简介:摘要目的随着医学科学的发展和检测手段的不断提高,免疫性不孕越来越受到人们的重视,免疫性不孕亦即由于生殖系统抗原的自身免疫或同种免疫所引起,如精子、精浆、卵透明带及卵巢内产生甾体激素的细胞均为特异性抗原,引起免疫反应产生相应抗体,阻碍精子与卵子结合及受精而致不孕。其中以精子抗体引起的不孕最为常见。现在,有关数据表示,在不孕不育夫妻中,因为支原体衣原体感染造成的人数,明显的增多起来。这种病原体可以入侵到男人的前列腺,引发急性与慢性的前腺炎。女性因为这样的病菌会引起宫颈内膜炎或盆腔炎,也会导致不孕不育。所以支原体衣原体和不孕不育有着很密切的关系。抗精子抗体,能使精子制动或粘附在宫颈粘液上而难以通过子宫颈,也可抑制精子顶体的活性,使精子不易穿透包绕卵细胞的卵丘、放射冠和透明带,阻碍精子与卵细胞的融合,或导致胚胎死亡和流产,严重影响男女的生育质量[1]。
简介:目的:观察一氧化氮合酶(NOS)在正常肝组织、肝硬化和原发性肝癌中表达的不同情况,分析其与微血管密度(MVD)之间的关系,探讨在原发性肝癌血管生成和肝癌细胞转移中的作用.方法:应用原位杂交技术,检测80例原发性肝癌、40例肝硬化、20例正常肝组织中NOS的表达定位情况,并用免疫组化技术检测微MVD.结果:肝癌、肝硬化中内皮细胞NOSmRNA的表达显著高于正常肝组织(P<0.01);肝癌细胞中NOSmRNA阳性率明显高于肝硬化中肝细胞,而后者又明显高于正常肝脏中肝细胞(P<0.01),此外,肝癌组织内皮细胞上NOSmRNA表达阳性者MVD显著高于阴性者(P<0.01).结论:①肝癌细胞cNOS的表达参与肝癌的发生过程;②肝癌血管内皮细胞NOS的表达在肝癌的血管生成中起重要作用.
简介:Toobserveanymalignancysufferer'shomocysteinelevelinplasma,andtostudyhomoeysteinehadtheinfluenceuponmalignancyhappened.MethodsByFluorescencePolarizationImmunoassay(FPIA)technologyandElectrochemiluinescenceImmuoassaytechnology,tomensurateandassaybetweenthetumormarkerandthetHeyin78patientswithmalignancyand50normalperson.ResultsMalignancysufferer'stumormarkerandhomocysteinelevelprominenceincrease,butnotthediseiphnariancreasedidchangedtherelationshipbetweenthetHeyandthetumormarker.ConclusionThetHeyinnotinfluencemalignancyresults,butacceleratedtoinfluencemalignaney
简介:Hypertriglyceridemiaisanimportantriskfactorformanydiseases.Inthisstudy,weevaluatetherelationshipbetweenhypertriglyceridemiaandotherdiseasessuchashypertension,coronaryheartdisease(CHD)anddiabetesmellitus(DM)inChinesePeople'sArmedPohceForces,andweinvestigatetheriskfactorsofhypertriglyceridemia.MethodsThestudypopulationcomprised3853cadresabove35yearsthroughrandomselectioninChinesePeople'sArmedPoliceForces.Informationaboutthecadresandtheirfamilieswasobtainedfromdetailedclinicalandlaboratoryexaminationandquestionnairesurvey.Hypertriglyceridemiawasdiagnosedwhentheconcentrationoffastingserumtriglycerdieswasabove2.3mmol/L.ResultsHypertriglyceridemiaisassociatedwithhypertension,CHDandDM(P<0.01),whilehypertriglyceridemiaisnotstaticallyassociatedwithTIAandcerebralinfarctionthoughthereisatendencyofhigherprevalenceofhypertriglyceridemiabethinTIAandcerebralinfarctiongroups(P>0.05).HigherBMI,Heavystaplefoodintake,propensityforfat-richdiet,smokingandalcoholuseareimprotantriskfactorsofhypertriglyceridemia,whileexerciseisbenefitforlowingtheconcentrationofserumtriglycerides.ConclusionElevatedtriglycerideslevelwhichisinfluencedbylifestyletosomeextentisassociatedwithmanydiseases,soadjustmentoflifestyleisimprotantforprimaryandsecondarypreventionofthesediseases.