/m2]、肿瘤最大径[2.8(1.6，3.5)cm与3.0(2.0，4.0)cm]、肿瘤侧别(左/右：19/17例与34/25例)、临床分期(T1～2/T3～4/Tis期：25/10/4例与49/10/0例)、多灶性肿瘤(3例与2例)比较差异均无统计学意义(P>0.05)；术侧合并肾积水(13例与39例，P＝0.004)、肿瘤位置(肾盂肾盏及上段输尿管/中段输尿管/下段输尿管：23/9/4例与35/4/20例，P＝0.005)的差异均有统计学意义。术中行P.R.E.S.S.技术膀胱袖套状切除时，以脐动脉索为解剖标志，扩大输尿管周围的盆底侧方腹膜外间隙，切开膀胱壁后形成气膀胱效应，进行充分的膀胱袖套状切除和确切的膀胱袖口关闭。记录围手术期临床指标及随访结果。比较四孔法组和五孔法组的相关临床指标，分析套管布局方式对手术操作的影响。结果本研究95例中，91例(95.8%)采用P.R.E.S.S.技术完成膀胱袖套状切除；1例(1.1%)因出血中转开放手术；3例(3.1%)因局部空间显露困难，仅以Hem-o-lok夹闭输尿管远端完成手术。手术时间中位值180(125，230)min。术中估计出血量中位值100(50，100)ml。总体并发症发生率10.5%(10/95)，其中术中并发症2例(2.1%)均为出血，1例术中输血400 ml，1例中转开放手术，未输血；术后并发症8例(8.4%)，其中Clavien-DindoⅡ级7例[继发出血3例，药物过敏、急性肾功能减退(血肌酐490 μmol/L)、肺部感染及淋巴漏各1例]，Ⅲa级1例(肠梗阻，局麻下置入肠梗阻导管)，患者经对症治疗后均顺利出院。四孔法组和五孔法组在手术中转率[8.3%(3/36)与1.7%(1/59)]、术中估计出血量(100 ml与60 ml)、术中淋巴结清扫率[25.0%(9/36)与20.3%(12/59)]、P.R.E.S.S.技术膀胱袖套状切除成功率[91.7%(33/36)与98.3%(58/59)]、并发症发生率[13.8%(5/36)与8.5%(5/59)]、肿瘤病理分期(pT1～2/pT3～4/pTis期：22/11/3例与37/19/3例)以及复发转移比例[8.3%(3/36)与3.4%(2/59)]方面差异均无统计学意义(P>0.05)；在手术时间(190 min与170 min，P＝0.011)和术后住院时间(5 d与6 d，P＝0.005)方面差异均有统计学意义。结论P．R.E.S.S.技术通过建立扩大的盆底侧方腹膜外间隙和气膀胱效应，以脐动脉索为解剖标志，可直视下确切地行膀胱袖套状切除术，用于单次体位完全后腹腔镜肾输尿管全长切除术安全、可行。五孔法布局较四孔法布局更适用于下段输尿管肿瘤患者，但可能延长术后住院时间。

简介：摘要目的探讨长链非编码RNA HCG22(lncRNA HCG22)对胃癌细胞生物学行为的影响及其机制。方法实时定量聚合酶链反应(RT-qPCR)检测正常胃上皮细胞GES-1和胃癌MGC-803、SGC-7901细胞lncRNA HCG22的表达；采用慢病毒过表达和对照载体感染MGC-803细胞，分为过表达组(LV-HCG22-OE)、对照组(LV-NC)和空白组(Blank)；细胞计数试剂盒(CCK-8)法检测24、48、72 h的吸光度值，集落形成实验检测细胞集落形成率；划痕愈合实验检测迁移能力；流式细胞术分析周期和凋亡；免疫荧光观察半胱氨酰天冬氨酸特异性蛋白酶-3(Caspase-3)荧光；蛋白质印迹法(Western blot)检测凋亡蛋白、自噬标志物以及蛋白激酶B(Akt)/P70S6激酶(P70S6K)通路蛋白的变化。两组间比较采用t检验。结果lncRNA HCG22在MGC-803(0.026±0.011)和SGC-7901的表达(0.048±0.012)低于GES-1细胞(1.000±0.123，t＝7.871、7.694，P<0.01)。上调lncRNA HCG22后，抑制细胞的增殖能力，LV-HCG22-OE组的吸光度值低于LV-NC组(24 h为0.295±0.015比0.501±0.014，48 h为0.526±0.012比0.952±0.048，72 h为0.929±0.016比1.381±0.020，t＝10.170、8.614、17.800，P<0.01)；集落形成率[(36.250±2.000)%比(53.880±3.375)%，t＝4.493，P<0.05]和迁移能力均低于LV-NC组[24 h为(32.940±1.315)%比(50.220±1.120)%，36 h为(63.970±1.500)%比(79.650±1.000)%，t＝10.010、8.698，P<0.05]。LV-HCG22-OE组G2/M期细胞比例增加，G1期减少；细胞凋亡率增加(17.980±3.120比3.667±0.997，t＝4.372，P<0.05)。共聚焦显微镜观察到Caspase-3荧光信号增加，Western blot结果显示，LV-HCG22-OE组B细胞淋巴瘤因子-xL(bcl-xL)和p62蛋白水平低于LV-NC组(t＝7.686、5.376，P<0.05)，B细胞淋巴瘤因子-2相关X蛋白(bax)，微管相关蛋白1轻链3B(LC3-Ⅱ)蛋白水平高于LV-NC组(t＝9.311、4.768，P<0.05)；LV-HCG22-OE组磷酸化蛋白激酶B(p-Akt)、磷酸化P70S6激酶(p-P70S6K)蛋白水平低于LV-NC组(p-Akt/Akt为0.426±0.085比0.891±0.012，t＝5.395，P<0.05；p-P70S6K/P70S6K为0.605±0.019比1.027±0.072，t＝5.639，P<0.05)。结论lncRNA HCG22可能通过Akt/P70S6K信号通路抑制MGC-803细胞增殖、迁移，诱导周期阻滞，促进凋亡和自噬。

简介：摘要目的探讨B超客观评估瘢痕及动态监测瘢痕的应用价值。方法2018年3月至2020年6月，郑州大学第一附属医院整形外科瘢痕患者59例(男38例、女21例，年龄8~49岁，平均20岁)，分为普通瘢痕组21例、增生性瘢痕组23例、瘢痕疙瘩组15例。59例患者均定期采用B超扫描瘢痕图像，测量瘢痕厚度。结果3个组瘢痕B超图像表现：普通瘢痕组真皮层回声强度不均匀，增生性瘢痕组及瘢痕疙瘩组真皮层均表现为明显低回声，部分瘢痕疙瘩病例可见少量血流信号。3个组瘢痕超声图像表现在12个月内均无显著变化。3个组瘢痕的厚度变化：普通瘢痕组厚度在12个月内无明显变化；增生性瘢痕组厚度在12个月内呈现出先增加后稳定的趋势。结论B超能辅助鉴别不同类型的瘢痕，更加客观准确地测量瘢痕厚度，并监测瘢痕的动态变化。

简介：摘要补体B因子(complement factor B，CFB)是补体替代途径中的一个重要因子，主要由肝细胞和巨噬细胞合成，是参与补体活化的重要成分。CFB参与机体防御，在细胞损伤及炎症过程中均起重要作用。目前研究发现CFB与非典型溶血性尿毒症、年龄相关性黄斑变性、心血管疾病、肿瘤等疾病相关。文章对CFB与以上疾病的关系及CFB抑制剂的发展作一综述。

简介：摘要微小RNA-125b(miR-125b)近年来被证明与多种肿瘤疾病关系密切，如肺癌、消化系统肿瘤、血液系统肿瘤等。miR-125b在肿瘤疾病的发生发展中起关键性作用，检测miR-125b的表达量可以评估各种肿瘤疾病治疗方式的疗效，并能辅助诊断肿瘤。探索miR-125b在肿瘤疾病中的机制对肿瘤治疗具有重大意义。

简介：摘要胸腺瘤是起源于胸腺上皮细胞的肿瘤，是一种具有良性细胞学特征、恶性生物学行为的肿瘤，国内外文献有对胸腺瘤远处转移的报道，常见的转移部位有肺、肝、纵隔等，发生于腹壁的转移罕见报道，且没有有效的治疗方法。本文就1例B2/B3混合型胸腺瘤腹壁转移病例进行报告，并回顾国内外相关文献报道，总结晚期转移性胸腺瘤的治疗方法。通过对腹壁转移灶的放疗，联合GM-CSF的应用，患者腹壁病灶退缩明显且不良反应轻微。该病例为合并肌无力的晚期转移性胸腺瘤的患者提供了新的治疗手段。

简介：AbstractMother-to-child transmission (MTCT) of hepatitis B virus (HBV) is the main cause of chronic hepatitis B. The prevention of MTCT plays a critical role in control chronic hepatitis B. The main purpose of the present clinical guidelines is to aid healthcare providers in managing pregnant women with positive HBsAg and in preventing MTCT of HBV. We recommend: (1) all pregnant women require prenatal screen for hepatitis B serological markers; (2) newborn infants of mothers with negative hepatitis B surface (HBsAg) require administration of hepatitis B vaccine on a 0, 1, and 6 month-schedule; (3) newborn infants of mothers with positive HBsAg need hepatitis B immunoglobulin (HBIG) and birth dose vaccine within 12 hours (the sooner the better) after birth, followed by injection of the second and third dose of hepatitis B vaccine at the age of one and six months respectively; (4) in preterm neonates or neonates with poor health conditions born to HBsAg-positive mothers, the immunoprophylaxis measures should be appropriately taken; (5) to further reduce MTCT of HBV, pregnant women with HBV DNA levels >2×105 IU/mL or positive hepatitis B e antigen may receive oral antivirals, starting from 28 to 32 weeks of gestation and discontinuing the drug on the delivery day; (6) cesarean section is not recommended to reduce MTCT of HBV; (7) breastfeeding is recommended in infants of HBsAg-positive mothers, regardless of maternally positive hepatitis B e antigen, maternal nipple injury or bleeding, oral mucosal injury in neonates or infants; (8) breastfeeding is recommended in infants born to HBsAg-positive mothers who require continuation of antiviral therapy after delivery, and the infants should be followed up to observe whether adverse effects develop; and (9) the infants born to HBsAg-positive mothers should be tested for hepatitis B serological markers at the age of 7-12 months, and those who are negative for HBsAg and anti-HBs should receive three doses of hepatitis B vaccine on the 0, 1, and 6 month-schedule as soon as possible.

简介：摘要目的观察急性缺血性脑血管病（AICVD）患者血浆S100A1蛋白、核因子-kβ p65（NF-kβ p65）、白细胞介素6（IL-6）水平变化及意义。方法选取江苏省苏北人民医院2020年4-11月收治的急性缺血性脑梗死患者（AICI组）141例和短暂性脑缺血发作患者（TIA组）20例，AICI组根据梗死灶的体积分为小梗死灶组（SCI组）78例、中梗死灶组（MCI组）32例和大梗死灶组（LCI组）31例，选取同期在该院体检的健康人31例为对照组（HC组）。对比AICI组、TIA组与HC组S100A1、NF-kβ p65、IL-6水平及不同梗死体积亚组之间S100A1、NF-kβ p65、IL-6水平的差异，分析S100A1、NF-kβ p65、IL-6与入院美国国立卫生研究院卒中量表（NIHSS）评分及脑梗死体积的相关性，绘制受试者工作特征（ROC）曲线，分析S100A1、NF-kβ p65、IL-6对AICI患者的诊断价值。结果AICI组S100A1［（230.96±39.37）ng/L］、NF-kβ p65［（3.99±0.65）mg/L］、IL-6［（13.32±1.57）ng/L］均明显高于TIA组的（185.85±43.24）ng/L、（3.58±0.74）mg/L、（11.61±1.67）ng/L（t=4.95、2.39、4.14，均P < 0.05）及HC组的（181.47±27.39）ng/L、（3.51±0.99）mg/L、（11.42±2.34）ng/L（t=6.54、3.32、5.55，均P < 0.05）；TIA组与HC组间差异均无统计学意义（均P > 0.05）。LCI组S100A1［（254.25±37.07）ng/L］、NF-kβ p65［（4.41±0.45）mg/L］、IL-6［（14.00±1.40）ng/L］均明显高于MCI组的（225.42±30.92）ng/L、（3.85±0.64）mg/L、（12.77±1.31）ng/L（t=3.04、3.60、3.20，均P < 0.05）和SCI组的（223.98±40.21）ng/L、（3.88±0.66）mg/L、（13.27±1.65）ng/L（t=3.79、4.01、2.25，均P < 0.05），MCI组与SCI组间差异均无统计学意义（均P > 0.05）。AICI患者S100A1、NF-kβ p65与脑梗死体积均呈正相关（r=0.24、0.27，均P < 0.05），S100A1、IL-6与AICI患者入院后NIHSS评分均呈正相关（r=0.24、0.28，均P < 0.05）；S100A1、NF-kβ p65、IL-6对AICI诊断的曲线下面积（AUC）分别为0.818、0.667、0.754，最佳截断值分别为181.03、3.50、10.79，相应灵敏度分别为95.0%、76.6%、97.2%，特异度分别为37.3%、45.1%、49.0%。结论AICI患者血浆S100A1、NF-kβ p65、IL-6水平明显升高，且与AICI病情严重程度密切相关。