简介：Inthepresentpaper,theauthorsreportafewoftypicalcasesofalergicdiseasesincludingpotlinosis,asthma,redeyesandswellingfaceanddermatitistreatedwithotopointsandsomebackshu-pointsaccordingtothesymptoms.Theresultshowedthatthecurativeeffectwassatisfactory.Itindicatesthatotopointshaveagoodantlanaphylacticeffect.

简介：AbstractCardiovascular disease (CVD) and environmental degradation are leading global health problems of our time. Recent studies have linked exposure to heavy metals to the risks of CVD and diabetes, particularly in populations from low- and middle-income countries, where concomitant rapid development occurs. In this review, we 1) assessed the totality, quantity, and consistency of the available epidemiological studies, linking heavy metal exposures to the risk of CVD (including stroke and coronary heart disease); 2) discussed the potential biological mechanisms underlying some tantalizing observations in humans; and 3) identified gaps in our knowledge base that must be investigated in future work. An accumulating body of evidence from both experimental and obser- vational studies implicates exposure to heavy metals, in a dose-response manner, in the increased risk of CVD. The limitations of most existing studies include insufficient statistical power, lack of comprehensive assessment of exposure, and cross-sectional design. Given the widespread exposure to heavy metals, an urgent need has emerged to investigate these putative associations of environmental exposures, either independently or jointly, with incident CVD outcomes prospectively in well-characterized cohorts of diverse populations, and to determine potential strategies to prevent and control the impacts of heavy metal exposure on the cardiometabolic health outcomes of individuals and populations.

简介：针灸在煽动性的肠疾病(IBD)的治疗的好治疗学的效果，而是它的功能的机制系统地没被解释。Metabolomics是象生活有机体的新陈代谢的反应一样包含代谢物的动态化学过程的科学学习。Metabolomics，有正直和动力学的一个研究方法，对应于针灸的全面规章的效果并且与繁体中文药(TCM)的全面概念和动态平衡的概念一致。在最近的年里，metabolomics广泛地被用于IBD的临床、试验性的学习，并且它的潜在的应用价值是一致地由研究人员承认了。在这篇文章，在针灸的metabolomics的申请地位被总结，并且由metabolomics在IBD的规定和控制学习针灸的机制的研究想法preliminarily被探索。

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简介：AbstractIn recent years, an increasing number of young women have been diagnosed with cancer, including some nulliparous women. Therefore, many young patients with early-stage cancer desire to preserve fertility after cytotoxic oncological treatments. It is important to develop a multidisciplinary approach to achieve the best outcomes for each patient. On the other hand, there has been a sharp increase in microRNAs (miRNAs) as potential biomarkers for the diagnosis, prognosis, and evaluation of treatment efficacy of several diseases. MiR-543 has been reported to affect the pathogenesis and progression of diseases via complex mechanisms. Understanding the regulatory role of miR-543 may aid comprehension of the pathogenesis and treatment of a broad range of diseases. Therefore, we provide an overview of the biogenesis, function, and role of miR-543 in various systems. These results shed light on the anticancer and endometrial protection role of miR-543 in young patients with gynecologic tumors and highlight the clinical potential of miR-543-based applications and related challenges.

简介：AbstractFecal microbiota transplantation (FMT) has been used as a core therapy for treating dysbiosis-related diseases by remodeling gut microbiota. The methodology and technology for improving FMT are stepping forward, mainly including washed microbiota transplantation (WMT), colonic transendoscopic enteral tubing (TET) for microbiota delivery, and purified Firmicutes spores from fecal matter. To improve the understanding of the clinical applications of FMT, we performed a systematic literature review on FMT published from 2011 to 2021. Here, we provided an overview of the reported clinical benefits of FMT, the methodology of processing FMT, the strategy of using FMT, and the regulations on FMT from a global perspective. A total of 782 studies were included for the final analysis. The present review profiled the effectiveness from all clinical FMT uses in 85 specific diseases as eight categories, including infections, gut diseases, microbiota–gut–liver axis, microbiota–gut–brain axis, metabolic diseases, oncology, hematological diseases, and other diseases. Although many further controlled trials will be needed, the dramatic increasing reports have shown the promising future of FMT for dysbiosis-related diseases in the gut or beyond the gut.

简介：AbstractBackground:We investigated whether periodontal diseases, specifically, periodontitis and gingivitis, could be risk factors of the incidence of intracranial aneurysms (IAs).Methods:We performed a case-control study to compare the differences in the periodontal disease parameters of 281 cases that were divided into the IAs group and non-IAs group. All cases underwent complete radiographic examination for IAs and examination for periodontal health.Results:Comparing with those in the non-IAs group, the cases in the IAs group were older (53.95 ± 8.56 vs 47.79 ± 12.33, p < 0.001) and had a higher incidence of hypertension (76 vs 34, p = 0.006). Univariate logistic regression analysis revealed that age (> 50 years) and hypertension were predictive risk factors of aneurysm formation (odds ratio [OR] 1.047, 95% confidence interval [95% CI] 1.022-1.073, p < 0.001 and OR 2.047, 95% CI 1.232-3.401, p = 0.006). In addition, univariate and multivariate logistic regression analyses showed that the parameters of periodontal diseases, including gingival index, plaque index, clinical attachment loss, and alveolar bone loss, were significantly associated with the occurrence of IAs (all p < 0.05). For further statistical investigation, the parameters of periodontal diseases were divided into four layers based on the quartered data. Poorer periodontal health condition (especially gingival index > 1.1 and plaque index > 1.5) had the correlation with IAs formation (p = 0.007 and p < 0.001).Conclusion:Severe gingivitis or periodontitis, combining with hypertension, is significantly associated with the incidence of IAs.

简介：维生素D3起来调整的蛋白质(VDUP1)1是涉及维持细胞的动态平衡的多功能的蛋白质。VDUP1被许多压力导致。相反地，VDUP1经常在各种各样的肿瘤纸巾和房间线被减少。VDUP1的在表示上通过房间周期拘捕禁止房间增长。VDUP1与thioredoxin(Trx)交往并且否定地调整表示和涉及氧化还原作用规定的Trx的抗氧化剂功能。VDUP1-/-鼠标比野类型的鼠标更产生carcinogenesis并且在包括自然漂亮房间的开发和函数建立免疫系统是有缺点的。而且，VDUP1-/-mice表演损害了Kreb调停周期的丰满的酸利用。在这评论，我们在多样的细胞的回答，特别地与增长的它的关系，apoptosis，区别，和象癌症那样的疾病和压力相关的疾病讨论了VDUP1的多功能的角色。

简介：Ahallmarkofallformsofneurodegenerativediseasesisimpairmentofneuronalfunctions,andinmanycasesneuronalcelldeath.Althoughtheetiologyofneurodegenerativediseasesmaybedistinct,differentdiseasesdisplayasimilarpathogenesis,forexampleabnormalimmunitywithinthecentralnervoussystem(CNS),activationofmacrophage/microgliaandtheinvolvementofproinflammatorycytokines.Recentstudiesshowthatneuronsinaneurodegenerativestateundergoahighlyregulatedprogrammedcelldeath,alsocalledapoptosis.TNF-relatedapoptosis-inducingligand(TRAIL),amemberoftheTNFfamily,hasbeenshowntobeinvolvedinapoptosisduringmanydiseases.Asonememberofadeathligandfamily,TRAILwasoriginallythoughttotargetonlytumorcellsandwasnotpresentinCNS.However,recentdatashowedthatTRAILwasunregulatedinHIV-1-infectedandimmune-activatedmacrophages,amajordiseaseinducingcellduringHIV-1-associateddementia(HAD).TRAILisalsoinducedonneuronbyβ-amyloidprotein,animportantpathogenforAlzheimer'sdisease.Inthisreview,wesummarizethepossiblecommonaspectsthatTRAILinvolvedthoseneurodegenerativediseases,TRAILinducedapoptosissignalingintheCNScells,andspecificroleofTRAILinindividualdiseases.Cellular&MolecularImmunology.2005;2(2):113-122.

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简介：AbstractInnate lymphoid cells (ILCs) are a group of lymphocytes without diversified antigen receptors encoded by gene rearrangement on T and B cells. ILCs, which are tissue-resident innate immune cells, expressed particularly in the mucosa or the barrier surface, contribute to the formation of lymphoid organs, the maintenance of tissue homeostasis, and the regulation of antimicrobial defenses. It has been recently reported that ILCs were enriched at the maternal-fetal interface. During a successful pregnancy, the maternal immune system must tolerate a fetus as an allograft. With the new defined of ILCs, a number of studies have shown that three types of ILCs are involved in embryonic development and pregnancy maintenance as well as the occurrence and development of pregnancy-related complications. This article reviews the types and roles of ILCs in normal pregnancy and pregnancy-related diseases.

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简介：Dr.YINMingisskilledatthepediatricdiseasesandwinsthetrustfromherpatientsandtheirfamilies.Ilearnedalotfromtheclinicalpracticewithherandnowtheexperienceisasfollows.

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简介：AbstractBackground:The association of milk intake with cardiovascular disease (CVD) and cause-specific mortality remained controversial and evidence among the Chinese population was limited. We aimed to study the relationship between milk intake and CVDs among general Chinese adults.Methods:A total of 104,957 participants received questionnaire survey. Results of physical examination such as anthropometric measurements and biochemical tests during 2007 to 2008, demographic data and their information on milk intake were collected through standardized questionnaires. Cox proportional hazard regression models were used to calculate hazard ratios (HRs) and their corresponding 95% confidence intervals (CIs) of CVD incidence, cause-specific mortality and all-cause mortality related to milk intake. Restricted cubic splines (RCSs) were applied to examine dose-response associations.Results:Among the 91,757 participants with a median follow-up period of 5.8 years, we documented 3877 CVD cases and 4091 all-cause deaths. Compared with participants who never consumed milk, the multivariate-adjusted HRs (95% CIs) of CVD incidence for 1 to 150 g/day, 151 to 299 g/day, and ≥300 g/day were 0.94 (0.86-1.03) (P > 0.05), 0.77 (0.66-0.89) (P < 0.05), and 0.59 (0.40-0.89) (P < 0.05), respectively; each 100 g increase of daily milk intake was associated with 11% lower risk of CVD incidence (HR, 0.89; 95% CI: 0.85-0.94; P < 0.001), and 11% lower risk of CVD mortality (HR, 0.89; 95% CI: 0.82-0.97; P = 0.008) after adjustment for age, sex, residential area, geographic region, education level, family history of CVD, smoking, alcohol drinking, physical activity level, body mass index, and healthy diet status (ideal or not). RCS analyses also showed a linear dose-response relationship with CVD (P for overall significance of the curve <0.001; P for non-linearity = 0.979; P for linearity <0.001) and stroke (P for overall significance of the curve = 0.010; P for non-linearity = 0.998; P for linearity = 0.002) incidence, and CVD mortality (P for overall significance of the curve = 0.045; P for non-linearity = 0.768; P for linearity = 0.014) within the current range of daily milk intake.Conclusions:Daily milk intake was associated with lower risk of CVD incidence and mortality in a linear inverse relationship. The findings provide new evidence for dietary recommendations in CVD prevention among Chinese adults and people with similar dietary pattern in other countries.

简介：AIMTo评估安全和27计量器(27G)的功效侧面为有跟随27GPPV的各种各样的vitreoretinal疾病的61只眼睛(58个病人)的临床的结果是的各种各样的vitreoretinaldiseases.METHODSThe的治疗的同等planavitrectomy(PPV)回顾地，reviewed.RESULTSSurgical指示包括了rhegmatogenous网膜的分开(n=24)，完整厚度的有斑点的洞(n=12)，糖尿病的retinopathy(n=11)，玻璃的出血(n=6)，Eales疾病(n=4)，病理学近视相关玻璃吝啬的后续是166.4牵敧祲刮卅?協桔???????????????挠灡?潬潴祭?????????????????????????浥瑡硯汹湩攭獯湩?€浩畭潮汦潵敲'諟Ｉ????????吗?????????????？？

简介：通过ubiquitin-proteasome系统的蛋白质降级是细胞内部的蛋白质的non-lysosomal解朊作用的主要小径。它在象房间周期的规定那样的许多基本细胞的过程起重要作用有免疫力、煽动性的回答的前进，分割，开发和区别，apoptosis，房间trafficking，和调整。这个系统的中央元素是到指向的蛋白质的ubiquitin的连接，它是然后由26Sproteasome认出了的共有原子价，腺苷triphosphate依赖的、多催化的朊酶。损坏，氧化，否则象控制许多批评细胞的函数的规章的蛋白质一样的错误褶层蛋白质在这降级进程的目标之中。这个系统的错误导致细胞的动态平衡的dysregulation和多重疾病的发展。在这评论，我们在煽动性、自体免疫的疾病的开发描述了基本生物化学和ubiquitin-proteasome系统，和它的复杂角色的分子的生物学。另外，与ubiquitin-proteasome系统有关的治疗和潜在的治疗学的目标也被讨论。细胞与分子的免疫学。2006；3(4):255-261。

简介：<正>Immunologicaltolerancetoselfisessentialformaintainingtheintegrityoftheorgansystems,anditsbreakdownmayleadtothedevelopmentofautoimmunediseases.Tolerancetoselfismaintainedthroughseveralmechanisms,whichincludenegativeselection,functionalinactivation(anergy)andsuppressionofautoreactivelymphocytes.However,onlynegativeselectionpermanentlyremovesautoreactivecellsthroughapoptosis.WhileithaslongbeenknownthatnegativeselectionrequiresaTcellreceptor(TCR)signal,itisunclearwhetheradeathligandsignalisalsoinvolved.TRAIL,thetumornecrosisfactor(TNF)-relatedapoptosis-inducingligand,isanewlydescribedmemberoftheTNFfamily.Unlikeotherdeathligandsof

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