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简介：<正>回顾性分析105例SARS患者使用NIPPV治疗的情况,包括适应证、参数调节、疗效和副作用观察,以及进行NIPPV治疗期间医务人员的感染率。结果:使用NIPPV者共24例,死亡5例。使用NIPPV最常见的副作用为皮下气肿,共出现4例,发生率为16.7％。治疗过程中无1例医务人员发生感染。提示NIPPV是治疗重症SARS安全而有效的方法,合理的使用NIPPV

简介：今年上半年,SARS在我国一些地区肆虐流行,严重威胁着人民群众的生命健康,影响了我国社会经济生活的正常秩序.从法律的角度,分析了防治SARS过程中的各类部门、机构、人员的法定职责以及相应法律责任.

简介：这就是控制SARS的强制治疗、强制隔离措施的法律依据,在很大程度上可以认定为在SARS疫情下的若干行政行为是行政强制制度中的即时强制,那么上述种种行政强制行为就应该是紧急状态下的行政行为

简介：ToinvestigatethesignificanceoftheSARS-associatedcoronavirus(SARS-CoV)antibody,detectedbyELISAandindirectimmunofluorescenceassays(IFA)fortheSARS-CoVVeroE6celllysates,innon-SARSsubjects,114serumsamplesfromhealthycontrolsand104serumspecimensfromautoimmunediseasepatientswerecollected.TheresultsofELISAshowedthatamong114serafromhealthycontrols,4(3.5%)werepositiveofSARS-CoV-IgGantibodyand114(100%)wereallnegativeofSARS-CoV-IgMantibody;thespecificityofSARS-CoV-IgGantibodyforSARSpatientswas96.5%,butthespecificityofbothSARS-CoV-IgGand-IgMantibodiesforSARSpatientswas100%.In58caseswithSLE,positiveratesofSARS-CoV-IgGand-IgMantibodieswere32.8%(19/58)and8.6%(5/58),respectively,inwhich11cases(19%)werepositiveofbothSARS-CoV-IgGand-IgMantibodies;in10caseswithSS,positiverateofbothSARS-CoV-IgGand-IgMantibodieswas10%(1/10);in16caseswithMCTD,positiverateofSARS-CoV-IgGwas37.5%(6/16),positiverateofbothSARS-CoV-IgGand-IgMantibodieswas6.3%(1/16);in20caseswithRA,onecasewaspositive(5%)ofSARS-CoV-IgG.However,ofallsampleswithpositiveSARS-CoV-IgGand-IgMantibodiesforautoimmunediseasesandhealthycontrols,SARS-CoVRNAandantibodieswereallnegativebyRT-PCRandIFA.AllserafornegativeorpositiveELISAresultswerealsonegativeorpositiveresultsusingELISAwithVeroE6cellslysates.ThesestudiesshowedthatSARS-CoVVeroE6celllysatesfortheELISAtodetectSARS-CoVantibodiescouldleadtothefalse-positivereactionsorcross-reactionsofSARS-CoVantibodiesinnon-SARSdiseasesandhealthycontrols,andthefalse-positivereactionsorcross-reactionswererelatedtoVeroE6celllysatesandautoantibodiesinnon-SARSpopulation.

简介：目的观察抗流感病毒药物阿比多尔(arbidole)体外抗SARS-CoV作用.方法以利巴韦林作为阳性对照药,采用MTT法和细胞病变(CPE)法,观察阿比多尔对SARS-CoV的抑制作用.结果MTT法测得阿比多尔对细胞的最大无毒浓度为10μg*ml-1,对SARS-CoV的IC50为7.14μg*ml-1,治疗指数TI为1.77.阳性对照药利巴韦林的IC50为66.1μg*ml-1,治疗指数TI>6.1.结论阿比多尔在体外对SARS-CoV有抑制作用.

简介：在与SARS第一次较量的初期,广东省有众多医护人员被SARS病毒击倒,有一些甚至被SARS夺走了宝贵生命,这是一起世界医学史罕见的事件.本文的目的是探讨导致众多医护人员感染SARS的原因,并从中吸取经验教训,避免此类人间悲剧重演.初步研究结果表明,导致众多医护人员感染SARS的原因是多方面的,既有内因,也有外因,其主要包括:(1)机体的免疫力不足以抵御SARS病毒的攻击:(2)SARS突如其来,医护人同对其认识不足,警惕性不高;(3)医护人员与SARS病人近距离接触,暴露于污染环境的时间过长;(4)医护人中未能及时获取疫情信息:(5)医护人员个人防护措施不力.在SARS疫苗面世之前,口罩是个人预防SARS病毒感染的最重要的武器.今后,在面对突然降临人间的传染病时,医护人员不但要勇于斗争,而且要善于斗争,在积极救治病人的同时,切实做好自身防护,防患于未然.

简介：AbstractHost immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), especially in children, are still under investigation. Children with coronavirus disease 2019 (COVID-19) constitute a significant study group of immune responses as they rarely present with severe clinical manifestations, require hospitalization, or develop complications such as multisystem inflammatory syndrome in children (MIS-C) associated with SARS-CoV-2 infection. The deciphering of children's immune responses during COVID-19 infection will provide information about the protective mechanisms, while new potential targets for future therapies are likely to be revealed. Despite the limited immunological studies in children with COVID-19, this review compares data between adults and children in terms of innate and adaptive immunity to SARS-CoV-2, discusses the possible reasons why children are mostly asymptomatic, and highlights unanswered or unclear immunological issues. Current evidence suggests that the activity of innate immunity seems to be crucial to the early phases of SARS-CoV-2 infection and adaptive memory immunity is vital to prevent reinfection.

简介：AbstractArtificial intelligence (AI) has proven time and time again to be a game-changer innovation in every walk of life, including medicine. Introduced by Dr. Gunn in 1976 to accurately diagnose acute abdominal pain and list potential differentials, AI has since come a long way. In particular, AI has been aiding in radiological diagnoses with good sensitivity and specificity by using machine learning algorithms. With the coronavirus disease 2019 pandemic, AI has proven to be more than just a tool to facilitate healthcare workers in decision making and limiting physician-patient contact during the pandemic. It has guided governments and key policymakers in formulating and implementing laws, such as lockdowns and travel restrictions, to curb the spread of this viral disease. This has been made possible by the use of social media to map severe acute respiratory syndrome coronavirus 2 hotspots, laying the basis of the "smart lockdown" strategy that has been adopted globally. However, these benefits might be accompanied with concerns regarding privacy and unconsented surveillance, necessitating authorities to develop sincere and ethical government–public relations.

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简介：2003年中国大地上抗击SARS(传染性非典型肺炎)的战役使疾病预防控制(以下简称:疾控)中心的知名度急剧上升,与此同时,政府、社会各方也全部聚焦于各级疾病预防控制部门.

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简介：摘 要：2020年，我国成功研制出新冠病毒灭活疫苗，在全球抗疫斗争中做出重要贡献，本文描述了新冠病毒灭活疫苗的研制方法，并深入了解中国国药集团新冠病毒疫苗制备工艺。

简介：总结急诊科抗击SARS工作中的组织与管理经验,以供广大护理同仁借鉴,包括以下三点防止人员感染的关键环节:①及早建立合理的隔离区域;②加强环境的消毒和患者的管理;③医务人员科学防护与心理支持.

简介：社会的文明、医学科学的进步,使得人们淡漠了过去危害人民健康的一些急性传染病,而今春的SARS流行给我们现行的疾病预防和控制提出了严峻的挑战,在医学教育中加强和重视预防医学教育、社区预防医学实践是医学教育工作者的责任,也是医学和社会发展的必然.

简介：AbstractImportance:In this study, we retrospectively investigated the seroprevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies within serum samples from children in Beijing, China. These findings provide preliminary guidance regarding population susceptibility to SARS-CoV-2, which will aid in establishing policy toward coronavirus disease 2019 (COVID-19) prevention and control.Objective:To understand the seropositivity of anti-SARS-CoV-2 IgM/IgG antibodies among children in Beijing, China, evaluate the susceptibility of children in Beijing to SARS-CoV-2, and provide prima facie evidence to guide SARS-CoV-2 prevention and control.Methods:IgM/IgG antibody kits (colloidal gold) were used to conduct preliminary screening of SARS-CoV-2 IgM/IgG antibodies in serum samples of children who presented to Beijing Children’s Hospital, Capital Medical University, having fever or requiring hospitalization, from March 2020 to August 2020. Statistical analysis of anti-SARS-CoV-2 antibody seropositivity was performed according to the children’s general demographic characteristics, timing of admission to hospital, presence of pneumonia, and viral nucleic acid test results.Results:The study included 19 797 children with both IgM and IgG antibody results. Twenty-four children had anti-SARS-CoV-2 IgM-positive results (positive rate of 1.2‰), twelve children had anti-SARS-CoV-2 IgG-positive results (positive rate of 0.6‰). Viral nucleic acid test results were negative for the above-mentioned children with positive antibody findings; during the study, two children exhibited positive viral nucleic acid test results, but their anti-SARS-CoV-2 IgM/IgG antibody results were negative. Anti-SARS-CoV-2 IgM antibody seropositivity was higher in the <1-year-old group than in the ≥6-year-old group. The rates of anti-SARS-CoV-2 IgM seropositivity was highest in August from March to August; IgG results did not significantly differ over time. The rates of anti-SARS-CoV-2 IgM or IgG seropositivity among children with and without suspected pneumonia did not significantly differ between groups.Interpretation:During the study period, the rates of anti-SARS-CoV-2 IgM/IgG antibody seropositivity were low among children who presented to Beijing Children’s Hospital, Capital Medical University. The findings suggest that children in Beijing are generally susceptible to SARS-CoV-2 infection; COVID-19 prevention and control measures should be strengthened to prevent disease in children.

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简介：传染性非典型肺炎(严重急性呼吸道综合症)。其主要的流行病学和临床特征基本有：极强的传染性、发热(>38℃)并伴咳嗽、呼吸加速、气促、或呼吸窘迫综合症、肺部罗音或有肺部实变体征之一以上。重症患者会出现呼吸困难、低氧血症、甚至出现休克、ARDS、MODS(多器官功能障碍综合征)。

简介：2003年初，中国突然发生了SARS暴发流行。在党中央的英明领导下，中华民族万众一心，经过可歌可泣的战斗，一举扭转了最初对SARS作战被动的局面，化解了危机，保障了人民的健康。