简介：摘要新型社区急需专业人才进行健康教育和管理。其中，全科医生具有明显的人才优势特征。总结以往全科医生作为专业健康管理人才在社区开展SARS健康教育，充分利用这一群体的专业优势，掌握和运用健康教育和健康促进的基本方法和规律，不断提高社区群众对疫情的认知和防范能力。实践证明，利用健康管理人才，能成功有效地控制和战胜不特定的疫情是必不可少的重要手段和利器。

简介：目的通过生物信息学与合成多肽方法,寻找SARS-CoVS蛋白的抗原表位,为抗SARS多肽疫苗的深入研究提供试验依据.方法利用网络共享软件对与S蛋白抗原性相关的参数进行预测分析,从而设计S蛋白的抗原表位多肽;将合成的抗原表位多肽免疫家兔,用ELISA法检测产生的抗体.结果ELISA法检测发现,设计合成的2个抗原表位多肽片段(残基348-380,434-470)在家兔体内均能诱导抗体产生.结论设计合成的2个抗原表位多肽片段中包含SARS-CoVS蛋白的抗原表位,免疫家兔后能产生特异性抗体.

简介：摘要Coronavirus disease 2019 (COVID-19) is a contagious infection disease, which may cause respiratory, physical, psychological, and generalized systemic dysfunction. The severity of disease ranges from an asymptomatic infection or mild illness to mild or severe pneumonia with respiratory failure and/or death. COVID-19 dramatically affects the pulmonary system. There is a lack of knowledge about the long-term outcomes of the disease and the possible sequelae and rehabilitation. This clinical practice guideline includes pulmonary rehabilitation (PR) recommendations for adult COVID-19 patients and has been developed in the light of the guidelines on the diagnosis and treatment of COVID-19 provided by the World Health Organization and Republic of Turkey, Ministry of Health, recently published scientific literature, and PR recommendations for COVID-19 regarding basic principles of PR. In this guideline, the contagiousness of COVID-19, recommendations on limited contact of patient with healthcare providers, and the evidence about possible benefits of PR were taken into consideration.

简介：AbstractThe novel betacoronavirus (Severe Acute Respiratory Syndrome Coronavirus 2, SARS-CoV-2) is a pathogen that causes deadly respiratory disease named coronavirus disease 2019 (COVID-19). The incidence of this disease has increased in the last few months affecting 257,832,881 people in 221 countries and 51,68,069 deaths worldwide according to Worldometer at 04:03 GMT on November 22, 2021. Thus, the emergence of this disease creates a challenge for health care providers in handling this pathogen and reducing its risk of transmission. In developing countries, this virus is treated in biosafety level 2 laboratories, where a high concentration of pathogen can easily affect the laboratory staff and cause the spread of this disease. Based on the epidemiology and characteristics of the SARS-CoV-2 virus already discussed in recent studies, we will provide biosafety guidelines and suggestions for safe handling and transportation of the SARS-CoV-2 virus in dealing with the current pandemic situation with a focus on increased infectivity of emerging new variants.

简介：AbstractIndirect effects of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic are difficult to calculate. Fear of intrahospital infection has led to a decrease in the use of emergency services and the performance of elective procedures. Several low- and middle-income countries have seen the number of institutional deliveries reduced, even in the absence of a follow-up program for home births. We present the case of a patient with adequate prenatal care and an institutional delivery plan who, due to the SARS-CoV-2 pandemic, chose to have a home delivery with unsafe conditions. The lack of supervision by health personnel and the absence of an immediate consultation plan facilitated the presentation of postpartum hemorrhage and poor neonatal results. Little attention has been paid during the pandemic to pregnant women who decide to have their birth at home. A broad discussion is necessary in this regard, to regain the confidence of the population and strengthen institutional births, or to strengthen midwife-assisted home births programs. Patients’ fear to acquiring SARS-CoV-2 infection inside hospitals is a factor that must be taken into account in prenatal care programs.

简介：目的：研究SARS冠状病毒（SARS-CoV）N蛋白与CYP4F3的相互作用。方法：应用免疫共沉淀、GST—pulldown、BIACORE实验验证SARS—CoVN蛋白与CYP4F3的相互作用。结果：SARS—CoVN蛋白与CYP4F3能够相互作用，BIA-CORE实验证实CYP4F3与SARS—CoVN蛋白的亲和常数为Ko=4．3×10^-11。结论：SARS—CoVN蛋白与CYP4F3在细胞内、外均能形成复合物，这为进一步探讨SARS—CoVN蛋白在SARS致病机理中的作用奠定了基础。

简介：SARS也称为严重急性呼吸综合征。对SARS恢复期医护人员进行认知记忆功能方面的研究，及早发现轻度认知障碍（MCI），对早期进行护理干预有着重要的意义。记忆学习是大脑的高级功能活动，是认知功能重要组成部分。研究发现，年龄匹配、具有相同文化背景的SARS患者的形象再认记忆和理解记忆能力均有所下降。了解SARS恢复期患者的记忆功能，可为及早进行护理干预提供依据。本研究对北京3家医院32例SARS患者和35例对照，自2003年8月-2004年8月进行随访，通过护理，提高医护人员的认知水平，现报道如下。

简介：AbstractBackground:Practitioners and researchers in the midst of overwhelming coronavirus disease 2019 (COVID-19) outbreaks are calling for new ways of looking at such pandemics, with an emphasis on human behavior and holistic considerations. Viral outbreaks are characterized by socio-behaviorally-oriented public health efforts aimed at reducing exposure and prevention of morbidity/mortality once infected. These efforts involve different points-of-view, generally, than do those aimed to understand the virus' natural history. Rampant spread of SARS-CoV-2infection in cities clearly signals that urban areas contain conditions favorable for rapid transmission of the virus.Main text:The Critical Medical Ecology model is a multidimensional, multilevel way of viewing pandemics comprehensively, rooted simultaneously in microbiology and in anthropology, with shared priority for evolution, context, stressors, homeostasis, adaptation, and power relationships. Viewing COVID-19 with a Critical Medical Ecological lens suggests three important interpretations: 1) COVID-19 is equally — if not more — a socially-driven disease as much as a biomedical disease, 2) the present interventions available for primary prevention of transmission are social and behavioral interventions, and 3) wide variation in COVID-19 hospitalization/death rates is not expected to significantly be attributable to a more virulent and rapidly-evolving virus, but rather to differences in social and behavioral factors — and power dynamics — rather than (solely) biological and clinical factors. Cities especially are challenged due to logistics and volume of patients, and lack of access to sustaining products and services for many residents living in isolation.Conclusions:In the end, SARS-CoV-2 is acting upon dynamic social human beings, entangled within structures and relationships that include but extend far beyond their cells, and in fact beyond their own individual behavior. As a comprehensive way of thinking, the Critical Medical Ecology model helps identify these elements and dynamics in the context of ecological processes that create, shape, and sustain people in their multidimensional, intersecting environments.

简介：目的建立SARS患者红细胞天然免疫粘附功能的快速检测方法，探讨天然免疫清除功能在评估SARS病情发展变化中的意义。方法红细胞天然免疫粘附功能快速检测方法：将lμl离心沉淀的红细胞和100μ1自身血浆与150μl定量的靶细胞混合，37℃水浴30min。1个结合5个或以上红细胞的靶细胞为一个粘附功能单位，计算粘附率。结果临床确诊为SARS的病人在收住院一周内其红细胞天然免疫粘附功能即不同程度地下降，并且随病情的加重持续降低，随病情好转开始回升，在完全恢复期出现一过性地高于正常人平均水平。随后稍有下降；死亡前病人的红细胞天然免疫粘附功能全部消失。结论红细胞天然免疫粘附功能快速检测方法操作简单、重复性和稳定性好，可作为临床动态观察SARS病情发展变化、疗效评估及预后判断的重要参考指标。

简介：摘要目的探讨新型冠状病毒（severe acute respiratory syndrome coronavirus 2，SARS-CoV-2）非结构蛋白1（nonstructural protein 1，NSP1）对I型干扰素（type I interferon，IFN-I）应答的影响及其作用机制。方法为研究SARS-CoV-2的NSP1对I型IFN产生的影响，构建NSP1表达质粒，并通过免疫荧光检测其蛋白表达能力。通过双荧光素酶报告基因实验检测NSP1对IFN-β启动子激活的作用。构建NSP1突变体M1（K163AH164A）和M2（△161-180），验证突变位点对IFN-β启动子激活的影响。结果NSP1显著抑制维甲酸诱导基因蛋白I、黑色素瘤分化相关蛋白5、线粒体抗病毒信号蛋白、TANK结合激酶1、干扰素调节因子3、干扰素调节因子7诱导的下游IFN-β启动子的激活，并对I型IFN通路的各关键分子的蛋白表达具有抑制作用，NSP1 C端的KH基序是其发挥抑制作用的关键位点。结论SARS-CoV-2 NSP1能够拮抗宿主I型干扰素免疫应答，实现病毒的天然免疫逃逸。

简介：

简介：

简介：目的研究SARS患者呼吸困难的发生发展与院前及入院时基本情况的关系.方法用统计学方法对115例SARS患者进行回顾性分析.结果不同程度呼吸困难患者院前最高体温、主诉天数及入院时呼吸频率有显著性差异,而入院时体温与呼吸困难不相关.结论可以从患者早期情况预测其呼吸困难发展趋势,及早就医、早期用药是减轻症状、缓解病情的重要措施.

简介：

简介：严重急性呼吸道综合征(SevereAcuteRespiratorySyndrome，SARS)是SARS新型冠状病毒(SARS-Coronaryvirus，SARS—CoV)引起的疾患，也是人类21世纪初面临的挑战性新感染性疾病。因其密切接触传染性、部分病例重症趋势及较高的病死率很快引起了全球的重视。高龄，基础疾病，吸……

简介：本文通过建立中国入境旅游外汇收入的SARIMA模型，定量分析了SARS对中国入境旅游收入的影响程度及影响时滞，克服了采用传统“同期比”方法分析该问题时不考虑旅游业自身发展趋势的不足，以期能得到关于SAILS对中国入境旅游收入影响的客观认识。

简介：一阵毒风欢过，号称第三产业中免疫力最强的房地产终于也打熬不住，接连几个响亮的喷嚏告诉人们，面对SARS，谁都不可能置身事外，即使你是暴利行业，即使你曾孵化出上百个中国富豪并且还继续孵化着。

简介：摘要研发安全有效的疫苗是预防、控制COVID-19流行的当务之急。本文综述严重急性呼吸综合征冠状病毒(SARS-CoV)和中东呼吸综合征冠状病毒(MERS-CoV)疫苗研究的进展和存在的问题，为同属β冠状病毒属的新型冠状病毒(2019-nCoV)疫苗研究提供借鉴。

简介：当人们利用科学技术去征服SARS病魔并取得不断胜利的同时，有关SARS的专利争夺战也在不断升温，这引起了很大的争论；在保护药品专利权人合理利益的同时如何限制其权利滥用，成为亟待解决的制度难题。WTO总理事会8月30日通过的《关于TRIPS协议和公共健康的多哈宣言第六段的执行决议》为笔者思考这一问题提供了思路。本文从SARS疫情与专利争夺战的事实描述出发，分析SARS专利的正效应及其社会成本以论证该权利限制的必要性，再从强制许可的角度讨论权利限制的可操作性，最后提出了我国针对SARS专利应采取的对策建议。

简介：<正>用酶联免疫吸附测定(ELISA)检测57例正常人、127例在SARS病房工作1个月的医护人员和73例不同病程SARS患者血浆抗SARS冠状病毒IgG抗体的水平。结果:正常人和医护人员血浆中尚未检测到抗SARS冠状病毒IgG抗体。SARS患者发病第0-7、8-10、11-14、15-20天后血浆中抗SARS冠状病毒IgG抗体的阳性率分别为0、33％、52％和86％,总阳性率为61％。提示ELISA检测血浆中抗SARS冠状病毒IgG抗体的特异