简介:FewerthanonemillionHIVinfectedindividualsarecurrentlyreceivinganti-retroviraltherapy.ThelimitationsofsuchtreatmenthaveunderscoredtheneedtodevelopmoreeffectivestrategiestocontrolthespreadandpathogenesisofHIV.Typically,naturallyoccurringprotectiveimmuneresponsesprovidetheparadigmforsuchdevelopment.ItisnowclearhoweverthatHIVcanutilisethemillieuofanactivatedimmunesystemtoitsownreplicativeadvantage.Mobilisationoftheimmuneresponse,intendedtothwartofHIVcontributestolackofimmunecontrolandthedevelopmentofprogressivediseaseinthemajorityofinfected,untreatedindividuals.FurtherdelineationoftheintimateinteractionsbetweentheHIVandtheimmunesystemwillbecriticalandrecentadvancesinthisdirectionarediscussed.
简介:ProteomicshasbeenwidelyusedinthelastfewyearstolookfornewbiomarkersanddecipherthemechanismofHIV-hostinteraction.Herein,wereviewtherecentdevelopmentsofHIV/AIDSproteomicresearch,includingthesamplesusedinHIV/AIDSrelatedresearch,thetechnologiesusedforproteomicstudy,thediagnosisbiomarkersofHIV-associateddiseaseespeciallyHIV-associatedneurocognitiveimpairment,themechanismsofHIV-hostinteraction,HIV-associateddementia,substanceabuse,andsoon.Intheendofthisreview,wealsogivesomeprospectsaboutthelimitationandfutureimprovementofHIV/AIDSproteomicresearch.
简介:AbstractTransmission network analysis is a crucial evaluation tool aiming to explore the characteristics of the human immunodeficiency virus epidemic, develop evidence-based prevention strategies, and contribute to various areas of human immunodeficiency virus/acquired immunodeficiency syndrome prevention and control. Over recent decades, transmission networks have made tremendous strides in terms of modes, methods, applications, and various other aspects. Transmission network methods, including social, sexual, and molecular transmission networks, have played a pivotal role. Each transmission network research method has its advantages, as well as its limitations. In this study, we established a systematic review of these aforementioned transmission networks with respect to their definitions, applications, limitations, recent progress, and synthetic applications.
简介:Mother-to-ChildHIVIAIDSTransmissionClinicalstudiesindicatethattheriskofperinatalHIV/AIDStransmission,ifnotinterrupted,isbetween15and50percent.Internationalstatisticsshowthateveryyear,thereare2.4millionHIV/AIDSinfectedpregnantwomenwhogivebirthto800,000infectedbabies.HIVinfectionhascausedworldinfantmortalitytoriseby75percent.StatisticspublishedbytheChineseMinistryofHealthshowthatinsomeareas,perinatalHIV/AIDStransmissionhasincreasedfrom0.1percentto0.6percent,andthat30to40percentofinfectedmotherspassthekillervirusontotheirbabies.
简介:SmallinterferingRNA(siRNA)andmicroRNA(miRNA)aresmallRNAsof18-25nucleotides(nt)inlengththatplayimportantrolesinregulatinggeneexpression.TheyareincorporatedintoanRNA-inducedsilencingcomplex(RISC)andserveasguidesforsilencingtheircorrespondingtargetmRNAsbasedoncomplementarybase-pairing.ThepromiseofgenesilencinghasledmanyresearcherstoconsidersiRNAasananti-viraltool.However,inlong-termsettings,manyvirusesappeartoescapefromthistherapeuticalstrategy.Anexampleofthismaybeseeninthecaseofhumanimmunodeficiencyvirustype-1(HIV-1)whichisabletoevadeRNAsilencingbyeithermutatingthesiRNAtargetedsequenceorbyencodingforapartialsuppressorofRNAi(RNAinterference).Ontheotherhand,becausemiRNAtargetingdoesnotrequireabsolutecomplementarityofbase-pairing,mutationalescapebyvirusesfrommiRNAspecifiedsilencingmaybemoredifficulttoachieve.Inthisreview,wediscussstratagemsusedbyvariousvirusestoavoidthecells'antiviralsi/mi-RNAdefensesandnotionsofhowvirusesmightcontrolandregulatehostcellgenesbyencodingviralmiRNAs(vmiRNAs).
简介:摘要目的观察基线HIV-1 RNA > 50万copies/mL的HIV-1感染者,在高效抗反转录病毒治疗(highly active antiretroviral therapy,HAART)前后外周血totalHIV-1 DNA的变化。方法从国家十二五科技重大专项课题中选取基线HIV-1 RNA > 50万copies/mL且HAART 96周HIV-1 RNA < 50 copies/mL的初治HIV-1感染者为试验组,年龄性别相当的基线HIV-1 RNA < 50万copies/mL的HIV-1感染者为对照组。检测两组患者基线和HAART 24、48、96周时total HIV-1 DNA水平。结果基线及HAART 96周,试验组total HIV-1 DNA均高于对照组3.48(3.21~3.80)lg copies/106 PBMCsvs 2.90(2.54~3.30)lg copies /106 PBMCs(p<0.001),2.82(2.38~2.96)lgcopies/106 PBMCs vs 2.37(1.99~2.65) lg copies /106 PBMCs(p=0.001)。HAART 24周、48周,试验组detal HIV-1 DNA较对照组高0.67(0.41~1.03)lg copies/106 PBMCs vs 0.39(0.09~0.73)lg copies/106 PBMCs(P<0.001), 0.8(0.46~1.16)lg copies/106 PBMCs vs 0.43(0.04~0.63)lg copies/106 PBMCs(P<0.001)。且HAART前后total HIV-1 DNA水平均与基线病载正相关。结论基线极高病载患者HAART 96周内存在较高total HIV DNA水平,建议选择强效HAART方案来有效降低储存库。
简介:Themonkhasauspiciouspatternstattooedonhisforearms,followingafolkbeliefthatthetattoocouldchaseevilspiritsaway,andprotecthimfromcontractinganyincurabledisease.ThefaithisshakynowintheshadowofHIV/AIDSloomingaroundtheManchunmanTempleof1,400yearsold,wherethe24-year-oldDuSuwasordained14yearsago."Yourmonkerydoesn’tnecessarilyimmunizeyoufromit(AIDS).Really,nothingcankeepthatevilawayunlessyouliveahealthylife—nodrugabuse,nounsafesex,"saystheyoungmonkshyly,glancingathistattooedrightwrist.Hebecameawareofthedreadfuldiseasewhenitclaimedthelifeofthevoungerbrotherofhismaster,asenior
简介:Objective:TomakeasummaryofthetrendsofHIV/AIDSepidemicandrouteoftransmissioninShenzhenfrom1992to2000toprovidescientificevidenceforthepolicy-makertoformulatestrategiesofHIV/AIDSpreventionandcontrolinShenzhen.Method:ToanalyzeHIV/AIDSsurveillancedatainShenzhenfrom1992to2000bysoftwareEpi-Info.Results:OnehundredandtwoHIVpositivecasesincluding18AIDScases(threecasesdeceased)wereidentifiedinShenzhenfrom1992to2000.Amongthe102cases,thoseinfectedviasexwere46.0%,intravenousdruguse42.9%.Blooddonation7.8%,bloodtransfusionrecipient3.9%,andindeterminate2%.Conclusion:InShenzhen,HIV/AIDSinfectionisspreadingandincreasingrapidly.EffectivepreventionmeasuresmustbetakentoreducetheHIVprevalenceassoonaspossible.
简介:AbstractBackground:Human brucellosis is a neglected public health issue in China and reports of HIV-infected individuals complicated with brucellosis are rare. This report describes the case of an HIV-infected patient complicated with brucellosis. We want to raise awareness of clinical diagnosis of brucellosis among clinicians. Furthermore, we should be more concerned about cases with pyrexia of unknown origin, especially in non-epidemic areas of brucellosis in China.Case presentation:We encountered the case of a 31-year-old HIV-infected male with a CD4+ T lymphocyte count of approximately 300. On May 1, 2019, the patient had onset of non-specific caustic irregular fever with body temperature reaching 41.0 ℃. He was admitted to two medical institutions in Yunnan with pyrexia of unknown origin. Finally, on day 7 of hospitalization in the Public Health Clinical Medical Center in Chengdu City, he was diagnosed as having brucellosis infection based on blood culture results.Conclusions:This is the first reported case of brucellosis concomitant with HIV infection in China. Laboratories in infectious disease hospitals and category A level III hospitals in the southern provinces of China should be equipped with reagents for clinical diagnosis of brucellosis and to strengthen the awareness of brucellosis diagnosis in China. Secondly, in provinces with a high incidence of AIDS and brucellosis such as Xinjiang and Henan, it is recommended to implement a joint examination strategy to ensure the early detection, diagnosis, and treatment of this infection.