简介：INTRODUCTIONTissueengineeringisapromisingapproachtolargesegmentalbonerepairfortrauma,replacementsurgery,skeletaldeficiencyorabnormaldevelopment.Thefabricationofboneregenerationscaffoldswithappropriateboneconductiveproperty,boneinductiveproperty,biodegradationpropertyandmechanicalpropertiesisthecruxofthisapproach.

简介：INTRODUCTIONBonebiomaterialshavebeenwelldevelopedinrecentyearsandfrequentlyusedclinicallyinorthopedic,traumaticandodontologicalsurgeries.Amongst,bioceramicsissimilartothemineralconstituentsofourskeletonandhighlyappraisedduetoitsexcellentcharacteristicsinbio-compatibility,mechanicalandbio-degradableproperties,andbone-inductivity.

简介：基本上在在vitro和细胞外的矩阵种相关房间上面做的织物工程。织物工程的一个主要目标到preparate多孔为房间的三尺寸脚手架增殖，移居，differention并且形成理想的织物和机关的结构。在这研究，各种各样的内容的效果和到chitosan的木钉的macromolecular重量被调查并且评估。chitosan的毛孔形态学被改变集中控制，PEG.Chitosan多孔的支架的macromolecular重量有interconecting孔。毛孔形态学能与改变木钉集中和macromolecular重量被控制。毛孔尺寸在之间1050嗯，在水里胀大的度是85.70%。

简介：Theeffectsofvariouscartilageextracellularmatrixontheconstructionofrabbitgrowthplatecartilagetissueinvitrowerestudied.Theresultsshowthatcollagen,proteoglycanandhyaluronicacidcanpromotethegrowthofculturedchondrocytesbuttheeffectsofvariouscartilageextracellularmatrix(ECM)onchondrocytedifferentiationaredifferent.Collagencanpromotethehypertrophyofchondrocyteswhileproteoglycanandhyaluronicacidinhibitthetransitionofmaturechondrocytesintohypertrophiedchondrocytes.

简介：FUNCTIONSOFCELLSSCAFFOLDINTHETISSUEENGINEERINGCell,cellsscaffoldandtheconstructionoftissueandorganarethreemainfactorsfortheTissueEngineering.Amainfunctionofcellsscaffoldintissueengineeringistoprovideanenvironmentforcellspropagation.

简介：INTRODUCTIONThecommonconstructionmethodoftissueengineeredarticularcartilageistoisolateandculturechondrocytes,transplantthemintothedegradablescaffoldmaterials,thentorepairthedefectofarticularcartilage.Wedesignedthisexperimenttoinvestigatethefeasibilityoftissueengineeredarticularcartilageconstructedbythetechniqueofcentrifugetubeculturewithoutscaffoldmaterials.

简介：ＡＰＲＥＬＩＭＩＮＡＲＹＡＮＡＬＹＳＩＳＦＯＲＴＨＥＲＭＯＤＹＮＡＭＩＣＭＯＤＥＬＯＦＴＩＳＳＵＥＨＥＡＴＩＮＧＤＵＲＩＮＧＲＡＤＩＯＦＲＥＱＵＥＮＣＹＡＢＬＡＴＩＯＮＡＰＲＥＬＩＭＩＮＡＲＹＡＮＡＬＹＳＩＳＦＯＲＴＨＥＲＭＯＤＹＮＡＭＩＣＭＯＤＥＬ...

简介：这研究的目的是准备PVA-GAG-COL，并且调查为织物工程用作脚手架的可行性合成的由聚乙烯化合物的酒精(PVA)的材料，glycosaminoglycan(作呕)并且骨胶原(关口)。PVA与各种各样的数量被混合作呕并且关口。不同比例的脚手架能与不同分子的重量和PVA的醇解度和不同数量被获得作呕，它展出了高水位线内容(60%-95%)并且与胀大的比率(120%-620%)显示出不同内部配置。SEM证明不同合成材料有不同多孔的结构。

简介：ＡＮＥＸＰＥＲＩＭＥＮＴＡＬＳＴＵＤＹＯＮＴＨＥＨＥＰＡＲＩＮ－ＦＲＥＥＨＥＭＯＤＩＡＬＹＳＩＳＯＦＨＥＭＯＰＨＡＮＡＤＳＯＲＰＴＩＯＮＡＮＥＸＰＥＲＩＭＥＮＴＡＬＳＴＵＤＹＯＮＴＨＥＨＥＰＡＲＩＮ－ＦＲＥＥＨＥＭＯＤＩＡＬＹＳＩＳＯＦＨＥＭＯＰＨＡ...

简介：Withthedevelopmentofbiomedicalengineering,thethermophysicalpropertiesoftheorgansandtissuesoflivinganimalsbecomeessential.However,becausetheytendtobeofirregularshapes,limitedsizesandwithlowintensityinnerheatsource,themeasuringofthethermophysicalpropertiesoftheorgansandtissuesoflivingan-imalsismuchmoredifficult.

简介：Objective:AnovelPVA-CaAlgcompositematerialbypolyvinylalcohol(PVA)andsodiumalginate(SA)wasfabricatedtoinvestigatethefeasibilityservingasascaffoldfortissueengineeringandtofindoutthemostidealproportionaccordingtotheirproperties.Methods:Film,graininessandspongescaffoldsofPVA-CaAlgwerefabricatedbythreedifferentmethods.Watercontentandswellingratioweretested.SEMwasusedtoobservetheconfigurationofthecrosssection.Results:DifferentproportionalscaffoldscouldbeobtainedwithdifferentPVAmolecularweight,alcoholysisdegreeanddifferentSAdosages.Thewatercontentofdifferentscaffoldsrangedfrom48%to93%andshoweddifferentinnerconfigurationwithswellingratiobetween120%and470%.SEMprovedthatdifferentcompositematerialshaddifferentporousstructures.Conclusion:AscaffoldfortissueengineeringwithhighwatercontentandproperswellingratiocanbefabricatedusingPVAandSA.Theporousstructureshowspotentialintissueengineeringandcellculture.

简介：Bioluminescenceimagingisakindofemergingdetectiontechnologyatcellular,molecularandgeneticlevel.Themostpopularbioluminescenceimagingmodelisdiffusionapproximation(DA).However,becauseoftheill-posednessoftheDA-basedinverseproblemandtheinstabilityofreconstructionalgorithms,thelocationaccuracyofthereconstructedsourcesislow.Radiativetransferequation(RTE),whichconsidersthedirectionofthephotonmigrationandtheeffectofabsorptionandscatteringintissues,canaccuratelyexpressthetransmissionofbioluminescentphotonsthroughthetissues.Inthispaper,westudiedthebioluminescenceimagingbasedontheRTE.2Dsimulationswereperformed,andquantitativeevaluationwasgivenbytheabsolutesourcepositionerror,therelativesourceareaerrorandtheminimumboundingbox.TheresultsoftheexperimentshowedthattheimagingqualitybasedonRTEwasbetterthanthatonebasedonDA.

简介：Inanefforttodevelopamethodforcartilagetissueengineering,researcherssuccessfullyusedcartilagecellsfromcowkneejoints.Bycreatingasuccessfulmethodwithconditionsconducivetogrowinghealthycartilagetissue,thefindingscouldhelpleadtoanewtreatmentcureforosteoarthritisusingstemcell-basedtissueengineering.Articularcartilageistissuethatisfoundonallthejointsurfacesinthebody.Sincethetissueis

简介：Intracerebralhaemorrhage（ICH）,whichhasrapidattackandhighdeathrate,usuallyleadstobadoutcomes.Poorprognosisofthisdiseaseisprimarilyduetothedifficultyofearlydiscovery.Earlydetectionordiagnosiswouldsignificantlyreducetherateofdisabilityandmortality,andimprovetheprognosisofthepatients.Thepurposeofthispaperistotestifyelectricalimpedancechangeanddetectionofbraintissueaftercerebralischemicwithelectricalimpedancetomography.Inthisstudy,electricalimpedancetomography（EIT）wasappliedtodetecttheonsetofmodeledonrabbitsinrealtime,ICHmodelgroupwereinjectedcollagenaseintheCorpusStriatumwhilerabbitsincontrolgroupwereinjectedthesamevolumeofsalinewithcollagenase.Thesubsequentprocesswasmonitoredcontinuouslybysystemofelectricalimpedancetomography;therabbitsweresacrificedbyintravenousinjectionofoverdoseofhydrationchlorinealdehyde,andthentakenintobeingscannedbycomputedtomography（CT）witharesolutionof1mmwithin10minafterdeath.Afterthat,thebrainsoftherabbitsweretakenout,fixedandcutintoslicestodetectthechangesofbraintissue.Wefoundthatone-dimensionalimpedanceandtwo-dimensional（2D）imagesofelectricresistanceofbrainoftherabbitspretreatedwithcoilagenaseobviouslychangedafterinjectionandthehemorrhagecouldbefoundintheslicesofbrainandtherewerechangesinthemodelrabbitsgroupnotonlytheelectricresistancebutalsothebraintissues.quantitativeindexcan＇tbeprovidedbydetectionofintracerebralhemorrhageAlthoughinrabbitswithelectricalimpedancetomography＇satthisstage,cerebralhemorrhagecancausebrainelectricalimpedancecharactersofthechange,thecompletedexperimentssuggestthatelectricalimoedancetomograophr（EIT）maybecomeaneffectivetechniauetodetectICH.

简介：Thisresearchusesalginateandhyaluronicacidasthemaincomponenttopreparesupport,thenexploresthepossibilitiesasatissueengineeringscaffold.Firstly,prepareHAwithvariousaveragemolecularweightandalginatewithdifferentviscosity,mixthemupatacertainproportionandmakeitintoaAlgCa2+-HAcompositescaffoldwithafilm-formingmethod.Thisarticlediscussesthefeasibilityofthisscaffoldusedintissueengineeringfieldaccordingtotheconsequenceofmoisturecontenttesting,mechanicalanalysis,andscanningelectronmicroscopyanalysis.ThestructureandpropertiesofAlgCa2+-HAcompositescaffoldarecloselyrelatedtosomefactorssuchasaveragemolecularweightofhyaluronicacid,hyaluronicacidconcentration,alginateviscosity,cross-linkingagentsandprocessingtechnology.TheAlgCa2+-HAcompositematerial,whichisatdifferentproportionsandaddingdifferentcross-linkingagent,hassomecertaincharacteristics:moisturecontentrangingfrom50%to95%,tensilestrengthbetween2.69N/mm2and4.299N/mm2,andelongationatbreakisabout58%to160%.ThepreparedAlgCa2+-HAcompositescaffoldscanbeusedastissueengineeringscaffoldsresultingfromitshighmoisturecontent,goodmechanicalpropertiesandidealporestructure.更多还原

简介：INTRODUCTIONApproximately400millionpersonsworldwidesufferfrombladderdisease.Individualswithend-stagebladderdiseaseoftenrequirebladderreplacementorrepair.Severalbladdersubstituteshavebeenattemptedwithbothorganicmaterialsandsynthetics.

简介：Theobjectiveofthispaperistodesignaporouspolyvinylalcohol(PVA)basedoncompositemembranewithcertainmechanicalstrengthandbiocompatibilitiesservingastissueregenerativescaffolds.PVA-glycosaminoglycan(GAG)-typeIcollagen(COL)compositemembranewasfabricatedbyPVAwithdifferentmolecularweight(Mw)andalcoholysisdegree(AD)beingblendedwithcertainamountsofGAGandCOLanddriedat38℃for24h.Thewatercontentofthecompositemembraneswerefrom61.9%to95.1%andswellingratiorangedfrom123.6%to621.7%.Scanningelectronmicroscope(SEM)analysisprovedthatPVA-GAG-COLcompositemembranehasporousandhomogenousstructure.Biocompatibilitytestresultsshowedthatthecompositemembranewasnontoxic,whichcouldpromoteadhesionandproliferationoffibroblastsonthecompositemembrane.Inconclusion,PVA-GAG-COLcompositemembranewithhighwatercontentandswellingratio,suitablemechanicalstrengthandgoodbiocompatibility,haspotentialintissueengineeringandregenerativemedicine.更多还原

简介：Theobjectiveofthisstudywastoproducetheporouscollagen-chitosan/Glycosanminglycans(GAG)forcornealceil-seedimplantasathree-dimensionaltissueengineeringscaffoldtoimprovetheregenerationcorneas.Theeffectofvariouscontentofglycerolasformporousagenttocollagen-chitosan/GAGpreservedaporousdimensionalstructurewasinvestigated.Theheat-dryingwasusedtoprepareporouscollagen-chitosan/GAGscaffold.Theporemorphologyofcollagenchitosan/GAGwascontrolledbychangingtheconcentrationofglycerolsolutionanddryingmethods.TheporousstructuremorphologywasobservedbySEM.Thediameteroftheporesform10to50μm.Thehighlyporousscaffoldhadinterconnectingpores.Thecornealcellmorphologywasobservedunderthelightmicroscope.Theseresultssuggestthatcollagen-chitosan/GAGshowedthatcornealcellhaveformedconfluentlayersandresemblethesurfaceofnormalcornealcellsurface.

简介：ＣＨＡＮＧＥＳＯＦ６－Ｋ－ＰＧＦ１ａＲＥＬＥＡＳＥＦＲＯＭＴＨＥＬＵＭＩＮＡＬＳＵＲＦＡＣＥＯＦＤＡＣＲＯＮＳＥＥＤＥＤＷＩＴＨＡＵＴＯＬＯＯＵＳＶＥＮＯＵＳＴＩＳＳＵＥＦＲＡＧＭＥＮＴＳＣＨＡＮＧＥＳＯＦ６－Ｋ－ＰＧＦ１ａＲＥＬＥＡＳＥＦＲＯＭＴＨ...