简介:Throughthesinusoidloadingdynamictriaxialtest,theliquefactionpropertyofsaturatedloessandsandselectedfromacivilairportofLanzhou,Gansuisexamined.Basedonthelaboratoryresults,acomprehensiveassessmentontheearthquakeliquefactionpotentialoftheloessandsandisgiven,usingtheliquefactionresistanceshearstressmethodandtheresultsofseismichazardassessment.Itisfoundthatundertheeffectofgroundmotionwithexceedanceprobabilityof10%within50years,theloessinthestudyismoresusceptibletoliquefactionthansand.
简介:Smallhydrositeslocatedinmountainenvironmentsareoftenonungaugedstreams.AsoftwarepackagecalledtheintegratedMethodforPower(IMP4.0)wasdesignedtoassistinexperienced,potentialdevelopersofsmaffhydrositesinsituationswherethecostofprofessionafengineeringadvicewouldbeprohibitive.
简介:Translationinitiationsites(TISs)areimportantsignalsincDNAsequences.InmanypreviousattemptstopredictTISsincDNAsequences,threemajorfactorsaffectthepredictionperformance:thenatureofthecDNAsequencesets,therelevantfeaturesselected,andtheclassificationmethodsused.Inthispaper,weexaminedifferentapproachestoselectandintegraterelevantfeaturesforTISprediction.Thetopselectedsignificantfeaturesincludethefeaturesfromthepositionweightmatrixandthepropensitymatrix,thenumberofnucleotideCinthesequencedownstreamATG,thenumberofdownstreamstopcodons,thenumberofupstreamATGs,andthenumberofsomeaminoacids,suchasaminoacidsAandD.Withthenumericaldatageneratedfromthesefeatures,differentclassificationmethods,includingdecisiontree,naiveBayes,andsupportvectormachine,wereappliedtothreeindependentsequencesets.Theidentifiedsignificantfeatureswerefoundtobebiologicallymeaningful,whiletheexperimentsshowedpromisingresults.
简介:探索真核细胞的抄写因素(TF)的性质有约束力的地点并且决定他们怎么不同于包围DNA序列,我们检验了与DNA有约束力的地点联系的四个特征:G+C内容,模式复杂性,palindromic结构,和Markov定序订。我们规章的主题的分析从TRANSFAC数据库获得了,用酵母内部是的遗传因子的序列背景,表明这四个特征在主题序列显示出可变丰富。例如,主题序列比是背景序列是更可能的有palindromic结构。另外,这些特征对规章的主题紧局部性,显示他们自己是主题序列的一个性质并且没被一般倡导者分享规章的主题在住的“环境”。由根据他们绑在的TF班毁坏主题序列,更特定的协会被识别。最后,当其它例如复杂性丰富,越过检验的种类是通用的时,我们发现一些关联例如G+C内容丰富,是种类特定的。这里提供的定量分析应该增加我们protein-DNA相互作用的理解并且也帮助通过生物信息学便于规章的主题的发现。
简介:TheroleplayedbythefunctionalgroupsofLaminariajaponicatreatedbymethanolandformaldehydeinbiosorptionoftheheavymetalswasinvestigated.Infraredspectroscopyanalysisandbiosorptionexperimentsshowthatbothcarboxylandaminogroupsjoininthesorption;chemicaltreatmentdecreasedthebiosorptionefficiencyoftheheavymetals.
简介:Proteinphosphorylationplaysanimportantroleinvariouscellularprocesses.Duetoitshighcomplexity,themechanismneedstobefurtherstudied.Inthelastfewyears,manymethodshavebeencontributedtothisfield,butalmostalloftheminvestigatedthemechanismbasedonproteinsequencesaroundproteinsites.Inthisstudy,weimplementanexplorationbycharacterizingthemicroenvironmentsurroundingphosphorylatedproteinsiteswithamodifiedshellmodel,andobtainsomesignificantpropertiesbytherank-sumtest,suchasthelackofsomeclassesofresidues,atoms,andsecondarystructures.Furthermore,wefindthatthedepletionofsomepropertiesaffectsproteinphosphorylationremarkably.Ourresultssuggestthatitisameaningfuldirectiontoexplorethemechanismofproteinphosphorylationfrommicroenvironmentandweexpectfurtherfindingsalongwiththeincreasingsizeofphosphorylationandproteinstructuredata.
简介:Itiswidelyknownthattheseismicresponsecharacteristicsofasoilsitedependsheavilyonseveralkeydynamicpropertiesofthesoilstratum,suchaspredominantfrequencyanddampingratio.Awidelyusedmethodforestimatingthepredominantfrequencyofasoilsitebyusingmicrotremorrecords,proposedbyNakamura,isinvestigatedtodetermineitseffectivenessinestimatingthedampingratio.TheauthorsconductedsomemicrotremormeasurementsofsoilsitesinHongKongandfoundthatNakamura'smethodmightalsobeusedtoestimatethedampingratioofasoilsite.DampingratiodatafromseveraltypicalsoilsiteswereobtainedfrombothNakamura'sratiocurvesusingthehalfpowerpointmethodandresonantcolumntests.Regressionanalysisindicatesthatthereisastrongcorrelationbetweenthedampingratiosderivedfromthesetwodifferentapproaches.
简介:ThebackdoororinformationleakofWebserverscanbedetectedbyusingWebMiningtechniquesonsomeabnormalWeblogandWebapplicationlogdata.ThesecurityofWebserverscanbeenhancedandthedamageofillegalaccesscanbeavoided.Firstly,thesystemfordiscoveringthepatternsofinformationleakagesinCGIscriptsfromWeblogdatawasproposed.Secondly,thosepatternsforsystemadministratorstomodifytheircodesandenhancetheirWebsitesecuritywereprovided.Thefollowingaspectsweredescribed:oneistocombinewebapplicationlogwithweblogtoextractmoreinformation,sowebdataminingcouldbeusedtomineweblogfordiscoveringtheinformationthatfirewallandInformationDetectionSystemcannotfind.AnotherapproachistoproposeanoperationmoduleofwebsitetoenhanceWebsitesecurity.Inclusterserversession,Density-BasedClusteringtechniqueisusedtoreduceresourcecostandobtainbetterefficiency.
简介:Thecalculationmethodaboutinfraredmulti-sitespassivesystemlocationisintroducedbasedontheprincipleoftheweightedleastsquaremethod,andthevariancematrixofestimatederrorisoffered.Throughdeduction,itcanbefoundoutthattreatedappraiseprecisioncanbedirectlyanalyzedanddeducedwithoutcarryingoutrealmeasureandreachingestimationvalue.Thesimulationresultshowsthatthesystemperformancebasedontheweightedleastsquaremethodismuchbetterthanthetraditionalpassivelocationmethod,anditcanbealsousedforreferencetotheresearchofthelocationalgorithmofsimilarsystem.
简介:抄写开始地点(TSS)区域与另外的倡导者元素相比显示出更大的可变性。我们被感兴趣由把信息内容用作一项措施寻找它的可变性。我们在这研究注意可变性在与15nt的块相比包围TSS区域的5核苷酸(nt)的块是重要的。这建议可以被包含的实际区域在在尺寸的5-10nt的范围。为Escherichia关口i,我们注意从dinucleotide替换矩阵的信息内容清楚地显示出更好的辨别,建议一些关联的存在。然而,为人,这效果是少得多,并且为老鼠,它实际上是不在的。我们能断定存在短期在TSS区域以内的关联是种类依赖者并且不是通用的。我们进一步观察到在除了TSS的mitochondrial控制元素有另外的可变区域。有效比较能仅仅在块上被做,这也被注意,当单个核苷酸比较不给我们任何可检测的信号时。
简介:BABAR[1]usestwoformatsforitsdata:ObjectivitydatabaseandROOT[1]files.Thisposterconcernsthedistributionofthelatter-forObjectivitydatasee[3].TheBABARanalysisdataisstoredinROOTfiles-oneperphysicsrunandanalysisselectionchannel-maintainedinalargedirectorytree,CurrentlyBABARhasmorethan4.5TBytesin200,000ROOTfiles.Thisdatais(mostly)producedatSLAC,butisrequiredforanalysisatuniversitiesandresearchcentresthroughouttheUSandEurope.TwobasicproblemsconfrontuswhenweseektoimportbulkdatafromSLACtoaninstitute'slocalstorageviathenetwork.Wemustdeterminewhichfilesmustbeimported(dependingonthelocalsiterequirementsandwhichfileshavealreadybeenimported),andwemustmaketheoptimumuseofthenetworkwhentransferringthedata,Basicftp-liketools(ftp,scp,etc)donotattempttosolvethefirstproblem.Moresophisticatedtoolslikersync[4],thewidely-usedmirror/synchronisationprogram,comparelocalandremotefilesystems,checkingforchanges(basedonfiledate,sizeand,ifdesired,anelaboratechecksum)inordertoonlycopynewormodifiedfiles,Howeverrsyncallowsforonlylimitedfileselection.Alsowhen,asinBABAR,anextremelylargedirectorystructuremustbescanned,rsynccantakeseveralhoursjusttodeterminewhichfilesneedtobecopied.Althoughrsync(andscp)provideson-the=flycompression,itdoesnotallowustooptimisethenetworktransferbyusingmultiplestreams,abjustingtheTCPwindowsizeorseparatingencryptedauthenticationfromunencrypteddatachannels.
简介:VertebrategenomesarecharacterizedwithCpGdeficiency,particularlyforGC-poorregions.TheGCcontent-relatedCpGdeficiencyisprobablycausedbycontext-dependentdeaminationofmethylatedCpGsites.ThishypothesiswasexaminedinthisstudybycomparingnucleotidefrequenciesatCpGflankingpo-sitionsamonginvertebrateandvertebrategenomes.Thefindingisatransitionofnucleotidepreferenceof5'Tto5'Aattheinvertebrate-vertebrateboundary,indi-catingthatalargenumberofCpGsiteswith5TsweredepletedbecauseofglobalDNAmethylationdevelopedinvertebrates.Atgenomelevel,weinvestigatedCpGobserved/expected(obs/exp)valuesin500bpfragments,andfoundthathigherCpGobs/expvalueisshowninGC-poorregionsofinvertebrategenomes(exceptseaurchin)butinGC-richsequencesofvertebrategenomes.WenextcomparedGCcontentatCpGflankingpositionswithgenomicaverage,showingthattheGCcontentislowerthantheaverageininvertebrategenomes,buthigherthanthatinvertebrategenomes.Theseresultsindicatethatalthough5'Tand5'AaredifferentininducingdeaminationofmethylatedCpGsites,GCcontentisevenmoreimportantinaffectingthedeaminationrate.Inallthetests,theresultsofseaurchinaresimilartovertebratesperhapsduetoitsfractionalDNAmethylation.CpGdeficiencyisthereforesuggestedtobemainlyaresultofhighmutationratesofmethylatedCpGsitesinGC-poorregions.