简介：PURPOSE：Vorinostat,ahistonedeacetylaseinhibitor,representsarationaltherapeutictargetinglioblastomamultiforme（GBM）.PATIENTSANDMETHODS：PatientswithrecurrentGBMwhohadreceivedoneorfewerchemotherapyregimensforprogressivediseasewereeligible.

简介：Markedresponseofgliomatosiscerebritotemozolomideandwholebrainradiotherapy.

简介：PURPOSE：ResistancetotemozolomidechemotherapyispartlymediatedbyO^6-methylguanine-DNAmethlytransferase（MGMT）.ProtractedtreatmentwithtemozolomidepotentiallyovercomesMGMTresistanceandimprovesoutcome.WeconductedaphaseIIstudyofprotracteddailytemozolomideinadultswithlow-gradegliomas.EXPERIMENTALDESIGN：PatientswithnewlydiagnosedoligodendrogliomaoroligoastrocytomawithaMIB-1indexof〉5%orrecurrentlow-gradegliomasreceivedtemozolomide（75mg/m^2/dayin11-weekcyclesof7weekson/4weeksoff）.Treatmentcontinuedforatotalofsixcyclesoruntiltumorprogressionorunacceptabletoxicity.Primaryendpointwasbestoverallresponserate;secondaryendpointswereprogression-freesurvival,overallsurvival,andtoxicity.

简介：BACKGROUND：In2004,arandomisedphaseⅢtrialbytheEuropeanOrganisationforResearchandTreatmentofCancer（EORTC）andNationalCancerInstituteofCanadaClinicalTrialsGroup（NCIC）reportedimprovedmedianand2-yearsurvivalforpatientswithglioblastomatreatedwithconcomitantandadjuvanttemozolomideandradiotherapy.We＇reportthefinalresultswithamedianfollow-upofmorethan5years.METHODS：Adultpatientswithnewlydiagnosedglioblastomawererandomlyassignedtoreceiveeitherstandardradiotherapyoridenticalradiotherapywithconcomitanttemozolomidefollowedbyuptosixcyclesofadjuvanttemozolomide.

简介：Monochromaticminibeamsradiotherapy：fromhealthytissue-sparingeffectstudiestowardfirstexperimentalgliomabearingratstherapy.

简介：PURPOSE：Toevaluatethetoxicityandresponserateofbortezomibwithconcurrentradiotherapyandtemozolomideinthetreatmentofpatientswithcentralnervoussystemmalignancies.PATIENTSANDMETHODS：Thisopen-label,dose-escalation,PhaseⅠclinicalstudyevaluatedthesafetyofthreedoselevelsofintravenouslyadministeredbortezomib（0.7,1.0,and1.3mg/m（2）/dose）onDays1,4,8,and11ofa21-daycycle,inadditiontoconcurrentradiotherapyandtemozolomideatadailydoseof75mg/m（2）startingonDay1.Theprimaryendpointwasdose-limitingtoxicity,definedasanyGrade4-5toxicityorGrade3toxicitydirectlyat-tr/butabletoprotocoltreatment,requiringhospitalizationand/orradiotherapyinterruption.

简介：研发前言Rockwell科学公司开发高温SiC电机传动系统Rockwell科学公司与美国空军研究实验室将共同开发高效、高温和小型的电机传动系统,应用于飞机和太空船。该项目主要开发基于SiC(碳化硅半导体)开关的磁阻电机传动,检验在200℃工作的容错电气传动装置。开发这种能在几乎无冷却的恶劣环境下工作的电机传动系统,关键是研发高温SiC开关,封装,控制电子学和电机。这些装置将显著降低电力电子的尺寸和重量。

简介：PURPOSE：ThisphaseⅡtrialwasdesignedtodefinetheroleofO^6-benzylguanine（O^6-BG）inrestoringtemozolomidesensitivityinpatientswithrecurrentorprogressive,temozolomidc-resistantmalignantgliomaandtoevaluatethesafetyofadministeringO^6-BGincombinationwithtemozolomide.PATIENTSANDMETHODS：Patientswereaccruedintotwoindependentstrataonthebasisofhistology：glioblastomamultifonne（GBM）andaanaplasticglioma.BothtemozolomideandO6-BGwereadministeredonday1ofa28-daytreatmentcycle.Patientswereadministereda1-hourO^6-BGinfusionatadoseof120mg/m^2followedimmediatelybya48-hourinfusionatadoseof30mg/m^2/d.

简介：PURPOSE：Toevaluatesingle-agentactivityofbevacizumabinpatientswithrecurrentglioblastoma.PATIENTSANDMETH-ODS：Patientswithrecurrentglioblastomaweretreatedwithbevacizumab10mg/kgevery2weeks.Aftertumorprogression,patientswereimmediatelytreatedwithbevacizumabincombinationwithirinotecan340mg/m^2or125mg/m^2every2weeks,dependingonuseofenzyme-inducingantiepilepticdrugs.Completepatientevaluationswererepeatedevery4weeks.RESULTS：Forty-eightheavilypretreatedpatientswereaccruedtothisstudy.Thromboembolicevents（12.5%）,hypertension（12.5%）,hypophosphatemia（6%）,andthrombocytopenia（6%）werethemostcommondrug-associatedadverseevents.Sixpatients（12.5%）wereremovedfromstudyfordrug-associatedtoxicity（fivethromboembolicevents,onebowelperforation）.

简介：

简介：PURPOSE：Fotemustineisanitrosoureacompoundusedforthetreatmentofmalignantgliomas,especiallyinFrance.Recently,anEORTC-NCICstudyhasshownthataconcomitantcombinationofradiotherapyplustemozolomide（anoralcytotoxicdrug）improvedsurvivalinglioblastomapatients.Wesetouttotestaconcurrentcombinationofradiotherapyandfotemustinefornewlymalignantgliomas.

简介：BACKGROUND：SupratentorialPNET（sPNET）arerareCNStumorsofembryonaloriginarisinginchildrenandadults.Thetreat-mentofsPNETforallagegroupsatourcancercenterhasbeenbasedonthemanagementofmedulloblastoma（MB）,involvingneurosurgicaldebulkingfollowedbyeranio-spinalirradiation（CS1）andsystemicchemotherapy.METHODS：MedicalrecordswerereviewedtogatherdemographicandclinicaldataaboutallembryonalCNStumorsinchildrenandadultsfrom2001to2007.Tumorpathology,clinicalmanagementandsurvivaldatawerealsoassessed,particularlyasregardsthosepatientswhoreceivedthePackerchemotherapyregimenforeithersPNETorMB.

简介：汽车零部件再制造业中各单位合作管理的探讨汽车行业是历史最悠久的再制造业之一。其中再制造部件包括刹车钳、发动机、伺服油泵以及交流发电机。而对于实现再制造部件的稳定供货源,是汽车部件再制造业面临的巨大挑战。供货源是可以与核心供货商签订协议来确定,比如：原始再制造商们也可以广泛的寻找

简介：Humanglioblastomas(GBM)arethoughttobeinitiatedbygliomastem-likecells(GSLCs).GSLCsalsoparticipateintumorneovascularizationbytransdifferentiatingintovascularendothelialcells.Here,wereportacriticalroleofGSLCsintheformationofvasculogenicmimicry(VM),whichdefineschannelslinedbytumorcellstosupplynutrientstoearlygrowingtumorsandtumor

简介：Glioblastomaisoneofthemostangiogenichumantumorsandcharacterizedbymicrovascularproliferations.Abetterunderstandingofglioblastomavasculatureisneededtooptimizeanti-angiogenictherapythathasshownapromisingbutincompleteefficacy.Thepresentstudyexamined48glioblastomasbyCD34endothelialmarkerperiodicacid-Schiff(PAS)dualstainingandfoundnon-endothelialcell-linedblood

简介：RoleofEarlyPostradiationMagneticResonanceImagingScansinChildrenwithDiffuseIntrinsicPontineGlioma.

简介：21世纪，你想要阅读三千六百年前的“书籍”——刻有甲骨文的龟甲、兽骨吗？请到博物馆。未来，你想阅读风光了两千多年的纸质书刊吗？也请到博物馆。

简介：

简介：消防专业书刊，是指由出版单位正式出版的有关记述消防专业的图书和刊物。我国最早的消防专业书刊有三本。

简介：近年来，图书馆书刊文献资料的订购数量逐年减少，信息文献资料的收藏能力日益萎缩，而读者对信息文献的需求却在不断的增加。对此，图书馆表现的无能为力。图书馆的日子难过，其主要原因是图书资料经费的异常短缺。造成书刊经费短缺的原因很多，其中最主要的原因有三个：...