简介：通过分析运用温病理论治疗上海市8例SARS患者的临床资料,认为SARS属中医温病范畴,病因以疫毒时邪为主,流通渠道为分邪与透邪,用药不可过于寒凉,甘寒之中配入咸寒,以及肺与大肠相表里理论在治疗中的应用.

简介：Thecorona-likespikesorpeplomersonthesurfaceofthevirionunderelectronicmicroscopearethemoststrikingfeaturesofcoronaviruses.TheS(spike)proteinisthelargeststructuralprotein,with1,255aminoacids,intheviralgenome.Itsstructurecanbedividedintothreeregions:alongN-terminalregionintheexte-rior,acharacteristictransmembrane(TM)region,andashortC-terminusintheinteriorofavirion.WedetectedfifteensubstitutionsofnucleotidesbycomparisonswiththeseventeenpublishedSARS-CoVgenomesequences,eight(53.3%)ofwhicharenon-synonymousmutationsleadingtoaminoacidalternationswithpredictedphysiochemicalchanges.ThepossibleantigenicdeterminantsoftheSproteinarepredicted,andtheresultisconfirmedbyELISA(enzyme-linkedimmunosorbentassay)withsynthesizedpeptides.AnotherprofoundfindingisthatthreedisulfidebondsaredefinedattheC-terminuswiththeN-terminusoftheE(envelope)pro-tein,basedonthetypicalsequenceandpositions,thusestablishingthestructuralconnectionwiththesetwoimportantstructuralproteins,ifconfirmed.Phyloge-neticanalysisrevealsseveralconservedregionsthatmightbepotentdrugtargets.

简介：SARS疫情将打击中国大陆经济成长。自2002年首次发现，SARS已成为影响全球的严重疫病，中国大陆地区尤属重灾区。截至5月6日，中国内地报告SARS病例累计已达4，409例，死亡214例，另有2，646例为疑似病例，短期内尚无疫情完全控制的迹象。

简介：AbstractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viruses spread unscrupulously virtually every corner on the planet in a very quick speed leading to an unprecedented world pandemic of COVID-19 claiming a great many of people’s life. Paramount importance has been given to the studies on the virus itself including genomic variation and viron structure, as well as cell entry pathway and tissue residence. Other than that, to learn the main characteristic of host immunity responding to SARS-CoV-2 infection is an eminent task for restraining virus and controlling disease progress. Beside antibody production in response to SARS-CoV-2 infection, host cellular immunity plays an indispensable role in impeding virus replication and expansion at various stages of COVID-19 disease. In this review, we summarized the recent knowledge regarding the aberrant regulation and dysfunction of multiple immune cells during SARS-CoV-2 infection. This includes the dysregulation of immune cell number, Th polarity, cytokine storm they implicated with, as well as cell function exhaustion after chronic virus stimulation. Notwithstanding that many obstacles remain to be overcome, studies on immunotherapy for COVID-19 treatment based on the known features of host immunity in response to SARS-CoV-2 infection offer us tangible benefits and hope for making this SARS-CoV-2 pandemic under control.

简介：Inthefirsttowmonthsofthisyear,Chineseaviationindustryhadmadeagoodbeginning,withthevolumeofpassengertransportationincreasingby11%comparedwiththesameperiodoflastyear.Ifthesituationcangoonlikethis,

简介：面前摆放着一本2003年5月5号的美国时代周刊，“SARS的真相”、“为何病毒扩散传播”，“中国的隐瞒”、“该如何害怕?”的字样配上老外戴着口罩的照片构成了整个封面。美国CDC报告美国本土SARS病列由5月初的40上升到20号的353个，在短短2周内上升了9倍，说来也有些可怕，但相比国内数以千计SAILS确诊病例，美国的个位数相对让人轻松许多。

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简介：SincetheoutbreakofaSARSepidemiclastyear,significantadvanceshavebeenmadeonourunderstandingofthemechanismsofinteractionbetweentheSARScoronavirus(CoV)andtheimmunesystem.StronghumoralresponseshavebeenfoundinmostpatientsfollowingSARS-CoVinfection,withhightitersofneutralizingAbspresentintheirconvalescentsera.Thenucleocapsid(N)andspike(S)proteinsofSARS-CoVappeartobethedominantantigensrecognizedbyserumAbs.CD4+TcellresponsesagainsttheNproteinhavebeenobservedinSARSpatientsandanHLA-A2-restrictedcytotoxicTlymphocyteepitopeintheSproteinhasbeenidentified.ItislikelythattheimmuneresponsesinducedbySARS-CoVinfectioncouldalsocausepathologicaldamagetothehost,especiallyinthecaseofproinflammatorycytokines.ThereisalsoevidencesuggestingthatSARS-CoVmightbeabletodirectlyinvadecellsoftheimmunesystem.OurunderstandingontheinteractionbetweenSARS-CoV,theimmunesystemandlocaltissuesisessentialtofuturediagnosis,controlandtreatmentofthisverycontagiousdisease.

简介：目的探村SARS对大学生心身健康的影响及规律。方法采用症状自评量表(SCL-90)．对某高校大学生进行抽样调查。结果调查真组内部SCL-90测评分，除人际敏感项以外．其不同年龄、性别组的各指标间未见显著性差异；调查组与常模组比较．调查组显著高于常模组的项目有阳性项目数、恐怖和精神病性。而显著低于常模姐的项目有阳性均分、躯体化及人际敏感等；同时揭示了调查组前10位阳性症状表现。结论SAILS封大学生心身健康造成了一定程度的影响．且有明显的症状表现。

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简介：AbstractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to evolve, generating new variants that pose a threat to global health; therefore, it is imperative to obtain safe and broad-spectrum antivirals against SARS-CoV-2 and its variants. To this end, we screened compounds for their ability to inhibit viral entry, which is a critical step in virus infection. Twenty compounds that have been previously reported to inhibit SARS-CoV-2 replication were tested by using pseudoviruses containing the spike protein from the original strain (SARS-CoV-2-WH01). The cytotoxicity of these compounds was determined. Furthermore, we identified six compounds with strong antagonistic activity against the WH01 pseudovirus, and low cytotoxicity was identified. These compounds were then evaluated for their efficacy against pseudoviruses expressing the spike protein from B.1.617.2 (Delta) and B.1.1.529 (Omicron), the two most prevalent circulating strains. These assays demonstrated that two phenothiazine compounds, trifluoperazine 2HCl and thioridazine HCl, inhibit the infection of Delta and Omicron pseudoviruses. Finally, we discovered that these two compounds were highly effective against authentic SARS-CoV-2 viruses, including the WH01, Delta, and Omicron strains. Our study identified potential broad-spectrum SARS-CoV-2 inhibitors and provided insights into the development of novel therapeutics.

简介：AbstractOmicron (B.1.1.529), the fifth variant of concern (VOC) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was firstly identified in November 2021 in South Africa. Omicron contains far more genome mutations than any other VOCs ever found, raising significant concerns about its increased transmissibility and immune evasion. Here, we report the importation of the Omicron variant into Beijing, China, in December 2021. Full-length genome sequences of five imported strains were obtained, with their genetic features characterized. Each strain contained 57 to 61 nucleotide substitutions, 39 deletions, and 9 insertions in the genome. Thirty to thirty-two amino acid changes were found in the spike proteins of the five strains. The phylogenetic tree constructed by the maximum likelihood method showed that all five imported genomes belonged to Omicron (BA.1) (alias of B.1.1.529.1), which is leading to the current surge of coronavirus disease 2019 (COVID-19) cases worldwide. The globally increased COVID-19 cases driven by the Omicron variant pose a significant challenge to disease prevention and control in China. Continuous viral genetic surveillance and increased testing among international travellers are required to contain this highly contagious variant.

简介：AbstractAt present, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spread worldwide, which has emerged multiple variants and brought a threat to global public health. To analyze the genomic characteristics and variations of SARS-CoV-2 imported into Beijing, we collected the respiratory tract specimens of 112 cases of coronavirus disease 2019 (COVID-19) from January to September 2021 in Beijing, China, including 40 local cases and 72 imported cases. The whole-genome sequences of the viruses were sequenced by the next-generation sequencing method. Variant markers and phylogenic features of SARS-CoV-2 were analyzed. Our results showed that in all 112 sequences, the mutations were concentrated in spike protein. D614G was found in all sequences, and mutations including L452R, T478K, P681R/H, and D950N in some cases. Furthermore, 112 sequences belonged to 23 lineages by phylogenetic analysis. B.1.1.7 (Alpha) and B.1.617.2 (Delta) lineages were dominant. Our study drew a variation image of SARS-CoV-2 and could help evaluate the potential risk of COVID-19 for pandemic preparedness and response.

简介：摘要新型冠状病毒肺炎疫情在世界范围肆虐，给全球公共卫生事业带来了极大冲击。本文从严重急性呼吸综合征冠状病毒2(SARS-CoV-2)引起的固有免疫应答、体液免疫应答、细胞免疫应答、免疫逃避与交叉免疫五方面对现有研究进行综述，希望通过阐述免疫机制中的作用靶点，为SARS-CoV-2的治疗与预防贡献新思路。

简介：北京协和医院感染内科和中国医学科学院艾滋病研究中心合作，通过针对“传染性非典型肺炎”（SARS）康复者的体液和细胞免疫应答的长期随访研究发现，SARS康复者体内持续存在高水平的中和抗体．这一研究结果对明确SARS的发病机制和今后相关疫苗的研发具有重要意义，也为临床治疗SARS提供了新的思路．该研究的相关文章，发表于最新一期的著名生物医学杂志《科学公共图书馆》（《PLOSONE》）上．

简介：目的评价SARS患者血清铁变化的意义。方法根据中国疾病预防控制中心颁布的诊断标准，66例全部为确诊病例，血清铁统一由我院检验科检测。结果大多数SARS患者的血清铁呈动态变化，从低到高再到恢复正常。结论SARS患者血清铁的变化积仅仅是本病的一种伴随现象还是血清铁参与了某些重要功能需要进一步研究。

简介：SARS是一种由新型的冠状病毒引起的呼吸道传染病，其流行特征表现为医院内感染和家庭内感染为主。SARS的传染源主要是感染SARS病毒并发病的患者，传播主要途径为呼吸道传播和密切接触传播，近距离接触病人的飞沫是重要的传播途径，该病的传染性强，在SARS疫苗尚未应用到人群进行免疫之前，人体对它普遍易感。预防和控制SARS的传播蔓延，必须加强传染源管理，阻断传播途径，保护易感人群。

简介：传染性非典型肺炎是由新型冠状病毒引起的具有严重传染性的急性呼吸道传染病，主要通过飞沫近距离传播。世界卫生组织将其命名为重症急性呼吸综合征(SARS)。自2002年11月在我国广东暴发以来，我国大陆累积临床诊断病例高达5000余例，全球累积病例超过8400例，死亡逾800例。

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