简介：AbstractBackground:Total ankle replacement (TAR) is a viable option for the treatment of end-stage ankle arthritis. In China, the INBONE-II implant is the only total ankle prosthesis approved since 2016. The purpose of this study is to report a large sample of findings for the TAR with INBONE-II prosthesis.Methods:A total of 64 patients with end-stage ankle arthritis, who underwent primary TAR using INBONE-II by the same surgeon from 2016 to 2019, at a single institution were included in this retrospective, single-center study. Clinical data, radiographic findings, survival rate, and complications were recorded and assessed pre-operatively and at the most recent follow-up.Results:A total of 64 patients were available for follow-up at least 2 years after surgery; the mean follow-up duration for clinical outcomes was 37.9 months (24–59 months), and for radiographic findings was 22.8 months (12–59 months). There were significant improvements (P < 0.01) in the American Orthopedic Foot and Ankle Society hindfoot scale, the visual analog scale for pain, and the Short Form-36. There were statistically significant differences between pre-operative and post-operative comparisons of the talar tilt angle (TT) and the tibial lateral surface angle (TLS) in the radiographic findings (TT from 4.7 ± 4.3° to 1.3 ± 1.3°, TLS from 80.4 ± 7.7° to 87.4 ± 2.3°, P < 0.01). There was no statistically significant difference in improvement of the tibial anterior surface angle (P = 0.14). Ten complications (all low grade) were recorded according to the Glazebrook classification system. The survivorship of the prosthesis was 100% (64/64).Conclusion:Patients who underwent TAR with INBONE-II prosthesis demonstrated significant improvements in all measures of pain and function as well as in radiographic findings. High survival and a low incidence of complications were observed in this study.

简介：Aperiodiclayeredmedium,withunitcellsconsistingofadielectricandanelectromagnetically-inducedtransparency(EIT)-basedatomicvapor,isdesignedforlightpropagationmanipulation.Consideringthatadestructivequantuminterferencerelevanttoatwo-photonresonanceemergesinEIT-basedatomsinteractingwithbothcontrolandprobefields,anEIT-basedperiodiclayeredmediumexhibitsaflexiblefrequency-sensitiveopticalresponse,whereaverysmallvariationintheprobefrequencycanleadtoadrasticvariationinreflectanceandtransmittance.ThepresentEIT-basedperiodiclayeredstructurecanresultincontrollableopticalprocessesthatdependsensitivelyontheexternalcontrolfield.Thetunableandsensitiveopticalresponseinducedbythequantuminterferenceofamulti-levelatomicsystemcanbeappliedinthefabricationofnewphotonicandquantumopticaldevices.Thismaterialwillalsoopenagoodperspectivefortheapplicationofsuchdesignsinseveralnewfields,includingphotonicmicrocircuitsorintegratedopticalcircuits.

简介：ThisworkprovidesacomprehensivetheoreticalanalysisofMHDunsteadyfreeconvectionviscoelasticfluidflowthroughaporousmedium.Themediumistreatedasincompressibleandopticallytransparent.Theflowofthefluidisinitiatedbyshearingactionofthemovingwallwithtimedependentsuction.Radiativeheatflowisconsideredintemperatureequation.Thecouplednonlinearproblemhasbeensolvedasymptotically.Approximatesolutionshavebeenobtainedforthemeanvelocity,meantemperatureusingmultiparameterperturbationtechnique.Theoriginalityofthepresentstudyistoinvestigatetheeffectofviscoelasticpropertyofthefluid(WaltersB?model)ontheflowandheattransferphenomenawhentheflowispermeatedthroughaporousmediumwithuniformporousmatrixsubjecttotransversemagneticfieldandtimedependentfluctuativesuctionattheboundarysurface.Thecaseofviscousflowhasbeendiscussedasaparticularcaseoncomparisonwiththeresultreportedearlieranditisingoodagreement.Flowreversalisindicatedincaseofviscoelasticfluidwithhighheatcapacityinthepresenceofmagneticfield.Thehighercoolingoftheplateincaseofviscoelasticflowalsocausesaflowreversal.

简介：Harmfulalgalblooms(HABs)haveledtoextensiveecologicalandenvironmentalissuesandhugeeconomiclosses.VariousHABcontroltechniqueshavebeendeveloped,andbiologicalmethodshavebeenpaidmoreattention.Algicidalbacteriaisageneraldesignationforbacteriawhichinhibitalgalgrowthinadirectorindirectmanner,andkillordamagethealgalcells.AmetabolitewhichisstronglytoxictothedinoflagellateAlexandriumtamarensewasproducedbystrainDH46ofthealga-lysingbacteriumAlteromonassp.Thecultureconditionswereoptimizedusingasingle-factortestmethod.Factorsincludingcarbonsource,nitrogensource,temperature,initialpHvalue,rotationalspeedandsalinitywerestudied.Theresultsshowedthatthecultivationofthebacteriaat28℃and180rmin-1withinitialpH7and30saltcontcentrationfavoredboththecellgrowthandthelysingeffectofstrainDH46.TheoptimalmediumcompositionforstrainDH46wasdeterminedbymeansofuniformdesignexperimentation,andthemostimportantcomponentsinfluencingthecelldensityweretryptone,yeastextract,solublestarch,NaNO3andMgSO4.Whenthefollowingculturemediumwasused(tryptone14.0g,yeastextract1.63g,solublestarch5.0g,NaNO31.6g,MgSO42.3gin1L),thelargestbacterialdryweight(7.36gL-1)wasobtained,whichwasanenhancementof107%comparedtotheinitialmedium;andthealgallysisratewasashighas98.4%whichincreasednearly10%afteroptimization.

简介：AbstractObjective:Collected human cumulus-oocyte complexes (COCs) are usually inseminated after 4 to 6 hours in in vitro fertilization (IVF) laboratories. The purpose of this study was to determine the effect of short-term pre-IVF incubation in culture medium on subsequent oocyte maturation, fertilization, and embryonic development, as well as clinical outcomes.Methods:Sixty patients were divided randomly into 2 groups, pre-IVF incubation for 5 hours: 1) with (+) the designed oocyte maturation medium; 2) without (-) the designed oocyte maturation medium (transferred directly to fertilization medium for 5 hours before insemination). Oocyte maturation and fertilization were assessed, and the rate of cleavage and good quality embryos were evaluated between the 2 groups on days 2 and 3, respectively. Blastocyst development was based on the remaining number of embryos on day 3, continuously cultured to day 5 after embryo transfer or frozen on day 3, and was compared between the 2 groups. Clinical pregnancy, implantation, and miscarriage rates were also compared.Results:Oocyte maturation rates did not differ between groups (85.8 ± 14.1% vs. 90.7 ± 9.1%). However, the range of oocyte maturation rates (58.3%-100.0%) for each patient was significantly higher in the (-) group than in the (+) pre-incubation group (71.4%-100.0%). There were no differences in fertilization rates (89.9 ± 10.0% vs. 86.5 ± 12.2%) and good quality embryos (70.8 ± 19.1% vs. 62.1 ± 23.7%) between groups; however, the blastocyst development rates were significantly different between groups (73.1 ± 20.1% vs. 58.8 ± 18.2%, P <0.05). Nevertheless, clinical pregnancy (62.5% vs. 61.1%) and implantation (46.9% vs. 47.2%) rates did not differ between groups.Conclusions:These results indicate that a short pre-IVF incubation time in the designed culture medium promotes oocyte maturation and embryonic development, suggesting that short pre-IVF incubation of COCs in the designed culture medium may be important for subsequent final oocyte maturation and early embryonic development.

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简介：Theinfluenceofinitialstrainstateonthedynamicresponseofanendbearingpileembeddedinisotropicsaturatedsoilisinvestigatedthroughthelinearizedtheoryofsmallelasticperturbationsuperposedonlargelystressedbodies.Thegoverningequationsforsoil,basedonBiot’sporoelasticitytheory,arederivedinthecylindricalcoordinates,andthepileismodeledbyusingtheone-dimensionalelastictheory.Theanalyticalsolutionsofpileimpedance,frequencyresponseofbothtwistangleandtimehistoryofvelocityresponseareobtainedbyusingofseparationofvariablestechnique.Finally,aparametricstudyoftheinfluenceofinitialstrainsonthetorsionalimpedance,twistangle,andvelocityresponseatthetopofthepileiscarriedout.

简介：SincethelowandmediumgradeoxideoresintheMainandEasternMiningAreasattheBayanOboMinehaveahighgradeofNb2O5andlargeorereservesandarerichinmanyelements,theyareofgreatervaluetouseindevelopmentandrecoverythanotherkindsofniobiummineralsresources.Thedisseminationcharacteristicsandprocessingpropertiesoffourtypesofniobiummineralsaresummarisedandmethodsandresultsofniobiummineralprocessingarealsodescribed.

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简介：Amutant(GQQ-M6)ofaSponge-Derivedstreptomycessp.GQQ-10obtainedbyUV-inducedmutationwasusedforproducingprodiginines(PGs).Singlefactorexperimentsandorthogonalarraydesign(OAD)methodswereemployedformediumoptimization.Inthesinglefactormethod,theeffectsofsolublestarch,glucose,soybeanflour,yeastextractandsodiumacetateonPGsproductionwereinvestigatedindividually.InthesubsequentOADexperiments,theconcentrationsofthese5keynutritionalcomponentscombinedwithsalinitywerefurtheradjusted.ThemutantstrainGQQ-M6gavea2.2-foldhigherPGsproductionthanthatoftheparentstrain;OADexperimentsofferedaPGsyieldof61mgL-1,whichwas10timeshigherthanthatoftheinitialGQQ-10strainundertheoriginalcultivationmode.

简介：Thispaperstudiesthethermal-diffusionanddiffusionthermo-effectsinthehydro-magneticunsteadyflowbyamixedconvectionboundarylayerpastanimpermeableverticalstretchingsheetinaporousmediuminthepresenceofchemicalreaction.Thevelocityofthestretchingsurface,thesurfacetemperature,andtheconcentrationareassumedtovarylinearlywiththedistancealongthesurface.Thegoverningpartialdifferentialequationsaretransformedintoself-similarunsteadyequationsusingsimilaritytransformationsandsolvednumericallybytheRunge-Kuttafourthorderschemeinassociationwiththeshootingmethodforthewholetransientdomainfromtheinitialstatetothefinalsteadystateflow.Numericalresultsforthevelocity,thetemperature,theconcentration,theskinfriction,andtheNusseltandSherwoodnumbersareshowngraphicallyforvariousflowparameters.Theresultsrevealthatthereisasmoothtransitionofflowfromunsteadystatetothefinalsteadystate.Aspecialcaseofourresultsisingoodagreementwithanearlierpublishedwork.

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简介：把压成薄片的弹性体的轴承广泛地在中国为small-to-medium-span高速公路桥被使用了，在哪个水泥砍钥匙横着被设置禁止大girder排水量。为了评估，更精确地衔接地震回答，轴承的合适的分析模型并且砍钥匙应该被开发。基于一系列周期的装载实验和分析，把压成薄片的弹性体的轴承的清醒的分析模型并且砍钥匙，能考虑机械降级，被开发。机械降级的效果被在大量山峰地面加速(针网阵列)下面在横向的方向检验一座small-to-medium-span桥的地震反应调查。为small-to-medium-span高速公路桥的损坏机制被决定，它能在最近的年里在地震期间解释地震损坏调查。把压成薄片的弹性体的轴承的机械性质将由于磨擦降级滑动的试验性的结果表演，而是减少的度依赖于影响参数。这能被结束把压成薄片的弹性体的轴承的机械降级并且砍钥匙在桥的地震反应起一个重要作用。把压成薄片的弹性体的轴承的机械性质的降级并且砍钥匙应该被包括评估更精确的桥牌地震性能。

简介：<正>Inthiswarmspringseason,IamhappytojoinallofyoufortheChinese-GermanSmallandMedium-sizedEntrepreneurs(SME)DialoguejointlysponsoredbyCAFIUandtheAdenauerFoundationofGermany.Weallknowthatthepastyearof2012wasthe40thanniversaryoftheestablishingofdiplomatic

简介：AbstractBackground:Pharmacological factors used to induce insulin resistance (IR) in in vitro models may not mimic the full in vivo features of type 2 diabetes mellitus (T2DM). This study aimed to examine the ability of diabetic serum (DS) to induce IR and investigate whether adipose-derived mesenchymal stem cell conditioned medium (ADMSC-CM) reverses DS-induced IR.Methods:DS was obtained from newly diagnosed T2DM patients. IR was induced in differentiated 3T3-L1 cells by employing dexamethasone, tumor necrosis factor alpha (TNF-α), palmitate and DS. Glucose uptake (2-[N-[7-nitrobenz-2-oxa-1,3-diazol-4-yl] amino]-2-deoxyglucose(2-NBDG) uptake assay), intracellular levels of reactive oxygen species (ROS), and superoxide radicals (O2-) (fluorescence microscopy and fluorometry) were analyzed in control and experimental samples. mRNA expression of key genes involved in glucose transport and inflammation were analyzed by using reverse transcription polymerase chain reaction (RT-PCR). Pro-inflammatory cytokines and phospho-insulin receptor substrate (IRS) (Ser-307) protein expression were analyzed by fluorescence activated cell sorter analysis. Statistical significance was determined by using one-way ANOVA followed by Tukey's multiple comparison tests.Results:ADMSC-CM significantly increased the DS-mediated decrease in 2-NBDG uptake (11.01 ± 0.50 vs. 7.20 ± 0.30, P < 0.01) and reduced DS-driven ROS (fluorescence count, 6.35 ± 0.46 vs. 9.80 ± 0.10, P < 0.01) and O2- (fluorescence count, 3.00 ± 0.10 vs. 4.60 ± 0.09, P < 0.01) production. Further, the ADMSC-CM restored DS-induced down regulation GLUT4 (1.52- fold, P < 0.05) as well as the up-regulation of PPARγ (0.35-fold, P < 0.01), and IKKβ (0.37-fold, P < 0.01) mRNA, and phospho-IRS (Ser-307) protein expression compared to the baseline (median fluorescence intensity, 88,192 ± 2720 vs. 65,450 ± 3111, P < 0.01). DS induced IR, similar to the traditionally used pharmacological factors, namely dexamethasone, TNF-α, and palmitate, which can be attributed to the significantly higher pro-inflammatory cytokines levels (TNF-α (2.28 ± 0.03 pg/mL vs. 2.38 ± 0.03 pg/mL, P < 0.01), interleukin 6 (IL)-6 (1.94 ± 0.02 pg/mL vs. 2.17 ± 0.04 pg/mL, P < 0.01), IL-17 (2.16 ± 0.02 pg/mL vs. 2.22 ± 0.002 pg/mL, P < 0.05), and interferon gamma (IFN-γ) (2.07 ± 0.02 pg/mL vs. 2.15 ± 0.04 pg/mL, P < 0.05)) in DS.Conclusions:DS can be explored as a novel inducer of IR in in vitro studies with further standardization, substituting the conventionally used pharmacological factors. Our findings also affirm the validity of ADMSC-CM as a prospective insulin sensitizer for T2DM therapy.

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简介：ThisstudysystematicallyreviewsandsummarizesrelocationandrevampingprojectofmediumandheavyplaterollingmillinBayiSteel.AfterdetailedanalysiswasmadeonthemaindeficiencyandproblemsoftheoriginalproductionlineofPudongSteel,systematicalintegrationandimprovementfortheprocessandequipmentwerecarriedoutaccordingly.Throughinnovativepracticeofintegration,BaosteelEngineeringhasgreatlyimprovedthetechnicalprocessandequipmentmake-up,aswellasthegradesandqualityoftheproducts.Theoriginalman-operatinglineisredesignedintoanautomaticsystemcontrolledbyLevel2computer,reachingtheadvancedtechnicallevelofhome-mademediumandheavyplateproductionlineinrecentyears.Theprojectisconstructedintwophases;TheoriginalproductmixofPudongSteelismaintainedasmuchaspossibleinPhaseI.After3500mmsinglestandfinishingmillisputintooperation,capacityofhot-rollingmediumandheavyplatereaches650000t/a,withthemaximumthicknessat40mm.Equipmentorfacilitiesarereservedforproductionofpipelinesteelandothergrades.Pipelinesteel,vesselplate,windpowerplateandotherTMCPandheattreatmentproductsareprojectedinPhaseⅡ.After4200mmroughingmillanditsmatchedfacilitiesareputintooperation,capacityofhot-rollingmediumandheavyplatewillreach120000t/a,withthemaximumthicknessat80mm.Throughtheoptimizationofprocessequipmentanditsfunction,therelocatedmediumandheavyplatemillproductionlinehasreachedadvancedlevelamongsimilardomesticmills.Theprominentachievementsoftheprojectaretherevampingofthicknesscontrolsystemofthefinishingmillandthenewlyinstalledshapecontrolsystem.Automationcontrolofthewholelineisrealized.

简介：AnewS-typeoferbium-ytterbiumco-dopedphosphateglasswaveguideamplifierintegratedwithcascadedmultilayermediumthinfilmfilterisproposed,thisS-typegeometrywaveguidestructureisusedtoachievealongpathinacompactchip,andobtainedhighergainwithlowerEr-dopedconcentration.Thecascadedmultilayermediumthinfilmfilterisutilizedtoachieveabroaderflatteninggainbandwidth.Theintrinsicalgainspectrumisobtainedbysolvingrateandpowerpropagationequations,theeffectoftransmittancespectrumofthinfilmfilteronflatteninggainisdiscussed.

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