简介：AbstractAs the entire world is under the grip of the coronavirus disease 2019 (COVID-19), and as many are eagerly trying to explain the origins of the virus and cause of the pandemic, it is imperative to place more attention on related potential biosafety risks. Biology and biotechnology have changed dramatically during the last ten years or so. Their reliance on digitization, automation, and their cyber-overlaps have created new vulnerabilities for unintended consequences and potentials for intended exploitation that are mostly under-appreciated. This study summarizes and elaborates on these new cyberbiosecurity challenges, (1) in terms of comprehending the evolving threat landscape and determining new risk potentials, (2) in developing adequate safeguarding measures, their validation and implementation, and (3) specific critical risks and consequences, many of them unique to the life-sciences. Drawing other's expertise and my previous work, this article reviews and critically interprets our current bio-economy situation. The goal is not to attribute causative aspects of past biosafety or biosecurity events, but to highlight the fact that the bioeconomy harbors unique features that have to be more critically assessed for their potential to unintentionally cause harm to human health or environment, or to be re-tasked with an intention to cause harm. It is concluded with recommendations that will need to be considered to help ensure converging and emerging biorisk challenges, in order to minimize vulnerabilities to the life-science enterprise, public health, and national security.

简介：随着手机的日益普及，甚至泛滥，越来越多的电影人也开始热衷于拍摄这一题材的作品。去年冯小刚打造的贺岁片《手机》引起了一片轰动，片中有一句台词：这哪里是手机，简直是手榴弹!而影片Cellular中手机的作用绝对不亚于手榴弹。

简介：Background:ConcernshavebeenexpressedaboutpotentialtoxicityofthesmokeproducedbytheburningofmoxaintraditionalChinesemedicine.Withtheadventofstrictanti-smokinglegislationintheUK,itwasdecidedtotestthevolatilesproducedbymoxibustionandcomparethemwithcurrentagreedsafeexposurelevels.

简介：Objective:InfraredTympanicThermometer(ITT)isoneofthemostusefulinstrumentsforaccuratelymeasuringtemperature.TheeffectsofearpathologiesonITTmeasurementremainunclear.Thepurposeofthisstudyistodetermineiftympanicmembraneperforation(TMP)affectsITTmeasurementsinadultpatients.Materialandmethods:Atotalof90adultpatientswithmonauralcentralTMPwereenrolledinthisstudy.Patientswerecategorizedintothreesubgroupsaccordingtoperforationsize(1-3mm,4-7mm,and8-10mm).Thetympanictemperaturesoftheaffectedandunaffectedsites,andsubgroupswerecomparedwitheachother.Results:Thisstudycontained54(60%)malesand36(40%)femalesrangingfrom20to58yearsofage(meanage:30.74±9.61years).ThemeantympanictemperatureofthesideaffectedwithTMPwas36.34oC±0.61oC.Themeantympanictemperatureoftheunaffectedsidewithhealthyandintacttympanicmembranewas36.33oC±0.6oC.ThePearsoncorrelationscoreforthetympanictemperaturesandthesizeofTMPwas0.22whichwasnotsignificant(r=-0.12).Conclusion:TMPandperforationsizedonotaffectITTmeasurementsinadultpatients.

简介：进行中的气候变化是对生物多样性的主要威胁。不管多么许多种类清楚地受不了进行中的气候变化，例如，其它由显示出范围扩大得益于它。然而，特定的特征哪个决定种类危险到气候变化？Phenotypic粘性，对环境变化被描述了为防卫的第一根线，可能在这里具有最大的重要性。对这个背景，我们这里在3铜蝴蝶种类在压力忍耐比较粘性，它在他们对气候变化的弱点可以证明不同。明确地，我们在成年阶段在acclimatization以后调查了热，寒冷和干燥抵抗到不同温度。我们证明在更高的温度的环境适应增加了热，但是减少冷忍耐和干燥抵抗。与我们的预言相反，种类没在压力抵抗显示出显著变化，尽管在温度的塑料能力强调抵抗确实越过种类变化了。总的来说，我们的结果似乎比speciesspecific模式反映populationrather。我们断定使用的人口的地理起源应该在比较研究被认为平。然而，我们的结果建议在这里学习的3种类，对气候变化的弱点没被压力抵抗首先在成年阶段决定。当昆虫学的研究仅仅实在太经常集中于成年人，当试着理解昆虫回答到环境变化时，我们主张更多的研究努力应该被奉献给另外的发展阶段。

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简介：AbstractBackground:Preterm premature rupture of membranes (PPROM) is associated with high neonatal morbidity and mortality. However, the influences of cesarean section (CS) on neonatal outcomes in preterm pregnancies complicated with PPROM are not well elucidated. The aim of this study was to investigate the influence of delivery modes on neonatal outcomes among pregnant women with PPROM.Methods:A retrospective cross-sectional study was conducted in 39 public hospitals in 14 cities in the mainland of China from January 1st, 2011 to December 31st, 2011. A total of 2756 singleton pregnancies complicated with PPROM were included. Adverse neonatal outcomes including early neonatal death, birth asphyxia, respiratory distress syndrome (RDS), pneumonia, infection, birth trauma, and 5-min/10-min Apgar scores were obtained from the hospital records. Binary variables and ordinal variables were respectively calculated by binary logistic regressions and ordinal regression. Numerical variables were compared by multiple linear regressions.Results:In total, 2756 newborns were involved in the analysis. Among them, 1166 newborns (42.31%) were delivered by CS and 1590 newborns belonged to vaginal delivery (VD) group. The CS proportion of PPROM obviously increased with the increase of gestational age (χ2 = 5.014, P = 0.025). Compared with CS group, VD was associated with a higher risk of total newborns mortality(odds ratio [OR], 2.38; 95% confidence interval [CI], 1.102–5.118; P = 0.027), and a lower level of pneumonia (OR, 0.32; 95% CI, 0.126–0.811; P = 0.016). However, after multivariable adjustment and stratification for gestational age, only pneumonia was significantly related with CS in 28 to 34 weeks group (OR, 0.34; 95% CI, 0.120–0.940; P = 0.038). There were no differences regarding to other adverse outcomes in the two groups, including neonatal mortality, birth asphyxia, Apgar scores, RDS, pneumonia, and sepsis.Conclusions:The proportion of CS of pregnant women with PPROM was very high in China. The mode of delivery does not affect neonatal outcomes of pregnancies complicated with PPROM.

简介：Nervefibersareattractedbysuturelessend-to-sidenervecoaptationintotherecipientnerve.Openingawindowintheepineuriumenhancesaxonattractionandmyelination.Theauthorsanalyzethefeaturesofnerverepairbyend-to-sidecoaptation.Theyhighlighttheknownmechanismsofaxonsproutinganddifferenthypothesesofstartupsignals(presenceorabsenceofanepineurialwindow,roleofSchwanncells,signalingfromthedistaltrunk).Theclinicalliteratureisalsopresentedanddifferencesbetweenexperimentalandclinicalapplicationsarepointedout.Theauthorsproposetheirpointofviewandperspectivesderivingfromrecentexperimentalandclinicalexperiences.

简介：Background:Apreviousstudyhasreporteda50%reductionindisuseatrophyofthequadricepsduringthefirst14daysafteranteriorcruciateligament(ACL)reconstruction.Afollow-uptrialisneededtoconfirmthesepromisingresults.ThepresentstudyaimstoinvestigatetheeffectofanocclusionstimulusonquadricepsatrophyafterACLreconstruction.Methods:Atotalof24subjectsparticipatedinthestudy.Theywererandomizedintotwogroups.Startingthe2nddayaftersurgery,theocclusiongroupreceivedanocclusionstimulusfor5min,followedbyremovaloftheocclusivepressurefor3min.Thiswasrepeatedfivetimesinonetrainingsession,twicedaily.Duringtheperiodofocclusivestimulus,thesubjectsperformed20lowloadexercisesforthequadriceps.Thecontrolgroupfollowedthesameexerciseprotocol,butwithouttheocclusionstimulus.Changesinquadricepsanatomicalcrosssectionarea(ACSA)weremeasuredusingaxialmagneticresonance(MR)imagesat40%and50%ofthelengthofthefemur.Results:BothgroupshadasignificantreductionofquadricepsACSAfrom2daysbeforesurgeryto16daysaftersurgery.Duringtheinterventionperiod,theocclusiongrouplost13.8%±1.1%(mean±SEM)andthecontrolgrouplost13.1%±1.0%oftheirquadricepsACSA,respectively.Therewasnosignificantdifferencebetweentheocclusionandcontrolgroupswithregardstoatrophyofthequadricepsmuscles.Conclusion:Inconflictwithotherstudiesusingasimilarprotocol,applicationofbloodflowrestrictionthefirst14daysafterACLreconstructiondidnotreducequadricepsACSAmuscleatrophymeasuredbyMRinapopulationofathletes.

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简介：PURPOSE:Weinvestigatethepatternsoffailureinthetreatmentofglioblastoma(GBM)basedonclinicaltargetvolume(CTV)marginsize,dosedeliveredtothesiteofinitialfailure,andtheuseoftemozolomideandintensity-modulatedradiotherapy(IMRT).METHODS:BetweenAugust2000andMay2010,161patientswithGBMweretreatedwithradiotherapywithorwithoutconcurrenttemozolomide.PatientsweretreatedwithCTVexpansionsthatrangedfrom5to20mmusingashrinkingfieldtechnique.PatternsoffailureandtimetoprogressionandoverallsurvivalwerecomparedbasedonCTVmargin,useoftemozolomide,anduseofIMRT.KaplanMeieranalysiswasusedtoestimatesurvivaltimes,andχtestwasusedforcomparisonofcohorts.RESULTS:Forpatientstreatedwith5-,10-,and15-to20-mmCTV,79%,77%,and86%experiencedfailuresinthe60Gyvolume,respectively.Forty-eightpercent,55%,and66%ofpatientswith5-,10-,and15-to20-mmCTVexperiencedfailuresinthe46Gyvolume,respectively.Therewasnostatisticaldifferencebetweenpatientstreatedwith5-,10-,15-to20-mmmarginswithregardto60Gyfailure(P=0.76),46Gyfailure(P=0.51),ormarginalfailure(P=0.73).Eightypercentofpatientsreceivingtemozolomideexperiencedfailuresinthe60Gyvolume.TherewasnoincreasedlikelihoodofmarginalfailuresinpatientsreceivingIMRT(P=0.97).CONCLUSIONS:Moderntreatmenttechniquesincludinguseofconcurrenttemozolmide,limitedCTVmarginsize,andIMRThavenotgreatlychangedthepatternsoffailureofGBM.

简介：Objective:TheobjectiveofthisstudywastoexaminetheeffectofhypothyroidismonhearingfunctioninpatientssurgicallytreatedfordifferentiatedthyroidcancerandsubsequentlyexperiencedhypothyroidismduringpreparationforfollowupI-131scintigraphyscanbyeitherrecombinanthumanthyroidstimulatinghormone(rhTSH)treatmentorthyroidhormonewithdrawal(THW).Methods:Atotalof55patientsundergoingI-131scintigraphyscanfollowingsurgeriesfordifferentiatedthyroidcancerwereincludedinthestudy,including25patientspreparedbyadministrationofrecombinantTSH(rhTSHGroup)and30patientsbythyroidhormonewithdrawal(THWGroup).Results:Airconductionthresholdsat1,2and4kHzforbothearswerehigherduringhypothyroidperiodthanduringeuthyroidperiodforpatientsintheTHWgroup(p<0.05)butnotforpatientsintherhTSHgroup.Conclusion:Sensorineuralhearinglosswasdetected,especiallyatlowfrequencies,inpatientswithDTCaftersurgicaltreatmentwhosehormonereplacementtherapywaswithdrawnbutnotinthosereceivingrhTSH.ItisthereforepreferredtouserhTSHwhenpreparingforI-131scintigraphyscaninpatientsatriskforhearingloss.

简介：Background：Mathematicalmodelsproposeleglengthasalimitingfactorindeterminingthemaximumwalkingvelocity.Thisstudyevaluatedtheeffectivenessofaleglength-basedmodelinpredictingmaximumwalkingvelocityinanappliedracewalkingsituation,bycomparingexperiencedandnoviceracewalkersduringconditionswherestrictlynoflighttime（FT）waspermittedandinsimulatedcompetitionconditions（i.e.,FT〈40ms）.Methods：Thirty-fourparticipants（18experiencedandl6noviceracewalkers）wererecruitedforthisinvestigation.AnOptojumpNextsystem（8m）wasusedtodeterminewalkingvelocity,stepfrequency,steplength,groundcontacttime,andFTduringracewalkingoverarangeofvelocities.ComparisonsweremadebetweennoviceandexperiencedparticipantsinpredictedmaximumvelocityandactualvelocitiesachievedwithnoflightandvelocitieswithFT〈40ms.Thetechnicaleffectivenessoftheparticipantswasassessedusingtheratioofmaximumvelocitytopredictedvelocity.Results：Innovices,nosignificantdifferencewasfoundbetweenpredictedandmaximumwalkingspeedswithoutFTbuttherewasasmall5.8%gaininmaximumspeedwhenFT≤40ms.Inexperiencedracewalkers,therewasasignificantreductioninmaximumwalkingspeedcomparedwithpredictedmaximum（p〈0.01）anda11.7%gaininmaximumwalkingspeedwithFT〈40ms.Conclusion：Leglengthwasagoodpredictorofmaximalwalkingvelocityinnovicewalkersbutnotagoodpredictorofmaximumwalkingspeedinwell-trainedwalkerswhoappeartohaveoptimisedtheirwalkingtechniquetomakeuseofnon-visibleflightperiodsoflessthan40ms.Thegaininvelocityabovepredictedmaximummaybeausefulindexofracewalkingproficiency.

简介：Therearecurrentlynofederallyapprovedneuroprotectiveagentstotreattraumaticbraininjury.Progesterone,ahydrophobicsteroidhormone,hasbeenshowninrecentstudiestoexhibitneuroprotectiveeffectsincontrolledcorticalimpactratmodels.Aktisaproteinkinaseknowntoplayaroleincellsignalingpathwaysthatreduceedema,inflammation,apoptosis,andpromotecellgrowthinthebrain.ThisstudyaimstodetermineifprogesteronemodulatesthephosphorylationofAktviaitsthreonine308phosphorylationsite.Phosphorylationatthethreonine308siteisoneofseveralsitesresponsibleforactivatingAktandenablingtheproteinkinasetocarryoutitsneuroprotectiveeffects.ToassesstheeffectsofprogesteroneonAktphosphorylation,C57BL/6miceweretreatedwithprogesterone(8mg/kg)at1(intraperitonally),6,24,and48hours(subcutaneously)postclosed-skulltraumaticbraininjury.Thehippocampuswasharvestedat72hourspostinjuryandpreparedforwesternblotanalysis.TraumaticbraininjurycausedasignificantdecreaseinAktphosphorylationcomparedtoshamoperation.However,micetreatedwithprogesteronefollowingtraumaticbraininjuryhadanincreaseinphosphorylationofAktcomparedtotraumaticbraininjuryvehicle.Ourfindingssuggestthatprogesteroneisaviabletreatmentoptionforactivatingneuroprotectivepathwaysaftertraumaticbraininjury.

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简介：Ecologyisnotavery'old'science,withaboutonehundredyearsofhistory.Intheearlyperiod,thegeneralattitudewasthatthestudyofundisturbedecologicalsystemswillprovideuswithcluesofhowtheworldisorganised.Tounderstandthisworld,weshouldstudythe

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简介：在这份报纸，我们关于詹姆士常数考虑下列问题：什么时候做平等J(X*)为Banach空间X的=J(X)抓住？一个Banach空格的詹姆士常数不一般来说与它的双空间的与一致，这被知道。事实上，我们已经有与对称或绝对的标准被装备的二维的normed空格的反例。然而，我们看那二维的空间X上的标准是否对称、绝对，然后平等J(X*)=J(X)抓住。这在二维的盒子中提供一个全球答案给这个问题。

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