简介:Livermetastasessynchronouslyormetachronouslyoccurinapproximately50%ofcolorectalcancerpatients.Multimodalitycomprehensivetreatmentisthebesttherapeuticstrategyforthesepatients.However,theoptimalpatternofmultimodalitytherapyisstillcontroversial,anditraisesseveralsignificantconcerns.Liverresectionisthemostimportanttreatmentforcolorectallivermetastases.ThedefinitionofresectabilityhasshiftedtofocusonthecompletionofR0resectionandnormalliverfunctionmaintenance.Theroleofneoadjuvantandadjuvantchemotherapystillneedstobeclarified.Themanagementofeitherprogressionorcompleteremissionduringneoadjuvantchemotherapyischallenging.Theoptimalsequencingofsurgeryandchemotherapyinsynchronouscolorectallivermetastasespatientsisstillunclear.Conversionalchemotherapy,portalveinembolization,two-stageresection,andtumorablationareeffectiveapproachestoimproveresectabilityforinitiallyunresectablepatients.Severaltechnicalissuesandconcernsrelatedtothesemethodsneedtobefurtherexplored.Forpatientswithdefinitelyunresectableliverdisease,thenecessityofresectingtheprimarytumorisstilldebatable,andevaluatingandpredictingtheefficacyoftargetedtherapydeservefurtherinvestigation.Thisreviewdiscussesdifferentpatternsandimportantconcernsofmultidisciplinarytreatmentofcolorectallivermetastases.
简介:Anti-androgentherapyistheleadingtreatmentforadvancedprostatecancerandiscommonlyusedforneoadjuvantoradjuvanttreatment.Bicalutamideisanon-steroidalanti-androgen,usedduringtheinitiationofandrogendeprivationtherapyalongwithaluteinizinghormone-releasinghormoneagonisttoreducethesymptomsoftumor-relatedflaresinpatientswithadvancedprostatecancer.Assideeffects,bicalutamidecancausefatigue,gynecomastia,anddecreasedlibidothroughcompetitiveandrogenreceptorblockade.Additionally,althoughnotascommon,drug-inducedliverinjuryhasalsobeenreported.Herein,wereportacaseofhepatotoxicitysecondarytobicalutamideuse.Typically,bicalutamideinducedhepatotoxicitydevelopsafterafewdays;however,inthiscase,hepaticinjuryoccurred5moaftertreatmentinitiation.Basedonthisrarecaseofdelayedliverinjury,werecommendcarefulmonitoringofliverfunctionthroughoutbicalutamidetreatmentforprostatecancer.
简介:Qidong(Jiangsu,China)hasbeenofinteresttocancerepidemiologistsandbiologistsbecause,untilrecently,itwasanendemicareaforlivercancer,havingamongstthehighestincidenceratesintheworld.TheestablishmentoftheQidongCancerRegistrytogetherwiththeQidongLiverCancerInstitutein1972haschartedthepatternsoflivercancerincidenceandmortalityinastablepopulationthroughoutaperiodofenormouseconomic,social,andenvironmentalchangesaswellasofimprovementsinhealthcaredelivery.UpdatedincidencetrendsinQidongaredescribed.Notably,theChinaage-standardizedincidencerateforlivercancerhasdroppedbyover50%inthepastseveraldecades.MolecularepidemiologicandgenomicdeepsequencingstudieshaveaffirmedthatinfectionwithhepatitisBvirusaswellasdietaryexposuretoaflatoxinsthroughcontaminationofdietarystaplessuchascorn,andtomicrocystins–blue-greenalgaltoxinsfoundinditchandpondwater–werelikelyimportantetiologicfactorsthataccountforthehighincidenceoflivercancerinthisregion.PublichealthinitiativestofacilitateuniversalvaccinationofnewbornsagainstHBVandtoimprovedrinkingwatersourcesinthisruralarea,aswellaseconomicandsocialmandatesserendipitouslyfacilitatingdietarydiversity,haveledtoprecipitousdeclinesinexposurestotheseetiologicfactors,concomitantlydrivingsubstantivedeclinesinthelivercancerincidenceseennowinQidong.Inthisregard,Qidongservesasatemplatefortheglobalimpactthatapackageofinterventionstrategiesmayexertoncancerburden.
简介:Objective:TodetectdifferentialproteinexpressioninmalignantandnormallivercelllinesinvitrousingtheSELDIProteinChipplatform,forinvestigatingthepathogenesisoflivercancer.Methods:Twocelllines,humannormallivercelllineL02andhepatomacelllineSMMC-7721wereculturedroutinely,harvestedingoodconditionandlysed.Afterquantification,thesupernatantofthelysatewastestedbyIMAC3(ImmobilizedMentalAffinityCapture)andWCX2(WeakCationExchange)chipsontheSELDI-TOF-MSProteinChipreader.Results:Proteinexpressiondifferedbetweenthemalignantandnormallivercelllines.Atotalof20differentiallyexpressedproteinswerefound,amongwhich,7werecapturedbytheIMAC3chipand14bytheWCX2chip.Peaksat5,419,7,979and11,265Dawerehigherandat8,103,8,492,10,160and11,304DalowerinSMMC-7721cellsbytheIMAC3chip;peaksat7,517,7,945and7,979Dawerehigherandat5,061,5,551,5,818,7,439,9,401,10,100,10,312,11,621,11,662,11,830and12,772DalowerinSMMC-7721cellsbytheWCX2chip.Interestingly,bothchipscapturedthe7,979Dapeak.Inaddition,the11,081DapeakcorrespondedpreciselywiththemolecularmassofthecalciumbindingproteinS100A10,whichmayparticipateintheformationoflivercancerinassociationwithp36.Conclusion:DetectingdifferentialproteinexpressioninmalignantandnormallivercelllinesusingtheSELDIProteinChipplatformwassimple,sensitiveandrepeatable.Theresultsweobtainedcanserveasabasisforinvestigatingthepathogenesisoflivercancerandaidthediscoveryofnewtherapeutictargets.
简介:联合对的热绝缘的管料绳在充满井的蒸气内垮掉,在管料在高温度和高压力蒸气被使用大约二年以后。与进一步的支票,大多数在内部、外部的管料之间的焊接关节也裂开了,这被发现。为事故的失败分析被化学作文的分析为服务环境的钢,微观结构观察,机械性质测试,和调查执行了。对的热绝缘的管料绳的早损坏被苛性的压力腐蚀主要导致的结果表演,它能被联合的不稳定的微观结构加强很长时间在高温度满足了。而且,为周期的蒸气注射的热绝缘的管子上的高pre-压力设计可能不对蒸气泛滥的状况合适,它将导致裂开的焊接关节。(编辑作者摘要)6个裁判员。
简介:Reinstallationofmobilejack-uprigsnexttoexistingfootprintsisaproblematicoperationbecausethespudcanlocatednearthefootprintsissubjectedtoeccentricand/orinclinedloadingconditions.Geotechnicalcentrifugestudieshavemeasuredtheseloadsforcombinationsofchangingfootprintgeometry,footprintsoilpropertiesandtheoffsetofthereinstallationfromthefootprintcentre.Thesetestshavebeenoffullmodelspudcansinordertoaccuratelymeasurethecombinedloadsdeveloped.Theyhavenotprovidedinformationonthemechanismsoffailureoccurringduringthiscomplexinstallation.Observationsfromavisualisationtest,whereahalfspudcanispenetratedagainstatransparentwindowinageotechnicalcentrifuge,arereportedinthispaper.Themechanismsoffailureatdifferentstagesduringthepenetrationarepresented.
简介:在这篇文章,合成关节在把负担弄弯下面被调查。L预先形成是关于合成联合失败的批评部件。学习在在弯曲下面的合成联合结构装载使用纤维布拉格的碳纤维的失败察觉被介绍栅栏(FBG)传感器。第一,基于一般有限元素方法(女性)软件,3-D合成关节的有限元素(FE)模型被建立,并且失败进程和合成关节的每薄板失败负担被最大的压力标准调查。然后,沿着FBG的长度的紧张分布被提取,并且FBG的思考系列根据紧张分发是计算的。最后,验证数字结果,一个测试计划被执行,FBG的试验性的系列被记录。试验性的结果显示失败定序并且相应批评大量失败与数字预言一致,并且失败负担的计算错误是不到6.4%。而且,它也验证损坏察觉系统的可行性。
简介:Inthispaper,forzero-failuredata(ti,ni),atmomentti,ifthepriordistributionofthefailureprobabilitypi=P{T<ti}isincompleteFisher-Zdistribution:Fisher-Z(0,λi;a,b),theauthorgivespihierarchicalBiyesianestimationandtheestimationofreliabilityunderzero-failuredataconditionisobtainedalso.Theauthoralsogivesapracticalcalculatingexampleusingthetheory.
简介:StandardTherapyforHeartFailureUntilnowtheprincipalfocusofheartfailuretherapyhasbeenonthesympatheticnervoussystemandtherenin-angiotensinsystem.Betablockadecounterstheunwantedeffectsofcatecholaminesonthemyocardiumaswellasmoderatelyreducingafterload.Sinceangiotensinisavasoconstrictorandhassometoxiceffectonthemyocardium,bothcontributingtoheartfailure,inhibitionoftherenin–angiotensinsystemhasbeenlogicaltherapyforheartfailure.However,useofangiotensinconvertingenzyme(ACE)inhibitorsmayincreasebradykininlevels,whichareresponsibleforthecoughthatmaybeassociatedwiththeiruseaswellasangioedemathatmayresultfromthesamemedications.