简介：Livermetastasessynchronouslyormetachronouslyoccurinapproximately50%ofcolorectalcancerpatients.Multimodalitycomprehensivetreatmentisthebesttherapeuticstrategyforthesepatients.However,theoptimalpatternofmultimodalitytherapyisstillcontroversial,anditraisesseveralsignificantconcerns.Liverresectionisthemostimportanttreatmentforcolorectallivermetastases.ThedefinitionofresectabilityhasshiftedtofocusonthecompletionofR0resectionandnormalliverfunctionmaintenance.Theroleofneoadjuvantandadjuvantchemotherapystillneedstobeclarified.Themanagementofeitherprogressionorcompleteremissionduringneoadjuvantchemotherapyischallenging.Theoptimalsequencingofsurgeryandchemotherapyinsynchronouscolorectallivermetastasespatientsisstillunclear.Conversionalchemotherapy,portalveinembolization,two-stageresection,andtumorablationareeffectiveapproachestoimproveresectabilityforinitiallyunresectablepatients.Severaltechnicalissuesandconcernsrelatedtothesemethodsneedtobefurtherexplored.Forpatientswithdefinitelyunresectableliverdisease,thenecessityofresectingtheprimarytumorisstilldebatable,andevaluatingandpredictingtheefficacyoftargetedtherapydeservefurtherinvestigation.Thisreviewdiscussesdifferentpatternsandimportantconcernsofmultidisciplinarytreatmentofcolorectallivermetastases.

简介：有免疫力的记忆是适应免疫的特点。然而，最近的研究给那个生来的杀手(NK)看了房间，天生的免疫系统的关键部件，也调停在鼠标和人的存储器回答。惊人地，记忆NK房间是在一些模型的肝居民，提出肝是否是为NK房间记忆的获得的一个特殊机关的问题。这里，我们由总结最近的进步考察NK房间记忆的特征并且讨论肝怎么可以产生开始和记忆的召回阶段。我们建议肝可以为记忆NK房间有唯一的先锋，它从房间从骨头髓导出的NK是发展地不同的。

简介：Anti-androgentherapyistheleadingtreatmentforadvancedprostatecancerandiscommonlyusedforneoadjuvantoradjuvanttreatment.Bicalutamideisanon-steroidalanti-androgen,usedduringtheinitiationofandrogendeprivationtherapyalongwithaluteinizinghormone-releasinghormoneagonisttoreducethesymptomsoftumor-relatedflaresinpatientswithadvancedprostatecancer.Assideeffects,bicalutamidecancausefatigue,gynecomastia,anddecreasedlibidothroughcompetitiveandrogenreceptorblockade.Additionally,althoughnotascommon,drug-inducedliverinjuryhasalsobeenreported.Herein,wereportacaseofhepatotoxicitysecondarytobicalutamideuse.Typically,bicalutamideinducedhepatotoxicitydevelopsafterafewdays;however,inthiscase,hepaticinjuryoccurred5moaftertreatmentinitiation.Basedonthisrarecaseofdelayedliverinjury,werecommendcarefulmonitoringofliverfunctionthroughoutbicalutamidetreatmentforprostatecancer.

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简介：Qidong(Jiangsu,China)hasbeenofinteresttocancerepidemiologistsandbiologistsbecause,untilrecently,itwasanendemicareaforlivercancer,havingamongstthehighestincidenceratesintheworld.TheestablishmentoftheQidongCancerRegistrytogetherwiththeQidongLiverCancerInstitutein1972haschartedthepatternsoflivercancerincidenceandmortalityinastablepopulationthroughoutaperiodofenormouseconomic,social,andenvironmentalchangesaswellasofimprovementsinhealthcaredelivery.UpdatedincidencetrendsinQidongaredescribed.Notably,theChinaage-standardizedincidencerateforlivercancerhasdroppedbyover50%inthepastseveraldecades.MolecularepidemiologicandgenomicdeepsequencingstudieshaveaffirmedthatinfectionwithhepatitisBvirusaswellasdietaryexposuretoaflatoxinsthroughcontaminationofdietarystaplessuchascorn,andtomicrocystins–blue-greenalgaltoxinsfoundinditchandpondwater–werelikelyimportantetiologicfactorsthataccountforthehighincidenceoflivercancerinthisregion.PublichealthinitiativestofacilitateuniversalvaccinationofnewbornsagainstHBVandtoimprovedrinkingwatersourcesinthisruralarea,aswellaseconomicandsocialmandatesserendipitouslyfacilitatingdietarydiversity,haveledtoprecipitousdeclinesinexposurestotheseetiologicfactors,concomitantlydrivingsubstantivedeclinesinthelivercancerincidenceseennowinQidong.Inthisregard,Qidongservesasatemplatefortheglobalimpactthatapackageofinterventionstrategiesmayexertoncancerburden.

简介：Objective:TodetectdifferentialproteinexpressioninmalignantandnormallivercelllinesinvitrousingtheSELDIProteinChipplatform,forinvestigatingthepathogenesisoflivercancer.Methods:Twocelllines,humannormallivercelllineL02andhepatomacelllineSMMC-7721wereculturedroutinely,harvestedingoodconditionandlysed.Afterquantification,thesupernatantofthelysatewastestedbyIMAC3(ImmobilizedMentalAffinityCapture)andWCX2(WeakCationExchange)chipsontheSELDI-TOF-MSProteinChipreader.Results:Proteinexpressiondifferedbetweenthemalignantandnormallivercelllines.Atotalof20differentiallyexpressedproteinswerefound,amongwhich,7werecapturedbytheIMAC3chipand14bytheWCX2chip.Peaksat5,419,7,979and11,265Dawerehigherandat8,103,8,492,10,160and11,304DalowerinSMMC-7721cellsbytheIMAC3chip;peaksat7,517,7,945and7,979Dawerehigherandat5,061,5,551,5,818,7,439,9,401,10,100,10,312,11,621,11,662,11,830and12,772DalowerinSMMC-7721cellsbytheWCX2chip.Interestingly,bothchipscapturedthe7,979Dapeak.Inaddition,the11,081DapeakcorrespondedpreciselywiththemolecularmassofthecalciumbindingproteinS100A10,whichmayparticipateintheformationoflivercancerinassociationwithp36.Conclusion:DetectingdifferentialproteinexpressioninmalignantandnormallivercelllinesusingtheSELDIProteinChipplatformwassimple,sensitiveandrepeatable.Theresultsweobtainedcanserveasabasisforinvestigatingthepathogenesisoflivercancerandaidthediscoveryofnewtherapeutictargets.

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简介：一条狭窄的隧道或裂缝的开发由于就在早朝的库下面尖隧道被报导了有用在批评的头条件以外在头承受增加。另外，最大的裂缝长度被强调了直到基础宽度的一半。由就裂缝而言开发批评的头的一个模型，批评的头能仅仅在某些条件下面与裂缝长度的发展增加，这被发现。尖失败数据的分析显示就裂缝长度而言的批评的头表情为批评的头组成一个潜在地有用的模型。

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简介：热障碍涂层(TBC)通常由于他们散布机械性质和严重服务条件展出不明确的一生。考虑这些无常，一个可靠性评价方法基于失败概率分析被建议。首先，一个限制状态方程被建立界定在失败和安全区域之间的边界，然后失败概率由在失败区域的概率密度功能的集成是计算的根据一阶或秒顺序时刻。与界面的失败有关的参数在TBC的二种类型跟随Weibull分布，这被显示出。TBC的界面的失败被材料性质和温度落下的热失配显著地在服务影响。

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简介：在一台半导体设备构造一根相连的金属线的原子被电子流动在高密度搬运。这现象被称为electromigration，它可以引起线失败。以便描绘electromigration失败，比较研究被执行，一些典型现象为薄、大的结构由破裂力学对待。薄结构的一个例子，被破裂力学对待，是硅石为通讯系统的光纤维。在由electromigration的一根金属线的损坏生长在光纤维使遭到了到静态的疲劳的硅石与裂缝生长比较被描绘。另外，简短比较在大结构在electromigration失败和一些破裂现象之间被做。

简介：联合对的热绝缘的管料绳在充满井的蒸气内垮掉，在管料在高温度和高压力蒸气被使用大约二年以后。与进一步的支票，大多数在内部、外部的管料之间的焊接关节也裂开了，这被发现。为事故的失败分析被化学作文的分析为服务环境的钢，微观结构观察，机械性质测试，和调查执行了。对的热绝缘的管料绳的早损坏被苛性的压力腐蚀主要导致的结果表演，它能被联合的不稳定的微观结构加强很长时间在高温度满足了。而且，为周期的蒸气注射的热绝缘的管子上的高pre-压力设计可能不对蒸气泛滥的状况合适，它将导致裂开的焊接关节。(编辑作者摘要)6个裁判员。

简介：Reinstallationofmobilejack-uprigsnexttoexistingfootprintsisaproblematicoperationbecausethespudcanlocatednearthefootprintsissubjectedtoeccentricand/orinclinedloadingconditions.Geotechnicalcentrifugestudieshavemeasuredtheseloadsforcombinationsofchangingfootprintgeometry,footprintsoilpropertiesandtheoffsetofthereinstallationfromthefootprintcentre.Thesetestshavebeenoffullmodelspudcansinordertoaccuratelymeasurethecombinedloadsdeveloped.Theyhavenotprovidedinformationonthemechanismsoffailureoccurringduringthiscomplexinstallation.Observationsfromavisualisationtest,whereahalfspudcanispenetratedagainstatransparentwindowinageotechnicalcentrifuge,arereportedinthispaper.Themechanismsoffailureatdifferentstagesduringthepenetrationarepresented.

简介：在这篇文章，合成关节在把负担弄弯下面被调查。L预先形成是关于合成联合失败的批评部件。学习在在弯曲下面的合成联合结构装载使用纤维布拉格的碳纤维的失败察觉被介绍栅栏(FBG)传感器。第一，基于一般有限元素方法(女性)软件，3-D合成关节的有限元素(FE)模型被建立，并且失败进程和合成关节的每薄板失败负担被最大的压力标准调查。然后，沿着FBG的长度的紧张分布被提取，并且FBG的思考系列根据紧张分发是计算的。最后，验证数字结果，一个测试计划被执行，FBG的试验性的系列被记录。试验性的结果显示失败定序并且相应批评大量失败与数字预言一致，并且失败负担的计算错误是不到6.4%。而且，它也验证损坏察觉系统的可行性。

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简介：Inthispaper,forzero-failuredata(ti,ni),atmomentti,ifthepriordistributionofthefailureprobabilitypi=P{T＜ti}isincompleteFisher-Zdistribution:Fisher-Z(0,λi;a,b),theauthorgivespihierarchicalBiyesianestimationandtheestimationofreliabilityunderzero-failuredataconditionisobtainedalso.Theauthoralsogivesapracticalcalculatingexampleusingthetheory.

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简介：StandardTherapyforHeartFailureUntilnowtheprincipalfocusofheartfailuretherapyhasbeenonthesympatheticnervoussystemandtherenin-angiotensinsystem.Betablockadecounterstheunwantedeffectsofcatecholaminesonthemyocardiumaswellasmoderatelyreducingafterload.Sinceangiotensinisavasoconstrictorandhassometoxiceffectonthemyocardium,bothcontributingtoheartfailure,inhibitionoftherenin–angiotensinsystemhasbeenlogicaltherapyforheartfailure.However,useofangiotensinconvertingenzyme(ACE)inhibitorsmayincreasebradykininlevels,whichareresponsibleforthecoughthatmaybeassociatedwiththeiruseaswellasangioedemathatmayresultfromthesamemedications.