简介:III.RareEarthSupplyandDemandinthepost-WTOEra1.SupplyItisestimatedthatexportquotawillkeepstableat31,000tonsorsointhenexttwoyears,thoughmerely50-60%ofrareearthexportquotaswereusedin2011and2012.Productionquotasmightbeadjustedwiththerareearthproductioninoverseacountriesandchangesinrareearthmarket.Besides,consolidationofrareearthindustryand
简介:ThedramatictransitionfromColdWartoworldpeaceisnotsomethingaccidental,butaninevitableoutcomeoflong-termevolutionofworldpoliticsandeconomics.Asaresultofthetransition,allcountriesoftheworldhavebeguntopaygreaterattentionnotonlytotheireconomicdevelopmentassuch,butthe
简介:Cochlearimplantationisauniquemethodtore-constructauditionforpatientswithseveretoprofoundhearingloss.Withincreasingclinicalapplicationofthistechnique,itsrehabilitativeeffectsinpatientshasbecomeanimportanttopicofhearingandspeechrehabilitationresearch.Thisarticleisanoverviewofhearingandspeechrehabilitativetraining,rehabilitativeefficacyevaluationandfactorsaffectingrehabilitationefficacyfollowingcochlearimplantation.
简介:Atransientpostanaphaserepositioningofthecentrioleisfoundtocontrolthecompletionofcytokinesis.Usingagreenfluorescentprotein-calmodulinfusionproteinasalivingcellprobe,wehavepreviouslyfoundthatcalmodulinisassociatedwiththeinitiationandprogressionofcytokinesis.Inthisstudy,wefurtherstudiedtheeffectofcalmodulinontherepositioningofthecentrioleandsubsequentcellcycleprogression.Whenactivityofcalmodulinisinhibited,theregressionofthecentriolefromtheintercellularbridgetothecellcenterisblocked,andthusthecompletionofcelldivisionisrepressedandtwodaughtercellsarelinkedbylongercellbridgeinperturbedcells.W7treatmentduringcytokinesisalsoresultsinunfinishedcytokinesisandstoppedG1phase.Theseresultssuggestthatcalmodulinactivityisrequiredforcentriolerepositioningandcanaffectthecompletionofcytokinesisandcellcycleprogression.
简介:Likeabigrockthrownintothepondofcurrentinternationalpowerconfiguration,theeventofSeptember11revealedtheturbulentundercurrentsbeneathitsseeminglytranquilsurface.ThesplashdowneffecthasspreadbeyondtheUnitedStatestoreacheverycornerofourplanet.Ithastriggeredrealignmentinbigpowerrelationsandwillhaveitsfar-
简介:TheendoftheColdWarandthetransitionfromglobalbipolaritytomultipolari-tyhaveexertedanunprecedentedlyprofoundimpactonSoutheastAsiasincetheSecondWorldWar.Thesubregionisexperiencinganewtransformationwithintra-subregionalstaterelationsandtherelationshipbetweenindigenousnationsandthemajorpowersundergoinganewroundofreadjustmentandrealignment.
简介:ProteinkinaseRAFisstrategicallylocatedinthe'Ras-MAP-kinasesignaltransductionpathway',aprinciplesystemwhichtransmitssignalsfromgrowthfactorreceptorstothenucleus,resultingincellproliferation.GrowthfactorresponsesaremediatedinpartbyactivationofRas,whichinturnactivatesRAFtophosphorylateMEK,itsdownstreamsubstrate.MEKactivatesMAPkinasetoinfluencenuclearevents.itisclear.however,thatanetworkofsignalsotherthanthosecarredbyRasplaysaroleinRAFregulation.Theseorthogonalinfluencesaremediatedbu:serine/threoninekinases,tyrosinekinases,andprotein-proteininteractions.AsafurthercomplicationtotheRAFnetwork,threeisoformsofRAFhavebeenestablishedwhichhavedivergentN-terminalregulatorydomains,Whereasthesedivergentregulatorydomainsimplicateisoform-specificfunctions,noclearevidenceorhypothesisfordistinctfunctionsforindividualisoformshasbeenpresented.Recently,'isoform-specificproteininteractions'havebeenidentifiedamongnumerousproteinsinteractingwithRAF,ThesestudiesmayservetodelineateindependentfunctionsforRAFisoforms.
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简介:AbstractThrombotic microangiopathy (TMA) is characterized by systemic microvascular thrombosis, target organ injury, anemia and thrombocytopenia. Thrombotic thrombocytopenic purpura, atypical hemolytic uremic syndrome and Shiga toxin E-coli-related hemolytic uremic syndrome are the three common forms of TMAs. Traditionally, TMA is encountered during pregnancy/postpartum period, malignant hypertension, systemic infections, malignancies, autoimmune disorders, etc. Recently, the patients presenting with trauma have been reported to suffer from TMA. TMA carries a high morbidity and mortality, and demands a prompt recognition and early intervention to limit the target organ injury. Because trauma surgeons are the first line of defense for patients presenting with trauma, the prompt recognition of TMA for these experts is critically important. Early treatment of post-traumatic TMA can help improve the patient outcomes, if the diagnosis is made early. The treatment of TMA is also different from acute blood loss anemia namely in that plasmapheresis is recommended rather than platelet transfusion. This article familiarizes trauma surgeons with TMA encountered in the context of trauma. Besides, it provides a simplified approach to establishing the diagnosis of TMA. Because trauma patients can require multiple transfusions, the development of disseminated intravascular coagulation must be considered. Therefore, the article also provides different features of disseminated intravascular coagulation and TMA. Finally, the article suggests practical points that can be readily applied to the management of these patients.
简介:Concussion,ormildtraumaticbraininjury,incidencerateshavereachedepidemiclevelsandimpairedposturalcontrolisacardinalsymptom.Thepurposeofthisreviewistoprovideanoverviewofthelinearandnon-linearassessmentsofpost-concussionposturalcontrol.Thecurrentacuteevaluationforconcussionutilizesthesubjectivebalanceerrorscoringsystem(BESS)toassessposturalcontrol.Whilethesensitivityoftheoveralltestbatteryishigh,thesensitivityoftheBESSisunacceptablylowand,withrepeatadministration,isunabletoaccuratelyidentifyrecovery.Sophisticatedmeasuresofposturalcontrol,utilizingtraditionallinearassessments,haveidentifiedimpairmentsinposturalcontrolwellbeyondBESSrecovery.Bothassessmentsofquietstanceandgaithaveidentifiedlingeringimpairmentsforatleast1monthpost-concussion.Recently,theapplicationofnon-linearmetricstoconcussionrecoveryhavebeguntoreceivelimitedattentionwiththemostcommonlyutilizedmetricbeingapproximateentropy(ApEn).ApEn,mostcommonlyinthemedial-lateralplane,hassuccessfullyidentifiedimpairedposturalcontrolintheacutepost-concussiontimeframeevenwhenlinearassessmentsofinstrumentedmeasuresareequivalenttohealthypre-injuryvalues;unfortunatelythesestudieshavenotgonebeyondtheacutephaseofrecovery.Onestudyhasidentifiedlingeringdeficitsinposturalcontrol,utilizingShannonandRenyientropymetrics,whichpersistatleastthroughclinicalrecoveryandreturntoparticipation.Finally,limitedevidencefromtwostudiessuggestthatindividualswithaprevioushistoryofasingleconcussion,evenmonthsoryearsprior,maydisplayalteredApEnmetrics.Overall,non-linearmetricsprovideafertileareaforfuturestudytofurthertheunderstandingofposturalcontrolimpairmentsacutelypost-concussionandaddressthecurrentchallengeofsensitiveidentificationofrecovery.
简介:目的将与traumatic以后癫痫观察在病人的生活的质量并且讨论影响因素。我们用生活Scale-31(QOL-31)的质量作为控制与traumatic以后癫痫和100个健康的人估计了105个病人,并且在消沉上进行了回顾的分析的方法,自我等级压抑规模(SDS)和自我等级焦虑规模(SAS),焦虑,损伤的地点,抓住的控制,EEG和治疗学的依从。有癫痫获得了的traumatic以后的结果病人很在QOL-31上比控制组降低(P<0.01),但是比SDS和SAS上的控制组高(P<0.01)。多重回归分析显示生活的质量上的主要影响因素是焦虑,治疗学的依从,消沉,损伤的癫痫的抓住和地点的差的控制。在有posttraumatic癫痫的病人的生活的质量显著地衰退了的结论。医生们应该与癫痫注意病人的心理、心理的问题,例如消沉和焦虑,提高治疗学的依从并且控制癫痫的抓住,它是改进预后的关键。