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简介：AIM:Toinvestigatetheprevalenceandriskfactorsofdiabeticretinopathy(DR)innorthernChinesepatientswithtype2diabetesmellitus(T2DM).METHODS:Thisretrospectivecross-sectionalstudywasperformedbetweenMay2011andApril2012.Atotalof1100patients(male/female,483/617)wereincludedinthisstudy.DRwasdefinedfollowingtheEarlyTreatmentDiabeticRetinopathyStudy(ETDRS)severityscale.Allincludedpatientsacceptedacomprehensiveophthalmicexaminationincludingretinalphotographs.Logisticregressionmodelswereusedtoestimateoddsratios(ORs)and95%confidenceinterval(CI)afteradjustingforageandgender.RESULTS:Retinopathywaspresentin307patientswithaprevalenceof27.9%.Inunivariatelogisticanalysis,presenceofDRwasassociatedwithlongerdurationofdiabetes(OR,5.70;95%CI,2.91-12.56),higherconcentrationoffastingbloodglucose(OR,12.94;95%CI,2.40-67.71),higherlevelofglycosylatedhemoglobinHbA1c(OR,5.50;95%CI,3.78-11.97)andinsulintreatment(OR,6.99;95%CI,1.39-35.12).ThelifestyleofpatientswithT2DMincludingsmoking,alcoholconsumptionandregularexerciseseemednotassociatedwiththedevelopmentofDR.CONCLUSION:Ourstudysuggeststhatfastingserumglucoseconcentration,HbA1clevel,durationofdiabetesandinsulintreatmentarepotentialriskfactorsforDRinnorthernChinesepatientswithT2DM,whilethelifestyleofincludedpatientsseemsnotassociatedwithDR.

简介：Inordertolowerthepowerconsumptionandimprovethecoefficientofresourceutilizationofcurrentcloudcomputingsystems,thispaperproposestworesourcepre-allocationalgorithmsbasedonthe'shutdowntheredundant,turnonthedemanded'strategyhere.Firstly,agreencloudcomputingmodelispresented,abstractingthetaskschedulingproblemtothevirtualmachinedeploymentissuewiththevirtualizationtechnology.Secondly,thefutureworkloadsofsystemneedtobepredicted:acubicexponentialsmoothingalgorithmbasedontheconservativecontrol(CESCC)strategyisproposed,combiningwiththecurrentstateandresourcedistributionofsystem,inordertocalculatethedemandofresourcesforthenextperiodoftaskrequests.Then,amulti-objectiveconstrainedoptimizationmodelofpowerconsumptionandalow-energyresourceallocationalgorithmbasedonprobabilisticmatching(RA-PM)areproposed.Inordertoreducethepowerconsumptionfurther,theresourceallocationalgorithmbasedontheimprovedsimulatedannealing(RA-ISA)isdesignedwiththeimprovedsimulatedannealingalgorithm.Experimentalresultsshowthatthepredictionandconservativecontrolstrategymakeresourcepre-allocationcatchupwithdemands,andimprovetheefficiencyofreal-timeresponseandthestabilityofthesystem.BothRA-PMandRA-ISAcanactivatefewerhosts,achievebetterloadbalanceamongthesetofhighapplicablehosts,maximizetheutilizationofresources,andgreatlyreducethepowerconsumptionofcloudcomputingsystems.

简介：AIMTo与类型2糖尿病mellitus(T2DM)在中国病人的一个队调查在C反应的蛋白质(CRP)和糖尿病的retinopathy(医生)之间的关系基于.METHODSCommunity的观察的队学习。有1131个参加者，在城市的北京在Desheng社区从2009年11月招募到2011年9月。病人们诊断了T2DM被招募并且经历由一张问询表，眼睛、人体测量的检查和实验室调查组成的标准化评估。医生的存在和严厉由七个领域被估计30°；渲染宫底相片。题目然后没有医生，任何医生，或威胁视觉的克尔普博士被分类进组与T2DM从1007个病人全部的学习subjects.RESULTSA的浆液被分析为分析被包括，包括408(40.5%)男人并且599(59.5%)女人。中部的CRP水平为男人是为女人和1.1mg/L的1.5mg/L(P=0.004，或0.37，95%CI0.18-0.74)。在为可能的covariates调整以后，CRP的高水平与任何医生的更低的流行被联系(P=0.02，或0.55，95%CI0.35-0.89)，然而并非与威胁视觉的医生联系了(P=0.62，或0.78，95%CI0.28-2.14)。在由性的层化以后，在CRP和医生之间的反的协会被发现在男人统计上重要(P=0.006，或0.35，95%CI0.16-0.73)，然而并非在女人(P=0.58，或0.88，95%CI0.29-1.16)与T2DM从一张中国人口拉的.CONCLUSIONThe数据建议那增加的CRP层次可以相反地与医生的开发被联系。

简介：Objective:Totestforpre-attentiveauditorydiscriminationskillsinIndianclassicalvocalmusiciansandnon-musicians.Design:Mismatchnegativity(MMN)wasrecordedtotestforpre-attentiveauditorydiscriminationskillswithapairofstimuliof/1000Hz/and/1100Hz/,with/1000Hz/asthefrequentstimulusand/1100Hz/astheinfrequentstimulus.Onset,offsetandpeaklatenciesweretheconsideredlatencyparameters,whereaspeakamplitudeandareaunderthecurvewereconsideredforamplitudeanalysis.Studysample:Exactly50participants,outofwhichtheexperimentalgrouphad25adultIndianclassicalvocalmusiciansand25age-matchednon-musiciansservedasthecontrolgroup,wereincludedinthestudy.ExperimentalgroupparticipantshadaminimumprofessionalmusicexperienceinIndianclassicvocalmusicof10years.However,controlgroupparticipantsdidnothaveanyformaltraininginmusic.Results:Descriptivestatisticsshowedbetterwaveformmorphologyintheexperimentalgroupascomparedtothecontrol.MANOVAshowedsignificantlybetteronsetlatency,peakamplitudeandareaunderthecurveintheexperimentalgroupbutnosignificantdifferenceintheoffsetandpeaklatenciesbetweenthetwogroups.Conclusion:Thepresentstudyprobablypointstowardstheenhancementofpre-attentiveauditorydiscriminationskillsinIndianclassicalvocalmusicianscomparedtonon-musicians.ItindicatesthatIndianclassicalmusicaltrainingenhancespre-attentiveauditorydiscriminationskillsinmusicians,leadingtohigherpeakamplitudeandagreaterareaunderthecurvecomparedtonon-musicians.

简介：AIM:Todeterminethebowelsymptomsassociatedwithdiabetesanddiabetes-relatedfactorsafterexcludinggastrointestinal(GI)organicdiseases.METHODS:Participantswere4738(603diabeticand4135non-diabetic)patientswhounderwentcolonoscopyandcompletedaquestionnaire.Onthedayofpre-colonoscopy,9symptoms(borborygmus,abdominaldistension,increasedflatus,constipation,diarrhea,loosestools,hardstools,fecalurgency,andincompleteevacuation)wereprospectivelyevaluatedona7-pointLikertscale.Thetest-retestreliabilityofthebowelsymptomscoresfromthebaselineandsecondquestionnaireswasanalyzedusingkappastatistics.Associationsbetweenbowelsymptomscoresanddiabetesordiabetes-relatedfactorswereanalyzedbyarank-orderedlogisticmodeladjustedforrelatedconfounders,andoddsratios(ORs)wereestimated.RESULTS:Inmultivariateanalysis,constipation[adjustedoddsratio(AOR)=1.57,CI:1.33-1.85,P<0.01]andhardstools(AOR=1.56,CI:1.33-1.84,P<0.01)wereassociatedwithdiabetes,andfecalurgency(AOR=1.16,CI:0.99-1.37,P=0.07)andincompleteevacuation(AOR=1.16,CI:1.00-1.36,P=0.06)weremarginallyassociatedwithdiabetes.ThesesymptomsremainedassociatedevenafterexcludingorganicGIdiseasesoncolonoscopy.Test-retestreliabilityofsymptomscorewithameandurationof3.2mowasgood(meankappa,0.69).Associationsofsymptomswithdiabetes-relatedfactorswerefound;constipationwithHbA1c≥8.0%(AOR=2.11,CI:1.19-3.73),bodymassindex(BMI)<25(AOR=2.11,CI:1.22-3.66),andinsulinuse(AOR=1.90,CI:1.08-3.36);hardstoolswithdiabetesduration(AOR=1.03,CI:1.00-1.07);fecalurgencywithBMI<25(AOR=1.73,CI:1.00-2.98);andincompleteevacuationwithBMI<25(AOR=2.60,CI:1.52-4.43),serumcreatininelevel(AOR=1.27,CI:1.10-1.47),andinsulinuse(AOR=1.92,CI:1.09-3.38).CONCLUSION:Diabetesisassociatedwithconstipation,hardstools,fecalurgency,andincompleteevacuation,andpoorglycemiccontrol,duration,leanness,andnephropathyaffecttheriskofthesesymptoms.

简介：ExogenoussubstancePaccelerateswoundhealingindiabetes,butthemechanismremainspoorlyunderstood.Here,weestablishedaratmodelbyintraperitoneallyinjectingstreptozotocin.Fourwounds(1.8cmdiameter)weredrilledusingaself-madepunchontotheback,bilateraltothevertebralcolumn,andthentreatedusingamnioticmembranewithepidermalstemcellsand/orsubstanceParoundandinthemiddleofthewounds.Withthecombinedtreatmentthewound-healingratewas100%at14days.Withprolongedtime,typeIcollagencontentgraduallyincreased,yettypeIIIcollagencontentgraduallydiminished.Abundantproteingeneproduct9.5-andsubstanceP-immunoreactivenervefibersregenerated.Partialnervefiberendingsextendedtotheepidermis.ThetherapeuticeffectsofcombinedsubstancePandepidermalstemcellswerebetterthanwithamnioticmembraneandeitherfactoralone.OurresultssuggestthatthecombinationofsubstancePandepidermalstemcellseffectivelycontributestonerveregenerationandwoundhealingindiabeticrats.

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简介：DyeingofPETmaterialsbytraditionalmethodspresentsseveralproblems.Plasmatechnologyhasreceivedenormousattentionasasolutionfortheenvironmentalproblemsrelatedwithtextilesurfacemodifications,andtherehasbeenarapiddevelopmentandcommercializationofplasmatechnologyoverthepastdecade.Inthiswork,thesynergisticeffectofatmosphericpressureplasmaonalkalineetchinganddeepcoloringofdyeingpropertiesonpolyethyleneterephthalate(PET)fabricsandfilmswasinvestigated.ThetopographicalchangesofthePETsurfacewereinvestigatedbyatomicforcemicroscopy(AFM)images,whichrevealedasmoothsurfacemorphologyoftheuntreatedsamplewhereasahighsurfaceroughnessfortheplasmaand/oralkalinetreatedsamples.TheeffectsofatmosphericpressureplasmaonalkalineetchingofthestructureandpropertiesofPETwereinvestigatedbymeansofdifferentialscanningcalorimetry(DSC),themainobjectiveofperformingDSCwastoinvestigatetheeffectoftheplasmapre-treatmentontheT_gandT_m.UsingatensilestrengthtesterYG065HandfollowingastandardprocedurethemaximumforceandelongationatmaximumforceofPETmaterialswasinvestigated.Oxygenandargonplasmapre-treatmentwasfoundtoincreasethePETfabricweightlossrate.ThecolorstrengthofPETfabricswasincreasedbyvariousplasmapre-treatmenttimes.ThepenetrationofplasmaandalkalinereactivespeciesdeepintothePETstructureresultsinbetterdyeabilityandleavesasignificanteffectontheK/Svaluesoftheplasmapre-treatedPET.Itindicatedthatplasmapre-treatmenthasagreatsynergisticeffectwiththealkalinetreatmentofPET.

简介：Atypeofself-cleaningpre-coatedsteelsheetwithexcellentself-cleaningperformancewasdevelopedusinghydrophilicsurfacetreatmenttechnology.Tounderstandtheself-cleaningpropertiesofthispre-coatedsteelsheetinanindustrialenvironment,theJiangjinnaturalenvironmentalteststationwaschosenastheoutdoorexposuretesttobeconducted,andtheself-cleaningperformanceofthesteelsheetwasstudiedbymeasuringthewatercontactangle,stainresistancefactor,colordifference,andglossofthesteelsheetduringtheoutdoorexposuretest.Thewatercontactangleoftheself-cleaningsteelsheetquicklydecreasedfrom84°to29°duringtheoutdoorexposuretest,andthesteelsheetshowedexcellenthydrophilicproperties,whichwerebeneficialtothespreadofraindropsanddetrimentaltotheaccumulationofthesurfacepollutants.Afteranoutdoorexposureof12months,theself-cleaningsteelsheethadahigherstainresistanceandcleanersurfacethanthecomparisonsamplesheet,demonstratingitsexcellentself-cleaningproperties.Moreover,thecolordifferenceandglossrateoftheself-cleaningsteelsheetweresimilartothoseofthepre-coatedsteelsheetwithouthydrophilicsurfacetreatment.Therefore,thehydrophilicsurfacetreatmenttechnologyusedinthisstudydidnotaffecttheanti-agingpropertyoftheself-cleaningsteelsheet.

简介：Differentoxygenandnitrogencontainingfunctionalgroupswerecreatedonthesurfaceofthemultiwalledcarbonnanotubes.Themulti-walledcarbonnanotubesweretreatedinultrasonicbathwithsulfuricornitricacid.Furthermorethesurfacetexturewasmodifiedbyincreaseoftheroughness.Inparticularaftertreatmentwiththeoxidizingnitricacid,incomparisontotheH_2SO_4orultra-sonictreatedsamples,cratersandedgesaredominatingthesurfacestructures.Manganeseoxidewasdepositedonthemultiwalledcarbonnanotubesbyprecipitationmechanism.Variousmanganeseoxidesareformedduringthedepositionprocess.Thesampleswerecharacterizedbyelementalanalysis,microscopy,thermalanalysis,Ramanspectroscopy,andbythezetapotentialaswellasX-raydiffractionmeasurements.Itwasshownthatthedepositedmanganeseoxidesarestabilizedratherbysurfacetextureofthemulti-walledcarbonnanotubesthanbycreatedfunctionalgroups.

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简介：Thequestforneuroprotectivedrugstoslowtheprogressionofneurodegenerativediseases(NDDs),includingAlzheimer'sdisease(AD),Parkinson'sdisease(PD),andHuntington'sdisease(HD),hasbeenlargelyunrewarding.Preclinicalevidencesuggeststhatrepurposingquetiapine,lithium,valproate,fluoxetine,donepezil,andmemantineforearlyandpre-symptomaticdisease-modificationinNDDsmaybepromisingandcanspareregulatorybarriers.Theliteratureofthesepsychotropicsinearlystageandpre-symptomaticAD,PD,andHDisreviewedandpropitiousfindingsfollow.Mildcognitiveimpairment(MCI)phaseofAD:salutaryhumanrandomizedcontrolledtrialfindingsforlow-doselithiumand,inselectedpatients,donepezilawaitreplication.Pre-symptomaticAD:humanepidemiologicaldataindicatethatlithiumreducesADrisk.Animalmodelstudies(AMS)revealencouragingresultsforquetiapine,lithium,donepezil,andmemantine.EarlyPD:valproateAMSfindingsshowpromise.Pre-symptomaticPD:lithiumandvalproateAMSfindingsareencouraging.EarlyHD:uncontrolledclinicaldataindicatenon-progressionwithlithium,fluoxetine,donepezil,andmemantine.Pre-symptomaticHD:lithiumandvalproateareauspiciousinAMS.Manyotherpromisingfindingsawaitingreplication(valproateinMCI;lithium,valproate,fluoxetineinpre-symptomaticAD;lithiuminearlyPD;lithium,valproate,fluoxetineinpre-symptomaticPD;donepezilinearlyHD;lithium,fluoxetine,memantineinpre-symptomaticHD)arereviewed.Dose-andstage-dependenteffectsareconsidered.Suggestionsforsignal-enhancementinhumantrialsareprovidedforeachNDDstage.

简介：在华南的Dajiangbian形成是统治siliciclastic的沉积继任，低档变态在卡赛西亚·布洛克的西方的边缘上扔了，并且被glaciogenicdiamictite(Sizhoushan形成)盖住。Sizhoushanglaciogenic阶层能被归因于Jiangkou冰川(Sturtian冰川)他们在华南与Jiangkou阶层分享stratigraphic和lithological类似的事件。在整个Dajiangbian形成的上面的部分的一些碳酸盐，燧石和页岩单位为碳酸盐碳同位素被取样(13Ccarb)和器官的碳同位素(13Corg)分析。geochemical的一个范围索引包括氧同位素(18O)并且Mn/Sr(Fe/Sr)比率建议主要的碳同位素价值在上面的Dajiangbian形成被保存。上面的Dajiangbian形成表演13C向上减少向的-0.1,的carb到-5.4。我们建议否定13在Sizhoushandiamictite下面的C旅行是有Pre-SturtianIslay13Ccarb异例并且与全球Neoproterozoic同位素地层学允许关联。我们发现碳酸盐和上面的Dajiangbian形成的器官的碳同位素数据被联合，与13Ccarb-13C在多重大陆上观察的org模式。

简介：AD-8Pre／AD-8P是天逸电子历经3年时间精心打造的旗舰级Hi—End前后级放大器，天逸将20多年在Hi—End功放方面的全部技术与经验都倾注于这款产品的设计之中。精心打磨与调校了3年，如今它将以项级Hi—end发烧器材身份震撼入市，希望能带给发烧友最极致的音乐享受。

简介：BackgroundMonocytetohighdensitylipoproteinratio(MHR)hasbeenconsideredasanovelparameterrelatedwithadverserenalandcardiovascularoutcomes.InthisstudyweinvestigatedtheassociationofMHRwithmajoradverseclinicalevents(MACEs)inpatientswithtype2diabetesmellitus(T2DM)undergoingelectivepercutaneouscoronaryintervention(PCI).MethodsConsecutiveT2DMpatientstreatedwithelectivePCIwereprospectivelyrecruitedbetweenJuly2008-January2016inDepartmentofCardiologyofPanyuCentralHospital.Subjectswerecategorizedintotwogroups:aspatientswhodevelopedMACEs(MACEs+)andpatientswhodidnotdevelopMACEs(MACEs-)duringhospitalization.MACEsweredefinedasthecompositeendpoints,includingall-causemortality,oracuteheartfailure,ortargetvesselrevascularization,orstrokeorrecurrentangina.ResultsAtotalof418patientswereincludedinthestudy.64patientsdevelopedMACEs(15.3%).IntheMACEs(+)patients,monocyteswerehigher(1.12[0.78-1.42]vs.0.72[0.68-0.92]109/L,P<0.01)andHDLcholesterollevelswerelower(0.87[0.72-1.21]vs.0.96[0.81-1.11]mmol/L,P<0.01).Inaddition,MHRwassignificantlyhigherintheMACEs(+)group(1.12[0.91-2.09]vs.0.73[0.54-0.93]109mmol/L,P<0.01).ThecutoffvalueofMHRforpredictingMACEswas22,withasensitivityof81%andaspecificityof75.1%(areaunderthecurve0.79,P<0.001).Inmultivariatelogisticregressionanalysis,MHRremainedanindependentfactorcorrelatedwithMACEs(OR=3.97,95%CI=1.38-11.5,P<0.01).ConclusionHigherMHRlevelsmaypredictMACEsdevelopmentafterelectivePCIinT2DMpatients.

简介：BackgroundTheearlyendothelialdysfunctionofcarotidarteryinpatientswithtype2diabetesmellitus(T2DM)hasbeenrecognized.However,thefeasibilityandsignificanceofcarotidarteryendothelialdysfunctiondetectedbyultrasoundradio-frequencytechnologyhasbeenseldomstudied.MethodsThe2Dultrasoundimagesofthebilateralcommoncarotidarteriesfrom112casesofT2DMpatientsand50casesofnormalsubjectsinourhospitalwerecollectedtomeasureintima-mediathicknessmeans(IMTm),end-systolicinnerdiameter(Ds),end-diastolicinnerdiameter(Dd),resistanceindex(RI),pulseindex(PI),andthesystole/diastoleratio(S/D).Wealsoobservedthevariationoftheintima-mediathickness(IMT)aswellastheelasticityindexesofthecommoncarotidartery,suchasthecompliancecoefficient(CC),elasticitycoefficient(β),pulsewavevelocity(PWV)andaugmentationindex(AIx)throughinstrumentswithbuilt-inultrasoundradio-frequencytechniques,includingquantitativeintima-mediathickness(QIMT)andquantitativeanalysisofarterialstiffness(QAS).Thedifferencesoftheabove-mentionedparametersbetweenthetwogroupswereanalyzed.ResultsTherewerenostatisticallysignificantdifferencesinIMTm,Ds,Dd,RI,PIandS/DraitoofthecommoncarotidarteriesbetweengroupT2DMandthenormalgroup(P>0.01).Theβ,PWVandAIxingroupT2DMwereremarkablyhigherthanthoseinthecontrolgroup,withCCvaluebeingsignificantlylowerthanthelater(P<0.01or0.05).ConclusionUltrasoundradio-frequencytechniqueoffersearlierandmoreeffectiveevaluationofcarotidarteryendothelialdysfunctioninT2DMpatientswhencomparedwithconventional2Dultrasound,establishingimagingfoundationfortheearlypreventionandtreatmentofcardio-cerebrovascularcomplicationsinT2DMpatients.

简介：刊登于国际杂志Diabetes上的一篇研究报告中，来自邓迪大学的研究人员通过研究发现，曾经被批准用于治疗2型糖尿病的新一代药物，在不需要与二甲双胍结合使用时或许会更加有效；这三种名为坎格列净（canagunozin）、达格列净（Dapagliflozin）和依帕列净（EmpagHnozin）的可以抑制钠一葡萄糖共转运体2（SGLT2）的新一代药物在过去两年里，在欧洲和美国被批准用于作用2型糖尿病的新型疗法。